Method for treating an inflammatory disease

ABSTRACT

Compounds of the formula                    
     and quaternary ammonium ions thereof, wherein R 1  and R 2  are the same or different and are carbocyclic aryl or aromatic heterocyclic; A is methylene, carbonyl or sulfonyl; B is a single bond, C 1 -C 4  alkylene or C 2 -C 4  alkenylene; D is oxygen or sulfur; E is C 2 -C 6  alkylene, C 1 -C 6  haloalkylene, C 3 -C 6  cycloalkane-1,1-diyl or C 3 -C 6 -cycloalkane-1,1-diylmethyl; G is C 1 -C 4  alkylene or C 2 -C 4  alkenylene; and L is —NR 3  or —C(R 4 )(R 5 ), wherein R 3  is a carbocyclic aryl or an aromatic heterocyclic; R 4  is hydrogen, carbocyclic aryl or aromatic heterocyclic; R 5  is —COR 6 , C 1 -C 6  alkyl, C 1 -C 6  alkoxy, amino, or acylamino, wherein R 6  is C 1 -C 6  alkyl or C 1 -C 6  alkoxy, or R 4  and R 5  together with the carbon atom to which they are attached represent a C 5 -C 10  cycloalkyl or a C 5 -C 10  heterocyclic. The compounds have tachykinin receptor antagonist activity and exhibit an activity against both the NK 1  and NK 2  receptors.

This is a division of application Ser. No. 08/758,421 filed Dec. 2, 1996 (U.S. Pat. No. 6,159,967).

BACKGROUND TO THE INVENTION

The present invention relates to a series of new heterocyclic compounds having tachykinin receptor antagonist activity. It also provides methods and compositions using them for therapeutic and prophylactic purposes, as well as processes for their preparation and intermediates used in their preparation.

The presence in the mammalian body of the various forms of tachykinin is associated with a variety of diseases and disorders, including respiratory diseases, such as asthma, bronchitis, rhinitis and coughs; allergies; ophthalmic inflammatory diseases, such as conjunctivitis and spring catarrh; dermal diseases, such as contact dermatitis, atopic dermatosis and urticaria; inflammatory diseases, such as rheumatism and arthrosis deformans; pain, such as migraine, headache and toothache; central nervous system diseases, such as anxiety and Alzheimer's disease; and gastrointestinal diseases, such as colitis; and cystitis; and many others. Inhibition of the activity of these forms of tachykinin will, therefore, result in a new therapy and/or prophylaxis for these diseases and disorders.

The compounds of the present invention exhibit antagonism generally to tachykinin receptors, but especially to the receptors for substance P (which receptors are generally referred to as “neurokinin 1 receptors” —NK₁) and the receptors for neurokinin A (which receptors are generally referred to as “neurokinin 2 receptors” —NK₂). It is a particular advantage of the compounds of the present invention that they exhibit antagonism to both of these receptors, a so-called “dual effect”.

Compounds which are structurally close to those of the present invention are disclosed in FR 2729952, FR 2729953 and FR 2729954. However, these are selective for the NK₁ receptors and none of these compounds exhibits the dual effects of the compounds of the present invention.

A few low molecular weight non-peptide compounds are known to exhibit antagonism to both of these receptors, for example some of the compounds disclosed in WO 9429309 (1994), WO 9417045 (1994), WO 9426735 (1994) and WO 9528389 (1995) exhibit such an effect. Typical examples of compounds which are disclosed in these documents are:

However, oral absorption of these compounds is poor. As a result, these prior art compounds cannot be administered by mouth and must be administered parenterally, for example by injection. It is well known in the medical field that administration of any drug by injection is undesirable, as either the patient must be trained (and some patients are inherently untrainable) or the drug must be administered by experienced staff, which is expensive and inconvenient both for the patient and the staff.

There is, therefore, a need for a new tachykinin receptor antagonist which exhibits the aforementioned dual effects, and which has good oral absorption and a low toxicity.

We have now discovered a series of new compounds which exhibit an activity against the NK₁ receptors which is at least equal to that of the prior art compounds showing a dual effect and which unexpectedly exhibit a much stronger activity against the NK₂ receptors.

BRIEF SUMMARY OF INVENTION

It is, therefore, an object of the present invention to provide a series of new heterocyclic compounds.

It is a further, and more specific, object of the present invention to provide such compounds which exhibit antagonism to tachykinin receptors.

It is a still further, and more specific, object of the present invention to provide such compounds which exhibit antagonism to those tachykinin receptors known as NK₁ and NK₂.

It is a still further, and more specific, object of the present invention to provide certain of such compounds which exhibit greatly improved activity.

Other objects and advantages of the present invention will become apparent as the description proceeds.

The compounds of the present invention are those compounds of formula (I):

and the quaternary ammonium derivative thereof of formula (Ia):

wherein:

R¹ and R² are the same as or different from each other, and each represents a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below;

A represents a methylene group, a carbonyl group or a sulfonyl group;

B represents a single bond between the groups represented by A and R¹, an alkylene group having from 1 to 4 carbon atoms or an alkenylene group having from 2 to 4 carbon atoms;

D represents an oxygen or sulfur atom;

E represents an alkylene group having from 1 to 6 carbon atoms, a haloalkylene group having from 1 to 6 carbon atoms, a cycloalkane-1,1-diyl group having from 3 to 6 carbon atoms, a cycloalkane-1,1-diylmethyl group having from 3 to 6 carbon atoms in the cycloalkane part, or a cycloalkane-1,1-di(ylmethyl) group having from 3 to 6 carbon atoms in the cycloalkane part;

G represents an alkylene group having from 1 to 4 carbon atoms or an alkenylene group having from 2 to 4 carbon atoms;

L represents a group of formula —N(R³)— or a group of formula —C(R⁴)(R⁵)—

wherein R³ represents a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below,

R⁴ represents a hydrogen atom, a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below, and

R⁵ represents a group of formula —CO—R⁶, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an amino group, an acylamino group, an alkyl group which has from 1 to 6 carbon atoms and which is substituted by an acylamino group, an acylamino group whose nitrogen atom is substituted with an alkyl group having from 1 to 6 carbon atoms, a hydroxy group, a hydroxyalkyl group having from 1 to 6 carbon atoms, an alkoxyalkyl group in which the alkoxy and alkyl parts each has from 1 to 6 carbon atoms, or an aralkyloxyalkyl group having from 1 to 6 carbon atoms in the oxyalkyl part, and in which the aralkyl part is an alkyl group which has from 1 to 4 carbon atoms and which is substituted by from 1 to 3 carbocyclic aryl groups which are unsubstituted or which are substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below,

wherein R⁶ represents an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, a group of formula —NR^(a)R^(b), a carbocyclic aryl group or a heterocyclic group, said aryl group and said heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below

wherein R^(a) represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an aliphatic carboxylic acyl group having from 1 to 6 carbon atoms, an alkanesulfonyl group having from 1 to 6 carbon atoms, a haloalkanesulfonyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a carbocyclic aryl group which is unsubstituted or which is substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below, or an aralkyl group in which an alkyl group having from 1 to 4 carbon atoms is substituted by from 1 to 3 carbocyclic aryl groups as defined above, and

R^(b) represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an aliphatic carboxylic acyl group having from 1 to 6 carbon atoms, an alkanesulfonyl group having from 1 to 6 carbon atoms, a haloalkanesulfonyl group having from 1 to 6 carbon atoms, a cycloalkyl group having from 3 to 8 carbon atoms, a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below, or an aralkyl group in which an alkyl group having from 1 to 4 carbon atoms is substituted by from 1 to 3 carbocyclic aryl groups as defined above,

or

R^(a) and R^(b) together with the nitrogen atom to which they are attached represent a nitrogen-containing heterocyclic group,

or

R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group having from 5 to 10 ring atoms, said group being unsubstituted or being substituted by at least one substituent selected from the group consisting of substituents β, defined below, and said heterocyclic group having a single hetero-atom selected from the group consisting of nitrogen, oxygen and sulfur atoms, or R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group as defined above which is fused to a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined below;

R⁷ represents an alkyl group having from 1 to 6 carbon atoms; and

said substituents α are selected from the group consisting of halogen atoms, alkyl groups having from 1 to 6 carbon atoms, haloalkyl groups having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms, aliphatic carboxylic acyl groups having from 1 to 6 carbon atoms, alkanesulfonyl groups having from 1 to 6 carbon atoms, haloalkanesulfonyl groups having from 1 to 6 carbon atoms, hydroxy groups, carboxy groups, alkoxycarbonyl groups having from 1 to 6 carbon atoms in the alkoxy part, acylamino groups having from 1 to 6 carbon atoms, alkanesulfonylamino groups having from 1 to 6 carbon atoms, haloalkanesulfonylamino groups having from 1 to 6 carbon atoms, amino groups, cyano groups, and alkylene groups having from 1 to 8 carbon atoms (to form a cycloalkyl group fused with the aryl or heterocyclic ring);

said substituents β are:

when substituting a carbon atom, oxo groups,

when substituting a nitrogen atom, selected from the group consisting of aliphatic acyl groups, alkanesulfonyl groups having from 1 to 6 carbon atoms, alkyl groups having from 1 to 6 carbon atoms which are unsubstituted or are substituted by at least one substituent preferably selected from the group consisting of substituents γ, defined below, carbocyclic aryl groups which are unsubstituted or are substituted by at least one substituent preferably selected from the group consisting of substituents α, defined above, and aralkyl groups in which an alkyl group having from 1 to 4 carbon atoms is substituted by from 1 to 3 carbocyclic aryl groups as defined above,

and, when substituting a sulfur atom, one or two oxygen atoms to form a sulfoxide or sulfone group; and

said substituents γ are selected from the group consisting of halogen atoms, alkoxy groups having from 1 to 6 carbon atoms, aliphatic carboxylic acyl groups having from 1 to 6 carbon atoms, alkanesulfonyl groups having from 1 to 6 carbon atoms, haloalkanesulfonyl groups having from 1 to 6 carbon atoms, hydroxy groups, carboxy groups, alkoxycarbonyl groups having from 1 to 6 carbon atoms in the alkoxy part, acylamino groups having from 1 to 6 carbon atoms, amino groups, and cyano groups;

and pharmaceutically acceptable salts and esters thereof.

The invention also provides a composition for the treatment or prophylaxis of central nervous system diseases, neurodegenerative diseases, respiratory diseases, inflammatory diseases, allergies, hypersensitivity diseases, ophthalmological diseases, skin diseases, addictions, somatic diseases caused by stress, sympathetic reflex dystrophy, dysthymia, undesirable immune reactions, diseases relating to immunopotentiation, digestive diseases, emesis, urinary bladder functional diseases, eosinophilia, diseases caused by abnormal blood flow, and pain, which comprises an effective amount of a compound of formula (I) or (Ia), or a pharmaceutically acceptable salt or ester thereof, in admixture with a pharmaceutically acceptable carrier or diluent.

The invention still further provides a method for the treatment or prophylaxis of a disease or disorder selected from the group consisting of central nervous system diseases, neurodegenerative diseases, respiratory diseases, inflammatory diseases, allergies, hypersensitivity diseases, ophthalmological diseases, skin diseases, addictions, somatic diseases caused by stress, sympathetic reflex dystrophy, dysthymia, undesirable immune reactions, diseases relating to immunopotentiation, digestive diseases, emesis, urinary bladder functional diseases, eosinophilia, diseases caused by abnormal blood flow, and pain, which comprises administering to an animal (which may be human) suffering from or susceptible to said disease or disorder an effective amount of a compound of formula (I) or (Ia), or a pharmaceutically acceptable salt or ester thereof.

The invention also provides a compound of formula (Iz):

wherein:

J represents an alkylene group having from 1 to 6 carbon atoms;

Ar represents a carbocyclic aryl group or aromatic heterocyclic group fused to the ring containing J and S, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined above;

R¹⁴′ represents a hydrogen atom or an amino-protecting group; and

S*→O represents a sulfoxide group in which the sulfur atom is in the S-configuration.

DETAILED DESCRIPTION OF INVENTION

Where R¹, R², R³, R⁴, R⁶, R^(a), R^(b), Ar or substituent β represents a carbocyclic aryl group, this has from 5 to 14, preferably from 6 to 14, more preferably from 6 to 10, and most preferably 6 or 10, ring carbon atoms. The group may have a single aromatic ring or it may have two or more fused aromatic rings. The group may be unsubstituted or it may be substituted by one or more substituents selected from the group consisting of substituents α, defined above and exemplified below. There is no particular restriction on the number of substituents, except such as may be imposed by the number of substitutable positions, and sometimes by steric constraints. However, in general, where the group is substituted, we prefer from 1 to 3 substituents. Examples of the unsubstituted groups include the phenyl, 1-naphthyl, 2-naphthyl, indenyl, phenanthrenyl and anthracenyl groups, of which the phenyl and naphthyl groups are preferred, the phenyl group being most preferred.

Examples of substituted groups include the 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl, 2,3-dimethoxyphenyl, 2,5-dimethoxyphenyl, 3,4-dimethoxyphenyl, 3,5-dimethoxyphenyl, 2,6-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, 2,4,5-trimethoxyphenyl, 2,3,4-trimethoxyphenyl, 2,3,5-trimethoxyphenyl, 2,3,6-trimethoxyphenyl, 2,4,6-trimethoxyphenyl, 2-ethoxyphenyl, 3-ethoxyphenyl, 4-ethoxyphenyl, 2-isopropoxyphenyl, 3-isopropoxyphenyl, 4-isopropoxyphenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2,4-dimethylphenyl, 2,3-dimethylphenyl, 2,5-dimethylphenyl, 3,4-dimethylphenyl, 3,5-dimethylphenyl, 2,6-dimethylphenyl, 3,4,5-trimethylphenyl, 2,4,5-trimethylphenyl, 2,3,4-trimethylphenyl, 2,3,5-trimethylphenyl, 2,3,6-trimethylphenyl, 2,4,6-trimethylphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2,4-dichlorophenyl, 2,3-dichlorophenyl, 2,5-dichlorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl, 2,6-dichlorophenyl, 3,4,5-trichlorophenyl, 2,4,5-trichlorophenyl, 2,3,4-trichlorophenyl, 2,3,5-trichlorophenyl, 2,3,6-trichlorophenyl, 2,4,6-trichlorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2,4-difluorophenyl, 2,3-difluorophenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 2,6-difluorophenyl, 3,4,5-trifluorophenyl, 2,4,5-trifluorophenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2,4-bis(trifluoromethyl)phenyl, 2,3-bis(trifluoromethyl)phenyl, 3,4-bis(trifluoromethyl)phenyl, 3,5-bis(trifluoromethyl)phenyl, 2,6-bis(trifluoromethyl)phenyl, 3,4,5-tris(trifluoromethyl)phenyl, 2,4,5-tris(trifluoromethyl)phenyl, 2-acetamidophenyl, 3-acetamidophenyl, 4-acetamidophenyl, 2-methoxycarbonylphenyl, 3-methoxycarbonylphenyl, and 4-methoxycarbonylphenyl groups.

Where substituent a is an alkylene group having from 1 to 8 carbon atoms, this forms, together with the two carbon atoms of the aryl group to which it is attached, a cycloalkyl group fused to the aryl group. An example of such a fused ring group is the indanyl group.

Where R¹, R², R³, R⁴, R⁶, R^(b), or Ar represents an aromatic heterocyclic group, this is a single ring which has from 5 to 7 ring atoms, of which from 1 to 3 atoms are hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, or is a fused ring system in which at least one of the rings is an aromatic heterocyclic group as defined above and the or each other ring is such an aromatic heterocyclic group or a carbocyclic aryl group as defined above. Where there are 3 hetero atoms in the aromatic heterocyclic group, these are preferably all nitrogen atoms or one or two are nitrogen atoms and, correspondingly, two or one are oxygen and/or sulfur atoms.

Examples of such aromatic heterocyclic groups include the furyl, thienyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl groups. Preferred groups are 5- to 7-membered aromatic heterocyclic groups which have at least one nitrogen atom and optionally one additional nitrogen, oxygen or sulfur atom. Examples of such groups include the pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl groups. Of these, the pyridyl, imidazolyl, oxazolyl, pyrazinyl and thiazolyl groups are more preferred.

Such an aromatic heterocyclic group may form a fused ring with another cyclic group, and examples of such fused ring systems include the indolyl, benzofuryl, benzothienyl, benzoxazolyl, benzoimidazolyl, isoquinolyl, quinolyl and quinoxalyl groups.

These aromatic heterocyclic groups may be unsubstituted or they may be substituted by one or more substituents selected from the group consisting of substituents α, defined above and exemplified below. There is no particular restriction on the number of substituents, except such as may be imposed by the number of substitutable positions, and sometimes by steric constraints. However, in general, where the group is substituted, we prefer from 1 to 3 substituents.

Alternatively, R⁶ may represent a non-aromatic (preferably saturated) heterocyclic group , this may have from 5 to 7 ring atoms, of which from 1 to 3 may be hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, at least one preferably being nitrogen. Examples of such groups include the pyrrolidinyl, piperidinyl, piperazinyl, N-methylpiperazinyl, morpholinyl, thiomorpholinyl, oxazolidinyl, thiazolidinyl, diazolidinyl, oxolanyl, thiolanyl and perhydropyridyl groups.

Where B or G represents an alkylene group having from 1 to 4 carbon atoms, this may be a straight or branched chain group having from 1 to 4 carbon atoms, and examples include the methylene, methylmethylene, ethylene, propylene, trimethylene, tetramethylene, 1-methyltrimethylene, 2-methyltrimethylene and 3-methyltrimethylene groups, of which we prefer the straight or branched chain alkylene groups having from 1 to 3 carbon atoms, more preferably the straight or branched chain alkylene groups having 2 or 3 carbon atoms, and most preferably the ethylene or trimethylene group.

Where B or G represents an alkenylene group having from 2 to 4 carbon atoms, this may be a straight or branched chain group having from 2 to 4 carbon atoms, and examples include the ethenylene, 2-propenylene, 1-methyl-2-propenylene, 2-methyl-2-propenylene, 2-ethyl-2-propenylene and 2-butenylene groups, of which we prefer the ethenylene, 2-propenylene and 3-butenylene groups, more preferably the ethenylene or 2-propynylene group.

Where E or J represents an alkylene group having from 1 to 6 carbon atoms, this may be a straight or branched chain group having from 1 to 6 carbon atoms, and examples include the methylene, methylmethylene, ethylene, propylene, trimethylene, tetramethylene, 1-methyltrimethylene, 2-methyltrimethylene, 3-methyltrimethylene, pentamethylene, hexamethylene, 1,1-dimethyltrimethylene, 2,2-dimethyltrimethylene, 1,1-dimethyltetramethylene and 2,2-dimethyltetramethylene groups, of which we prefer the straight or branched chain alkylene groups having from 1 to 4 carbon atoms, more preferably the methylene or ethylene group.

E may also represent a haloalkylene group having from 1 to 6 carbon atoms and substituted by from 1 to 3 halogen atoms, preferably selected from the group consisting of fluorine, chlorine, bromine and iodine atoms, in which the alkylene group may be any of the unsubstituted alkylene groups exemplified above.

Where E represents a cycloalkane-1,1-diyl group having from 3 to 6 carbon atoms, this is a group of formula

where m is an integer from 2 to 5. Where E represents a cycloalkane-1,1-diylmethyl group having from 3 to 6 carbon atoms in the cycloalkane part, this is a group of formula

wherein m is as defined above. Where E represents acycloalkane-1,1-di(ylmethyl) group having from 3 to 6 carbon atoms in the cycloalkane part, this is a group of formula

wherein m is as defined above.

Examples of these groups include the cyclopropane-1,1-diyl, cyclobutane-1,1-diyl, cyclopentane-1,1-diyl, cyclohexane-1,1-diyl, cyclopropane-1,1-diylmethyl, cyclobutane-1,1-diylmethyl, cyclopentane-1,1-diylmethyl, cyclohexane-1,1-diylmethyl, cyclopropane-1,1-di(ylmethyl), cyclobutane-1,1-di(ylmethyl), cyclopentane-1,1-di(ylmethyl) and cyclohexane-1,1-di(ylmethyl) groups, of which we prefer the cyclopropane-1,1-diyl, cyclobutane-1,1-diyl, cyclopropane-1,1-diylmethyl and cyclobutane-1,1-diylmethyl groups.

Where R⁵, R⁶, R⁷, R^(a), R^(b), substituent α or substituent β represents an alkyl group having from 1 to 6 carbon atoms, this may be a straight or branched chain alkyl group having from 1 to 6, carbon atoms, and examples include the methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, t-butyl, pentyl, isopentyl, 2-methylbutyl, neopentyl, 1-ethylpropyl, hexyl, isohexyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 3,3-dimethylbutyl, 2,2-dimethylbutyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl and 2-ethylbutyl groups, preferably straight or branched chain alkyl groups having from 1 to 4 carbon atoms, such as the methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl and t-butyl groups, of which the methyl and ethyl groups are preferred.

Where R⁵, R⁶, R^(a), R^(b), substituent γ or substituent α represents an alkoxy group having from 1 to 6 carbon atoms, this may be a straight or branched chain alkoxy group having from 1 to 6 carbon atoms, and examples include the methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy, t-butoxy, pentyloxy, isopentyloxy, 2-methylbutoxy, neopentyloxy, 1-ethylpropoxy, hexyloxy, isohexyloxy, 4-methylpentyloxy, 3-methylpentyloxy, 2-methylpentyloxy, 1-methylpentyloxy, 3,3-dimethylbutoxy, 2,2-dimethylbutoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,3-dimethylbutyl and 2-ethylbutyl groups, preferably straight or branched chain alkoxy groups having from 1 to 4 carbon atoms, such as the methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy and t-butoxy groups, of which the methoxy and ethoxy groups are preferred.

Where R⁵ represents an acylamino group, the acyl part of this group may be selected from a variety of acyl groups well known in the art. For example, it may be:

an aliphatic acyl group, such as an alkanoyl group, preferably having from 1 to 21 carbon atoms, more preferably from 1 to 6 carbon atoms and most preferably from 2 to 6 carbon atoms, for example a formyl, acetyl, propionyl, butyryl, isobutyryl, pivaloyl, valeryl, isovaleryl, octanoyl, nonanoyl, decanoyl, 3-methylnonanoyl, 8-methylnonanoyl, 3-ethyloctanoyl, 3,7-dimethyloctanoyl, undecanoyl, dodecanoyl, tridecanoyl, tetradecanoyl, pentadecanoyl, hexadecanoyl, 1-methylpentadecanoyl, 14-methylpentadecanoyl, 13,13-dimethyltetradecanoyl, heptadecanoyl, 15-methylhexadecanoyl, octadecanoyl, 1-methylheptadecanoyl, nonadecanoyl, icosanoyl or henicosanoyl group;

a haloalkanoyl group, in which the alkanoyl part may be any of the alkanoyl groups exemplified above other than the formyl group, but is preferably a group having from 2 to 6 carbon atoms, and which preferably has from 1 to 3 halogen atoms, for example a chloroacetyl, dichloroacetyl, trichloroacetyl or trifluoroacetyl group;

an alkoxyalkanoyl group in which the alkoxy part has from 1 to 6 carbon atoms and may be any of the alkoxy groups exemplified above in relation to R⁵ etc., and the alkanoyl part may be any of the alkanoyl groups exemplified above other than the formyl group, but is preferably a group having from 2 to 6 carbon atoms, for example a methoxyacetyl group;

an alkenoyl or alkynoyl group, preferably having from 3 to 6 carbon atoms, for example an acryloyl, propioloyl, methacryloyl, crotonoyl, isocrotonoyl or (E)-2-methyl-2-butenoyl group;

an aromatic acyl group, in which the aryl part may be as defined and exemplified above in relation to R¹ etc., for example an unsubstituted arylcarbonyl group, such as a benzoyl, 1-naphthoyl or 2-naphthoyl group;

a halogen-substituted arylcarbonyl group, in which the aryl part may be as defined and exemplified above in relation to R¹ etc., for example a 2-bromobenzoyl or 4-chlorobenzoyl group;

an alkyl-substituted arylcarbonyl group, in which the aryl part may be as defined and exemplified above in relation to R¹ etc. and the alkyl part may be as defined and exemplified above in relation to R⁵ etc., for example a 2,4,6-trimethylbenzoyl or 4-toluoyl group;

an alkoxy-substituted arylcarbonyl group, in which the aryl part may be as defined and exemplified above in relation to R¹ etc. and the alkoxy part may be as defined and exemplified above in relation to R⁵ etc., for example a 4-anisoyl group;

a nitro-substituted arylcarbonyl group, in which the aryl part may be as defined and exemplified above in relation to R¹ etc., for example a 4-nitrobenzoyl or 2-nitrobenzoyl group;

an alkoxycarbonyl-substituted arylcarbonyl group, in which the aryl part may be as defined and exemplified above in relation to R¹ etc. and the alkoxy part of the alkoxycarbonyl group may be as defined and exemplified above in relation to R⁵ etc., for example a 2-(methoxycarbonyl)benzoyl group;

an aryl-substituted arylcarbonyl group, in which each aryl part may be as defined and exemplified above in relation to R¹ etc., for example a 4-phenylbenzoyl group;

an alkoxycarbonyl group having from 1 to 6, preferably from 1 to 4, carbon atoms in the alkoxy part (i.e. a total of from 2 to 7, preferably from 2 to 5, carbon atoms), for example a methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, t-butoxycarbonyl, pentyloxycarbonyl, isopentyloxycarbonyl, 2-methylbutoxycarbonyl, neopentyloxycarbonyl, 1-ethylpropoxycarbonyl, hexyloxycarbonyl, isohexyloxycarbonyl, 4-methylpentyloxycarbonyl, 3-methylpentyloxycarbonyl, 2-methylpentyloxycarbonyl, 1-methylpentyloxycarbonyl, 3,3-dimethylbutoxycarbonyl, 2,2-dimethylbutoxycarbonyl, 1,1-dimethylbutoxycarbonyl, 1,2-dimethylbutoxycarbonyl, 1,3-dimethylbutoxycarbonyl, 2,3-dimethylbutoxycarbonyl and 2-ethylbutoxycarbonyl groups, preferably the methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl and t-butoxycarbonyl groups, of which the methoxycarbonyl, ethoxycarbonyl, t-butoxycarbonyl and isobutoxycarbonyl groups are preferred;

an alkoxycarbonyl group substituted with a halogen atom or a trialkylsilyl group having from 1 to 6 carbon atoms in each alkyl part, such as the 2,2,2-trichloroethoxycarbonyl or 2-trimethylsilylethoxycarbonyl groups;

an alkenylcarbonyl group having from 2 to 6 carbon atoms in the alkenyl part, such as the vinylcarbonyl and allylcarbonyl groups;

an aralkylcarbonyl group whose aryl ring may be substituted with 1 or 2 alkoxy groups having from 1 to 6 carbon atoms or nitro groups, such as the benzylcarbonyl, phenacyl, 4-methoxybenzylcarbonyl, 3,4-dimethoxybenzylcarbonyl, 2-nitrobenzylcarbonyl and 4-nitrobenzylcarbonyl groups;

an alkanesulfonyl group having from 1 to 6 carbon atoms, such as the methanesulfonyl, ethanesulfonyl and 1-propanesulfonyl groups;

a fluorinated alkanesulfonyl group having from 1 to 6 carbon atoms, such as the trifluoromethanesulfonyl and pentafluoroethanesulfonyl groups;

an arylsulfonyl group in which the aryl part may be as defined and exemplified above in relation to R¹ etc., such as the benzenesulfonyl and p-toluenesulfonyl groups.

Of these, we prefer the aliphatic acyl groups, the aromatic acyl groups and the alkanesulfonyl groups.

Where R⁵ represents an alkyl group which has from 1 to 6 carbon atoms and which is substituted by an acylamino group, the alkyl part may be any of the alkyl groups defined and exemplified above in relation to R⁵, and the acyl substituent may also be any of the acyl groups defined and exemplified above in relation to R⁵.

Where R⁵ represents an acylamino group whose nitrogen atom is substituted with an alkyl group having from 1 to 6 carbon atoms, the acyl substituent may be any of the acyl groups defined and exemplified above in relation to R⁵, and the alkyl part may also be any of the alkyl groups defined and exemplified above in relation to R⁵.

Where R⁵ represents a hydroxyalkyl group having from 1 to 6 carbon atoms, this may be any one of the above alkyl groups which is substituted by at least one hydroxy group, for example the hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, hydroxypentyl, or hydroxyhexyl group.

Where R⁵ represents an alkoxyalkyl group, the alkoxy and alkyl parts may be independently selected from the corresponding groups defined and exemplified above in relation to R⁵. Examples of such alkoxyalkyl groups include the methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, butoxymethyl, isobutoxymethyl, sec-butoxymethyl, t-butoxymethyl, pentyloxymethyl, isopentyloxymethyl, neopentyloxymethyl, hexyloxymethyl, isohexyloxymethyl, methoxyethyl, ethoxyethyl, propoxyethyl, isopropoxyethyl, butoxyethyl, isobutoxyethyl, sec-butoxyethyl, t-butoxyethyl, pentyloxyethyl, isopentyloxyethyl, neopentyloxyethyl, hexyloxyethyl, isohexyloxyethyl, methoxypropyl, ethoxypropyl, propoxypropyl, isopropoxypropyl, butoxypropyl, isobutoxypropyl, sec-butoxypropyl, t-butoxypropyl, pentyloxypropyl, isopentyloxypropyl, neopentyloxypropyl, hexyloxypropyl, isohexyloxypropyl, methoxybutyl, ethoxybutyl, propoxybutyl, isopropoxybutyl, butoxybutyl, isobutoxybutyl, sec-butoxybutyl, t-butoxybutyl, pentyloxybutyl, isopentyloxybutyl, neopentyloxybutyl, hexyloxybutyl, isohexyloxybutyl, methoxypentyl, ethoxypentyl, propoxypentyl, isopropoxypentyl, butoxypentyl, isobutoxypentyl, sec-butoxypentyl, t-butoxypentyl, pentyloxypentyl, isopentyloxypentyl, neopentyloxypentyl, hexyloxypentyl, isohexyloxypentyl, methoxyhexyl, ethoxyhexyl, propoxyhexyl, isopropoxyhexyl, butoxyhexyl, isobutoxyhexyl, sec-butoxyhexyl, t-butoxyhexyl, pentyloxyhexyl, isopentyloxyhexyl, neopentyloxyhexyl, hexyloxyhexyl and isohexyloxyhexyl groups.

Where R⁵ represents an aralkyloxyalkyl group, the aralkyl part is an alkyl group which has from 1 to 4 carbon atoms and which is substituted by from 1 to 3 carbocyclic aryl groups which are unsubstituted or which are substituted by at least one substituent preferably selected from the group consisting of substituents α, defined above and exemplified below, and the alkyl part of the oxyalkyl group has from 1 to 6 carbon atoms. The alkyl parts may be any of the alkyl groups exemplified above in relation to R⁵. The aralkyl part of the group may be any of the aralkyl groups defined and exemplified below in relation to substituents β. Specific examples of such groups include the benzyloxymethyl, α-naphthylmethoxymethyl, β-naphthylmethoxymethyl, phenethyloxymethyl, 2-benzyloxyethyl, 2-α-naphthylmethoxyethyl, 2-β-naphthylmethoxyethyl, 2-phenethyloxyethyl, 3-benzyloxypropyl, 3-α-naphthylmethoxypropyl, 3-β-naphthylmethoxypropyl, 3-phenethyloxypropyl, 4-benzyloxybutyl, 4-α-naphthylmethoxybutyl, 4-β-naphthylmethoxybutyl, 4-phenethyloxybutyl, 5-benzyloxypentyl, 5-α-naphthylmethoxypentyl, 5-β-naphthylmethoxypentyl, 5-phenethyloxypentyl, 6-benzyloxyhexyl, 6-α-naphthylmethoxyhexyl, 6-β-naphthylmethoxyhexyl and 6-phenethyloxyhexyl groups. The aryl parts of these groups may be substituted or unsubstituted, and, if substituted, the substituents are selected from the group consisting of substituents α, defined above.

Where R^(a) or R^(b), substituent α or substituent γ represents an aliphatic carboxylic acyl group, this may be any of the aliphatic acyl groups, haloalkanoyl groups, alkoxyalkanoyl groups, alkenoyl groups, alkynoyl groups, alkoxycarbonyl groups, alkoxycarbonyl groups substituted with a halogen atom, and alkenylcarbonyl groups, defined and exemplified above in relation to R⁵, particularly the formyl, acetyl, propionyl, butyryl, isobutyryl, pentanoyl, pivaloyl, valeryl and isovaleryl groups, preferably the acetyl and propionyl groups.

Where R^(a) or R^(b), substituent α or substituent γ represents an alkanesulfonyl group, or a haloalkanesulfonyl group, this may be any of those groups defined and exemplified above in relation to R⁵ or substituent β.

Where R^(a) or R^(b) represents a cycloalkyl group, this has from 3 to 8 ring carbon atoms, and examples include the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl groups, of which the cyclopentyl and cyclohexyl groups are preferred.

Where R^(a) and R^(b), together with the nitrogen atom to which they are attached, represent a nitrogen-containing heterocyclic group, this may have from 5 to 7 ring atoms, of which from 1 to 3 may be hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, at least one being nitrogen. The heterocyclic group is preferably a saturated (non-aromatic) group. Examples of such groups include the pyrrolidino, piperidino, piperazino, N-methylpiperazino, morpholino and thiomorpholino groups.

Where R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group having from 5 to 10 ring atoms, this group is unsubstituted or is substituted by at least one substituent selected from the group consisting of substituents β, defined above. The heterocyclic group has a single hetero-atom selected from the group consisting of nitrogen, oxygen and sulfur atoms. Alternatively, R⁴ and R⁵ together with the carbon atom to which they are attached may represent a cycloalkyl or heterocyclic group as defined above which is fused to a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α, defined above. Examples of such groups include the aromatic and saturated heterocyclic groups exemplified above in relation to R^(a) and R^(b), R¹ etc. and R⁶, respectively, and the cycloalkyl groups exemplified above in relation to R^(a) and R^(b).

A particularly preferred group which may be represented by R⁴ and R⁵ together is the group of formula:

in which Ar, J and S*→O are as defined above.

Where substituent α or substituent γ represents a halogen atom, this may be a fluorine, chlorine, bromine or iodine atom, preferably a fluorine or chlorine atom.

Where substituent a represents a haloalkyl group, the alkyl part may be a straight or branched chain group having from 1 to 6, preferably from 1 to 3, carbon atoms. There is no restriction on the number of halogen atoms, except that imposed by the number of substitutable positions; however, in general, from 1 to 3 halogen atoms are preferred. Examples of such groups include the trifluoromethyl, trichloromethyl, difluoromethyl, dichloromethyl, dibromomethyl, fluoromethyl, chloromethyl, bromomethyl, iodomethyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, 2-bromoethyl, 2-chloroethyl, 2-fluoroethyl, 2-iodoethyl, 2,2-dibromoethyl, 3-bromopropyl, 3-chloropropyl, 3-fluoropropyl, 3-iodopropyl, 4-bromobutyl, 4-chlorobutyl, 4-fluorobutyl, 4-iodobutyl, 5-bromopentyl, 5-chloropentyl, 5-fluoropentyl, 5-iodopentyl, 6-bromohexyl, 6-chlorohexyl, 6-fluorohexyl and 6-iodohexyl, of which we prefer the trifluoromethyl, 2-bromoethyl, 2-chloroethyl and 2-fluoroethyl groups.

Where substituent α or substituent γ represents an alkoxycarbonyl group having from 1 to 6 carbon atoms in the alkoxy part, this may be any of the groups defined and exemplified above in relation to R⁵.

Where substituent α or substituent γ represents an acylamino group, the acyl part of this may be any of the groups exemplified above for R⁵, etc. Specific preferred examples of such groups include aliphatic carboxylic acylamino groups, such as the formamido, acetamido, propionamido, butyramido, isobutyramido, pentanoylamino, pivaloylamino, valerylamino and isovalerylamino groups, preferably the acetamido and propionamido groups.

Where substituent β represents an alkanesulfonyl group having from 1 to 6 carbon atoms, this may be a straight or branched chain group having from 1 to 6, preferably from 1 to 4, carbon atoms, and examples include the methanesulfonyl, ethanesulfonyl, propanesulfonyl, isopropanesulfonyl, butanesulfonyl, isobutanesulfonyl, sec-butanesulfonyl, t-butanesulfonyl, pentanesulfonyl, isopentanesulfonyl, neopentanesulfonyl, 2-methylbutanesulfonyl, 1-ethylpropanesulfonyl, 4-methylpentanesulfonyl, 3-methylpentanesulfonyl, 2-methylpentanesulfonyl, 1-methylpentanesulfonyl, 3,3-dimethylbutanesulfonyl, 2,2-dimethylbutanesulfonyl, 1,1-dimethylbutanesulfonyl, 1,2-dimethylbutanesulfonyl, 1,3-dimethylbutanesulfonyl, 2,3-dimethylbutanesulfonyl, 2-ethylbutanesulfonyl, hexanesulfonyl and isohexanesulfonyl groups. Of these, we prefer those alkanesulfonyl groups having from 1 to 4 carbon atoms, preferably the methanesulfonyl, ethanesulfonyl, propanesulfonyl, isopropanesulfonyl, butanesulfonyl and isobutanesulfonyl groups, and most preferably the methanesulfonyl group.

Where R^(a) or R^(b) or substituent , represents an aralkyl group in which an alkyl group having from 1 to 4 carbon atoms is substituted by from 1 to 3 carbocyclic aryl groups, this is as defined above, and examples include the benzyl, α-naphthylmethyl, β-naphthylmethyl, indenylmethyl, phenanthrenylmethyl, anthracenylmethyl, diphenylmethyl, triphenylmethyl, 1-phenethyl, 2-phenethyl, 1-α-naphthylethyl, 2-α-naphthylethyl, 1-β-naphthylethyl, 2-β-naphthylethyl, 1-phenylpropyl, 2-phenylpropyl, 3-phenylpropyl, 1-α-naphthylpropyl, 2-α-naphthylpropyl, 3-α-naphthylpropyl, 1-β-naphthylpropyl, 2-β-naphthylpropyl, 3-β-naphthylpropyl, 1-phenylbutyl, 2-phenylbutyl, 3-phenylbutyl, 4-phenylbutyl, 1-α-naphthylbutyl, 2-α-naphthylbutyl, 3-α-naphthylbutyl, 4-α-naphthylbutyl, 1-β-naphthylbutyl, 2-β-naphthylbutyl, 3-β-naphthylbutyl, 4-β-naphthylbutyl, 1-phenylpentyl, 2-phenylpentyl, 3-phenylpentyl, 4-phenylpentyl, 5-phenylpentyl, 1-α-naphthylpentyl, 2-α-naphthylpentyl, 3-α-naphthylpentyl, 4-α-naphthylpentyl, 5-α-naphthylpentyl, 1-β-naphthylpentyl, 2-β-naphthylpentyl, 3-β-naphthylpentyl, 4-β-naphthylpentyl, 5-β-naphthylpentyl, 1-phenylhexyl, 2-phenylhexyl, 3-phenylhexyl, 4-phenylhexyl, 5-phenylhexyl, 6-phenylhexyl, 1-α-naphthylhexyl, 2-α-naphthylhexyl, 3-α-naphthylhexyl, 4-α-naphthylhexyl, 5-α-naphthylhexyl, 6-α-naphthylhexyl, 1-β-naphthylhexyl, 2-β-naphthylhexyl, 3-β-naphthylhexyl, 4-β-naphthylhexyl, 5-β-naphthylhexyl and 6-β-naphthylhexyl groups, of which we prefer those aralkyl groups in which the aryl group moiety is benzene and the alkyl group has from 1 to 4 carbon atoms, more preferably the benzyl group or the phenethyl group.

Where substituent α represents an alkanesulfonylamino group, or a haloalkanesulfonylamino group, the alkanesulfonyl or haloalkanesulfonyl part of this may be any of those groups defined and exemplified above in relation to R⁵ or substituent β.

Where R^(14′) represents an amino-protecting group, this may be any of the aliphatic acyl groups, the aromatic acyl groups and the alkoxycarbonyl groups defined and exemplified above in relation to R⁵ etc., or the alkenyloxycarbonyl groups, the aralkyloxycarbonyl groups and the silyl groups as defined and exemplified below in relation to ester groups, preferably an alkoxycarbonyl group. Of these, we particularly prefer the t-butoxycarbonyl group.

Each compound of the present invention contains a basic group in its molecule and can thus form acid addition salts. Examples of such acid addition salts include: salts with mineral acids, especially hydrohalic acids (such as hydrofluoric acid, hydrobromic acid, hydroiodic acid or hydrochloric acid), nitric acid, perchloric acid, carbonic acid, sulfuric acid or phosphoric acid; salts with lower alkylsulfonic acids, such as methanesulfonic acid, trifluoromethanesulfonic acid or ethanesulfonic acid; salts with arylsulfonic acids, such as benzenesulfonic acid or p-toluenesulfonic acid; salts with organic carboxylic acids, such as acetic acid, fumaric acid, tartaric acid, oxalic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid or citric acid; and salts with amino acids, such as glycine, arginine, ornithine, lysine, glutamic acid or aspartic acid.

Since the compounds of formula (I) of the present invention can be converted into a quaternary amine by modifying the nitrogen atom of the piperidino or piperazino group in the molecule with a group R⁷, and thus salts of the compounds of formula (I) having a cation and an anion (which may be any atom or group which can form an anion, and examples thereof include halogen ion such as chlorine ion, and iodine ion) are also included in the present invention.

The compounds of formula (I) of the present invention can sometimes be converted into a hydrate by absorption of water or adhesion of absorbed water when they are allowed to stand in the atmosphere, and such hydrates are also included in the present invention.

The compounds of formula (I) of the present invention can form esters, which also form part of the present invention. Where the compound is intended for therapeutic use, the ester should be pharmaceutically acceptable, which, as is well known, means that it should not be more toxic (or unacceptably more toxic) than the parent compound, nor should it be less active (or unacceptably less active) than the parent compound. Such esters can be regarded as either “general” esters or “biologically cleavable” esters, either of which may act as protecting groups.

The “general” esters are esters which can be cleaved by a chemical process such as hydrogenolysis, hydrolysis, electrolysis, photolysis and the like. Examples of groups which can form esters with a hydroxy group include:

the above aliphatic acyl groups;

the above aromatic acyl groups;

tetrahydropyranyl or tetrahydrothiopyranyl groups, such as the tetrahydropyran-2-yl, 3-bromotetrahydropyran-2-yl, 4-methoxytetrahydropyran-4-yl, tetrathiopyran-2-yl and 4-methoxytetrahydrothiopyran-4-yl groups;

tetrahydrofuranyl or tetrahydrothiofuranyl groups, such as the tetrahydrofuran-2-yl and tetrahydrothiofuran-2-yl groups;

silyl groups, such as the trialkylsilyl groups having from 1 to 6 carbon atoms in each alkyl part (e.g. trimethylsilyl, triethylsilyl, isopropyldimethylsilyl, t-butyldimethylsilyl, methyldiisopropylsilyl, methyldi-t-butylsilyl and triisopropylsilyl groups), trialkylsilyl groups having from 1 to 6 carbon atoms in each alkyl part and in which one or two of the alkyl groups are replaced by aryl groups as defined and exemplified above in relation to R¹ etc. (e.g. diphenylmethylsilyl, diphenylbutylsilyl, diphenylisopropylsilyl and phenyldiusopropylsilyl groups);

optionally substituted alkoxymethyl groups having from 1 to 6 carbon atoms in the alkoxy part, such as the alkoxymethyl groups (e.g. the methoxymethyl, 1,1-dimethyl-1-methoxymethyl, ethoxymethyl, propoxyrnethyl, isopropoxymethyl, butoxymethyl and t-butoxymethyl groups), alkoxylated alkoxymethyl groups having from 1 to 6 carbon atoms in each alkoxy part (e.g. the 2-methoxyethoxymethyl group), haloalkoxymethyl groups having from 1 to 6 carbon atoms in the alkoxy part [e.g. the 2,2,2-trichloroethoxymethyl and bis(2-chloroethoxy)methyl groups];

substituted ethyl groups, such as alkoxylated ethyl groups having from 1 to 6 carbon atoms in the alkoxy part (e.g. the 1-ethoxyethyl and 1-isopropoxyethyl groups), haloethyl groups (e.g. the 2,2,2-trichloroethyl group);

aralkyl groups as defined above in relation to substituents β, preferably alkyl groups substituted with from 1 to 3 aryl groups (e.g. the benzyl, α-naphthylmethyl, β-naphthylmethyl, diphenylmethyl, triphenylmethyl, α-naphthyldiphenylmethyl and 9-anthrylmethyl groups), lower alkyl groups substituted with from 1 to 3 aryl groups, whose aryl ring is substituted with a lower alkyl, lower alkoxy, nitro, halogen or cyano group (e.g. the 4-methylbenzyl, 2,4,6-trimethylbenzyl, 3,4,5-trimethylbenzyl, 4-methoxybenzyl, 4-methoxyphenyldiphenylmethyl, 2-nitrobenzyl, 4-nitrobenzyl, 4-chlorobenzyl, 4-bromobenzyl and 4-cyanobenzyl groups);

the above alkoxycarbonyl groups;

alkenyloxycarbonyl groups, such as the vinyloxycarbonyl and allyloxycarbonyl groups;

aralkyloxycarbonyl groups whose aryl ring may be substituted with 1 or 2 lower alkoxy or nitro groups, such as the benzyloxycarbonyl, 4-methoxybenzyloxycarbonyl, 3,4-dimethoxybenzyloxycarbonyl, 2-nitrobenzyloxycarbonyl and 4-nitrobenzyloxycarbonyl groups.

Biologically cleavable esters contain groups which can be cleaved by a biological process, such as biodegradation, to form a free acid or a salt thereof. It can be determined whether an ester is biologically cleavable by administering it to an experimental animal (e.g. a rat or mouse) due to phlebclysis, examining the body fluid of the animal after administration and detecting an original compound or a pharmaceutical acceptable salt thereof.

Examples of biologically cleavable esters include:

1-(acyloxy) lower alkyl groups, such as the 1-(aliphatic acyloxy) lower alkyl groups (e.g. the formyloxymethyl, acetoxymethyl, dimethylaminoacetoxymethyl, propionyloxymethyl, butyryloxymethyl, pivaloyloxymethyl, valeryloxymethyl, isovaleryloxymethyl, hexanoyloxymethyl, 1-formyloxyethyl, 1-acetoxyethyl, 1-propionyloxyethyl, 1-butyryloxyethyl, 1-pivaloyloxyethyl, 1-valeryloxyethyl, 1-isovaleryloxyethyl, 1-hexanoyloxyethyl, 1-formyloxypropyl, 1-acetoxypropyl, 1-propionyloxypropyl, 1-butyryloxypropyl, 1-pivalolyloxypropyl, 1-valeryloxypropyl, 1-isovaleryloxypropyl, 1-hexanoyloxypropyl, 1-acetoxybutyl, 1-propionyloxybutyl, 1-butyryloxybutyl, 1-pivaloyloxybutyl, 1-acetoxypentyl, 1-propionyloxypentyl, 1-butyryloxypentyl, 1-pivaloyloxypentyl and 1-pivaloyloxyhexyl groups);

1-(cycloalkyl carbonyloxy) lower alkyl groups (e.g. the cyclopentylcarbonyloxymethyl, cyclohexylcarbonyloxymethyl, 1-cyclopentylcarbonyloxyethyl, 1-cyclohexylcarbonyloxyethyl, 1-cyclopentylcarbonyloxypropyl, 1-cyclohexylcarbonyloxypropyl, 1-cylopentylcarbonyloxybutyl and 1-cyclohexylcarbonyloxybutyl groups);

1-(aromatic acyloxy) lower alkyl groups (e.g. the benzoyloxymethyl group);

carbonyloxyalkyl groups, such as the (alkoxycarbonyloxy)alkyl groups and (cycloalkoxycarbonyloxy)alkyl groups (e.g. the methoxycarbonyloxymethyl, ethoxycarbonyloxymethyl, propoxycarbonyloxymethyl, isopropoxycarbonyloxymethyl, butoxycarbonyloxymethyl, isobutoxycarbonyloxymethyl, pentyloxycarbonyloxymethyl, hexyloxycarbonyloxymethyl, cyclohexyloxycarbonyloxymethyl, cyclohexyloxycarbonyloxy(cyclohexyl)methyl, 1-(methoxycarbonyloxy)ethyl, 1-(ethoxycarbonyloxy)ethyl, 1-(propoxycarbonyloxy)ethyl, 1-(isopropoxycarbonyloxy)ethyl, 1-(butoxycarbonyloxy)ethyl, 1-(isobutoxycarbonyloxy)ethyl, 1-(t-butoxycarbonyloxy)ethyl, 1-(pentyloxycarbonyloxy)ethyl, 1-(hexyloxycarbonyloxy)ethyl, 1-(cyclopentyloxycarbonyloxy)ethyl, 1-(cyclopentylcarbonyloxy)propyl, 1-(cyclohexyloxycarbonyloxy)propyl, 1-(cyclopentyloxycarbonyloxy)butyl, 1-(cyclohexyloxycarbonyloxy)butyl, 1-(cyclohexyloxycarbonyloxy)ethyl, 1-(ethoxycarbonyloxy)propyl, 2-(methoxycarbonyloxy)ethyl, 2-(ethoxycarbonyloxy)ethyl, 2-(propoxycarbonyloxy)ethyl, 2-(isopropoxycarbonyloxy)ethyl, 2-(butoxycarbonyloxy)ethyl, 2-(isobutoxycarbonyloxy)ethyl, 2-(pentyloxycarbonyloxy)ethyl, 2-(hexyloxycarbonyloxy)ethyl, 1-(methoxycarbonyloxy)propyl, 1-(ethoxycarbonyloxy)propyl, 1-(propoxycarbonyloxy)propyl, 1-(isopropoxycarbonyloxy)propyl, 1-(butoxycarbonyloxy)propyl, 1-(isobutoxycarbonyloxy)propyl, 1-(pentyloxycarbonyloxy)propyl, 1-(hexyloxycarbonyloxy)propyl, 1-(methoxycarbonyloxy)butyl, 1-(ethoxycarbonyloxy)butyl, 1-(propoxycarbonyloxy)butyl, 1-(isopropoxycarbonyloxy)butyl, 1-(butoxycarbonyloxy)butyl, 1-(isobutoxycarbonyloxy)butyl, 1-(methoxycarbonyloxy)pentyl, 1-(ethoxycarbonyloxy)pentyl, 1-(methoxycarbonyloxy)hexyl and 1-(ethoxycarbonyloxy)hexyl groups);

oxodioxolenylmethyl groups (e.g. the (5-phenyl-2-oxo-1,3-dioxolen-4-yl)-methyl, [5-(4-methylphenyl)-2-oxo-1,3-dioxolen-4-yl]methyl, [5-(4-methoxyphenyl)-2-oxo-1,3-dioxolen-4-yl]methyl, [5-(4-fluorophenyl)-2-oxo-1,3-dioxolen-4-yl]methyl, [5-(4-chlorophenyl)-2-oxo-1,3-dioxolen-4-yl]methyl, (2-oxo-1,3-dioxolen-4-yl)methyl, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl, (5-ethyl-2-oxo-1,3-dioxolen-4-yl)methyl, (5-propyl-2-oxo-1,3-dioxolen-4-yl)methyl, (5-isopropyl-2-oxo-1,3-dioxolen-4-yl)methyl and (5-butyl-2-oxo-1,3-dioxolen-4-yl)methyl groups);

phthalidyl groups, such as the phthalidyl, dimethylphthalidyl and dimethoxyphthalidyl groups;

the above aliphatic acyl groups;

the above aromatic acyl groups;

half ester salt residues of succinic acid;

phosphate salt residues;

ester forming residues such as with amino acids;

1-(acyloxy)alkyloxycarbonyl groups, such as the pivaloyloxymethoxycarbonyl group.

Of these, we prefer the carbonyloxyalkyl groups.

The compounds of formula (I) of the present invention have an asymmetric carbon atom in the molecule, and stereoisomers whose asymmetric carbon atom has the R or S configurations are present. The stereoisomers whose asymmetric carbon atom has the R or S configurations and a mixture thereof having any proportion are also included in the present invention.

Preferred classes of compounds of the present invention are those compounds of formula (I) and salts and esters thereof in which E represents a methylene group and

(A1) R¹ and R² are the same or different and each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α;

(B1) R² represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α;

(C1) A represents a carbonyl group;

(D1) B is a single bond;

(E1) D is an oxygen atom;

(F1) G is an alkylene group having from 1 to 4 carbon atoms;

(G1) G is an alkylene group having 2 or 3 carbon atoms;

(H1) R³ represents an aromatic heterocyclic group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α;

(I1) L represents a group of formula —C(R⁴)(R⁵)—;

(J1) R⁴ represents a carbocyclic aryl group or an aromatic heterocyclic group;

(K1) R⁵ represents a group of formula —CO—R⁶ (where R⁶ represents an alkyl group having from 1 to 6 carbon atoms or a group of formula —NR^(a)R^(b));

(L1) R⁵ represents an amino group, an acylamino group or a hydroxy group;

(M1) R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group having from 5 to 10 ring atoms, said group being unsubstituted or being substituted by at least one substituent selected from the group consisting of substituents β, and said heterocyclic group having a single hetero-atom selected from the group consisting of nitrogen, oxygen and sulfur atoms, or R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group as defined above which is fused to a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α.

Further preferred classes of compounds of the present invention are those compounds of formula (I) and salts and esters thereof in which E represents a group of formula —(CH₂)_(n)— in which n is an integer from 2 to 4, and

(A2) R¹ and R² are the same or different and each represents a carbocyclic aryl group, an aromatic heterocyclic group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents a;

(B2) R² represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents c;

(C2) A represents a carbonyl group;

(D2) B represents a single bond;

(E2) D represents an oxygen atom;

(F2) G represents an alkylene group having 1 to 4 carbon atoms;

(G2) G represents an alkylene group having 2 to 3 carbon atoms;

(H2) R³ represents an aromatic heterocyclic group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α;

(I2) L represents a group of the general formula —C(R⁴)(R⁵)—;

(J2) R⁴ represents a carbocyclic aryl group or an aromatic heterocyclic group;

(K2) R⁵ represents a group of formula —CO—R⁶ (wherein R⁶ represents an alkyl group having from 1 to 6 carbon atoms or a group of formula —NR^(a)R^(b));

(L2) R⁵ represents an amino group, an acylamino group or a hydroxy group;

(M2) n is 2 or 3;

(N2) n is 2;

(O2) R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group having from 5 to 10 ring atoms, said group being unsubstituted or being substituted by at least one substituent selected from the group consisting of substituents β, and said heterocyclic group having a single hetero-atom selected from the group consisting of nitrogen, oxygen and sulfur atoms, or R⁴ and R⁵ together with the carbon atom to which they are attached represent a cycloalkyl or heterocyclic group as defined above which is fused to a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent preferably selected from the group consisting of substituents α.

Still further preferred classes of compounds of the present invention are those compounds of formula (I) and salts and esters thereof in which R⁴ and R⁵ together with the carbon atom to which they are attached represent a group of formula:

and

(A3) R¹ represents a carbocyclic aryl group, an aromatic heterocyclic group, or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α;

(B3) R¹ represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α¹; substituents α¹ are selected from the group consisting of alkyl groups having from 1 to 6 carbon atoms, haloalkyl groups having from 1 to 6 carbon atoms, and alkoxy groups having from 1 to 6 carbon atoms;

(C3) R² represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α;

(D3) R² represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 halogen atoms;

(E3) A represents a carbonyl group;

(F3) B represents a single bond;

(G3) D represents an oxygen atom;

(H3) E represents a C₁₋₄ alkylene group or a C₃₋₈ alkylene group which contains a C₃₋₆ cycloalkane-1,1-diyl group;

(I3) E represents a methylene, ethylene, dimethylmethylene, 1,1-dimethylethylene, 2,2-dimethylethylene, cyclopropane-1,1-diyl, cyclobutane-1,1-diyl, cyclopentane-1,1-diyl, cyclohexane-1,1-diyl, cyclopropane-1,1-diylmethyl, cyclobutane-1,1-diylmethyl, cyclopentane-1,1-diylmethyl or cyclohexane-1,1-diylmethyl group;

(J3) G represents a C₁₋₄ alkylene group;

(K3) G represents a C₂₋₃ alkylene group;

(L3) J represents a C₁₋₄ alkylene group;

(M3) J represents a methylene or ethylene group;

(N3) the ring Ar represents a carbocyclic aryl group, a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α or an aromatic heterocyclic group;

(O3) the ring Ar represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of substituents α.

Examples of certain of the compounds of the present invention, which can be prepared as described hereinafter in the Examples, are shown in the following formulae (I-1), (I-2) and (I-3). The substituent groups are as defined in the corresponding one of Tables 1, 2 and 3, i.e. Table 1 relates to formula (I-1), etc.

Each of the compound numbers shown in these Tables covers 2 compounds, one in which G represents a dimethylene group (which may be referred to by the number assigned to it in the Table and the suffix “a”) and one in which G represents a trimethylene group (which may be referred to by the number assigned to it in the Table and the suffix “b”).

Moreover, each of Compounds No. 2-1537 to 2-3072 also covers compounds in which B can represent a single bond or a CH₂ group. These may be identified by a further suffix, α or β, respectively, so that, for example, Compound No. 2-1537 where G represents a dimethylene group and B represents a single bond may be known as Compound No. 2-1537aα, Compound No. 2-1537 where G represents a dimethylene group and B represents a CH₂ group may be known as Compound No. 2-1537aβ, Compound No. 2-1537 where G represents a trimethylene group and B represents a single bond may be known as Compound No. 2-1537bα, and Compound No. 2-1537 where G represents a trimethylene group and B represents a CH₂ group may be known as Compound No. 2-1537bβ.

Certain of the names of substituent groups are abbreviated in the Tables, as follows:

cBu cyclobutane-1,1-diyl cHx cyclohexane-1,1-diyl Me methyl Ph phenyl cPn cyclopentane-1,1-diyl cPr cyclopropane-1,1-diyl

Also, the groups having the following formulae are referred to by the associated reference Sub-xx as shown below:

TABLE 1 Cpd. No. R¹ R² A B Z 1-1   Sub-33 3,4-diClPh CH₂ Single bond Sub-1  1-2   Sub-33 3,4-diClPh CH₂ Single bond Sub-2  1-3   Sub-33 3,4-diClPh CH₂ Single bond Sub-3  1-4   Sub-33 3,4-diClPh CH₂ Single bond Sub-4  1-5   Sub-33 3,4-diClPh CH₂ Single bond Sub-5  1-6   Sub-33 3,4-diClPh CH₂ Single bond Sub-6  1-7   Sub-33 3,4-diClPh CH₂ Single bond Sub-7  1-8   Sub-33 3,4-diClPh CH₂ Single bond Sub-8  1-9   Sub-33 3,4-diClPh CH₂ Single bond Sub-9  1-10  Sub-33 3,4-diClPh CH₂ Single bond Sub-10 1-11  Sub-33 3,4-diClPh CH₂ Single bond Sub-11 1-12  Sub-33 3,4-diClPh CH₂ Single bond Sub-12 1-13  Sub-33 3,4-diClPh CH₂ Single bond Sub-13 1-14  Sub-33 3,4-diClPh CH₂ Single bond Sub-14 1-15  Sub-33 3,4-diClPh CH₂ Single bond Sub-15 1-16  Sub-33 3,4-diClPh CH₂ Single bond Sub-16 1-17  Sub-33 3,4-diClPh CH₂ Single bond Sub-17 1-18  Sub-33 3,4-diClPh CH₂ Single bond Sub-18 1-19  Sub-33 3,4-diClPh CH₂ Single bond Sub-19 1-20  Sub-33 3,4-diClPh CH₂ Single bond Sub-20 1-21  Sub-33 3,4-diClPh CH₂ Single bond Sub-21 1-22  Sub-33 3,4-diClPh CH₂ Single bond Sub-22 1-23  Sub-33 3,4-diClPh CH₂ Single bond Sub-23 1-24  Sub-33 3,4-diClPh CH₂ Single bond Sub-24 1-25  Sub-33 3,4-diClPh CH₂ Single bond Sub-25 1-26  Sub-33 3,4-diClPh CH₂ Single bond Sub-26 1-27  Sub-33 3,4-diClPh CH₂ Single bond Sub-27 1-28  Sub-33 3,4-diClPh CH₂ Single bond Sub-28 1-29  Sub-33 3,4-diClPh CH₂ Single bond Sub-29 1-30  Sub-33 3,4-diClPh CH₂ Single bond Sub-30 1-31  Sub-33 3,4-diClPh CH₂ Single bond Sub-31 1-32  Sub-33 3,4-diClPh CH₂ Single bond Sub-32 1-33  Sub-34 3,4-diClPh CH₂ Single bond Sub-1  1-34  Sub-34 3,4-diClPh CH₂ Single bond Sub-2  1-35  Sub-34 3,4-diClPh CH₂ Single bond Sub-3  1-36  Sub-34 3,4-diClPh CH₂ Single bond Sub-4  1-37  Sub-34 3,4-diClPh CH₂ Single bond Sub-5  1-38  Sub-34 3,4-diClPh CH₂ Single bond Sub-6  1-39  Sub-34 3,4-diClPh CH₂ Single bond Sub-7  1-40  Sub-34 3,4-diClPh CH₂ Single bond Sub-8  1-41  Sub-34 3,4-diClPh CH₂ Single bond Sub-9  1-42  Sub-34 3,4-diClPh CH₂ Single bond Sub-10 1-43  Sub-34 3,4-diClPh CH₂ Single bond Sub-11 1-44  Sub-34 3,4-diClPh CH₂ Single bond Sub-12 1-45  Sub-34 3,4-diClPh CH₂ Single bond Sub-13 1-46  Sub-34 3,4-diClPh CH₂ Single bond Sub-14 1-47  Sub-34 3,4-diClPh CH₂ Single bond Sub-15 1-48  Sub-34 3,4-diClPh CH₂ Single bond Sub-16 1-49  Sub-34 3,4-diClPh CH₂ Single bond Sub-17 1-50  Sub-34 3,4-diClPh CH₂ Single bond Sub-18 1-51  Sub-34 3,4-diClPh CH₂ Single bond Sub-19 1-52  Sub-34 3,4-diClPh CH₂ Single bond Sub-20 1-53  Sub-34 3,4-diClPh CH₂ Single bond Sub-21 1-54  Sub-34 3,4-diClPh CH₂ Single bond Sub-22 1-55  Sub-34 3,4-diClPh CH₂ Single bond Sub-23 1-56  Sub-34 3,4-diClPh CH₂ Single bond Sub-24 1-57  Sub-34 3,4-diClPh CH₂ Single bond Sub-25 1-58  Sub-34 3,4-diClPh CH₂ Single bond Sub-26 1-59  Sub-34 3,4-diClPh CH₂ Single bond Sub-27 1-60  Sub-34 3,4-diClPh CH₂ Single bond Sub-28 1-61  Sub-34 3,4-diClPh CH₂ Single bond Sub-29 1-62  Sub-34 3,4-diClPh CH₂ Single bond Sub-30 1-63  Sub-34 3,4-diClPh CH₂ Single bond Sub-31 1-64  Sub-34 3,4-diClPh CH₂ Single bond Sub-32 1-65  Sub-35 3,4-diClPh CH₂ Single bond Sub-1  1-66  Sub-35 3,4-diClPh CH₂ Single bond Sub-2  1-67  Sub-35 3,4-diClPh CH₂ Single bond Sub-3  1-68  Sub-35 3,4-diClPh CH₂ Single bond Sub-4  1-69  Sub-35 3,4-diClPh CH₂ Single bond Sub-5  1-70  Sub-35 3,4-diClPh CH₂ Single bond Sub-6  1-71  Sub-35 3,4-diClPh CH₂ Single bond Sub-7  1-72  Sub-35 3,4-diClPh CH₂ Single bond Sub-8  1-73  Sub-35 3,4-diClPh CH₂ Single bond Sub-9  1-74  Sub-35 3,4-diClPh CH₂ Single bond Sub-10 1-75  Sub-35 3,4-diClPh CH₂ Single bond Sub-11 1-76  Sub-35 3,4-diClPh CH₂ Single bond Sub-12 1-77  Sub-35 3,4-diClPh CH₂ Single bond Sub-13 1-78  Sub-35 3,4-diClPh CH₂ Single bond Sub-14 1-79  Sub-35 3,4-diClPh CH₂ Single bond Sub-15 1-80  Sub-35 3,4-diClPh CH₂ Single bond Sub-16 1-81  Sub-35 3,4-diClPh CH₂ Single bond Sub-17 1-82  Sub-35 3,4-diClPh CH₂ Single bond Sub-18 1-83  Sub-35 3,4-diClPh CH₂ Single bond Sub-19 1-84  Sub-35 3,4-diClPh CH₂ Single bond Sub-20 1-85  Sub-35 3,4-diClPh CH₂ Single bond Sub-21 1-86  Sub-35 3,4-diClPh CH₂ Single bond Sub-22 1-87  Sub-35 3,4-diClPh CH₂ Single bond Sub-23 1-88  Sub-35 3,4-diClPh CH₂ Single bond Sub-24 1-89  Sub-35 3,4-diClPh CH₂ Single bond Sub-25 1-90  Sub-35 3,4-diClPh CH₂ Single bond Sub-26 1-91  Sub-35 3,4-diClPh CH₂ Single bond Sub-27 1-92  Sub-35 3,4-diClPh CH₂ Single bond Sub-28 1-93  Sub-35 3,4-diClPh CH₂ Single bond Sub-29 1-94  Sub-35 3,4-diClPh CH₂ Single bond Sub-30 1-95  Sub-35 3,4-diClPh CH₂ Single bond Sub-31 1-96  Sub-35 3,4-diClPh CH₂ Single bond Sub-32 1-97  Sub-36 3,4-diClPh CH₂ Single bond Sub-1  1-98  Sub-36 3,4-diClPh CH₂ Single bond Sub-2  1-99  Sub-36 3,4-diClPh CH₂ Single bond Sub-3  1-100  Sub-36 3,4-diClPh CH₂ Single bond Sub-4  1-101  Sub-36 3,4-diClPh CH₂ Single bond Sub-5  1-102  Sub-36 3,4-diClPh CH₂ Single bond Sub-6  1-103  Sub-36 3,4-diClPh CH₂ Single bond Sub-7  1-104  Sub-36 3,4-diClPh CH₂ Single bond Sub-8  1-105  Sub-36 3,4-diClPh CH₂ Single bond Sub-9  1-106  Sub-36 3,4-diClPh CH₂ Single bond Sub-10 1-107  Sub-36 3,4-diClPh CH₂ Single bond Sub-11 1-108  Sub-36 3,4-diClPh CH₂ Single bond Sub-12 1-109  Sub-36 3,4-diClPh CH₂ Single bond Sub-13 1-110  Sub-36 3,4-diClPh CH₂ Single bond Sub-14 1-111  Sub-36 3,4-diClPh CH₂ Single bond Sub-15 1-112  Sub-36 3,4-diClPh CH₂ Single bond Sub-16 1-113  Sub-36 3,4-diClPh CH₂ Single bond Sub-17 1-114  Sub-36 3,4-diClPh CH₂ Single bond Sub-18 1-115  Sub-36 3,4-diClPh CH₂ Single bond Sub-19 1-116  Sub-36 3,4-diClPh CH₂ Single bond Sub-20 1-117  Sub-36 3,4-diClPh CH₂ Single bond Sub-21 1-118  Sub-36 3,4-diClPh CH₂ Single bond Sub-22 1-119  Sub-36 3,4-diClPh CH₂ Single bond Sub-23 1-120  Sub-36 3,4-diClPh CH₂ Single bond Sub-24 1-121  Sub-36 3,4-diClPh CH₂ Single bond Sub-25 1-122  Sub-36 3,4-diClPh CH₂ Single bond Sub-26 1-123  Sub-36 3,4-diClPh CH₂ Single bond Sub-27 1-124  Sub-36 3,4-diClPh CH₂ Single bond Sub-28 1-125  Sub-36 3,4-diClPh CH₂ Single bond Sub-29 1-126  Sub-36 3,4-diClPh CH₂ Single bond Sub-30 1-127  Sub-36 3,4-diClPh CH₂ Single bond Sub-31 1-128  Sub-36 3,4-diClPh CH₂ Single bond Sub-32 1-129  Sub-37 3,4-diClPh CH₂ Single bond Sub-1  1-130  Sub-37 3,4-diClPh CH₂ Single bond Sub-2  1-131  Sub-37 3,4-diClPh CH₂ Single bond Sub-3  1-132  Sub-37 3,4-diClPh CH₂ Single bond Sub-4  1-133  Sub-37 3,4-diClPh CH₂ Single bond Sub-5  1-134  Sub-37 3,4-diClPh CH₂ Single bond Sub-6  1-135  Sub-37 3,4-diClPh CH₂ Single bond Sub-7  1-136  Sub-37 3,4-diClPh CH₂ Single bond Sub-8  1-137  Sub-37 3,4-diClPh CH₂ Single bond Sub-9  1-138  Sub-37 3,4-diClPh CH₂ Single bond Sub-10 1-139  Sub-37 3,4-diClPh CH₂ Single bond Sub-11 1-140  Sub-37 3,4-diClPh CH₂ Single bond Sub-12 1-141  Sub-37 3,4-diClPh CH₂ Single bond Sub-13 1-142  Sub-37 3,4-diClPh CH₂ Single bond Sub-14 1-143  Sub-37 3,4-diClPh CH₂ Single bond Sub-15 1-144  Sub-37 3,4-diClPh CH₂ Single bond Sub-16 1-145  Sub-37 3,4-diClPh CH₂ Single bond Sub-17 1-146  Sub-37 3,4-diClPh CH₂ Single bond Sub-18 1-147  Sub-37 3,4-diClPh CH₂ Single bond Sub-19 1-148  Sub-37 3,4-diClPh CH₂ Single bond Sub-20 1-149  Sub-37 3,4-diClPh CH₂ Single bond Sub-21 1-150  Sub-37 3,4-diClPh CH₂ Single bond Sub-22 1-151  Sub-37 3,4-diClPh CH₂ Single bond Sub-23 1-152  Sub-37 3,4-diClPh CH₂ Single bond Sub-24 1-153  Sub-37 3,4-diClPh CH₂ Single bond Sub-25 1-154  Sub-37 3,4-diClPh CH₂ Single bond Sub-26 1-155  Sub-37 3,4-diClPh CH₂ Single bond Sub-27 1-156  Sub-37 3,4-diClPh CH₂ Single bond Sub-28 1-157  Sub-37 3,4-diClPh CH₂ Single bond Sub-29 1-158  Sub-37 3,4-diClPh CH₂ Single bond Sub-30 1-159  Sub-37 3,4-diClPh CH₂ Single bond Sub-31 1-160  Sub-37 3,4-diClPh CH₂ Single bond Sub-32 1-161  Sub-38 3,4-diClPh CH₂ Single bond Sub-1  1-162  Sub-38 3,4-diClPh CH₂ Single bond Sub-2  1-163  Sub-38 3,4-diClPh CH₂ Single bond Sub-3  1-164  Sub-38 3,4-diClPh CH₂ Single bond Sub-4  1-165  Sub-38 3,4-diClPh CH₂ Single bond Sub-5  1-166  Sub-38 3,4-diClPh CH₂ Single bond Sub-6  1-167  Sub-38 3,4-diClPh CH₂ Single bond Sub-7  1-168  Sub-38 3,4-diClPh CH₂ Single bond Sub-8  1-169  Sub-38 3,4-diClPh CH₂ Single bond Sub-9  1-170  Sub-38 3,4-diClPh CH₂ Single bond Sub-10 1-171  Sub-38 3,4-diClPh CH₂ Single bond Sub-11 1-172  Sub-38 3,4-diClPh CH₂ Single bond Sub-12 1-173  Sub-38 3,4-diClPh CH₂ Single bond Sub-13 1-174  Sub-38 3,4-diClPh CH₂ Single bond Sub-14 1-175  Sub-38 3,4-diClPh CH₂ Single bond Sub-15 1-176  Sub-38 3,4-diClPh CH₂ Single bond Sub-16 1-177  Sub-38 3,4-diClPh CH₂ Single bond Sub-17 1-178  Sub-38 3,4-diClPh CH₂ Single bond Sub-18 1-179  Sub-38 3,4-diClPh CH₂ Single bond Sub-19 1-180  Sub-38 3,4-diClPh CH₂ Single bond Sub-20 1-181  Sub-38 3,4-diClPh CH₂ Single bond Sub-21 1-182  Sub-38 3,4-diClPh CH₂ Single bond Sub-22 1-183  Sub-38 3,4-diClPh CH₂ Single bond Sub-23 1-184  Sub-38 3,4-diClPh CH₂ Single bond Sub-24 1-185  Sub-38 3,4-diClPh CH₂ Single bond Sub-25 1-186  Sub-38 3,4-diClPh CH₂ Single bond Sub-26 1-187  Sub-38 3,4-diClPh CH₂ Single bond Sub-27 1-188  Sub-38 3,4-diClPh CH₂ Single bond Sub-28 1-189  Sub-38 3,4-diClPh CH₂ Single bond Sub-29 1-190  Sub-38 3,4-diClPh CH₂ Single bond Sub-30 1-191  Sub-38 3,4-diClPh CH₂ Single bond Sub-31 1-192  Sub-38 3,4-diClPh CH₂ Single bond Sub-32 1-193  Sub-39 3,4-diClPh CH₂ Single bond Sub-1  1-194  Sub-39 3,4-diClPh CH₂ Single bond Sub-2  1-195  Sub-39 3,4-diClPh CH₂ Single bond Sub-3  1-196  Sub-39 3,4-diClPh CH₂ Single bond Sub-4  1-197  Sub-39 3,4-diClPh CH₂ Single bond Sub-5  1-198  Sub-39 3,4-diClPh CH₂ Single bond Sub-6  1-199  Sub-39 3,4-diClPh CH₂ Single bond Sub-7  1-200  Sub-39 3,4-diClPh CH₂ Single bond Sub-8  1-201  Sub-39 3,4-diClPh CH₂ Single bond Sub-9  1-202  Sub-39 3,4-diClPh CH₂ Single bond Sub-10 1-203  Sub-39 3,4-diClPh CH₂ Single bond Sub-11 1-204  Sub-39 3,4-diClPh CH₂ Single bond Sub-12 1-205  Sub-39 3,4-diClPh CH₂ Single bond Sub-13 1-206  Sub-39 3,4-diClPh CH₂ Single bond Sub-14 1-207  Sub-39 3,4-diClPh CH₂ Single bond Sub-15 1-208  Sub-39 3,4-diClPh CH₂ Single bond Sub-16 1-209  Sub-39 3,4-diClPh CH₂ Single bond Sub-17 1-210  Sub-39 3,4-diClPh CH₂ Single bond Sub-18 1-211  Sub-39 3,4-diClPh CH₂ Single bond Sub-19 1-212  Sub-39 3,4-diClPh CH₂ Single bond Sub-20 1-213  Sub-39 3,4-diClPh CH₂ Single bond Sub-21 1-214  Sub-39 3,4-diClPh CH₂ Single bond Sub-22 1-215  Sub-39 3,4-diClPh CH₂ Single bond Sub-23 1-216  Sub-39 3,4-diClPh CH₂ Single bond Sub-24 1-217  Sub-39 3,4-diClPh CH₂ Single bond Sub-25 1-218  Sub-39 3,4-diClPh CH₂ Single bond Sub-26 1-219  Sub-39 3,4-diClPh CH₂ Single bond Sub-27 1-220  Sub-39 3,4-diClPh CH₂ Single bond Sub-28 1-221  Sub-39 3,4-diClPh CH₂ Single bond Sub-29 1-222  Sub-39 3,4-diClPh CH₂ Single bond Sub-30 1-223  Sub-39 3,4-diClPh CH₂ Single bond Sub-31 1-224  Sub-39 3,4-diClPh CH₂ Single bond Sub-32 1-225  Sub-40 3,4-diClPh CH₂ Single bond Sub-1  1-226  Sub-40 3,4-diClPh CH₂ Single bond Sub-2  1-227  Sub-40 3,4-diClPh CH₂ Single bond Sub-3  1-228  Sub-40 3,4-diClPh CH₂ Single bond Sub-4  1-229  Sub-40 3,4-diClPh CH₂ Single bond Sub-5  1-230  Sub-40 3,4-diClPh CH₂ Single bond Sub-6  1-231  Sub-40 3,4-diClPh CH₂ Single bond Sub-7  1-232  Sub-40 3,4-diClPh CH₂ Single bond Sub-8  1-233  Sub-40 3,4-diClPh CH₂ Single bond Sub-9  1-234  Sub-40 3,4-diClPh CH₂ Single bond Sub-10 1-235  Sub-40 3,4-diClPh CH₂ Single bond Sub-11 1-236  Sub-40 3,4-diClPh CH₂ Single bond Sub-12 1-237  Sub-40 3,4-diClPh CH₂ Single bond Sub-13 1-238  Sub-40 3,4-diClPh CH₂ Single bond Sub-14 1-239  Sub-40 3,4-diClPh CH₂ Single bond Sub-15 1-240  Sub-40 3,4-diClPh CH₂ Single bond Sub-16 1-241  Sub-40 3,4-diClPh CH₂ Single bond Sub-17 1-242  Sub-40 3,4-diClPh CH₂ Single bond Sub-18 1-243  Sub-40 3,4-diClPh CH₂ Single bond Sub-19 1-244  Sub-40 3,4-diClPh CH₂ Single bond Sub-20 1-245  Sub-40 3,4-diClPh CH₂ Single bond Sub-21 1-246  Sub-40 3,4-diClPh CH₂ Single bond Sub-22 1-247  Sub-40 3,4-diClPh CH₂ Single bond Sub-23 1-248  Sub-40 3,4-diClPh CH₂ Single bond Sub-24 1-249  Sub-40 3,4-diClPh CH₂ Single bond Sub-25 1-250  Sub-40 3,4-diClPh CH₂ Single bond Sub-26 1-251  Sub-40 3,4-diClPh CH₂ Single bond Sub-27 1-252  Sub-40 3,4-diClPh CH₂ Single bond Sub-28 1-253  Sub-40 3,4-diClPh CH₂ Single bond Sub-29 1-254  Sub-40 3,4-diClPh CH₂ Single bond Sub-30 1-255  Sub-40 3,4-diClPh CH₂ Single bond Sub-31 1-256  Sub-40 3,4-diClPh CH₂ Single bond Sub-32 1-257  Sub-41 3,4-diClPh CH₂ Single bond Sub-1  1-258  Sub-41 3,4-diClPh CH₂ Single bond Sub-2  1-259  Sub-41 3,4-diClPh CH₂ Single bond Sub-3  1-260  Sub-41 3,4-diClPh CH₂ Single bond Sub-4  1-261  Sub-41 3,4-diClPh CH₂ Single bond Sub-5  1-262  Sub-41 3,4-diClPh CH₂ Single bond Sub-6  1-263  Sub-41 3,4-diClPh CH₂ Single bond Sub-7  1-264  Sub-41 3,4-diClPh CH₂ Single bond Sub-8  1-265  Sub-41 3,4-diClPh CH₂ Single bond Sub-9  1-266  Sub-41 3,4-diClPh CH₂ Single bond Sub-10 1-267  Sub-41 3,4-diClPh CH₂ Single bond Sub-11 1-268  Sub-41 3,4-diClPh CH₂ Single bond Sub-12 1-269  Sub-41 3,4-diClPh CH₂ Single bond Sub-13 1-270  Sub-41 3,4-diClPh CH₂ Single bond Sub-14 1-271  Sub-41 3,4-diClPh CH₂ Single bond Sub-15 1-272  Sub-41 3,4-diClPh CH₂ Single bond Sub-16 1-273  Sub-41 3,4-diClPh CH₂ Single bond Sub-17 1-274  Sub-41 3,4-diClPh CH₂ Single bond Sub-18 1-275  Sub-41 3,4-diClPh CH₂ Single bond Sub-19 1-276  Sub-41 3,4-diClPh CH₂ Single bond Sub-20 1-277  Sub-41 3,4-diClPh CH₂ Single bond Sub-21 1-278  Sub-41 3,4-diClPh CH₂ Single bond Sub-22 1-279  Sub-41 3,4-diClPh CH₂ Single bond Sub-23 1-280  Sub-41 3,4-diClPh CH₂ Single bond Sub-24 1-281  Sub-41 3,4-diClPh CH₂ Single bond Sub-25 1-282  Sub-41 3,4-diClPh CH₂ Single bond Sub-26 1-283  Sub-41 3,4-diClPh CH₂ Single bond Sub-27 1-284  Sub-41 3,4-diClPh CH₂ Single bond Sub-28 1-285  Sub-41 3,4-diClPh CH₂ Single bond Sub-29 1-286  Sub-41 3,4-diClPh CH₂ Single bond Sub-30 1-287  Sub-41 3,4-diClPh CH₂ Single bond Sub-31 1-288  Sub-41 3,4-diClPh CH₂ Single bond Sub-32 1-289  Sub-42 3,4-diClPh CH₂ Single bond Sub-1  1-290  Sub-42 3,4-diClPh CH₂ Single bond Sub-2  1-291  Sub-42 3,4-diClPh CH₂ Single bond Sub-3  1-292  Sub-42 3,4-diClPh CH₂ Single bond Sub-4  1-293  Sub-42 3,4-diClPh CH₂ Single bond Sub-5  1-294  Sub-42 3,4-diClPh CH₂ Single bond Sub-6  1-295  Sub-42 3,4-diClPh CH₂ Single bond Sub-7  1-296  Sub-42 3,4-diClPh CH₂ Single bond Sub-8  1-297  Sub-42 3,4-diClPh CH₂ Single bond Sub-9  1-298  Sub-42 3,4-diClPh CH₂ Single bond Sub-10 1-299  Sub-42 3,4-diClPh CH₂ Single bond Sub-11 1-300  Sub-42 3,4-diClPh CH₂ Single bond Sub-12 1-301  Sub-42 3,4-diClPh CH₂ Single bond Sub-13 1-302  Sub-42 3,4-diClPh CH₂ Single bond Sub-14 1-303  Sub-42 3,4-diClPh CH₂ Single bond Sub-15 1-304  Sub-42 3,4-diClPh CH₂ Single bond Sub-16 1-305  Sub-42 3,4-diClPh CH₂ Single bond Sub-17 1-306  Sub-42 3,4-diClPh CH₂ Single bond Sub-18 1-307  Sub-42 3,4-diClPh CH₂ Single bond Sub-19 1-308  Sub-42 3,4-diClPh CH₂ Single bond Sub-20 1-309  Sub-42 3,4-diClPh CH₂ Single bond Sub-21 1-310  Sub-42 3,4-diClPh CH₂ Single bond Sub-22 1-311  Sub-42 3,4-diClPh CH₂ Single bond Sub-23 1-312  Sub-42 3,4-diClPh CH₂ Single bond Sub-24 1-313  Sub-42 3,4-diClPh CH₂ Single bond Sub-25 1-314  Sub-42 3,4-diClPh CH₂ Single bond Sub-26 1-315  Sub-42 3,4-diClPh CH₂ Single bond Sub-27 1-316  Sub-42 3,4-diClPh CH₂ Single bond Sub-28 1-317  Sub-42 3,4-diClPh CH₂ Single bond Sub-29 1-318  Sub-42 3,4-diClPh CH₂ Single bond Sub-30 1-319  Sub-42 3,4-diClPh CH₂ Single bond Sub-31 1-320  Sub-42 3,4-diClPh CH₂ Single bond Sub-32 1-321  Sub-43 3,4-diClPh CH₂ Single bond Sub-1  1-322  Sub-43 3,4-diClPh CH₂ Single bond Sub-2  1-323  Sub-43 3,4-diClPh CH₂ Single bond Sub-3  1-324  Sub-43 3,4-diClPh CH₂ Single bond Sub-4  1-325  Sub-43 3,4-diClPh CH₂ Single bond Sub-5  1-326  Sub-43 3,4-diClPh CH₂ Single bond Sub-6  1-327  Sub-43 3,4-diClPh CH₂ Single bond Sub-7  1-328  Sub-43 3,4-diClPh CH₂ Single bond Sub-8  1-329  Sub-43 3,4-diClPh CH₂ Single bond Sub-9  1-340  Sub-43 3,4-diClPh CH₂ Single bond Sub-10 1-341  Sub-43 3,4-diClPh CH₂ Single bond Sub-11 1-342  Sub-43 3,4-diClPh CH₂ Single bond Sub-12 1-343  Sub-43 3,4-diClPh CH₂ Single bond Sub-13 1-344  Sub-43 3,4-diClPh CH₂ Single bond Sub-14 1-345  Sub-43 3,4-diClPh CH₂ Single bond Sub-15 1-346  Sub-43 3,4-diClPh CH₂ Single bond Sub-16 1-347  Sub-43 3,4-diClPh CH₂ Single bond Sub-17 1-348  Sub-43 3,4-diClPh CH₂ Single bond Sub-18 1-349  Sub-43 3,4-diClPh CH₂ Single bond Sub-19 1-340  Sub-43 3,4-diClPh CH₂ Single bond Sub-20 1-341  Sub-43 3,4-diClPh CH₂ Single bond Sub-21 1-342  Sub-43 3,4-diClPh CH₂ Single bond Sub-22 1-343  Sub-43 3,4-diClPh CH₂ Single bond Sub-23 1-344  Sub-43 3,4-diClPh CH₂ Single bond Sub-24 1-345  Sub-43 3,4-diClPh CH₂ Single bond Sub-25 1-346  Sub-43 3,4-diClPh CH₂ Single bond Sub-26 1-347  Sub-43 3,4-diClPh CH₂ Single bond Sub-27 1-348  Sub-43 3,4-diClPh CH₂ Single bond Sub-28 1-349  Sub-43 3,4-diClPh CH₂ Single bond Sub-29 1-350  Sub-43 3,4-diClPh CH₂ Single bond Sub-30 1-351  Sub-43 3,4-diClPh CH₂ Single bond Sub-31 1-352  Sub-43 3,4-diClPh CH₂ Single bond Sub-32 1-353  Sub-44 3,4-diClPh CH₂ Single bond Sub-1  1-354  Sub-44 3,4-diClPh CH₂ Single bond Sub-2  1-355  Sub-44 3,4-diClPh CH₂ Single bond Sub-3  1-356  Sub-44 3,4-diClPh CH₂ Single bond Sub-4  1-357  Sub-44 3,4-diClPh CH₂ Single bond Sub-5  1-358  Sub-44 3,4-diClPh CH₂ Single bond Sub-6  1-359  Sub-44 3,4-diClPh CH₂ Single bond Sub-7  1-360  Sub-44 3,4-diClPh CH₂ Single bond Sub-8  1-361  Sub-44 3,4-diClPh CH₂ Single bond Sub-9  1-362  Sub-44 3,4-diClPh CH₂ Single bond Sub-10 1-363  Sub-44 3,4-diClPh CH₂ Single bond Sub-11 1-364  Sub-44 3,4-diClPh CH₂ Single bond Sub-12 1-365  Sub-44 3,4-diClPh CH₂ Single bond Sub-13 1-366  Sub-44 3,4-diClPh CH₂ Single bond Sub-14 1-367  Sub-44 3,4-diClPh CH₂ Single bond Sub-15 1-368  Sub-44 3,4-diClPh CH₂ Single bond Sub-16 1-369  Sub-44 3,4-diClPh CH₂ Single bond Sub-17 1-370  Sub-44 3,4-diClPh CH₂ Single bond Sub-18 1-371  Sub-44 3,4-diClPh CH₂ Single bond Sub-19 1-372  Sub-44 3,4-diClPh CH₂ Single bond Sub-20 1-373  Sub-44 3,4-diClPh CH₂ Single bond Sub-21 1-374  Sub-44 3,4-diClPh CH₂ Single bond Sub-22 1-375  Sub-44 3,4-diClPh CH₂ Single bond Sub-23 1-376  Sub-44 3,4-diClPh CH₂ Single bond Sub-24 1-377  Sub-44 3,4-diClPh CH₂ Single bond Sub-25 1-378  Sub-44 3,4-diClPh CH₂ Single bond Sub-26 1-379  Sub-44 3,4-diClPh CH₂ Single bond Sub-27 1-380  Sub-44 3,4-diClPh CH₂ Single bond Sub-28 1-381  Sub-44 3,4-diClPh CH₂ Single bond Sub-29 1-382  Sub-44 3,4-diClPh CH₂ Single bond Sub-30 1-383  Sub-44 3,4-diClPh CH₂ Single bond Sub-31 1-384  Sub-44 3,4-diClPh CH₂ Single bond Sub-32 1-385  Sub-45 3,4-diClPh CH₂ Single bond Sub-1  1-386  Sub-45 3,4-diClPh CH₂ Single bond Sub-2  1-387  Sub-45 3,4-diClPh CH₂ Single bond Sub-3  1-388  Sub-45 3,4-diClPh CH₂ Single bond Sub-4  1-389  Sub-45 3,4-diClPh CH₂ Single bond Sub-5  1-390  Sub-45 3,4-diClPh CH₂ Single bond Sub-6  1-391  Sub-45 3,4-diClPh CH₂ Single bond Sub-7  1-392  Sub-45 3,4-diClPh CH₂ Single bond Sub-8  1-393  Sub-45 3,4-diClPh CH₂ Single bond Sub-9  1-394  Sub-45 3,4-diClPh CH₂ Single bond Sub-10 1-395  Sub-45 3,4-diClPh CH₂ Single bond Sub-11 1-396  Sub-45 3,4-diClPh CH₂ Single bond Sub-12 1-397  Sub-45 3,4-diClPh CH₂ Single bond Sub-13 1-398  Sub-45 3,4-diClPh CH₂ Single bond Sub-14 1-399  Sub-45 3,4-diClPh CH₂ Single bond Sub-15 1-400  Sub-45 3,4-diClPh CH₂ Single bond Sub-16 1-401  Sub-45 3,4-diClPh CH₂ Single bond Sub-17 1-402  Sub-45 3,4-diClPh CH₂ Single bond Sub-18 1-403  Sub-45 3,4-diClPh CH₂ Single bond Sub-19 1-404  Sub-45 3,4-diClPh CH₂ Single bond Sub-20 1-405  Sub-45 3,4-diClPh CH₂ Single bond Sub-21 1-406  Sub-45 3,4-diClPh CH₂ Single bond Sub-22 1-407  Sub-45 3,4-diClPh CH₂ Single bond Sub-23 1-408  Sub-45 3,4-diClPh CH₂ Single bond Sub-24 1-409  Sub-45 3,4-diClPh CH₂ Single bond Sub-25 1-410  Sub-45 3,4-diClPh CH₂ Single bond Sub-26 1-411  Sub-45 3,4-diClPh CH₂ Single bond Sub-27 1-412  Sub-45 3,4-diClPh CH₂ Single bond Sub-28 1-413  Sub-45 3,4-diClPh CH₂ Single bond Sub-29 1-414  Sub-45 3,4-diClPh CH₂ Single bond Sub-30 1-415  Sub-45 3,4-diClPh CH₂ Single bond Sub-31 1-416  Sub-45 3,4-diClPh CH₂ Single bond Sub-32 1-417  Sub-46 3,4-diClPh CH₂ Single bond Sub-1  1-418  Sub-46 3,4-diClPh CH₂ Single bond Sub-2  1-419  Sub-46 3,4-diClPh CH₂ Single bond Sub-3  1-420  Sub-46 3,4-diClPh CH₂ Single bond Sub-4  1-421  Sub-46 3,4-diClPh CH₂ Single bond Sub-5  1-422  Sub-46 3,4-diClPh CH₂ Single bond Sub-6  1-423  Sub-46 3,4-diClPh CH₂ Single bond Sub-7  1-424  Sub-46 3,4-diClPh CH₂ Single bond Sub-8  1-425  Sub-46 3,4-diClPh CH₂ Single bond Sub-9  1-426  Sub-46 3,4-diClPh CH₂ Single bond Sub-10 1-427  Sub-46 3,4-diClPh CH₂ Single bond Sub-11 1-428  Sub-46 3,4-diClPh CH₂ Single bond Sub-12 1-429  Sub-46 3,4-diClPh CH₂ Single bond Sub-13 1-430  Sub-46 3,4-diClPh CH₂ Single bond Sub-14 1-431  Sub-46 3,4-diClPh CH₂ Single bond Sub-15 1-432  Sub-46 3,4-diClPh CH₂ Single bond Sub-16 1-433  Sub-46 3,4-diClPh CH₂ Single bond Sub-17 1-434  Sub-46 3,4-diClPh CH₂ Single bond Sub-18 1-435  Sub-46 3,4-diClPh CH₂ Single bond Sub-19 1-436  Sub-46 3,4-diClPh CH₂ Single bond Sub-20 1-437  Sub-46 3,4-diClPh CH₂ Single bond Sub-21 1-438  Sub-46 3,4-diClPh CH₂ Single bond Sub-22 1-439  Sub-46 3,4-diClPh CH₂ Single bond Sub-23 1-440  Sub-46 3,4-diClPh CH₂ Single bond Sub-24 1-441  Sub-46 3,4-diClPh CH₂ Single bond Sub-25 1-442  Sub-46 3,4-diClPh CH₂ Single bond Sub-26 1-443  Sub-46 3,4-diClPh CH₂ Single bond Sub-27 1-444  Sub-46 3,4-diClPh CH₂ Single bond Sub-28 1-445  Sub-46 3,4-diClPh CH₂ Single bond Sub-29 1-446  Sub-46 3,4-diClPh CH₂ Single bond Sub-30 1-447  Sub-46 3,4-diClPh CH₂ Single bond Sub-31 1-448  Sub-46 3,4-diClPh CH₂ Single bond Sub-32 1-449  Sub-47 3,4-diClPh CH₂ Single bond Sub-1  1-450  Sub-47 3,4-diClPh CH₂ Single bond Sub-2  1-451  Sub-47 3,4-diClPh CH₂ Single bond Sub-3  1-452  Sub-47 3,4-diClPh CH₂ Single bond Sub-4  1-453  Sub-47 3,4-diClPh CH₂ Single bond Sub-5  1-454  Sub-47 3,4-diClPh CH₂ Single bond Sub-6  1-455  Sub-47 3,4-diClPh CH₂ Single bond Sub-7  1-456  Sub-47 3,4-diClPh CH₂ Single bond Sub-8  1-457  Sub-47 3,4-diClPh CH₂ Single bond Sub-9  1-458  Sub-47 3,4-diClPh CH₂ Single bond Sub-10 1-459  Sub-47 3,4-diClPh CH₂ Single bond Sub-11 1-460  Sub-47 3,4-diClPh CH₂ Single bond Sub-12 1-461  Sub-47 3,4-diClPh CH₂ Single bond Sub-13 1-462  Sub-47 3,4-diClPh CH₂ Single bond Sub-14 1-463  Sub-47 3,4-diClPh CH₂ Single bond Sub-15 1-464  Sub-47 3,4-diClPh CH₂ Single bond Sub-16 1-465  Sub-47 3,4-diClPh CH₂ Single bond Sub-17 1-466  Sub-47 3,4-diClPh CH₂ Single bond Sub-18 1-467  Sub-47 3,4-diClPh CH₂ Single bond Sub-19 1-468  Sub-47 3,4-diClPh CH₂ Single bond Sub-20 1-469  Sub-47 3,4-diClPh CH₂ Single bond Sub-21 1-470  Sub-47 3,4-diClPh CH₂ Single bond Sub-22 1-471  Sub-47 3,4-diClPh CH₂ Single bond Sub-23 1-472  Sub-47 3,4-diClPh CH₂ Single bond Sub-24 1-473  Sub-47 3,4-diClPh CH₂ Single bond Sub-25 1-474  Sub-47 3,4-diClPh CH₂ Single bond Sub-26 1-475  Sub-47 3,4-diClPh CH₂ Single bond Sub-27 1-476  Sub-47 3,4-diClPh CH₂ Single bond Sub-28 1-477  Sub-47 3,4-diClPh CH₂ Single bond Sub-29 1-478  Sub-47 3,4-diClPh CH₂ Single bond Sub-30 1-479  Sub-47 3,4-diClPh CH₂ Single bond Sub-31 1-480  Sub-47 3,4-diClPh CH₂ Single bond Sub-32 1-481  Sub-48 3,4-diClPh CH₂ Single bond Sub-1  1-482  Sub-48 3,4-diClPh CH₂ Single bond Sub-2  1-483  Sub-48 3,4-diClPh CH₂ Single bond Sub-3  1-484  Sub-48 3,4-diClPh CH₂ Single bond Sub-4  1-485  Sub-48 3,4-diClPh CH₂ Single bond Sub-5  1-486  Sub-48 3,4-diClPh CH₂ Single bond Sub-6  1-487  Sub-48 3,4-diClPh CH₂ Single bond Sub-7  1-488  Sub-48 3,4-diClPh CH₂ Single bond Sub-8  1-489  Sub-48 3,4-diClPh CH₂ Single bond Sub-9  1-490  Sub-48 3,4-diClPh CH₂ Single bond Sub-10 1-491  Sub-48 3,4-diClPh CH₂ Single bond Sub-11 1-492  Sub-48 3,4-diClPh CH₂ Single bond Sub-12 1-493  Sub-48 3,4-diClPh CH₂ Single bond Sub-13 1-494  Sub-48 3,4-diClPh CH₂ Single bond Sub-14 1-495  Sub-48 3,4-diClPh CH₂ Single bond Sub-15 1-496  Sub-48 3,4-diClPh CH₂ Single bond Sub-16 1-497  Sub-48 3,4-diClPh CH₂ Single bond Sub-17 1-498  Sub-48 3,4-diClPh CH₂ Single bond Sub-18 1-499  Sub-48 3,4-diClPh CH₂ Single bond Sub-19 1-500  Sub-48 3,4-diClPh CH₂ Single bond Sub-20 1-501  Sub-48 3,4-diClPh CH₂ Single bond Sub-21 1-502  Sub-48 3,4-diClPh CH₂ Single bond Sub-22 1-503  Sub-48 3,4-diClPh CH₂ Single bond Sub-23 1-504  Sub-48 3,4-diClPh CH₂ Single bond Sub-24 1-505  Sub-48 3,4-diClPh CH₂ Single bond Sub-25 1-506  Sub-48 3,4-diClPh CH₂ Single bond Sub-26 1-507  Sub-48 3,4-diClPh CH₂ Single bond Sub-27 1-508  Sub-48 3,4-diClPh CH₂ Single bond Sub-28 1-509  Sub-48 3,4-diClPh CH₂ Single bond Sub-29 1-510  Sub-48 3,4-diClPh CH₂ Single bond Sub-30 1-511  Sub-48 3,4-diClPh CH₂ Single bond Sub-31 1-512  Sub-48 3,4-diClPh CH₂ Single bond Sub-32 1-513  Sub-49 3,4-diClPh CH₂ Single bond Sub-1  1-514  Sub-49 3,4-diClPh CH₂ Single bond Sub-2  1-515  Sub-49 3,4-diClPh CH₂ Single bond Sub-3  1-516  Sub-49 3,4-diClPh CH₂ Single bond Sub-4  1-517  Sub-49 3,4-diClPh CH₂ Single bond Sub-5  1-518  Sub-49 3,4-diClPh CH₂ Single bond Sub-6  1-519  Sub-49 3,4-diClPh CH₂ Single bond Sub-7  1-520  Sub-49 3,4-diClPh CH₂ Single bond Sub-8  1-521  Sub-49 3,4-diClPh CH₂ Single bond Sub-9  1-522  Sub-49 3,4-diClPh CH₂ Single bond Sub-10 1-523  Sub-49 3,4-diClPh CH₂ Single bond Sub-11 1-524  Sub-49 3,4-diClPh CH₂ Single bond Sub-12 1-525  Sub-49 3,4-diClPh CH₂ Single bond Sub-13 1-526  Sub-49 3,4-diClPh CH₂ Single bond Sub-14 1-527  Sub-49 3,4-diClPh CH₂ Single bond Sub-15 1-528  Sub-49 3,4-diClPh CH₂ Single bond Sub-16 1-529  Sub-49 3,4-diClPh CH₂ Single bond Sub-17 1-530  Sub-49 3,4-diClPh CH₂ Single bond Sub-18 1-531  Sub-49 3,4-diClPh CH₂ Single bond Sub-19 1-532  Sub-49 3,4-diClPh CH₂ Single bond Sub-20 1-533  Sub-49 3,4-diClPh CH₂ Single bond Sub-21 1-534  Sub-49 3,4-diClPh CH₂ Single bond Sub-22 1-535  Sub-49 3,4-diClPh CH₂ Single bond Sub-23 1-536  Sub-49 3,4-diClPh CH₂ Single bond Sub-24 1-537  Sub-49 3,4-diClPh CH₂ Single bond Sub-25 1-538  Sub-49 3,4-diClPh CH₂ Single bond Sub-26 1-539  Sub-49 3,4-diClPh CH₂ Single bond Sub-27 1-540  Sub-49 3,4-diClPh CH₂ Single bond Sub-28 1-541  Sub-49 3,4-diClPh CH₂ Single bond Sub-29 1-542  Sub-49 3,4-diClPh CH₂ Single bond Sub-30 1-543  Sub-49 3,4-diClPh CH₂ Single bond Sub-31 1-544  Sub-49 3,4-diClPh CH₂ Single bond Sub-32 1-545  Sub-50 3,4-diClPh CH₂ Single bond Sub-1  1-546  Sub-50 3,4-diClPh CH₂ Single bond Sub-2  1-547  Sub-50 3,4-diClPh CH₂ Single bond Sub-3  1-548  Sub-50 3,4-diClPh CH₂ Single bond Sub-4  1-549  Sub-50 3,4-diClPh CH₂ Single bond Sub-5  1-550  Sub-50 3,4-diClPh CH₂ Single bond Sub-6  1-551  Sub-50 3,4-diClPh CH₂ Single bond Sub-7  1-552  Sub-50 3,4-diClPh CH₂ Single bond Sub-8  1-553  Sub-50 3,4-diClPh CH₂ Single bond Sub-9  1-554  Sub-50 3,4-diClPh CH₂ Single bond Sub-10 1-555  Sub-50 3,4-diClPh CH₂ Single bond Sub-11 1-556  Sub-50 3,4-diClPh CH₂ Single bond Sub-12 1-557  Sub-50 3,4-diClPh CH₂ Single bond Sub-13 1-558  Sub-50 3,4-diClPh CH₂ Single bond Sub-14 1-559  Sub-50 3,4-diClPh CH₂ Single bond Sub-15 1-560  Sub-50 3,4-diClPh CH₂ Single bond Sub-16 1-561  Sub-50 3,4-diClPh CH₂ Single bond Sub-17 1-562  Sub-50 3,4-diClPh CH₂ Single bond Sub-18 1-563  Sub-50 3,4-diClPh CH₂ Single bond Sub-19 1-564  Sub-50 3,4-diClPh CH₂ Single bond Sub-20 1-565  Sub-50 3,4-diClPh CH₂ Single bond Sub-21 1-566  Sub-50 3,4-diClPh CH₂ Single bond Sub-22 1-567  Sub-50 3,4-diClPh CH₂ Single bond Sub-23 1-568  Sub-50 3,4-diClPh CH₂ Single bond Sub-24 1-569  Sub-50 3,4-diClPh CH₂ Single bond Sub-25 1-570  Sub-50 3,4-diClPh CH₂ Single bond Sub-26 1-571  Sub-50 3,4-diClPh CH₂ Single bond Sub-27 1-572  Sub-50 3,4-diClPh CH₂ Single bond Sub-28 1-573  Sub-50 3,4-diClPh CH₂ Single bond Sub-29 1-574  Sub-50 3,4-diClPh CH₂ Single bond Sub-30 1-575  Sub-50 3,4-diClPh CH₂ Single bond Sub-31 1-576  Sub-50 3,4-diClPh CH₂ Single bond Sub-32 1-577  Sub-51 3,4-diClPh CH₂ Single bond Sub-1  1-578  Sub-51 3,4-diClPh CH₂ Single bond Sub-2  1-579  Sub-51 3,4-diClPh CH₂ Single bond Sub-3  1-580  Sub-51 3,4-diClPh CH₂ Single bond Sub-4  1-581  Sub-51 3,4-diClPh CH₂ Single bond Sub-5  1-582  Sub-51 3,4-diClPh CH₂ Single bond Sub-6  1-583  Sub-51 3,4-diClPh CH₂ Single bond Sub-7  1-584  Sub-51 3,4-diClPh CH₂ Single bond Sub-8  1-585  Sub-51 3,4-diClPh CH₂ Single bond Sub-9  1-586  Sub-51 3,4-diClPh CH₂ Single bond Sub-10 1-587  Sub-51 3,4-diClPh CH₂ Single bond Sub-11 1-588  Sub-51 3,4-diClPh CH₂ Single bond Sub-12 1-589  Sub-51 3,4-diClPh CH₂ Single bond Sub-13 1-590  Sub-51 3,4-diClPh CH₂ Single bond Sub-14 1-591  Sub-51 3,4-diClPh CH₂ Single bond Sub-15 1-592  Sub-51 3,4-diClPh CH₂ Single bond Sub-16 1-593  Sub-51 3,4-diClPh CH₂ Single bond Sub-17 1-594  Sub-51 3,4-diClPh CH₂ Single bond Sub-18 1-595  Sub-51 3,4-diClPh CH₂ Single bond Sub-19 1-596  Sub-51 3,4-diClPh CH₂ Single bond Sub-20 1-597  Sub-51 3,4-diClPh CH₂ Single bond Sub-21 1-598  Sub-51 3,4-diClPh CH₂ Single bond Sub-22 1-599  Sub-51 3,4-diClPh CH₂ Single bond Sub-23 1-600  Sub-51 3,4-diClPh CH₂ Single bond Sub-24 1-601  Sub-51 3,4-diClPh CH₂ Single bond Sub-25 1-602  Sub-51 3,4-diClPh CH₂ Single bond Sub-26 1-603  Sub-51 3,4-diClPh CH₂ Single bond Sub-27 1-604  Sub-51 3,4-diClPh CH₂ Single bond Sub-28 1-605  Sub-51 3,4-diClPh CH₂ Single bond Sub-29 1-606  Sub-51 3,4-diClPh CH₂ Single bond Sub-30 1-607  Sub-51 3,4-diClPh CH₂ Single bond Sub-31 1-608  Sub-51 3,4-diClPh CH₂ Single bond Sub-32 1-609  Sub-52 3,4-diClPh CH₂ Single bond Sub-1  1-610  Sub-52 3,4-diClPh CH₂ Single bond Sub-2  1-611  Sub-52 3,4-diClPh CH₂ Single bond Sub-3  1-612  Sub-52 3,4-diClPh CH₂ Single bond Sub-4  1-613  Sub-52 3,4-diClPh CH₂ Single bond Sub-5  1-614  Sub-52 3,4-diClPh CH₂ Single bond Sub-6  1-615  Sub-52 3,4-diClPh CH₂ Single bond Sub-7  1-616  Sub-52 3,4-diClPh CH₂ Single bond Sub-8  1-617  Sub-52 3,4-diClPh CH₂ Single bond Sub-9  1-618  Sub-52 3,4-diClPh CH₂ Single bond Sub-10 1-619  Sub-52 3,4-diClPh CH₂ Single bond Sub-11 1-620  Sub-52 3,4-diClPh CH₂ Single bond Sub-12 1-621  Sub-52 3,4-diClPh CH₂ Single bond Sub-13 1-622  Sub-52 3,4-diClPh CH₂ Single bond Sub-14 1-623  Sub-52 3,4-diClPh CH₂ Single bond Sub-15 1-624  Sub-52 3,4-diClPh CH₂ Single bond Sub-16 1-625  Sub-52 3,4-diClPh CH₂ Single bond Sub-17 1-626  Sub-52 3,4-diClPh CH₂ Single bond Sub-18 1-627  Sub-52 3,4-diClPh CH₂ Single bond Sub-19 1-628  Sub-52 3,4-diClPh CH₂ Single bond Sub-20 1-629  Sub-52 3,4-diClPh CH₂ Single bond Sub-21 1-630  Sub-52 3,4-diClPh CH₂ Single bond Sub-22 1-631  Sub-52 3,4-diClPh CH₂ Single bond Sub-23 1-632  Sub-52 3,4-diClPh CH₂ Single bond Sub-24 1-633  Sub-52 3,4-diClPh CH₂ Single bond Sub-25 1-634  Sub-52 3,4-diClPh CH₂ Single bond Sub-26 1-635  Sub-52 3,4-diClPh CH₂ Single bond Sub-27 1-636  Sub-52 3,4-diClPh CH₂ Single bond Sub-28 1-637  Sub-52 3,4-diClPh CH₂ Single bond Sub-29 1-638  Sub-52 3,4-diClPh CH₂ Single bond Sub-30 1-639  Sub-52 3,4-diClPh CH₂ Single bond Sub-31 1-640  Sub-52 3,4-diClPh CH₂ Single bond Sub-32 1-641  Sub-53 3,4-diClPh CH₂ Single bond Sub-1  1-642  Sub-53 3,4-diClPh CH₂ Single bond Sub-2  1-643  Sub-53 3,4-diClPh CH₂ Single bond Sub-3  1-644  Sub-53 3,4-diClPh CH₂ Single bond Sub-4  1-645  Sub-53 3,4-diClPh CH₂ Single bond Sub-5  1-646  Sub-53 3,4-diClPh CH₂ Single bond Sub-6  1-647  Sub-53 3,4-diClPh CH₂ Single bond Sub-7  1-648  Sub-53 3,4-diClPh CH₂ Single bond Sub-8  1-649  Sub-53 3,4-diClPh CH₂ Single bond Sub-9  1-650  Sub-53 3,4-diClPh CH₂ Single bond Sub-10 1-651  Sub-53 3,4-diClPh CH₂ Single bond Sub-11 1-652  Sub-53 3,4-diClPh CH₂ Single bond Sub-12 1-653  Sub-53 3,4-diClPh CH₂ Single bond Sub-13 1-654  Sub-53 3,4-diClPh CH₂ Single bond Sub-14 1-655  Sub-53 3,4-diClPh CH₂ Single bond Sub-15 1-656  Sub-53 3,4-diClPh CH₂ Single bond Sub-16 1-657  Sub-53 3,4-diClPh CH₂ Single bond Sub-17 1-658  Sub-53 3,4-diClPh CH₂ Single bond Sub-18 1-659  Sub-53 3,4-diClPh CH₂ Single bond Sub-19 1-660  Sub-53 3,4-diClPh CH₂ Single bond Sub-20 1-661  Sub-53 3,4-diClPh CH₂ Single bond Sub-21 1-662  Sub-53 3,4-diClPh CH₂ Single bond Sub-22 1-663  Sub-53 3,4-diClPh CH₂ Single bond Sub-23 1-664  Sub-53 3,4-diClPh CH₂ Single bond Sub-24 1-665  Sub-53 3,4-diClPh CH₂ Single bond Sub-25 1-666  Sub-53 3,4-diClPh CH₂ Single bond Sub-26 1-667  Sub-53 3,4-diClPh CH₂ Single bond Sub-27 1-668  Sub-53 3,4-diClPh CH₂ Single bond Sub-28 1-669  Sub-53 3,4-diClPh CH₂ Single bond Sub-29 1-670  Sub-53 3,4-diClPh CH₂ Single bond Sub-30 1-671  Sub-53 3,4-diClPh CH₂ Single bond Sub-31 1-672  Sub-53 3,4-diClPh CH₂ Single bond Sub-32 1-673  Sub-54 3,4-diClPh CH₂ Single bond Sub-1  1-674  Sub-54 3,4-diClPh CH₂ Single bond Sub-2  1-675  Sub-54 3,4-diClPh CH₂ Single bond Sub-3  1-676  Sub-54 3,4-diClPh CH₂ Single bond Sub-4  1-677  Sub-54 3,4-diClPh CH₂ Single bond Sub-5  1-678  Sub-54 3,4-diClPh CH₂ Single bond Sub-6  1-679  Sub-54 3,4-diClPh CH₂ Single bond Sub-7  1-680  Sub-54 3,4-diClPh CH₂ Single bond Sub-8  1-681  Sub-54 3,4-diClPh CH₂ Single bond Sub-9  1-682  Sub-54 3,4-diClPh CH₂ Single bond Sub-10 1-683  Sub-54 3,4-diClPh CH₂ Single bond Sub-11 1-684  Sub-54 3,4-diClPh CH₂ Single bond Sub-12 1-685  Sub-54 3,4-diClPh CH₂ Single bond Sub-13 1-686  Sub-54 3,4-diClPh CH₂ Single bond Sub-14 1-687  Sub-54 3,4-diClPh CH₂ Single bond Sub-15 1-688  Sub-54 3,4-diClPh CH₂ Single bond Sub-16 1-689  Sub-54 3,4-diClPh CH₂ Single bond Sub-17 1-690  Sub-54 3,4-diClPh CH₂ Single bond Sub-18 1-691  Sub-54 3,4-diClPh CH₂ Single bond Sub-19 1-692  Sub-54 3,4-diClPh CH₂ Single bond Sub-20 1-693  Sub-54 3,4-diClPh CH₂ Single bond Sub-21 1-694  Sub-54 3,4-diClPh CH₂ Single bond Sub-22 1-695  Sub-54 3,4-diClPh CH₂ Single bond Sub-23 1-696  Sub-54 3,4-diClPh CH₂ Single bond Sub-24 1-697  Sub-54 3,4-diClPh CH₂ Single bond Sub-25 1-698  Sub-54 3,4-diClPh CH₂ Single bond Sub-26 1-699  Sub-54 3,4-diClPh CH₂ Single bond Sub-27 1-700  Sub-54 3,4-diClPh CH₂ Single bond Sub-28 1-701  Sub-54 3,4-diClPh CH₂ Single bond Sub-29 1-702  Sub-54 3,4-diClPh CH₂ Single bond Sub-30 1-703  Sub-54 3,4-diClPh CH₂ Single bond Sub-31 1-704  Sub-54 3,4-diClPh CH₂ Single bond Sub-32 1-705  Sub-55 3,4-diClPh CH₂ Single bond Sub-1  1-706  Sub-55 3,4-diClPh CH₂ Single bond Sub-2  1-707  Sub-55 3,4-diClPh CH₂ Single bond Sub-3  1-708  Sub-55 3,4-diClPh CH₂ Single bond Sub-4  1-709  Sub-55 3,4-diClPh CH₂ Single bond Sub-5  1-710  Sub-55 3,4-diClPh CH₂ Single bond Sub-6  1-711  Sub-55 3,4-diClPh CH₂ Single bond Sub-7  1-712  Sub-55 3,4-diClPh CH₂ Single bond Sub-8  1-713  Sub-55 3,4-diClPh CH₂ Single bond Sub-9  1-714  Sub-55 3,4-diClPh CH₂ Single bond Sub-10 1-715  Sub-55 3,4-diClPh CH₂ Single bond Sub-11 1-716  Sub-55 3,4-diClPh CH₂ Single bond Sub-12 1-717  Sub-55 3,4-diClPh CH₂ Single bond Sub-13 1-718  Sub-55 3,4-diClPh CH₂ Single bond Sub-14 1-719  Sub-55 3,4-diClPh CH₂ Single bond Sub-15 1-720  Sub-55 3,4-diClPh CH₂ Single bond Sub-16 1-721  Sub-55 3,4-diClPh CH₂ Single bond Sub-17 1-722  Sub-55 3,4-diClPh CH₂ Single bond Sub-18 1-723  Sub-55 3,4-diClPh CH₂ Single bond Sub-19 1-724  Sub-55 3,4-diClPh CH₂ Single bond Sub-20 1-725  Sub-55 3,4-diClPh CH₂ Single bond Sub-21 1-726  Sub-55 3,4-diClPh CH₂ Single bond Sub-22 1-727  Sub-55 3,4-diClPh CH₂ Single bond Sub-23 1-728  Sub-55 3,4-diClPh CH₂ Single bond Sub-24 1-729  Sub-55 3,4-diClPh CH₂ Single bond Sub-25 1-730  Sub-55 3,4-diClPh CH₂ Single bond Sub-26 1-731  Sub-55 3,4-diClPh CH₂ Single bond Sub-27 1-732  Sub-55 3,4-diClPh CH₂ Single bond Sub-28 1-733  Sub-55 3,4-diClPh CH₂ Single bond Sub-29 1-734  Sub-55 3,4-diClPh CH₂ Single bond Sub-30 1-735  Sub-55 3,4-diClPh CH₂ Single bond Sub-31 1-736  Sub-55 3,4-diClPh CH₂ Single bond Sub-32 1-737  Sub-56 3,4-diClPh CH₂ Single bond Sub-1  1-738  Sub-56 3,4-diClPh CH₂ Single bond Sub-2  1-739  Sub-56 3,4-diClPh CH₂ Single bond Sub-3  1-740  Sub-56 3,4-diClPh CH₂ Single bond Sub-4  1-741  Sub-56 3,4-diClPh CH₂ Single bond Sub-5  1-742  Sub-56 3,4-diClPh CH₂ Single bond Sub-6  1-743  Sub-56 3,4-diClPh CH₂ Single bond Sub-7  1-744  Sub-56 3,4-diClPh CH₂ Single bond Sub-8  1-745  Sub-56 3,4-diClPh CH₂ Single bond Sub-9  1-746  Sub-56 3,4-diClPh CH₂ Single bond Sub-10 1-747  Sub-56 3,4-diClPh CH₂ Single bond Sub-11 1-748  Sub-56 3,4-diClPh CH₂ Single bond Sub-12 1-749  Sub-56 3,4-diClPh CH₂ Single bond Sub-13 1-750  Sub-56 3,4-diClPh CH₂ Single bond Sub-14 1-751  Sub-56 3,4-diClPh CH₂ Single bond Sub-15 1-752  Sub-56 3,4-diClPh CH₂ Single bond Sub-16 1-753  Sub-56 3,4-diClPh CH₂ Single bond Sub-17 1-754  Sub-56 3,4-diClPh CH₂ Single bond Sub-18 1-755  Sub-56 3,4-diClPh CH₂ Single bond Sub-19 1-756  Sub-56 3,4-diClPh CH₂ Single bond Sub-20 1-757  Sub-56 3,4-diClPh CH₂ Single bond Sub-21 1-758  Sub-56 3,4-diClPh CH₂ Single bond Sub-22 1-759  Sub-56 3,4-diClPh CH₂ Single bond Sub-23 1-760  Sub-56 3,4-diClPh CH₂ Single bond Sub-24 1-761  Sub-56 3,4-diClPh CH₂ Single bond Sub-25 1-762  Sub-56 3,4-diClPh CH₂ Single bond Sub-26 1-763  Sub-56 3,4-diClPh CH₂ Single bond Sub-27 1-764  Sub-56 3,4-diClPh CH₂ Single bond Sub-28 1-765  Sub-56 3,4-diClPh CH₂ Single bond Sub-29 1-766  Sub-56 3,4-diClPh CH₂ Single bond Sub-30 1-767  Sub-56 3,4-diClPh CH₂ Single bond Sub-31 1-768  Sub-56 3,4-diClPh CH₂ Single bond Sub-32 1-769  Sub-57 3,4-diClPh CH₂ Single bond Sub-1  1-770  Sub-57 3,4-diClPh CH₂ Single bond Sub-2  1-771  Sub-57 3,4-diClPh CH₂ Single bond Sub-3  1-772  Sub-57 3,4-diClPh CH₂ Single bond Sub-4  1-773  Sub-57 3,4-diClPh CH₂ Single bond Sub-5  1-774  Sub-57 3,4-diClPh CH₂ Single bond Sub-6  1-775  Sub-57 3,4-diClPh CH₂ Single bond Sub-7  1-776  Sub-57 3,4-diClPh CH₂ Single bond Sub-8  1-777  Sub-57 3,4-diClPh CH₂ Single bond Sub-9  1-778  Sub-57 3,4-diClPh CH₂ Single bond Sub-10 1-779  Sub-57 3,4-diClPh CH₂ Single bond Sub-11 1-780  Sub-57 3,4-diClPh CH₂ Single bond Sub-12 1-781  Sub-57 3,4-diClPh CH₂ Single bond Sub-13 1-782  Sub-57 3,4-diClPh CH₂ Single bond Sub-14 1-783  Sub-57 3,4-diClPh CH₂ Single bond Sub-15 1-784  Sub-57 3,4-diClPh CH₂ Single bond Sub-16 1-785  Sub-57 3,4-diClPh CH₂ Single bond Sub-17 1-786  Sub-57 3,4-diClPh CH₂ Single bond Sub-18 1-787  Sub-57 3,4-diClPh CH₂ Single bond Sub-19 1-788  Sub-57 3,4-diClPh CH₂ Single bond Sub-20 1-789  Sub-57 3,4-diClPh CH₂ Single bond Sub-21 1-790  Sub-57 3,4-diClPh CH₂ Single bond Sub-22 1-791  Sub-57 3,4-diClPh CH₂ Single bond Sub-23 1-792  Sub-57 3,4-diClPh CH₂ Single bond Sub-24 1-793  Sub-57 3,4-diClPh CH₂ Single bond Sub-25 1-794  Sub-57 3,4-diClPh CH₂ Single bond Sub-26 1-795  Sub-57 3,4-diClPh CH₂ Single bond Sub-27 1-796  Sub-57 3,4-diClPh CH₂ Single bond Sub-28 1-797  Sub-57 3,4-diClPh CH₂ Single bond Sub-29 1-798  Sub-57 3,4-diClPh CH₂ Single bond Sub-30 1-799  Sub-57 3,4-diClPh CH₂ Single bond Sub-31 1-800  Sub-57 3,4-diClPh CH₂ Single bond Sub-32 1-801  Sub-58 3,4-diClPh CH₂ Single bond Sub-1  1-802  Sub-58 3,4-diClPh CH₂ Single bond Sub-2  1-803  Sub-58 3,4-diClPh CH₂ Single bond Sub-3  1-804  Sub-58 3,4-diClPh CH₂ Single bond Sub-4  1-805  Sub-58 3,4-diClPh CH₂ Single bond Sub-5  1-806  Sub-58 3,4-diClPh CH₂ Single bond Sub-6  1-807  Sub-58 3,4-diClPh CH₂ Single bond Sub-7  1-808  Sub-58 3,4-diClPh CH₂ Single bond Sub-8  1-809  Sub-58 3,4-diClPh CH₂ Single bond Sub-9  1-810  Sub-58 3,4-diClPh CH₂ Single bond Sub-10 1-811  Sub-58 3,4-diClPh CH₂ Single bond Sub-11 1-812  Sub-58 3,4-diClPh CH₂ Single bond Sub-12 1-813  Sub-58 3,4-diClPh CH₂ Single bond Sub-13 1-814  Sub-58 3,4-diClPh CH₂ Single bond Sub-14 1-815  Sub-58 3,4-diClPh CH₂ Single bond Sub-15 1-816  Sub-58 3,4-diClPh CH₂ Single bond Sub-16 1-817  Sub-58 3,4-diClPh CH₂ Single bond Sub-17 1-818  Sub-58 3,4-diClPh CH₂ Single bond Sub-18 1-819  Sub-58 3,4-diClPh CH₂ Single bond Sub-19 1-820  Sub-58 3,4-diClPh CH₂ Single bond Sub-20 1-821  Sub-58 3,4-diClPh CH₂ Single bond Sub-21 1-822  Sub-58 3,4-diClPh CH₂ Single bond Sub-22 1-823  Sub-58 3,4-diClPh CH₂ Single bond Sub-23 1-824  Sub-58 3,4-diClPh CH₂ Single bond Sub-24 1-825  Sub-58 3,4-diClPh CH₂ Single bond Sub-25 1-826  Sub-58 3,4-diClPh CH₂ Single bond Sub-26 1-827  Sub-58 3,4-diClPh CH₂ Single bond Sub-27 1-828  Sub-58 3,4-diClPh CH₂ Single bond Sub-28 1-829  Sub-58 3,4-diClPh CH₂ Single bond Sub-29 1-830  Sub-58 3,4-diClPh CH₂ Single bond Sub-30 1-831  Sub-58 3,4-diClPh CH₂ Single bond Sub-31 1-832  Sub-58 3,4-diClPh CH₂ Single bond Sub-32 1-833  Sub-59 3,4-diClPh CH₂ Single bond Sub-1  1-834  Sub-59 3,4-diClPh CH₂ Single bond Sub-2  1-835  Sub-59 3,4-diClPh CH₂ Single bond Sub-3  1-836  Sub-59 3,4-diClPh CH₂ Single bond Sub-4  1-837  Sub-59 3,4-diClPh CH₂ Single bond Sub-5  1-838  Sub-59 3,4-diClPh CH₂ Single bond Sub-6  1-839  Sub-59 3,4-diClPh CH₂ Single bond Sub-7  1-840  Sub-59 3,4-diClPh CH₂ Single bond Sub-8  1-841  Sub-59 3,4-diClPh CH₂ Single bond Sub-9  1-842  Sub-59 3,4-diClPh CH₂ Single bond Sub-10 1-843  Sub-59 3,4-diClPh CH₂ Single bond Sub-11 1-844  Sub-59 3,4-diClPh CH₂ Single bond Sub-12 1-845  Sub-59 3,4-diClPh CH₂ Single bond Sub-13 1-846  Sub-59 3,4-diClPh CH₂ Single bond Sub-14 1-847  Sub-59 3,4-diClPh CH₂ Single bond Sub-15 1-848  Sub-59 3,4-diClPh CH₂ Single bond Sub-16 1-849  Sub-59 3,4-diClPh CH₂ Single bond Sub-17 1-850  Sub-59 3,4-diClPh CH₂ Single bond Sub-18 1-851  Sub-59 3,4-diClPh CH₂ Single bond Sub-19 1-852  Sub-59 3,4-diClPh CH₂ Single bond Sub-20 1-853  Sub-59 3,4-diClPh CH₂ Single bond Sub-21 1-854  Sub-59 3,4-diClPh CH₂ Single bond Sub-22 1-855  Sub-59 3,4-diClPh CH₂ Single bond Sub-23 1-856  Sub-59 3,4-diClPh CH₂ Single bond Sub-24 1-857  Sub-59 3,4-diClPh CH₂ Single bond Sub-25 1-858  Sub-59 3,4-diClPh CH₂ Single bond Sub-26 1-859  Sub-59 3,4-diClPh CH₂ Single bond Sub-27 1-860  Sub-59 3,4-diClPh CH₂ Single bond Sub-28 1-861  Sub-59 3,4-diClPh CH₂ Single bond Sub-29 1-862  Sub-59 3,4-diClPh CH₂ Single bond Sub-30 1-863  Sub-59 3,4-diClPh CH₂ Single bond Sub-31 1-864  Sub-59 3,4-diClPh CH₂ Single bond Sub-32 1-865  Sub-60 3,4-diClPh CH₂ Single bond Sub-1  1-866  Sub-60 3,4-diClPh CH₂ Single bond Sub-2  1-867  Sub-60 3,4-diClPh CH₂ Single bond Sub-3  1-868  Sub-60 3,4-diClPh CH₂ Single bond Sub-4  1-869  Sub-60 3,4-diClPh CH₂ Single bond Sub-5  1-870  Sub-60 3,4-diClPh CH₂ Single bond Sub-6  1-871  Sub-60 3,4-diClPh CH₂ Single bond Sub-7  1-872  Sub-60 3,4-diClPh CH₂ Single bond Sub-8  1-873  Sub-60 3,4-diClPh CH₂ Single bond Sub-9  1-874  Sub-60 3,4-diClPh CH₂ Single bond Sub-10 1-875  Sub-60 3,4-diClPh CH₂ Single bond Sub-11 1-876  Sub-60 3,4-diClPh CH₂ Single bond Sub-12 1-877  Sub-60 3,4-diClPh CH₂ Single bond Sub-13 1-878  Sub-60 3,4-diClPh CH₂ Single bond Sub-14 1-879  Sub-60 3,4-diClPh CH₂ Single bond Sub-15 1-880  Sub-60 3,4-diClPh CH₂ Single bond Sub-16 1-881  Sub-60 3,4-diClPh CH₂ Single bond Sub-17 1-882  Sub-60 3,4-diClPh CH₂ Single bond Sub-18 1-883  Sub-60 3,4-diClPh CH₂ Single bond Sub-19 1-884  Sub-60 3,4-diClPh CH₂ Single bond Sub-20 1-885  Sub-60 3,4-diClPh CH₂ Single bond Sub-21 1-886  Sub-60 3,4-diClPh CH₂ Single bond Sub-22 1-887  Sub-60 3,4-diClPh CH₂ Single bond Sub-23 1-888  Sub-60 3,4-diClPh CH₂ Single bond Sub-24 1-889  Sub-60 3,4-diClPh CH₂ Single bond Sub-25 1-890  Sub-60 3,4-diClPh CH₂ Single bond Sub-26 1-891  Sub-60 3,4-diClPh CH₂ Single bond Sub-27 1-892  Sub-60 3,4-diClPh CH₂ Single bond Sub-28 1-893  Sub-60 3,4-diClPh CH₂ Single bond Sub-29 1-894  Sub-60 3,4-diClPh CH₂ Single bond Sub-30 1-895  Sub-60 3,4-diClPh CH₂ Single bond Sub-31 1-896  Sub-60 3,4-diClPh CH₂ Single bond Sub-32 1-897  Sub-61 3,4-diClPh CH₂ Single bond Sub-1  1-898  Sub-61 3,4-diClPh CH₂ Single bond Sub-2  1-899  Sub-61 3,4-diClPh CH₂ Single bond Sub-3  1-900  Sub-61 3,4-diClPh CH₂ Single bond Sub-4  1-901  Sub-61 3,4-diClPh CH₂ Single bond Sub-5  1-902  Sub-61 3,4-diClPh CH₂ Single bond Sub-6  1-903  Sub-61 3,4-diClPh CH₂ Single bond Sub-7  1-904  Sub-61 3,4-diClPh CH₂ Single bond Sub-8  1-905  Sub-61 3,4-diClPh CH₂ Single bond Sub-9  1-906  Sub-61 3,4-diClPh CH₂ Single bond Sub-10 1-907  Sub-61 3,4-diClPh CH₂ Single bond Sub-11 1-908  Sub-61 3,4-diClPh CH₂ Single bond Sub-12 1-909  Sub-61 3,4-diClPh CH₂ Single bond Sub-13 1-910  Sub-61 3,4-diClPh CH₂ Single bond Sub-14 1-911  Sub-61 3,4-diClPh CH₂ Single bond Sub-15 1-912  Sub-61 3,4-diClPh CH₂ Single bond Sub-16 1-913  Sub-61 3,4-diClPh CH₂ Single bond Sub-17 1-914  Sub-61 3,4-diClPh CH₂ Single bond Sub-18 1-915  Sub-61 3,4-diClPh CH₂ Single bond Sub-19 1-916  Sub-61 3,4-diClPh CH₂ Single bond Sub-20 1-917  Sub-61 3,4-diClPh CH₂ Single bond Sub-21 1-918  Sub-61 3,4-diClPh CH₂ Single bond Sub-22 1-919  Sub-61 3,4-diClPh CH₂ Single bond Sub-23 1-920  Sub-61 3,4-diClPh CH₂ Single bond Sub-24 1-921  Sub-61 3,4-diClPh CH₂ Single bond Sub-25 1-922  Sub-61 3,4-diClPh CH₂ Single bond Sub-26 1-923  Sub-61 3,4-diClPh CH₂ Single bond Sub-27 1-924  Sub-61 3,4-diClPh CH₂ Single bond Sub-28 1-925  Sub-61 3,4-diClPh CH₂ Single bond Sub-29 1-926  Sub-61 3,4-diClPh CH₂ Single bond Sub-30 1-927  Sub-61 3,4-diClPh CH₂ Single bond Sub-31 1-928  Sub-61 3,4-diClPh CH₂ Single bond Sub-32 1-929  Sub-62 3,4-diClPh CH₂ Single bond Sub-1  1-930  Sub-62 3,4-diClPh CH₂ Single bond Sub-2  1-931  Sub-62 3,4-diClPh CH₂ Single bond Sub-3  1-932  Sub-62 3,4-diClPh CH₂ Single bond Sub-4  1-933  Sub-62 3,4-diClPh CH₂ Single bond Sub-5  1-934  Sub-62 3,4-diClPh CH₂ Single bond Sub-6  1-935  Sub-62 3,4-diClPh CH₂ Single bond Sub-7  1-936  Sub-62 3,4-diClPh CH₂ Single bond Sub-8  1-937  Sub-62 3,4-diClPh CH₂ Single bond Sub-9  1-938  Sub-62 3,4-diClPh CH₂ Single bond Sub-10 1-939  Sub-62 3,4-diClPh CH₂ Single bond Sub-11 1-940  Sub-62 3,4-diClPh CH₂ Single bond Sub-12 1-941  Sub-62 3,4-diClPh CH₂ Single bond Sub-13 1-942  Sub-62 3,4-diClPh CH₂ Single bond Sub-14 1-943  Sub-62 3,4-diClPh CH₂ Single bond Sub-15 1-944  Sub-62 3,4-diClPh CH₂ Single bond Sub-16 1-945  Sub-62 3,4-diClPh CH₂ Single bond Sub-17 1-946  Sub-62 3,4-diClPh CH₂ Single bond Sub-18 1-947  Sub-62 3,4-diClPh CH₂ Single bond Sub-19 1-948  Sub-62 3,4-diClPh CH₂ Single bond Sub-20 1-949  Sub-62 3,4-diClPh CH₂ Single bond Sub-21 1-950  Sub-62 3,4-diClPh CH₂ Single bond Sub-22 1-951  Sub-62 3,4-diClPh CH₂ Single bond Sub-23 1-952  Sub-62 3,4-diClPh CH₂ Single bond Sub-24 1-953  Sub-62 3,4-diClPh CH₂ Single bond Sub-25 1-954  Sub-62 3,4-diClPh CH₂ Single bond Sub-26 1-955  Sub-62 3,4-diClPh CH₂ Single bond Sub-27 1-956  Sub-62 3,4-diClPh CH₂ Single bond Sub-28 1-957  Sub-62 3,4-diClPh CH₂ Single bond Sub-29 1-958  Sub-62 3,4-diClPh CH₂ Single bond Sub-30 1-959  Sub-62 3,4-diClPh CH₂ Single bond Sub-31 1-960  Sub-62 3,4-diClPh CH₂ Single bond Sub-32 1-961  Sub-63 3,4-diClPh CH₂ Single bond Sub-1  1-962  Sub-63 3,4-diClPh CH₂ Single bond Sub-2  1-963  Sub-63 3,4-diClPh CH₂ Single bond Sub-3  1-964  Sub-63 3,4-diClPh CH₂ Single bond Sub-4  1-965  Sub-63 3,4-diClPh CH₂ Single bond Sub-5  1-966  Sub-63 3,4-diClPh CH₂ Single bond Sub-6  1-967  Sub-63 3,4-diClPh CH₂ Single bond Sub-7  1-968  Sub-63 3,4-diClPh CH₂ Single bond Sub-8  1-969  Sub-63 3,4-diClPh CH₂ Single bond Sub-9  1-970  Sub-63 3,4-diClPh CH₂ Single bond Sub-10 1-971  Sub-63 3,4-diClPh CH₂ Single bond Sub-11 1-972  Sub-63 3,4-diClPh CH₂ Single bond Sub-12 1-973  Sub-63 3,4-diClPh CH₂ Single bond Sub-13 1-974  Sub-63 3,4-diClPh CH₂ Single bond Sub-14 1-975  Sub-63 3,4-diClPh CH₂ Single bond Sub-15 1-976  Sub-63 3,4-diClPh CH₂ Single bond Sub-16 1-977  Sub-63 3,4-diClPh CH₂ Single bond Sub-17 1-978  Sub-63 3,4-diClPh CH₂ Single bond Sub-18 1-979  Sub-63 3,4-diClPh CH₂ Single bond Sub-19 1-980  Sub-63 3,4-diClPh CH₂ Single bond Sub-20 1-981  Sub-63 3,4-diClPh CH₂ Single bond Sub-21 1-982  Sub-63 3,4-diClPh CH₂ Single bond Sub-22 1-983  Sub-63 3,4-diClPh CH₂ Single bond Sub-23 1-984  Sub-63 3,4-diClPh CH₂ Single bond Sub-24 1-985  Sub-63 3,4-diClPh CH₂ Single bond Sub-25 1-986  Sub-63 3,4-diClPh CH₂ Single bond Sub-26 1-987  Sub-63 3,4-diClPh CH₂ Single bond Sub-27 1-988  Sub-63 3,4-diClPh CH₂ Single bond Sub-28 1-989  Sub-63 3,4-diClPh CH₂ Single bond Sub-29 1-990  Sub-63 3,4-diClPh CH₂ Single bond Sub-30 1-991  Sub-63 3,4-diClPh CH₂ Single bond Sub-31 1-992  Sub-63 3,4-diClPh CH₂ Single bond Sub-32 1-993  Sub-64 3,4-diClPh CH₂ Single bond Sub-1  1-994  Sub-64 3,4-diClPh CH₂ Single bond Sub-2  1-995  Sub-64 3,4-diClPh CH₂ Single bond Sub-3  1-996  Sub-64 3,4-diClPh CH₂ Single bond Sub-4  1-997  Sub-64 3,4-diClPh CH₂ Single bond Sub-5  1-998  Sub-64 3,4-diClPh CH₂ Single bond Sub-6  1-999  Sub-64 3,4-diClPh CH₂ Single bond Sub-7  1-1000 Sub-64 3,4-diClPh CH₂ Single bond Sub-8  1-1001 Sub-64 3,4-diClPh CH₂ Single bond Sub-9  1-1002 Sub-64 3,4-diClPh CH₂ Single bond Sub-10 1-1003 Sub-64 3,4-diClPh CH₂ Single bond Sub-11 1-1004 Sub-64 3,4-diClPh CH₂ Single bond Sub-12 1-1005 Sub-64 3,4-diClPh CH₂ Single bond Sub-13 1-1006 Sub-64 3,4-diClPh CH₂ Single bond Sub-14 1-1007 Sub-64 3,4-diClPh CH₂ Single bond Sub-15 1-1008 Sub-64 3,4-diClPh CH₂ Single bond Sub-16 1-1009 Sub-64 3,4-diClPh CH₂ Single bond Sub-17 1-1010 Sub-64 3,4-diClPh CH₂ Single bond Sub-18 1-1011 Sub-64 3,4-diClPh CH₂ Single bond Sub-19 1-1012 Sub-64 3,4-diClPh CH₂ Single bond Sub-20 1-1013 Sub-64 3,4-diClPh CH₂ Single bond Sub-21 1-1014 Sub-64 3,4-diClPh CH₂ Single bond Sub-22 1-1015 Sub-64 3,4-diClPh CH₂ Single bond Sub-23 1-1016 Sub-64 3,4-diClPh CH₂ Single bond Sub-24 1-1017 Sub-64 3,4-diClPh CH₂ Single bond Sub-25 1-1018 Sub-64 3,4-diClPh CH₂ Single bond Sub-26 1-1019 Sub-64 3,4-diClPh CH₂ Single bond Sub-27 1-1020 Sub-64 3,4-diClPh CH₂ Single bond Sub-28 1-1021 Sub-64 3,4-diClPh CH₂ Single bond Sub-29 1-1022 Sub-64 3,4-diClPh CH₂ Single bond Sub-30 1-1023 Sub-64 3,4-diClPh CH₂ Single bond Sub-31 1-1024 Sub-64 3,4-diClPh CH₂ Single bond Sub-32 1-1025 Sub-33 3,4-diClPh CO Single bond Sub-1  1-1026 Sub-33 3,4-diClPh CO Single bond Sub-2  1-1027 Sub-33 3,4-diClPh CO Single bond Sub-3  1-1028 Sub-33 3,4-diClPh CO Single bond Sub-4  1-1029 Sub-33 3,4-diClPh CO Single bond Sub-5  1-1030 Sub-33 3,4-diClPh CO Single bond Sub-6  1-1031 Sub-33 3,4-diClPh CO Single bond Sub-7  1-1032 Sub-33 3,4-diClPh CO Single bond Sub-8  1-1033 Sub-33 3,4-diClPh CO Single bond Sub-9  1-1034 Sub-33 3,4-diClPh CO Single bond Sub-10 1-1035 Sub-33 3,4-diClPh CO Single bond Sub-11 1-1036 Sub-33 3,4-diClPh CO Single bond Sub-12 1-1037 Sub-33 3,4-diClPh CO Single bond Sub-13 1-1038 Sub-33 3,4-diClPh CO Single bond Sub-14 1-1039 Sub-33 3,4-diClPh CO Single bond Sub-15 1-1040 Sub-33 3,4-diClPh CO Single bond Sub-16 1-1041 Sub-33 3,4-diClPh CO Single bond Sub-17 1-1042 Sub-33 3,4-diClPh CO Single bond Sub-18 1-1043 Sub-33 3,4-diClPh CO Single bond Sub-19 1-1044 Sub-33 3,4-diClPh CO Single bond Sub-20 1-1045 Sub-33 3,4-diClPh CO Single bond Sub-21 1-1046 Sub-33 3,4-diClPh CO Single bond Sub-22 1-1047 Sub-33 3,4-diClPh CO Single bond Sub-23 1-1048 Sub-33 3,4-diClPh CO Single bond Sub-24 1-1049 Sub-33 3,4-diClPh CO Single bond Sub-25 1-1050 Sub-33 3,4-diClPh CO Single bond Sub-26 1-1051 Sub-33 3,4-diClPh CO Single bond Sub-27 1-1052 Sub-33 3,4-diClPh CO Single bond Sub-28 1-1053 Sub-33 3,4-diClPh CO Single bond Sub-29 1-1054 Sub-33 3,4-diClPh CO Single bond Sub-30 1-1055 Sub-33 3,4-diClPh CO Single bond Sub-31 1-1056 Sub-33 3,4-diClPh CO Single bond Sub-32 1-1057 Sub-34 3,4-diClPh CO Single bond Sub-1  1-1058 Sub-34 3,4-diClPh CO Single bond Sub-2  1-1059 Sub-34 3,4-diClPh CO Single bond Sub-3  1-1060 Sub-34 3,4-diClPh CO Single bond Sub-4  1-1061 Sub-34 3,4-diClPh CO Single bond Sub-5  1-1062 Sub-34 3,4-diClPh CO Single bond Sub-6  1-1063 Sub-34 3,4-diClPh CO Single bond Sub-7  1-1064 Sub-34 3,4-diClPh CO Single bond Sub-8  1-1065 Sub-34 3,4-diClPh CO Single bond Sub-9  1-1066 Sub-34 3,4-diClPh CO Single bond Sub-10 1-1067 Sub-34 3,4-diClPh CO Single bond Sub-11 1-1068 Sub-34 3,4-diClPh CO Single bond Sub-12 1-1069 Sub-34 3,4-diClPh CO Single bond Sub-13 1-1070 Sub-34 3,4-diClPh CO Single bond Sub-14 1-1071 Sub-34 3,4-diClPh CO Single bond Sub-15 1-1072 Sub-34 3,4-diClPh CO Single bond Sub-16 1-1073 Sub-34 3,4-diClPh CO Single bond Sub-17 1-1074 Sub-34 3,4-diClPh CO Single bond Sub-18 1-1075 Sub-34 3,4-diClPh CO Single bond Sub-19 1-1076 Sub-34 3,4-diClPh CO Single bond Sub-20 1-1077 Sub-34 3,4-diClPh CO Single bond Sub-21 1-1078 Sub-34 3,4-diClPh CO Single bond Sub-22 1-1079 Sub-34 3,4-diClPh CO Single bond Sub-23 1-1080 Sub-34 3,4-diClPh CO Single bond Sub-24 1-1081 Sub-34 3,4-diClPh CO Single bond Sub-25 1-1082 Sub-34 3,4-diClPh CO Single bond Sub-26 1-1083 Sub-34 3,4-diClPh CO Single bond Sub-27 1-1084 Sub-34 3,4-diClPh CO Single bond Sub-28 1-1085 Sub-34 3,4-diClPh CO Single bond Sub-29 1-1086 Sub-34 3,4-diClPh CO Single bond Sub-30 1-1087 Sub-34 3,4-diClPh CO Single bond Sub-31 1-1088 Sub-34 3,4-diClPh CO Single bond Sub-32 1-1089 Sub-35 3,4-diClPh CO Single bond Sub-1  1-1090 Sub-35 3,4-diClPh CO Single bond Sub-2  1-1091 Sub-35 3,4-diClPh CO Single bond Sub-3  1-1092 Sub-35 3,4-diClPh CO Single bond Sub-4  1-1093 Sub-35 3,4-diClPh CO Single bond Sub-5  1-1094 Sub-35 3,4-diClPh CO Single bond Sub-6  1-1095 Sub-35 3,4-diClPh CO Single bond Sub-7  1-1096 Sub-35 3,4-diClPh CO Single bond Sub-8  1-1097 Sub-35 3,4-diClPh CO Single bond Sub-9  1-1098 Sub-35 3,4-diClPh CO Single bond Sub-10 1-1099 Sub-35 3,4-diClPh CO Single bond Sub-11 1-1100 Sub-35 3,4-diClPh CO Single bond Sub-12 1-1101 Sub-35 3,4-diClPh CO Single bond Sub-13 1-1102 Sub-35 3,4-diClPh CO Single bond Sub-14 1-1103 Sub-35 3,4-diClPh CO Single bond Sub-15 1-1104 Sub-35 3,4-diClPh CO Single bond Sub-16 1-1105 Sub-35 3,4-diClPh CO Single bond Sub-17 1-1106 Sub-35 3,4-diClPh CO Single bond Sub-18 1-1107 Sub-35 3,4-diClPh CO Single bond Sub-19 1-1108 Sub-35 3,4-diClPh CO Single bond Sub-20 1-1109 Sub-35 3,4-diClPh CO Single bond Sub-21 1-1110 Sub-35 3,4-diClPh CO Single bond Sub-22 1-1111 Sub-35 3,4-diClPh CO Single bond Sub-23 1-1112 Sub-35 3,4-diClPh CO Single bond Sub-24 1-1113 Sub-35 3,4-diClPh CO Single bond Sub-25 1-1114 Sub-35 3,4-diClPh CO Single bond Sub-26 1-1115 Sub-35 3,4-diClPh CO Single bond Sub-27 1-1116 Sub-35 3,4-diClPh CO Single bond Sub-28 1-1117 Sub-35 3,4-diClPh CO Single bond Sub-29 1-1118 Sub-35 3,4-diClPh CO Single bond Sub-30 1-1119 Sub-35 3,4-diClPh CO Single bond Sub-31 1-1120 Sub-35 3,4-diClPh CO Single bond Sub-32 1-1121 Sub-36 3,4-diClPh CO Single bond Sub-1  1-1122 Sub-36 3,4-diClPh CO Single bond Sub-2  1-1123 Sub-36 3,4-diClPh CO Single bond Sub-3  1-1124 Sub-36 3,4-diClPh CO Single bond Sub-4  1-1125 Sub-36 3,4-diClPh CO Single bond Sub-5  1-1126 Sub-36 3,4-diClPh CO Single bond Sub-6  1-1127 Sub-36 3,4-diClPh CO Single bond Sub-7  1-1128 Sub-36 3,4-diClPh CO Single bond Sub-8  1-1129 Sub-36 3,4-diClPh CO Single bond Sub-9  1-1130 Sub-36 3,4-diClPh CO Single bond Sub-10 1-1131 Sub-36 3,4-diClPh CO Single bond Sub-11 1-1132 Sub-36 3,4-diClPh CO Single bond Sub-12 1-1133 Sub-36 3,4-diClPh CO Single bond Sub-13 1-1134 Sub-36 3,4-diClPh CO Single bond Sub-14 1-1135 Sub-36 3,4-diClPh CO Single bond Sub-15 1-1136 Sub-36 3,4-diClPh CO Single bond Sub-16 1-1137 Sub-36 3,4-diClPh CO Single bond Sub-17 1-1138 Sub-36 3,4-diClPh CO Single bond Sub-18 1-1139 Sub-36 3,4-diClPh CO Single bond Sub-19 1-1140 Sub-36 3,4-diClPh CO Single bond Sub-20 1-1141 Sub-36 3,4-diClPh CO Single bond Sub-21 1-1142 Sub-36 3,4-diClPh CO Single bond Sub-22 1-1143 Sub-36 3,4-diClPh CO Single bond Sub-23 1-1144 Sub-36 3,4-diClPh CO Single bond Sub-24 1-1145 Sub-36 3,4-diClPh CO Single bond Sub-25 1-1146 Sub-36 3,4-diClPh CO Single bond Sub-26 1-1147 Sub-36 3,4-diClPh CO Single bond Sub-27 1-1148 Sub-36 3,4-diClPh CO Single bond Sub-28 1-1149 Sub-36 3,4-diClPh CO Single bond Sub-29 1-1150 Sub-36 3,4-diClPh CO Single bond Sub-30 1-1151 Sub-36 3,4-diClPh CO Single bond Sub-31 1-1152 Sub-36 3,4-diClPh CO Single bond Sub-32 1-1153 Sub-37 3,4-diClPh CO Single bond Sub-1  1-1154 Sub-37 3,4-diClPh CO Single bond Sub-2  1-1155 Sub-37 3,4-diClPh CO Single bond Sub-3  1-1156 Sub-37 3,4-diClPh CO Single bond Sub-4  1-1157 Sub-37 3,4-diClPh CO Single bond Sub-5  1-1158 Sub-37 3,4-diClPh CO Single bond Sub-6  1-1159 Sub-37 3,4-diClPh CO Single bond Sub-7  1-1160 Sub-37 3,4-diClPh CO Single bond Sub-8  1-1161 Sub-37 3,4-diClPh CO Single bond Sub-9  1-1162 Sub-37 3,4-diClPh CO Single bond Sub-10 1-1163 Sub-37 3,4-diClPh CO Single bond Sub-11 1-1164 Sub-37 3,4-diClPh CO Single bond Sub-12 1-1165 Sub-37 3,4-diClPh CO Single bond Sub-13 1-1166 Sub-37 3,4-diClPh CO Single bond Sub-14 1-1167 Sub-37 3,4-diClPh CO Single bond Sub-15 1-1168 Sub-37 3,4-diClPh CO Single bond Sub-16 1-1169 Sub-37 3,4-diClPh CO Single bond Sub-17 1-1170 Sub-37 3,4-diClPh CO Single bond Sub-18 1-1171 Sub-37 3,4-diClPh CO Single bond Sub-19 1-1172 Sub-37 3,4-diClPh CO Single bond Sub-20 1-1173 Sub-37 3,4-diClPh CO Single bond Sub-21 1-1174 Sub-37 3,4-diClPh CO Single bond Sub-22 1-1175 Sub-37 3,4-diClPh CO Single bond Sub-23 1-1176 Sub-37 3,4-diClPh CO Single bond Sub-24 1-1177 Sub-37 3,4-diClPh CO Single bond Sub-25 1-1178 Sub-37 3,4-diClPh CO Single bond Sub-26 1-1179 Sub-37 3,4-diClPh CO Single bond Sub-27 1-1180 Sub-37 3,4-diClPh CO Single bond Sub-28 1-1181 Sub-37 3,4-diClPh CO Single bond Sub-29 1-1182 Sub-37 3,4-diClPh CO Single bond Sub-30 1-1183 Sub-37 3,4-diClPh CO Single bond Sub-31 1-1184 Sub-37 3,4-diClPh CO Single bond Sub-32 1-1185 Sub-38 3,4-diClPh CO Single bond Sub-1  1-1186 Sub-38 3,4-diClPh CO Single bond Sub-2  1-1187 Sub-38 3,4-diClPh CO Single bond Sub-3  1-1188 Sub-38 3,4-diClPh CO Single bond Sub-4  1-1189 Sub-38 3,4-diClPh CO Single bond Sub-5  1-1190 Sub-38 3,4-diClPh CO Single bond Sub-6  1-1191 Sub-38 3,4-diClPh CO Single bond Sub-7  1-1192 Sub-38 3,4-diClPh CO Single bond Sub-8  1-1193 Sub-38 3,4-diClPh CO Single bond Sub-9  1-1194 Sub-38 3,4-diClPh CO Single bond Sub-10 1-1195 Sub-38 3,4-diClPh CO Single bond Sub-11 1-1196 Sub-38 3,4-diClPh CO Single bond Sub-12 1-1197 Sub-38 3,4-diClPh CO Single bond Sub-13 1-1198 Sub-38 3,4-diClPh CO Single bond Sub-14 1-1199 Sub-38 3,4-diClPh CO Single bond Sub-15 1-1200 Sub-38 3,4-diClPh CO Single bond Sub-16 1-1201 Sub-38 3,4-diClPh CO Single bond Sub-17 1-1202 Sub-38 3,4-diClPh CO Single bond Sub-18 1-1203 Sub-38 3,4-diClPh CO Single bond Sub-19 1-1204 Sub-38 3,4-diClPh CO Single bond Sub-20 1-1205 Sub-38 3,4-diClPh CO Single bond Sub-21 1-1206 Sub-38 3,4-diClPh CO Single bond Sub-22 1-1207 Sub-38 3,4-diClPh CO Single bond Sub-23 1-1208 Sub-38 3,4-diClPh CO Single bond Sub-24 1-1209 Sub-38 3,4-diClPh CO Single bond Sub-25 1-1210 Sub-38 3,4-diClPh CO Single bond Sub-26 1-1211 Sub-38 3,4-diClPh CO Single bond Sub-27 1-1212 Sub-38 3,4-diClPh CO Single bond Sub-28 1-1213 Sub-38 3,4-diClPh CO Single bond Sub-29 1-1214 Sub-38 3,4-diClPh CO Single bond Sub-30 1-1215 Sub-38 3,4-diClPh CO Single bond Sub-31 1-1216 Sub-38 3,4-diClPh CO Single bond Sub-32 1-1217 Sub-39 3,4-diClPh CO Single bond Sub-1  1-1218 Sub-39 3,4-diClPh CO Single bond Sub-2  1-1219 Sub-39 3,4-diClPh CO Single bond Sub-3  1-1220 Sub-39 3,4-diClPh CO Single bond Sub-4  1-1221 Sub-39 3,4-diClPh CO Single bond Sub-5  1-1222 Sub-39 3,4-diClPh CO Single bond Sub-6  1-1223 Sub-39 3,4-diClPh CO Single bond Sub-7  1-1224 Sub-39 3,4-diClPh CO Single bond Sub-8  1-1225 Sub-39 3,4-diClPh CO Single bond Sub-9  1-1226 Sub-39 3,4-diClPh CO Single bond Sub-10 1-1227 Sub-39 3,4-diClPh CO Single bond Sub-11 1-1228 Sub-39 3,4-diClPh CO Single bond Sub-12 1-1229 Sub-39 3,4-diClPh CO Single bond Sub-13 1-1230 Sub-39 3,4-diClPh CO Single bond Sub-14 1-1231 Sub-39 3,4-diClPh CO Single bond Sub-15 1-1232 Sub-39 3,4-diClPh CO Single bond Sub-16 1-1233 Sub-39 3,4-diClPh CO Single bond Sub-17 1-1234 Sub-39 3,4-diClPh CO Single bond Sub-18 1-1235 Sub-39 3,4-diClPh CO Single bond Sub-19 1-1236 Sub-39 3,4-diClPh CO Single bond Sub-20 1-1237 Sub-39 3,4-diClPh CO Single bond Sub-21 1-1238 Sub-39 3,4-diClPh CO Single bond Sub-22 1-1239 Sub-39 3,4-diClPh CO Single bond Sub-23 1-1240 Sub-39 3,4-diClPh CO Single bond Sub-24 1-1241 Sub-39 3,4-diClPh CO Single bond Sub-25 1-1242 Sub-39 3,4-diClPh CO Single bond Sub-26 1-1243 Sub-39 3,4-diClPh CO Single bond Sub-27 1-1244 Sub-39 3,4-diClPh CO Single bond Sub-28 1-1245 Sub-39 3,4-diClPh CO Single bond Sub-29 1-1246 Sub-39 3,4-diClPh CO Single bond Sub-30 1-1247 Sub-39 3,4-diClPh CO Single bond Sub-31 1-1248 Sub-39 3,4-diClPh CO Single bond Sub-32 1-1249 Sub-40 3,4-diClPh CO Single bond Sub-1  1-1250 Sub-40 3,4-diClPh CO Single bond Sub-2  1-1251 Sub-40 3,4-diClPh CO Single bond Sub-3  1-1252 Sub-40 3,4-diClPh CO Single bond Sub-4  1-1253 Sub-40 3,4-diClPh CO Single bond Sub-5  1-1254 Sub-40 3,4-diClPh CO Single bond Sub-6  1-1255 Sub-40 3,4-diClPh CO Single bond Sub-7  1-1256 Sub-40 3,4-diClPh CO Single bond Sub-8  1-1257 Sub-40 3,4-diClPh CO Single bond Sub-9  1-1258 Sub-40 3,4-diClPh CO Single bond Sub-10 1-1259 Sub-40 3,4-diClPh CO Single bond Sub-11 1-1260 Sub-40 3,4-diClPh CO Single bond Sub-12 1-1261 Sub-40 3,4-diClPh CO Single bond Sub-13 1-1262 Sub-40 3,4-diClPh CO Single bond Sub-14 1-1263 Sub-40 3,4-diClPh CO Single bond Sub-15 1-1264 Sub-40 3,4-diClPh CO Single bond Sub-16 1-1265 Sub-40 3,4-diClPh CO Single bond Sub-17 1-1266 Sub-40 3,4-diClPh CO Single bond Sub-18 1-1267 Sub-40 3,4-diClPh CO Single bond Sub-19 1-1268 Sub-40 3,4-diClPh CO Single bond Sub-20 1-1269 Sub-40 3,4-diClPh CO Single bond Sub-21 1-1270 Sub-40 3,4-diClPh CO Single bond Sub-22 1-1271 Sub-40 3,4-diClPh CO Single bond Sub-23 1-1272 Sub-40 3,4-diClPh CO Single bond Sub-24 1-1273 Sub-40 3,4-diClPh CO Single bond Sub-25 1-1274 Sub-40 3,4-diClPh CO Single bond Sub-26 1-1275 Sub-40 3,4-diClPh CO Single bond Sub-27 1-1276 Sub-40 3,4-diClPh CO Single bond Sub-28 1-1277 Sub-40 3,4-diClPh CO Single bond Sub-29 1-1278 Sub-40 3,4-diClPh CO Single bond Sub-30 1-1279 Sub-40 3,4-diClPh CO Single bond Sub-31 1-1280 Sub-40 3,4-diClPh CO Single bond Sub-32 1-1281 Sub-41 3,4-diClPh CO Single bond Sub-1  1-1282 Sub-41 3,4-diClPh CO Single bond Sub-2  1-1283 Sub-41 3,4-diClPh CO Single bond Sub-3  1-1284 Sub-41 3,4-diClPh CO Single bond Sub-4  1-1285 Sub-41 3,4-diClPh CO Single bond Sub-5  1-1286 Sub-41 3,4-diClPh CO Single bond Sub-6  1-1287 Sub-41 3,4-diClPh CO Single bond Sub-7  1-1288 Sub-41 3,4-diClPh CO Single bond Sub-8  1-1289 Sub-41 3,4-diClPh CO Single bond Sub-9  1-1290 Sub-41 3,4-diClPh CO Single bond Sub-10 1-1291 Sub-41 3,4-diClPh CO Single bond Sub-11 1-1292 Sub-41 3,4-diClPh CO Single bond Sub-12 1-1293 Sub-41 3,4-diClPh CO Single bond Sub-13 1-1294 Sub-41 3,4-diClPh CO Single bond Sub-14 1-1295 Sub-41 3,4-diClPh CO Single bond Sub-15 1-1296 Sub-41 3,4-diClPh CO Single bond Sub-16 1-1297 Sub-41 3,4-diClPh CO Single bond Sub-17 1-1298 Sub-41 3,4-diClPh CO Single bond Sub-18 1-1299 Sub-41 3,4-diClPh CO Single bond Sub-19 1-1300 Sub-41 3,4-diClPh CO Single bond Sub-20 1-1301 Sub-41 3,4-diClPh CO Single bond Sub-21 1-1302 Sub-41 3,4-diClPh CO Single bond Sub-22 1-1303 Sub-41 3,4-diClPh CO Single bond Sub-23 1-1304 Sub-41 3,4-diClPh CO Single bond Sub-24 1-1305 Sub-41 3,4-diClPh CO Single bond Sub-25 1-1306 Sub-41 3,4-diClPh CO Single bond Sub-26 1-1307 Sub-41 3,4-diClPh CO Single bond Sub-27 1-1308 Sub-41 3,4-diClPh CO Single bond Sub-28 1-1309 Sub-41 3,4-diClPh CO Single bond Sub-29 1-1310 Sub-41 3,4-diClPh CO Single bond Sub-30 1-1311 Sub-41 3,4-diClPh CO Single bond Sub-31 1-1312 Sub-41 3,4-diClPh CO Single bond Sub-32 1-1313 Sub-42 3,4-diClPh CO Single bond Sub-1  1-1314 Sub-42 3,4-diClPh CO Single bond Sub-2  1-1315 Sub-42 3,4-diClPh CO Single bond Sub-3  1-1316 Sub-42 3,4-diClPh CO Single bond Sub-4  1-1317 Sub-42 3,4-diClPh CO Single bond Sub-5  1-1318 Sub-42 3,4-diClPh CO Single bond Sub-6  1-1319 Sub-42 3,4-diClPh CO Single bond Sub-7  1-1320 Sub-42 3,4-diClPh CO Single bond Sub-8  1-1321 Sub-42 3,4-diClPh CO Single bond Sub-9  1-1322 Sub-42 3,4-diClPh CO Single bond Sub-10 1-1323 Sub-42 3,4-diClPh CO Single bond Sub-11 1-1324 Sub-42 3,4-diClPh CO Single bond Sub-12 1-1325 Sub-42 3,4-diClPh CO Single bond Sub-13 1-1326 Sub-42 3,4-diClPh CO Single bond Sub-14 1-1327 Sub-42 3,4-diClPh CO Single bond Sub-15 1-1328 Sub-42 3,4-diClPh CO Single bond Sub-16 1-1329 Sub-42 3,4-diClPh CO Single bond Sub-17 1-1330 Sub-42 3,4-diClPh CO Single bond Sub-18 1-1331 Sub-42 3,4-diClPh CO Single bond Sub-19 1-1332 Sub-42 3,4-diClPh CO Single bond Sub-20 1-1333 Sub-42 3,4-diClPh CO Single bond Sub-21 1-1334 Sub-42 3,4-diClPh CO Single bond Sub-22 1-1335 Sub-42 3,4-diClPh CO Single bond Sub-23 1-1336 Sub-42 3,4-diClPh CO Single bond Sub-24 1-1337 Sub-42 3,4-diClPh CO Single bond Sub-25 1-1338 Sub-42 3,4-diClPh CO Single bond Sub-26 1-1339 Sub-42 3,4-diClPh CO Single bond Sub-27 1-1340 Sub-42 3,4-diClPh CO Single bond Sub-28 1-1341 Sub-42 3,4-diClPh CO Single bond Sub-29 1-1342 Sub-42 3,4-diClPh CO Single bond Sub-30 1-1343 Sub-42 3,4-diClPh CO Single bond Sub-31 1-1344 Sub-42 3,4-diClPh CO Single bond Sub-32 1-1345 Sub-43 3,4-diClPh CO Single bond Sub-1  1-1346 Sub-43 3,4-diClPh CO Single bond Sub-2  1-1347 Sub-43 3,4-diClPh CO Single bond Sub-3  1-1348 Sub-43 3,4-diClPh CO Single bond Sub-4  1-1349 Sub-43 3,4-diClPh CO Single bond Sub-5  1-1350 Sub-43 3,4-diClPh CO Single bond Sub-6  1-1351 Sub-43 3,4-diClPh CO Single bond Sub-7  1-1352 Sub-43 3,4-diClPh CO Single bond Sub-8  1-1353 Sub-43 3,4-diClPh CO Single bond Sub-9  1-1354 Sub-43 3,4-diClPh CO Single bond Sub-10 1-1355 Sub-43 3,4-diClPh CO Single bond Sub-11 1-1356 Sub-43 3,4-diClPh CO Single bond Sub-12 1-1357 Sub-43 3,4-diClPh CO Single bond Sub-13 1-1358 Sub-43 3,4-diClPh CO Single bond Sub-14 1-1359 Sub-43 3,4-diClPh CO Single bond Sub-15 1-1360 Sub-43 3,4-diClPh CO Single bond Sub-16 1-1361 Sub-43 3,4-diClPh CO Single bond Sub-17 1-1362 Sub-43 3,4-diClPh CO Single bond Sub-18 1-1363 Sub-43 3,4-diClPh CO Single bond Sub-19 1-1364 Sub-43 3,4-diClPh CO Single bond Sub-20 1-1365 Sub-43 3,4-diClPh CO Single bond Sub-21 1-1366 Sub-43 3,4-diClPh CO Single bond Sub-22 1-1367 Sub-43 3,4-diClPh CO Single bond Sub-23 1-1368 Sub-43 3,4-diClPh CO Single bond Sub-24 1-1369 Sub-43 3,4-diClPh CO Single bond Sub-25 1-1370 Sub-43 3,4-diClPh CO Single bond Sub-26 1-1371 Sub-43 3,4-diClPh CO Single bond Sub-27 1-1372 Sub-43 3,4-diClPh CO Single bond Sub-28 1-1373 Sub-43 3,4-diClPh CO Single bond Sub-29 1-1374 Sub-43 3,4-diClPh CO Single bond Sub-30 1-1375 Sub-43 3,4-diClPh CO Single bond Sub-31 1-1376 Sub-43 3,4-diClPh CO Single bond Sub-32 1-1377 Sub-44 3,4-diClPh CO Single bond Sub-1  1-1378 Sub-44 3,4-diClPh CO Single bond Sub-2  1-1379 Sub-44 3,4-diClPh CO Single bond Sub-3  1-1380 Sub-44 3,4-diClPh CO Single bond Sub-4  1-1381 Sub-44 3,4-diClPh CO Single bond Sub-5  1-1382 Sub-44 3,4-diClPh CO Single bond Sub-6  1-1383 Sub-44 3,4-diClPh CO Single bond Sub-7  1-1384 Sub-44 3,4-diClPh CO Single bond Sub-8  1-1385 Sub-44 3,4-diClPh CO Single bond Sub-9  1-1386 Sub-44 3,4-diClPh CO Single bond Sub-10 1-1387 Sub-44 3,4-diClPh CO Single bond Sub-11 1-1388 Sub-44 3,4-diClPh CO Single bond Sub-12 1-1389 Sub-44 3,4-diClPh CO Single bond Sub-13 1-1390 Sub-44 3,4-diClPh CO Single bond Sub-14 1-1391 Sub-44 3,4-diClPh CO Single bond Sub-15 1-1392 Sub-44 3,4-diClPh CO Single bond Sub-16 1-1393 Sub-44 3,4-diClPh CO Single bond Sub-17 1-1394 Sub-44 3,4-diClPh CO Single bond Sub-18 1-1395 Sub-44 3,4-diClPh CO Single bond Sub-19 1-1396 Sub-44 3,4-diClPh CO Single bond Sub-20 1-1397 Sub-44 3,4-diClPh CO Single bond Sub-21 1-1398 Sub-44 3,4-diClPh CO Single bond Sub-22 1-1399 Sub-44 3,4-diClPh CO Single bond Sub-23 1-1400 Sub-44 3,4-diClPh CO Single bond Sub-24 1-1401 Sub-44 3,4-diClPh CO Single bond Sub-25 1-1402 Sub-44 3,4-diClPh CO Single bond Sub-26 1-1403 Sub-44 3,4-diClPh CO Single bond Sub-27 1-1404 Sub-44 3,4-diClPh CO Single bond Sub-28 1-1405 Sub-44 3,4-diClPh CO Single bond Sub-29 1-1406 Sub-44 3,4-diClPh CO Single bond Sub-30 1-1407 Sub-44 3,4-diClPh CO Single bond Sub-31 1-1408 Sub-44 3,4-diClPh CO Single bond Sub-32 1-1409 Sub-45 3,4-diClPh CO Single bond Sub-1  1-1410 Sub-45 3,4-diClPh CO Single bond Sub-2  1-1411 Sub-45 3,4-diClPh CO Single bond Sub-3  1-1412 Sub-45 3,4-diClPh CO Single bond Sub-4  1-1413 Sub-45 3,4-diClPh CO Single bond Sub-5  1-1414 Sub-45 3,4-diClPh CO Single bond Sub-6  1-1415 Sub-45 3,4-diClPh CO Single bond Sub-7  1-1416 Sub-45 3,4-diClPh CO Single bond Sub-8  1-1417 Sub-45 3,4-diClPh CO Single bond Sub-9  1-1418 Sub-45 3,4-diClPh CO Single bond Sub-10 1-1419 Sub-45 3,4-diClPh CO Single bond Sub-11 1-1420 Sub-45 3,4-diClPh CO Single bond Sub-12 1-1421 Sub-45 3,4-diClPh CO Single bond Sub-13 1-1422 Sub-45 3,4-diClPh CO Single bond Sub-14 1-1423 Sub-45 3,4-diClPh CO Single bond Sub-15 1-1424 Sub-45 3,4-diClPh CO Single bond Sub-16 1-1425 Sub-45 3,4-diClPh CO Single bond Sub-17 1-1426 Sub-45 3,4-diClPh CO Single bond Sub-18 1-1427 Sub-45 3,4-diClPh CO Single bond Sub-19 1-1428 Sub-45 3,4-diClPh CO Single bond Sub-20 1-1429 Sub-45 3,4-diClPh CO Single bond Sub-21 1-1430 Sub-45 3,4-diClPh CO Single bond Sub-22 1-1431 Sub-45 3,4-diClPh CO Single bond Sub-23 1-1432 Sub-45 3,4-diClPh CO Single bond Sub-24 1-1433 Sub-45 3,4-diClPh CO Single bond Sub-25 1-1434 Sub-45 3,4-diClPh CO Single bond Sub-26 1-1435 Sub-45 3,4-diClPh CO Single bond Sub-27 1-1436 Sub-45 3,4-diClPh CO Single bond Sub-28 1-1437 Sub-45 3,4-diClPh CO Single bond Sub-29 1-1438 Sub-45 3,4-diClPh CO Single bond Sub-30 1-1439 Sub-45 3,4-diClPh CO Single bond Sub-31 1-1440 Sub-45 3,4-diClPh CO Single bond Sub-32 1-1441 Sub-46 3,4-diClPh CO Single bond Sub-1  1-1442 Sub-46 3,4-diClPh CO Single bond Sub-2  1-1443 Sub-46 3,4-diClPh CO Single bond Sub-3  1-1444 Sub-46 3,4-diClPh CO Single bond Sub-4  1-1445 Sub-46 3,4-diClPh CO Single bond Sub-5  1-1446 Sub-46 3,4-diClPh CO Single bond Sub-6  1-1447 Sub-46 3,4-diClPh CO Single bond Sub-7  1-1448 Sub-46 3,4-diClPh CO Single bond Sub-8  1-1449 Sub-46 3,4-diClPh CO Single bond Sub-9  1-1450 Sub-46 3,4-diClPh CO Single bond Sub-10 1-1451 Sub-46 3,4-diClPh CO Single bond Sub-11 1-1452 Sub-46 3,4-diClPh CO Single bond Sub-12 1-1453 Sub-46 3,4-diClPh CO Single bond Sub-13 1-1454 Sub-46 3,4-diClPh CO Single bond Sub-14 1-1455 Sub-46 3,4-diClPh CO Single bond Sub-15 1-1456 Sub-46 3,4-diClPh CO Single bond Sub-16 1-1457 Sub-46 3,4-diClPh CO Single bond Sub-17 1-1458 Sub-46 3,4-diClPh CO Single bond Sub-18 1-1459 Sub-46 3,4-diClPh CO Single bond Sub-19 1-1460 Sub-46 3,4-diClPh CO Single bond Sub-20 1-1461 Sub-46 3,4-diClPh CO Single bond Sub-21 1-1462 Sub-46 3,4-diClPh CO Single bond Sub-22 1-1463 Sub-46 3,4-diClPh CO Single bond Sub-23 1-1464 Sub-46 3,4-diClPh CO Single bond Sub-24 1-1465 Sub-46 3,4-diClPh CO Single bond Sub-25 1-1466 Sub-46 3,4-diClPh CO Single bond Sub-26 1-1467 Sub-46 3,4-diClPh CO Single bond Sub-27 1-1468 Sub-46 3,4-diClPh CO Single bond Sub-28 1-1469 Sub-46 3,4-diClPh CO Single bond Sub-29 1-1470 Sub-46 3,4-diClPh CO Single bond Sub-30 1-1471 Sub-46 3,4-diClPh CO Single bond Sub-31 1-1472 Sub-46 3,4-diClPh CO Single bond Sub-32 1-1473 Sub-47 3,4-diClPh CO Single bond Sub-1  1-1474 Sub-47 3,4-diClPh CO Single bond Sub-2  1-1475 Sub-47 3,4-diClPh CO Single bond Sub-3  1-1476 Sub-47 3,4-diClPh CO Single bond Sub-4  1-1477 Sub-47 3,4-diClPh CO Single bond Sub-5  1-1478 Sub-47 3,4-diClPh CO Single bond Sub-6  1-1479 Sub-47 3,4-diClPh CO Single bond Sub-7  1-1480 Sub-47 3,4-diClPh CO Single bond Sub-8  1-1481 Sub-47 3,4-diClPh CO Single bond Sub-9  1-1482 Sub-47 3,4-diClPh CO Single bond Sub-10 1-1483 Sub-47 3,4-diClPh CO Single bond Sub-11 1-1484 Sub-47 3,4-diClPh CO Single bond Sub-12 1-1485 Sub-47 3,4-diClPh CO Single bond Sub-13 1-1486 Sub-47 3,4-diClPh CO Single bond Sub-14 1-1487 Sub-47 3,4-diClPh CO Single bond Sub-15 1-1488 Sub-47 3,4-diClPh CO Single bond Sub-16 1-1489 Sub-47 3,4-diClPh CO Single bond Sub-17 1-1490 Sub-47 3,4-diClPh CO Single bond Sub-18 1-1491 Sub-47 3,4-diClPh CO Single bond Sub-19 1-1492 Sub-47 3,4-diClPh CO Single bond Sub-20 1-1493 Sub-47 3,4-diClPh CO Single bond Sub-21 1-1494 Sub-47 3,4-diClPh CO Single bond Sub-22 1-1495 Sub-47 3,4-diClPh CO Single bond Sub-23 1-1496 Sub-47 3,4-diClPh CO Single bond Sub-24 1-1497 Sub-47 3,4-diClPh CO Single bond Sub-25 1-1498 Sub-47 3,4-diClPh CO Single bond Sub-26 1-1499 Sub-47 3,4-diClPh CO Single bond Sub-27 1-1500 Sub-47 3,4-diClPh CO Single bond Sub-28 1-1501 Sub-47 3,4-diClPh CO Single bond Sub-29 1-1502 Sub-47 3,4-diClPh CO Single bond Sub-30 1-1503 Sub-47 3,4-diClPh CO Single bond Sub-31 1-1504 Sub-47 3,4-diClPh CO Single bond Sub-32 1-1505 Sub-48 3,4-diClPh CO Single bond Sub-1  1-1506 Sub-48 3,4-diClPh CO Single bond Sub-2  1-1507 Sub-48 3,4-diClPh CO Single bond Sub-3  1-1508 Sub-48 3,4-diClPh CO Single bond Sub-4  1-1509 Sub-48 3,4-diClPh CO Single bond Sub-5  1-1510 Sub-48 3,4-diClPh CO Single bond Sub-6  1-1511 Sub-48 3,4-diClPh CO Single bond Sub-7  1-1512 Sub-48 3,4-diClPh CO Single bond Sub-8  1-1513 Sub-48 3,4-diClPh CO Single bond Sub-9  1-1514 Sub-48 3,4-diClPh CO Single bond Sub-10 1-1515 Sub-48 3,4-diClPh CO Single bond Sub-11 1-1516 Sub-48 3,4-diClPh CO Single bond Sub-12 1-1517 Sub-48 3,4-diClPh CO Single bond Sub-13 1-1518 Sub-48 3,4-diClPh CO Single bond Sub-14 1-1519 Sub-48 3,4-diClPh CO Single bond Sub-15 1-1520 Sub-48 3,4-diClPh CO Single bond Sub-16 1-1521 Sub-48 3,4-diClPh CO Single bond Sub-17 1-1522 Sub-48 3,4-diClPh CO Single bond Sub-18 1-1523 Sub-48 3,4-diClPh CO Single bond Sub-19 1-1524 Sub-48 3,4-diClPh CO Single bond Sub-20 1-1525 Sub-48 3,4-diClPh CO Single bond Sub-21 1-1526 Sub-48 3,4-diClPh CO Single bond Sub-22 1-1527 Sub-48 3,4-diClPh CO Single bond Sub-23 1-1528 Sub-48 3,4-diClPh CO Single bond Sub-24 1-1529 Sub-48 3,4-diClPh CO Single bond Sub-25 1-1530 Sub-48 3,4-diClPh CO Single bond Sub-26 1-1531 Sub-48 3,4-diClPh CO Single bond Sub-27 1-1532 Sub-48 3,4-diClPh CO Single bond Sub-28 1-1533 Sub-48 3,4-diClPh CO Single bond Sub-29 1-1534 Sub-48 3,4-diClPh CO Single bond Sub-30 1-1535 Sub-48 3,4-diClPh CO Single bond Sub-31 1-1536 Sub-48 3,4-diClPh CO Single bond Sub-32 1-1537 Sub-49 3,4-diClPh CO Single bond Sub-1  1-1538 Sub-49 3,4-diClPh CO Single bond Sub-2  1-1539 Sub-49 3,4-diClPh CO Single bond Sub-3  1-1540 Sub-49 3,4-diClPh CO Single bond Sub-4  1-1541 Sub-49 3,4-diClPh CO Single bond Sub-5  1-1542 Sub-49 3,4-diClPh CO Single bond Sub-6  1-1543 Sub-49 3,4-diClPh CO Single bond Sub-7  1-1544 Sub-49 3,4-diClPh CO Single bond Sub-8  1-1545 Sub-49 3,4-diClPh CO Single bond Sub-9  1-1546 Sub-49 3,4-diClPh CO Single bond Sub-10 1-1547 Sub-49 3,4-diClPh CO Single bond Sub-11 1-1548 Sub-49 3,4-diClPh CO Single bond Sub-12 1-1549 Sub-49 3,4-diClPh CO Single bond Sub-13 1-1550 Sub-49 3,4-diClPh CO Single bond Sub-14 1-1551 Sub-49 3,4-diClPh CO Single bond Sub-15 1-1552 Sub-49 3,4-diClPh CO Single bond Sub-16 1-1553 Sub-49 3,4-diClPh CO Single bond Sub-17 1-1554 Sub-49 3,4-diClPh CO Single bond Sub-18 1-1555 Sub-49 3,4-diClPh CO Single bond Sub-19 1-1556 Sub-49 3,4-diClPh CO Single bond Sub-20 1-1557 Sub-49 3,4-diClPh CO Single bond Sub-21 1-1558 Sub-49 3,4-diClPh CO Single bond Sub-22 1-1559 Sub-49 3,4-diClPh CO Single bond Sub-23 1-1560 Sub-49 3,4-diClPh CO Single bond Sub-24 1-1561 Sub-49 3,4-diClPh CO Single bond Sub-25 1-1562 Sub-49 3,4-diClPh CO Single bond Sub-26 1-1563 Sub-49 3,4-diClPh CO Single bond Sub-27 1-1564 Sub-49 3,4-diClPh CO Single bond Sub-28 1-1565 Sub-49 3,4-diClPh CO Single bond Sub-29 1-1566 Sub-49 3,4-diClPh CO Single bond Sub-30 1-1567 Sub-49 3,4-diClPh CO Single bond Sub-31 1-1568 Sub-49 3,4-diClPh CO Single bond Sub-32 1-1569 Sub-50 3,4-diClPh CO Single bond Sub-1  1-1570 Sub-50 3,4-diClPh CO Single bond Sub-2  1-1571 Sub-50 3,4-diClPh CO Single bond Sub-3  1-1572 Sub-50 3,4-diClPh CO Single bond Sub-4  1-1573 Sub-50 3,4-diClPh CO Single bond Sub-5  1-1574 Sub-50 3,4-diClPh CO Single bond Sub-6  1-1575 Sub-50 3,4-diClPh CO Single bond Sub-7  1-1576 Sub-50 3,4-diClPh CO Single bond Sub-8  1-1577 Sub-50 3,4-diClPh CO Single bond Sub-9  1-1578 Sub-50 3,4-diClPh CO Single bond Sub-10 1-1579 Sub-50 3,4-diClPh CO Single bond Sub-11 1-1580 Sub-50 3,4-diClPh CO Single bond Sub-12 1-1581 Sub-50 3,4-diClPh CO Single bond Sub-13 1-1582 Sub-50 3,4-diClPh CO Single bond Sub-14 1-1583 Sub-50 3,4-diClPh CO Single bond Sub-15 1-1584 Sub-50 3,4-diClPh CO Single bond Sub-16 1-1585 Sub-50 3,4-diClPh CO Single bond Sub-17 1-1586 Sub-50 3,4-diClPh CO Single bond Sub-18 1-1587 Sub-50 3,4-diClPh CO Single bond Sub-19 1-1588 Sub-50 3,4-diClPh CO Single bond Sub-20 1-1589 Sub-50 3,4-diClPh CO Single bond Sub-21 1-1590 Sub-50 3,4-diClPh CO Single bond Sub-22 1-1591 Sub-50 3,4-diClPh CO Single bond Sub-23 1-1592 Sub-50 3,4-diClPh CO Single bond Sub-24 1-1593 Sub-50 3,4-diClPh CO Single bond Sub-25 1-1594 Sub-50 3,4-diClPh CO Single bond Sub-26 1-1595 Sub-50 3,4-diClPh CO Single bond Sub-27 1-1596 Sub-50 3,4-diClPh CO Single bond Sub-28 1-1597 Sub-50 3,4-diClPh CO Single bond Sub-29 1-1598 Sub-50 3,4-diClPh CO Single bond Sub-30 1-1599 Sub-50 3,4-diClPh CO Single bond Sub-31 1-1600 Sub-50 3,4-diClPh CO Single bond Sub-32 1-1601 Sub-51 3,4-diClPh CO Single bond Sub-1  1-1602 Sub-51 3,4-diClPh CO Single bond Sub-2  1-1603 Sub-51 3,4-diClPh CO Single bond Sub-3  1-1604 Sub-51 3,4-diClPh CO Single bond Sub-4  1-1605 Sub-51 3,4-diClPh CO Single bond Sub-5  1-1606 Sub-51 3,4-diClPh CO Single bond Sub-6  1-1607 Sub-51 3,4-diClPh CO Single bond Sub-7  1-1608 Sub-51 3,4-diClPh CO Single bond Sub-8  1-1609 Sub-51 3,4-diClPh CO Single bond Sub-9  1-1610 Sub-51 3,4-diClPh CO Single bond Sub-10 1-1611 Sub-51 3,4-diClPh CO Single bond Sub-11 1-1612 Sub-51 3,4-diClPh CO Single bond Sub-12 1-1613 Sub-51 3,4-diClPh CO Single bond Sub-13 1-1614 Sub-51 3,4-diClPh CO Single bond Sub-14 1-1615 Sub-51 3,4-diClPh CO Single bond Sub-15 1-1616 Sub-51 3,4-diClPh CO Single bond Sub-16 1-1617 Sub-51 3,4-diClPh CO Single bond Sub-17 1-1618 Sub-51 3,4-diClPh CO Single bond Sub-18 1-1619 Sub-51 3,4-diClPh CO Single bond Sub-19 1-1620 Sub-51 3,4-diClPh CO Single bond Sub-20 1-1621 Sub-51 3,4-diClPh CO Single bond Sub-21 1-1622 Sub-51 3,4-diClPh CO Single bond Sub-22 1-1623 Sub-51 3,4-diClPh CO Single bond Sub-23 1-1624 Sub-51 3,4-diClPh CO Single bond Sub-24 1-1625 Sub-51 3,4-diClPh CO Single bond Sub-25 1-1626 Sub-51 3,4-diClPh CO Single bond Sub-26 1-1627 Sub-51 3,4-diClPh CO Single bond Sub-27 1-1628 Sub-51 3,4-diClPh CO Single bond Sub-28 1-1629 Sub-51 3,4-diClPh CO Single bond Sub-29 1-1630 Sub-51 3,4-diClPh CO Single bond Sub-30 1-1631 Sub-51 3,4-diClPh CO Single bond Sub-31 1-1632 Sub-51 3,4-diClPh CO Single bond Sub-32 1-1633 Sub-52 3,4-diClPh CO Single bond Sub-1  1-1634 Sub-52 3,4-diClPh CO Single bond Sub-2  1-1635 Sub-52 3,4-diClPh CO Single bond Sub-3  1-1636 Sub-52 3,4-diClPh CO Single bond Sub-4  1-1637 Sub-52 3,4-diClPh CO Single bond Sub-5  1-1638 Sub-52 3,4-diClPh CO Single bond Sub-6  1-1639 Sub-52 3,4-diClPh CO Single bond Sub-7  1-1640 Sub-52 3,4-diClPh CO Single bond Sub-8  1-1641 Sub-52 3,4-diClPh CO Single bond Sub-9  1-1642 Sub-52 3,4-diClPh CO Single bond Sub-10 1-1643 Sub-52 3,4-diClPh CO Single bond Sub-11 1-1644 Sub-52 3,4-diClPh CO Single bond Sub-12 1-1645 Sub-52 3,4-diClPh CO Single bond Sub-13 1-1646 Sub-52 3,4-diClPh CO Single bond Sub-14 1-1647 Sub-52 3,4-diClPh CO Single bond Sub-15 1-1648 Sub-52 3,4-diClPh CO Single bond Sub-16 1-1649 Sub-52 3,4-diClPh CO Single bond Sub-17 1-1650 Sub-52 3,4-diClPh CO Single bond Sub-18 1-1651 Sub-52 3,4-diClPh CO Single bond Sub-19 1-1652 Sub-52 3,4-diClPh CO Single bond Sub-20 1-1653 Sub-52 3,4-diClPh CO Single bond Sub-21 1-1654 Sub-52 3,4-diClPh CO Single bond Sub-22 1-1655 Sub-52 3,4-diClPh CO Single bond Sub-23 1-1656 Sub-52 3,4-diClPh CO Single bond Sub-24 1-1657 Sub-52 3,4-diClPh CO Single bond Sub-25 1-1658 Sub-52 3,4-diClPh CO Single bond Sub-26 1-1659 Sub-52 3,4-diClPh CO Single bond Sub-27 1-1660 Sub-52 3,4-diClPh CO Single bond Sub-28 1-1661 Sub-52 3,4-diClPh CO Single bond Sub-29 1-1662 Sub-52 3,4-diClPh CO Single bond Sub-30 1-1663 Sub-52 3,4-diClPh CO Single bond Sub-31 1-1664 Sub-52 3,4-diClPh CO Single bond Sub-32 1-1665 Sub-53 3,4-diClPh CO Single bond Sub-1  1-1666 Sub-53 3,4-diClPh CO Single bond Sub-2  1-1667 Sub-53 3,4-diClPh CO Single bond Sub-3  1-1668 Sub-53 3,4-diClPh CO Single bond Sub-4  1-1669 Sub-53 3,4-diClPh CO Single bond Sub-5  1-1670 Sub-53 3,4-diClPh CO Single bond Sub-6  1-1671 Sub-53 3,4-diClPh CO Single bond Sub-7  1-1672 Sub-53 3,4-diClPh CO Single bond Sub-8  1-1673 Sub-53 3,4-diClPh CO Single bond Sub-9  1-1674 Sub-53 3,4-diClPh CO Single bond Sub-10 1-1675 Sub-53 3,4-diClPh CO Single bond Sub-11 1-1676 Sub-53 3,4-diClPh CO Single bond Sub-12 1-1677 Sub-53 3,4-diClPh CO Single bond Sub-13 1-1678 Sub-53 3,4-diClPh CO Single bond Sub-14 1-1679 Sub-53 3,4-diClPh CO Single bond Sub-15 1-1680 Sub-53 3,4-diClPh CO Single bond Sub-16 1-1681 Sub-53 3,4-diClPh CO Single bond Sub-17 1-1682 Sub-53 3,4-diClPh CO Single bond Sub-18 1-1683 Sub-53 3,4-diClPh CO Single bond Sub-19 1-1684 Sub-53 3,4-diClPh CO Single bond Sub-20 1-1685 Sub-53 3,4-diClPh CO Single bond Sub-21 1-1686 Sub-53 3,4-diClPh CO Single bond Sub-22 1-1687 Sub-53 3,4-diClPh CO Single bond Sub-23 1-1688 Sub-53 3,4-diClPh CO Single bond Sub-24 1-1689 Sub-53 3,4-diClPh CO Single bond Sub-25 1-1690 Sub-53 3,4-diClPh CO Single bond Sub-26 1-1691 Sub-53 3,4-diClPh CO Single bond Sub-27 1-1692 Sub-53 3,4-diClPh CO Single bond Sub-28 1-1693 Sub-53 3,4-diClPh CO Single bond Sub-29 1-1694 Sub-53 3,4-diClPh CO Single bond Sub-30 1-1695 Sub-53 3,4-diClPh CO Single bond Sub-31 1-1696 Sub-53 3,4-diClPh CO Single bond Sub-32 1-1697 Sub-54 3,4-diClPh CO Single bond Sub-1  1-1698 Sub-54 3,4-diClPh CO Single bond Sub-2  1-1699 Sub-54 3,4-diClPh CO Single bond Sub-3  1-1700 Sub-54 3,4-diClPh CO Single bond Sub-4  1-1701 Sub-54 3,4-diClPh CO Single bond Sub-5  1-1702 Sub-54 3,4-diClPh CO Single bond Sub-6  1-1703 Sub-54 3,4-diClPh CO Single bond Sub-7  1-1704 Sub-54 3,4-diClPh CO Single bond Sub-8  1-1705 Sub-54 3,4-diClPh CO Single bond Sub-9  1-1706 Sub-54 3,4-diClPh CO Single bond Sub-10 1-1707 Sub-54 3,4-diClPh CO Single bond Sub-11 1-1708 Sub-54 3,4-diClPh CO Single bond Sub-12 1-1709 Sub-54 3,4-diClPh CO Single bond Sub-13 1-1710 Sub-54 3,4-diClPh CO Single bond Sub-14 1-1711 Sub-54 3,4-diClPh CO Single bond Sub-15 1-1712 Sub-54 3,4-diClPh CO Single bond Sub-16 1-1713 Sub-54 3,4-diClPh CO Single bond Sub-17 1-1714 Sub-54 3,4-diClPh CO Single bond Sub-18 1-1715 Sub-54 3,4-diClPh CO Single bond Sub-19 1-1716 Sub-54 3,4-diClPh CO Single bond Sub-20 1-1717 Sub-54 3,4-diClPh CO Single bond Sub-21 1-1718 Sub-54 3,4-diClPh CO Single bond Sub-22 1-1719 Sub-54 3,4-diClPh CO Single bond Sub-23 1-1720 Sub-54 3,4-diClPh CO Single bond Sub-24 1-1721 Sub-54 3,4-diClPh CO Single bond Sub-25 1-1722 Sub-54 3,4-diClPh CO Single bond Sub-26 1-1723 Sub-54 3,4-diClPh CO Single bond Sub-27 1-1724 Sub-54 3,4-diClPh CO Single bond Sub-28 1-1725 Sub-54 3,4-diClPh CO Single bond Sub-29 1-1726 Sub-54 3,4-diClPh CO Single bond Sub-30 1-1727 Sub-54 3,4-diClPh CO Single bond Sub-31 1-1728 Sub-54 3,4-diClPh CO Single bond Sub-32 1-1729 Sub-55 3,4-diClPh CO Single bond Sub-1  1-1730 Sub-55 3,4-diClPh CO Single bond Sub-2  1-1731 Sub-55 3,4-diClPh CO Single bond Sub-3  1-1732 Sub-55 3,4-diClPh CO Single bond Sub-4  1-1733 Sub-55 3,4-diClPh CO Single bond Sub-5  1-1734 Sub-55 3,4-diClPh CO Single bond Sub-6  1-1735 Sub-55 3,4-diClPh CO Single bond Sub-7  1-1736 Sub-55 3,4-diClPh CO Single bond Sub-8  1-1737 Sub-55 3,4-diClPh CO Single bond Sub-9  1-1738 Sub-55 3,4-diClPh CO Single bond Sub-10 1-1739 Sub-55 3,4-diClPh CO Single bond Sub-11 1-1740 Sub-55 3,4-diClPh CO Single bond Sub-12 1-1741 Sub-55 3,4-diClPh CO Single bond Sub-13 1-1742 Sub-55 3,4-diClPh CO Single bond Sub-14 1-1743 Sub-55 3,4-diClPh CO Single bond Sub-15 1-1744 Sub-55 3,4-diClPh CO Single bond Sub-16 1-1745 Sub-55 3,4-diClPh CO Single bond Sub-17 1-1746 Sub-55 3,4-diClPh CO Single bond Sub-18 1-1747 Sub-55 3,4-diClPh CO Single bond Sub-19 1-1748 Sub-55 3,4-diClPh CO Single bond Sub-20 1-1749 Sub-55 3,4-diClPh CO Single bond Sub-21 1-1750 Sub-55 3,4-diClPh CO Single bond Sub-22 1-1751 Sub-55 3,4-diClPh CO Single bond Sub-23 1-1752 Sub-55 3,4-diClPh CO Single bond Sub-24 1-1753 Sub-55 3,4-diClPh CO Single bond Sub-25 1-1754 Sub-55 3,4-diClPh CO Single bond Sub-26 1-1755 Sub-55 3,4-diClPh CO Single bond Sub-27 1-1756 Sub-55 3,4-diClPh CO Single bond Sub-28 1-1757 Sub-55 3,4-diClPh CO Single bond Sub-29 1-1758 Sub-55 3,4-diClPh CO Single bond Sub-30 1-1759 Sub-55 3,4-diClPh CO Single bond Sub-31 1-1760 Sub-55 3,4-diClPh CO Single bond Sub-32 1-1761 Sub-56 3,4-diClPh CO Single bond Sub-1  1-1762 Sub-56 3,4-diClPh CO Single bond Sub-2  1-1763 Sub-56 3,4-diClPh CO Single bond Sub-3  1-1764 Sub-56 3,4-diClPh CO Single bond Sub-4  1-1765 Sub-56 3,4-diClPh CO Single bond Sub-5  1-1766 Sub-56 3,4-diClPh CO Single bond Sub-6  1-1767 Sub-56 3,4-diClPh CO Single bond Sub-7  1-1768 Sub-56 3,4-diClPh CO Single bond Sub-8  1-1769 Sub-56 3,4-diClPh CO Single bond Sub-9  1-1770 Sub-56 3,4-diClPh CO Single bond Sub-10 1-1771 Sub-56 3,4-diClPh CO Single bond Sub-11 1-1772 Sub-56 3,4-diClPh CO Single bond Sub-12 1-1773 Sub-56 3,4-diClPh CO Single bond Sub-13 1-1774 Sub-56 3,4-diClPh CO Single bond Sub-14 1-1775 Sub-56 3,4-diClPh CO Single bond Sub-15 1-1776 Sub-56 3,4-diClPh CO Single bond Sub-16 1-1777 Sub-56 3,4-diClPh CO Single bond Sub-17 1-1778 Sub-56 3,4-diClPh CO Single bond Sub-18 1-1779 Sub-56 3,4-diClPh CO Single bond Sub-19 1-1780 Sub-56 3,4-diClPh CO Single bond Sub-20 1-1781 Sub-56 3,4-diClPh CO Single bond Sub-21 1-1782 Sub-56 3,4-diClPh CO Single bond Sub-22 1-1783 Sub-56 3,4-diClPh CO Single bond Sub-23 1-1784 Sub-56 3,4-diClPh CO Single bond Sub-24 1-1785 Sub-56 3,4-diClPh CO Single bond Sub-25 1-1786 Sub-56 3,4-diClPh CO Single bond Sub-26 1-1787 Sub-56 3,4-diClPh CO Single bond Sub-27 1-1788 Sub-56 3,4-diClPh CO Single bond Sub-28 1-1789 Sub-56 3,4-diClPh CO Single bond Sub-29 1-1790 Sub-56 3,4-diClPh CO Single bond Sub-30 1-1791 Sub-56 3,4-diClPh CO Single bond Sub-31 1-1792 Sub-56 3,4-diClPh CO Single bond Sub-32 1-1793 Sub-57 3,4-diClPh CO Single bond Sub-1  1-1794 Sub-57 3,4-diClPh CO Single bond Sub-2  1-1795 Sub-57 3,4-diClPh CO Single bond Sub-3  1-1796 Sub-57 3,4-diClPh CO Single bond Sub-4  1-1797 Sub-57 3,4-diClPh CO Single bond Sub-5  1-1798 Sub-57 3,4-diClPh CO Single bond Sub-6  1-1799 Sub-57 3,4-diClPh CO Single bond Sub-7  1-1800 Sub-57 3,4-diClPh CO Single bond Sub-8  1-1801 Sub-57 3,4-diClPh CO Single bond Sub-9  1-1802 Sub-57 3,4-diClPh CO Single bond Sub-10 1-1803 Sub-57 3,4-diClPh CO Single bond Sub-11 1-1804 Sub-57 3,4-diClPh CO Single bond Sub-12 1-1805 Sub-57 3,4-diClPh CO Single bond Sub-13 1-1806 Sub-57 3,4-diClPh CO Single bond Sub-14 1-1807 Sub-57 3,4-diClPh CO Single bond Sub-15 1-1808 Sub-57 3,4-diClPh CO Single bond Sub-16 1-1809 Sub-57 3,4-diClPh CO Single bond Sub-17 1-1810 Sub-57 3,4-diClPh CO Single bond Sub-18 1-1811 Sub-57 3,4-diClPh CO Single bond Sub-19 1-1812 Sub-57 3,4-diClPh CO Single bond Sub-20 1-1813 Sub-57 3,4-diClPh CO Single bond Sub-21 1-1814 Sub-57 3,4-diClPh CO Single bond Sub-22 1-1815 Sub-57 3,4-diClPh CO Single bond Sub-23 1-1816 Sub-57 3,4-diClPh CO Single bond Sub-24 1-1817 Sub-57 3,4-diClPh CO Single bond Sub-25 1-1818 Sub-57 3,4-diClPh CO Single bond Sub-26 1-1819 Sub-57 3,4-diClPh CO Single bond Sub-27 1-1820 Sub-57 3,4-diClPh CO Single bond Sub-28 1-1821 Sub-57 3,4-diClPh CO Single bond Sub-29 1-1822 Sub-57 3,4-diClPh CO Single bond Sub-30 1-1823 Sub-57 3,4-diClPh CO Single bond Sub-31 1-1824 Sub-57 3,4-diClPh CO Single bond Sub-32 1-1825 Sub-58 3,4-diClPh CO Single bond Sub-1  1-1826 Sub-58 3,4-diClPh CO Single bond Sub-2  1-1827 Sub-58 3,4-diClPh CO Single bond Sub-3  1-1828 Sub-58 3,4-diClPh CO Single bond Sub-4  1-1829 Sub-58 3,4-diClPh CO Single bond Sub-5  1-1830 Sub-58 3,4-diClPh CO Single bond Sub-6  1-1831 Sub-58 3,4-diClPh CO Single bond Sub-7  1-1832 Sub-58 3,4-diClPh CO Single bond Sub-8  1-1833 Sub-58 3,4-diClPh CO Single bond Sub-9  1-1834 Sub-58 3,4-diClPh CO Single bond Sub-10 1-1835 Sub-58 3,4-diClPh CO Single bond Sub-11 1-1836 Sub-58 3,4-diClPh CO Single bond Sub-12 1-1837 Sub-58 3,4-diClPh CO Single bond Sub-13 1-1838 Sub-58 3,4-diClPh CO Single bond Sub-14 1-1839 Sub-58 3,4-diClPh CO Single bond Sub-15 1-1840 Sub-58 3,4-diClPh CO Single bond Sub-16 1-1841 Sub-58 3,4-diClPh CO Single bond Sub-17 1-1842 Sub-58 3,4-diClPh CO Single bond Sub-18 1-1843 Sub-58 3,4-diClPh CO Single bond Sub-19 1-1844 Sub-58 3,4-diClPh CO Single bond Sub-20 1-1845 Sub-58 3,4-diClPh CO Single bond Sub-21 1-1846 Sub-58 3,4-diClPh CO Single bond Sub-22 1-1847 Sub-58 3,4-diClPh CO Single bond Sub-23 1-1848 Sub-58 3,4-diClPh CO Single bond Sub-24 1-1849 Sub-58 3,4-diClPh CO Single bond Sub-25 1-1850 Sub-58 3,4-diClPh CO Single bond Sub-26 1-1851 Sub-58 3,4-diClPh CO Single bond Sub-27 1-1852 Sub-58 3,4-diClPh CO Single bond Sub-28 1-1853 Sub-58 3,4-diClPh CO Single bond Sub-29 1-1854 Sub-58 3,4-diClPh CO Single bond Sub-30 1-1855 Sub-58 3,4-diClPh CO Single bond Sub-31 1-1856 Sub-58 3,4-diClPh CO Single bond Sub-32 1-1857 Sub-59 3,4-diClPh CO Single bond Sub-1  1-1858 Sub-59 3,4-diClPh CO Single bond Sub-2  1-1859 Sub-59 3,4-diClPh CO Single bond Sub-3  1-1860 Sub-59 3,4-diClPh CO Single bond Sub-4  1-1861 Sub-59 3,4-diClPh CO Single bond Sub-5  1-1862 Sub-59 3,4-diClPh CO Single bond Sub-6  1-1863 Sub-59 3,4-diClPh CO Single bond Sub-7  1-1864 Sub-59 3,4-diClPh CO Single bond Sub-8  1-1865 Sub-59 3,4-diClPh CO Single bond Sub-9  1-1866 Sub-59 3,4-diClPh CO Single bond Sub-10 1-1867 Sub-59 3,4-diClPh CO Single bond Sub-11 1-1868 Sub-59 3,4-diClPh CO Single bond Sub-12 1-1869 Sub-59 3,4-diClPh CO Single bond Sub-13 1-1870 Sub-59 3,4-diClPh CO Single bond Sub-14 1-1871 Sub-59 3,4-diClPh CO Single bond Sub-15 1-1872 Sub-59 3,4-diClPh CO Single bond Sub-16 1-1873 Sub-59 3,4-diClPh CO Single bond Sub-17 1-1874 Sub-59 3,4-diClPh CO Single bond Sub-18 1-1875 Sub-59 3,4-diClPh CO Single bond Sub-19 1-1876 Sub-59 3,4-diClPh CO Single bond Sub-20 1-1877 Sub-59 3,4-diClPh CO Single bond Sub-21 1-1878 Sub-59 3,4-diClPh CO Single bond Sub-22 1-1879 Sub-59 3,4-diClPh CO Single bond Sub-23 1-1880 Sub-59 3,4-diClPh CO Single bond Sub-24 1-1881 Sub-59 3,4-diClPh CO Single bond Sub-25 1-1882 Sub-59 3,4-diClPh CO Single bond Sub-26 1-1883 Sub-59 3,4-diClPh CO Single bond Sub-27 1-1884 Sub-59 3,4-diClPh CO Single bond Sub-28 1-1885 Sub-59 3,4-diClPh CO Single bond Sub-29 1-1886 Sub-59 3,4-diClPh CO Single bond Sub-30 1-1887 Sub-59 3,4-diClPh CO Single bond Sub-31 1-1888 Sub-59 3,4-diClPh CO Single bond Sub-32 1-1889 Sub-60 3,4-diClPh CO Single bond Sub-1  1-1890 Sub-60 3,4-diClPh CO Single bond Sub-2  1-1891 Sub-60 3,4-diClPh CO Single bond Sub-3  1-1892 Sub-60 3,4-diClPh CO Single bond Sub-4  1-1893 Sub-60 3,4-diClPh CO Single bond Sub-5  1-1894 Sub-60 3,4-diClPh CO Single bond Sub-6  1-1895 Sub-60 3,4-diClPh CO Single bond Sub-7  1-1896 Sub-60 3,4-diClPh CO Single bond Sub-8  1-1897 Sub-60 3,4-diClPh CO Single bond Sub-9  1-1898 Sub-60 3,4-diClPh CO Single bond Sub-10 1-1899 Sub-60 3,4-diClPh CO Single bond Sub-11 1-1900 Sub-60 3,4-diClPh CO Single bond Sub-12 1-1901 Sub-60 3,4-diClPh CO Single bond Sub-13 1-1902 Sub-60 3,4-diClPh CO Single bond Sub-14 1-1903 Sub-60 3,4-diClPh CO Single bond Sub-15 1-1904 Sub-60 3,4-diClPh CO Single bond Sub-16 1-1905 Sub-60 3,4-diClPh CO Single bond Sub-17 1-1906 Sub-60 3,4-diClPh CO Single bond Sub-18 1-1907 Sub-60 3,4-diClPh CO Single bond Sub-19 1-1908 Sub-60 3,4-diClPh CO Single bond Sub-20 1-1909 Sub-60 3,4-diClPh CO Single bond Sub-21 1-1910 Sub-60 3,4-diClPh CO Single bond Sub-22 1-1911 Sub-60 3,4-diClPh CO Single bond Sub-23 1-1912 Sub-60 3,4-diClPh CO Single bond Sub-24 1-1913 Sub-60 3,4-diClPh CO Single bond Sub-25 1-1914 Sub-60 3,4-diClPh CO Single bond Sub-26 1-1915 Sub-60 3,4-diClPh CO Single bond Sub-27 1-1916 Sub-60 3,4-diClPh CO Single bond Sub-28 1-1917 Sub-60 3,4-diClPh CO Single bond Sub-29 1-1918 Sub-60 3,4-diClPh CO Single bond Sub-30 1-1919 Sub-60 3,4-diClPh CO Single bond Sub-31 1-1920 Sub-60 3,4-diClPh CO Single bond Sub-32 1-1921 Sub-61 3,4-diClPh CO Single bond Sub-1  1-1922 Sub-61 3,4-diClPh CO Single bond Sub-2  1-1923 Sub-61 3,4-diClPh CO Single bond Sub-3  1-1924 Sub-61 3,4-diClPh CO Single bond Sub-4  1-1925 Sub-61 3,4-diClPh CO Single bond Sub-5  1-1926 Sub-61 3,4-diClPh CO Single bond Sub-6  1-1927 Sub-61 3,4-diClPh CO Single bond Sub-7  1-1928 Sub-61 3,4-diClPh CO Single bond Sub-8  1-1929 Sub-61 3,4-diClPh CO Single bond Sub-9  1-1930 Sub-61 3,4-diClPh CO Single bond Sub-10 1-1931 Sub-61 3,4-diClPh CO Single bond Sub-11 1-1932 Sub-61 3,4-diClPh CO Single bond Sub-12 1-1933 Sub-61 3,4-diClPh CO Single bond Sub-13 1-1934 Sub-61 3,4-diClPh CO Single bond Sub-14 1-1935 Sub-61 3,4-diClPh CO Single bond Sub-15 1-1936 Sub-61 3,4-diClPh CO Single bond Sub-16 1-1937 Sub-61 3,4-diClPh CO Single bond Sub-17 1-1938 Sub-61 3,4-diClPh CO Single bond Sub-18 1-1939 Sub-61 3,4-diClPh CO Single bond Sub-19 1-1940 Sub-61 3,4-diClPh CO Single bond Sub-20 1-1941 Sub-61 3,4-diClPh CO Single bond Sub-21 1-1942 Sub-61 3,4-diClPh CO Single bond Sub-22 1-1943 Sub-61 3,4-diClPh CO Single bond Sub-23 1-1944 Sub-61 3,4-diClPh CO Single bond Sub-24 1-1945 Sub-61 3,4-diClPh CO Single bond Sub-25 1-1946 Sub-61 3,4-diClPh CO Single bond Sub-26 1-1947 Sub-61 3,4-diClPh CO Single bond Sub-27 1-1948 Sub-61 3,4-diClPh CO Single bond Sub-28 1-1949 Sub-61 3,4-diClPh CO Single bond Sub-29 1-1950 Sub-61 3,4-diClPh CO Single bond Sub-30 1-1951 Sub-61 3,4-diClPh CO Single bond Sub-31 1-1952 Sub-61 3,4-diClPh CO Single bond Sub-32 1-1953 Sub-62 3,4-diClPh CO Single bond Sub-1  1-1954 Sub-62 3,4-diClPh CO Single bond Sub-2  1-1955 Sub-62 3,4-diClPh CO Single bond Sub-3  1-1956 Sub-62 3,4-diClPh CO Single bond Sub-4  1-1957 Sub-62 3,4-diClPh CO Single bond Sub-5  1-1958 Sub-62 3,4-diClPh CO Single bond Sub-6  1-1959 Sub-62 3,4-diClPh CO Single bond Sub-7  1-1960 Sub-62 3,4-diClPh CO Single bond Sub-8  1-1961 Sub-62 3,4-diClPh CO Single bond Sub-9  1-1962 Sub-62 3,4-diClPh CO Single bond Sub-10 1-1963 Sub-62 3,4-diClPh CO Single bond Sub-11 1-1964 Sub-62 3,4-diClPh CO Single bond Sub-12 1-1965 Sub-62 3,4-diClPh CO Single bond Sub-13 1-1966 Sub-62 3,4-diClPh CO Single bond Sub-14 1-1967 Sub-62 3,4-diClPh CO Single bond Sub-15 1-1968 Sub-62 3,4-diClPh CO Single bond Sub-16 1-1969 Sub-62 3,4-diClPh CO Single bond Sub-17 1-1970 Sub-62 3,4-diClPh CO Single bond Sub-18 1-1971 Sub-62 3,4-diClPh CO Single bond Sub-19 1-1972 Sub-62 3,4-diClPh CO Single bond Sub-20 1-1973 Sub-62 3,4-diClPh CO Single bond Sub-21 1-1974 Sub-62 3,4-diClPh CO Single bond Sub-22 1-1975 Sub-62 3,4-diClPh CO Single bond Sub-23 1-1976 Sub-62 3,4-diClPh CO Single bond Sub-24 1-1977 Sub-62 3,4-diClPh CO Single bond Sub-25 1-1978 Sub-62 3,4-diClPh CO Single bond Sub-26 1-1979 Sub-62 3,4-diClPh CO Single bond Sub-27 1-1980 Sub-62 3,4-diClPh CO Single bond Sub-28 1-1981 Sub-62 3,4-diClPh CO Single bond Sub-29 1-1982 Sub-62 3,4-diClPh CO Single bond Sub-30 1-1983 Sub-62 3,4-diClPh CO Single bond Sub-31 1-1984 Sub-62 3,4-diClPh CO Single bond Sub-32 1-1985 Sub-63 3,4-diClPh CO Single bond Sub-1  1-1986 Sub-63 3,4-diClPh CO Single bond Sub-2  1-1987 Sub-63 3,4-diClPh CO Single bond Sub-3  1-1988 Sub-63 3,4-diClPh CO Single bond Sub-4  1-1989 Sub-63 3,4-diClPh CO Single bond Sub-5  1-1990 Sub-63 3,4-diClPh CO Single bond Sub-6  1-1991 Sub-63 3,4-diClPh CO Single bond Sub-7  1-1992 Sub-63 3,4-diClPh CO Single bond Sub-8  1-1993 Sub-63 3,4-diClPh CO Single bond Sub-9  1-1994 Sub-63 3,4-diClPh CO Single bond Sub-10 1-1995 Sub-63 3,4-diClPh CO Single bond Sub-11 1-1996 Sub-63 3,4-diClPh CO Single bond Sub-12 1-1997 Sub-63 3,4-diClPh CO Single bond Sub-13 1-1998 Sub-63 3,4-diClPh CO Single bond Sub-14 1-1999 Sub-63 3,4-diClPh CO Single bond Sub-15 1-2000 Sub-63 3,4-diClPh CO Single bond Sub-16 1-2001 Sub-63 3,4-diClPh CO Single bond Sub-17 1-2002 Sub-63 3,4-diClPh CO Single bond Sub-18 1-2003 Sub-63 3,4-diClPh CO Single bond Sub-19 1-2004 Sub-63 3,4-diClPh CO Single bond Sub-20 1-2005 Sub-63 3,4-diClPh CO Single bond Sub-21 1-2006 Sub-63 3,4-diClPh CO Single bond Sub-22 1-2007 Sub-63 3,4-diClPh CO Single bond Sub-23 1-2008 Sub-63 3,4-diClPh CO Single bond Sub-24 1-2009 Sub-63 3,4-diClPh CO Single bond Sub-25 1-2010 Sub-63 3,4-diClPh CO Single bond Sub-26 1-2011 Sub-63 3,4-diClPh CO Single bond Sub-27 1-2012 Sub-63 3,4-diClPh CO Single bond Sub-28 1-2013 Sub-63 3,4-diClPh CO Single bond Sub-29 1-2014 Sub-63 3,4-diClPh CO Single bond Sub-30 1-2015 Sub-63 3,4-diClPh CO Single bond Sub-31 1-2016 Sub-63 3,4-diClPh CO Single bond Sub-32 1-2017 Sub-64 3,4-diClPh CO Single bond Sub-1  1-2018 Sub-64 3,4-diClPh CO Single bond Sub-2  1-2019 Sub-64 3,4-diClPh CO Single bond Sub-3  1-2020 Sub-64 3,4-diClPh CO Single bond Sub-4  1-2021 Sub-64 3,4-diClPh CO Single bond Sub-5  1-2022 Sub-64 3,4-diClPh CO Single bond Sub-6  1-2023 Sub-64 3,4-diClPh CO Single bond Sub-7  1-2024 Sub-64 3,4-diClPh CO Single bond Sub-8  1-2025 Sub-64 3,4-diClPh CO Single bond Sub-9  1-2026 Sub-64 3,4-diClPh CO Single bond Sub-10 1-2027 Sub-64 3,4-diClPh CO Single bond Sub-11 1-2028 Sub-64 3,4-diClPh CO Single bond Sub-12 1-2029 Sub-64 3,4-diClPh CO Single bond Sub-13 1-2030 Sub-64 3,4-diClPh CO Single bond Sub-14 1-2031 Sub-64 3,4-diClPh CO Single bond Sub-15 1-2032 Sub-64 3,4-diClPh CO Single bond Sub-16 1-2033 Sub-64 3,4-diClPh CO Single bond Sub-17 1-2034 Sub-64 3,4-diClPh CO Single bond Sub-18 1-2035 Sub-64 3,4-diClPh CO Single bond Sub-19 1-2036 Sub-64 3,4-diClPh CO Single bond Sub-20 1-2037 Sub-64 3,4-diClPh CO Single bond Sub-21 1-2038 Sub-64 3,4-diClPh CO Single bond Sub-22 1-2039 Sub-64 3,4-diClPh CO Single bond Sub-23 1-2040 Sub-64 3,4-diClPh CO Single bond Sub-24 1-2041 Sub-64 3,4-diClPh CO Single bond Sub-25 1-2042 Sub-64 3,4-diClPh CO Single bond Sub-26 1-2043 Sub-64 3,4-diClPh CO Single bond Sub-27 1-2044 Sub-64 3,4-diClPh CO Single bond Sub-28 1-2045 Sub-64 3,4-diClPh CO Single bond Sub-29 1-2046 Sub-64 3,4-diClPh CO Single bond Sub-30 1-2047 Sub-64 3,4-diClPh CO Single bond Sub-31 1-2048 Sub-64 3,4-diClPh CO Single bond Sub-32 1-2049 Sub-33 3,4-diClPh SO₂ Single bond Sub-1  1-2050 Sub-33 3,4-diClPh SO₂ Single bond Sub-2  1-2051 Sub-33 3,4-diClPh SO₂ Single bond Sub-3  1-2052 Sub-33 3,4-diClPh SO₂ Single bond Sub-4  1-2053 Sub-33 3,4-diClPh SO₂ Single bond Sub-5  1-2054 Sub-33 3,4-diClPh SO₂ Single bond Sub-6  1-2055 Sub-33 3,4-diClPh SO₂ Single bond Sub-7  1-2056 Sub-33 3,4-diClPh SO₂ Single bond Sub-8  1-2057 Sub-33 3,4-diClPh SO₂ Single bond Sub-9  1-2058 Sub-33 3,4-diClPh SO₂ Single bond Sub-10 1-2059 Sub-33 3,4-diClPh SO₂ Single bond Sub-11 1-2060 Sub-33 3,4-diClPh SO₂ Single bond Sub-12 1-2061 Sub-33 3,4-diClPh SO₂ Single bond Sub-13 1-2062 Sub-33 3,4-diClPh SO₂ Single bond Sub-14 1-2063 Sub-33 3,4-diClPh SO₂ Single bond Sub-15 1-2064 Sub-33 3,4-diClPh SO₂ Single bond Sub-16 1-2065 Sub-33 3,4-diClPh SO₂ Single bond Sub-17 1-2066 Sub-33 3,4-diClPh SO₂ Single bond Sub-18 1-2067 Sub-33 3,4-diClPh SO₂ Single bond Sub-19 1-2068 Sub-33 3,4-diClPh SO₂ Single bond Sub-20 1-2069 Sub-33 3,4-diClPh SO₂ Single bond Sub-21 1-2070 Sub-33 3,4-diClPh SO₂ Single bond Sub-22 1-2071 Sub-33 3,4-diClPh SO₂ Single bond Sub-23 1-2072 Sub-33 3,4-diClPh SO₂ Single bond Sub-24 1-2073 Sub-33 3,4-diClPh SO₂ Single bond Sub-25 1-2074 Sub-33 3,4-diClPh SO₂ Single bond Sub-26 1-2075 Sub-33 3,4-diClPh SO₂ Single bond Sub-27 1-2076 Sub-33 3,4-diClPh SO₂ Single bond Sub-28 1-2077 Sub-33 3,4-diClPh SO₂ Single bond Sub-29 1-2078 Sub-33 3,4-diClPh SO₂ Single bond Sub-30 1-2079 Sub-33 3,4-diClPh SO₂ Single bond Sub-31 1-2080 Sub-33 3,4-diClPh SO₂ Single bond Sub-32 1-2081 Sub-34 3,4-diClPh SO₂ Single bond Sub-1  1-2082 Sub-34 3,4-diClPh SO₂ Single bond Sub-2  1-2083 Sub-34 3,4-diClPh SO₂ Single bond Sub-3  1-2084 Sub-34 3,4-diClPh SO₂ Single bond Sub-4  1-2085 Sub-34 3,4-diClPh SO₂ Single bond Sub-5  1-2086 Sub-34 3,4-diClPh SO₂ Single bond Sub-6  1-2087 Sub-34 3,4-diClPh SO₂ Single bond Sub-7  1-2088 Sub-34 3,4-diClPh SO₂ Single bond Sub-8  1-2089 Sub-34 3,4-diClPh SO₂ Single bond Sub-9  1-2090 Sub-34 3,4-diClPh SO₂ Single bond Sub-10 1-2091 Sub-34 3,4-diClPh SO₂ Single bond Sub-11 1-2092 Sub-34 3,4-diClPh SO₂ Single bond Sub-12 1-2093 Sub-34 3,4-diClPh SO₂ Single bond Sub-13 1-2094 Sub-34 3,4-diClPh SO₂ Single bond Sub-14 1-2095 Sub-34 3,4-diClPh SO₂ Single bond Sub-15 1-2096 Sub-34 3,4-diClPh SO₂ Single bond Sub-16 1-2097 Sub-34 3,4-diClPh SO₂ Single bond Sub-17 1-2098 Sub-34 3,4-diClPh SO₂ Single bond Sub-18 1-2099 Sub-34 3,4-diClPh SO₂ Single bond Sub-19 1-2100 Sub-34 3,4-diClPh SO₂ Single bond Sub-20 1-2101 Sub-34 3,4-diClPh SO₂ Single bond Sub-21 1-2102 Sub-34 3,4-diClPh SO₂ Single bond Sub-22 1-2103 Sub-34 3,4-diClPh SO₂ Single bond Sub-23 1-2104 Sub-34 3,4-diClPh SO₂ Single bond Sub-24 1-2105 Sub-34 3,4-diClPh SO₂ Single bond Sub-25 1-2106 Sub-34 3,4-diClPh SO₂ Single bond Sub-26 1-2107 Sub-34 3,4-diClPh SO₂ Single bond Sub-27 1-2108 Sub-34 3,4-diClPh SO₂ Single bond Sub-28 1-2109 Sub-34 3,4-diClPh SO₂ Single bond Sub-29 1-2110 Sub-34 3,4-diClPh SO₂ Single bond Sub-30 1-2111 Sub-34 3,4-diClPh SO₂ Single bond Sub-31 1-2112 Sub-34 3,4-diClPh SO₂ Single bond Sub-32 1-2113 Sub-35 3,4-diClPh SO₂ Single bond Sub-1  1-2114 Sub-35 3,4-diClPh SO₂ Single bond Sub-2  1-2115 Sub-35 3,4-diClPh SO₂ Single bond Sub-3  1-2116 Sub-35 3,4-diClPh SO₂ Single bond Sub-4  1-2117 Sub-35 3,4-diClPh SO₂ Single bond Sub-5  1-2118 Sub-35 3,4-diClPh SO₂ Single bond Sub-6  1-2119 Sub-35 3,4-diClPh SO₂ Single bond Sub-7  1-2121 Sub-35 3,4-diClPh SO₂ Single bond Sub-8  1-2121 Sub-35 3,4-diClPh SO₂ Single bond Sub-9  1-2122 Sub-35 3,4-diClPh SO₂ Single bond Sub-10 1-2123 Sub-35 3,4-diClPh SO₂ Single bond Sub-11 1-2124 Sub-35 3,4-diClPh SO₂ Single bond Sub-12 1-2125 Sub-35 3,4-diClPh SO₂ Single bond Sub-13 1-2126 Sub-35 3,4-diClPh SO₂ Single bond Sub-14 1-2127 Sub-35 3,4-diClPh SO₂ Single bond Sub-15 1-2128 Sub-35 3,4-diClPh SO₂ Single bond Sub-16 1-2129 Sub-35 3,4-diClPh SO₂ Single bond Sub-17 1-2130 Sub-35 3,4-diClPh SO₂ Single bond Sub-18 1-2131 Sub-35 3,4-diClPh SO₂ Single bond Sub-19 1-2132 Sub-35 3,4-diClPh SO₂ Single bond Sub-20 1-2133 Sub-35 3,4-diClPh SO₂ Single bond Sub-21 1-2134 Sub-35 3,4-diClPh SO₂ Single bond Sub-22 1-2135 Sub-35 3,4-diClPh SO₂ Single bond Sub-23 1-2136 Sub-35 3,4-diClPh SO₂ Single bond Sub-24 1-2137 Sub-35 3,4-diClPh SO₂ Single bond Sub-25 1-2138 Sub-35 3,4-diClPh SO₂ Single bond Sub-26 1-2139 Sub-35 3,4-diClPh SO₂ Single bond Sub-27 1-2140 Sub-35 3,4-diClPh SO₂ Single bond Sub-28 1-2141 Sub-35 3,4-diClPh SO₂ Single bond Sub-29 1-2142 Sub-35 3,4-diClPh SO₂ Single bond Sub-30 1-2143 Sub-35 3,4-diClPh SO₂ Single bond Sub-31 1-2144 Sub-35 3,4-diClPh SO₂ Single bond Sub-32 1-2145 Sub-36 3,4-diClPh SO₂ Single bond Sub-1  1-2146 Sub-36 3,4-diClPh SO₂ Single bond Sub-2  1-2147 Sub-36 3,4-diClPh SO₂ Single bond Sub-3  1-2148 Sub-36 3,4-diClPh SO₂ Single bond Sub-4  1-2149 Sub-36 3,4-diClPh SO₂ Single bond Sub-5  1-2150 Sub-36 3,4-diClPh SO₂ Single bond Sub-6  1-2151 Sub-36 3,4-diClPh SO₂ Single bond Sub-7  1-2152 Sub-36 3,4-diClPh SO₂ Single bond Sub-8  1-2153 Sub-36 3,4-diClPh SO₂ Single bond Sub-9  1-2154 Sub-36 3,4-diClPh SO₂ Single bond Sub-10 1-2155 Sub-36 3,4-diClPh SO₂ Single bond Sub-11 1-2156 Sub-36 3,4-diClPh SO₂ Single bond Sub-12 1-2157 Sub-36 3,4-diClPh SO₂ Single bond Sub-13 1-2158 Sub-36 3,4-diClPh SO₂ Single bond Sub-14 1-2159 Sub-36 3,4-diClPh SO₂ Single bond Sub-15 1-2160 Sub-36 3,4-diClPh SO₂ Single bond Sub-16 1-2161 Sub-36 3,4-diClPh SO₂ Single bond Sub-17 1-2162 Sub-36 3,4-diClPh SO₂ Single bond Sub-18 1-2163 Sub-36 3,4-diClPh SO₂ Single bond Sub-19 1-2164 Sub-36 3,4-diClPh SO₂ Single bond Sub-20 1-2165 Sub-36 3,4-diClPh SO₂ Single bond Sub-21 1-2166 Sub-36 3,4-diClPh SO₂ Single bond Sub-22 1-2167 Sub-36 3,4-diClPh SO₂ Single bond Sub-23 1-2168 Sub-36 3,4-diClPh SO₂ Single bond Sub-24 1-2169 Sub-36 3,4-diClPh SO₂ Single bond Sub-25 1-2170 Sub-36 3,4-diClPh SO₂ Single bond Sub-26 1-2171 Sub-36 3,4-diClPh SO₂ Single bond Sub-27 1-2172 Sub-36 3,4-diClPh SO₂ Single bond Sub-28 1-2173 Sub-36 3,4-diClPh SO₂ Single bond Sub-29 1-2174 Sub-36 3,4-diClPh SO₂ Single bond Sub-30 1-2175 Sub-36 3,4-diClPh SO₂ Single bond Sub-31 1-2176 Sub-36 3,4-diClPh SO₂ Single bond Sub-32 1-2177 Sub-37 3,4-diClPh SO₂ Single bond Sub-1  1-2178 Sub-37 3,4-diClPh SO₂ Single bond Sub-2  1-2179 Sub-37 3,4-diClPh SO₂ Single bond Sub-3  1-2180 Sub-37 3,4-diClPh SO₂ Single bond Sub-4  1-2181 Sub-37 3,4-diClPh SO₂ Single bond Sub-5  1-2182 Sub-37 3,4-diClPh SO₂ Single bond Sub-6  1-2183 Sub-37 3,4-diClPh SO₂ Single bond Sub-7  1-2184 Sub-37 3,4-diClPh SO₂ Single bond Sub-8  1-2185 Sub-37 3,4-diClPh SO₂ Single bond Sub-9  1-2186 Sub-37 3,4-diClPh SO₂ Single bond Sub-10 1-2187 Sub-37 3,4-diClPh SO₂ Single bond Sub-11 1-2188 Sub-37 3,4-diClPh SO₂ Single bond Sub-12 1-2189 Sub-37 3,4-diClPh SO₂ Single bond Sub-13 1-2190 Sub-37 3,4-diClPh SO₂ Single bond Sub-14 1-2191 Sub-37 3,4-diClPh SO₂ Single bond Sub-15 1-2192 Sub-37 3,4-diClPh SO₂ Single bond Sub-16 1-2193 Sub-37 3,4-diClPh SO₂ Single bond Sub-17 1-2194 Sub-37 3,4-diClPh SO₂ Single bond Sub-18 1-2195 Sub-37 3,4-diClPh SO₂ Single bond Sub-19 1-2196 Sub-37 3,4-diClPh SO₂ Single bond Sub-20 1-2197 Sub-37 3,4-diClPh SO₂ Single bond Sub-21 1-2198 Sub-37 3,4-diClPh SO₂ Single bond Sub-22 1-2199 Sub-37 3,4-diClPh SO₂ Single bond Sub-23 1-2200 Sub-37 3,4-diClPh SO₂ Single bond Sub-24 1-2201 Sub-37 3,4-diClPh SO₂ Single bond Sub-25 1-2202 Sub-37 3,4-diClPh SO₂ Single bond Sub-26 1-2203 Sub-37 3,4-diClPh SO₂ Single bond Sub-27 1-2204 Sub-37 3,4-diClPh SO₂ Single bond Sub-28 1-2205 Sub-37 3,4-diClPh SO₂ Single bond Sub-29 1-2206 Sub-37 3,4-diClPh SO₂ Single bond Sub-30 1-2207 Sub-37 3,4-diClPh SO₂ Single bond Sub-31 1-2208 Sub-37 3,4-diClPh SO₂ Single bond Sub-32 1-2209 Sub-38 3,4-diClPh SO₂ Single bond Sub-1  1-2210 Sub-38 3,4-diClPh SO₂ Single bond Sub-2  1-2211 Sub-38 3,4-diClPh SO₂ Single bond Sub-3  1-2212 Sub-38 3,4-diClPh SO₂ Single bond Sub-4  1-2213 Sub-38 3,4-diClPh SO₂ Single bond Sub-5  1-2214 Sub-38 3,4-diClPh SO₂ Single bond Sub-6  1-2215 Sub-38 3,4-diClPh SO₂ Single bond Sub-7  1-2216 Sub-38 3,4-diClPh SO₂ Single bond Sub-8  1-2217 Sub-38 3,4-diClPh SO₂ Single bond Sub-9  1-2218 Sub-38 3,4-diClPh SO₂ Single bond Sub-10 1-2219 Sub-38 3,4-diClPh SO₂ Single bond Sub-11 1-2221 Sub-38 3,4-diClPh SO₂ Single bond Sub-12 1-2221 Sub-38 3,4-diClPh SO₂ Single bond Sub-13 1-2222 Sub-38 3,4-diClPh SO₂ Single bond Sub-14 1-2223 Sub-38 3,4-diClPh SO₂ Single bond Sub-15 1-2224 Sub-38 3,4-diClPh SO₂ Single bond Sub-16 1-2225 Sub-38 3,4-diClPh SO₂ Single bond Sub-17 1-2226 Sub-38 3,4-diClPh SO₂ Single bond Sub-18 1-2227 Sub-38 3,4-diClPh SO₂ Single bond Sub-19 1-2228 Sub-38 3,4-diClPh SO₂ Single bond Sub-20 1-2229 Sub-38 3,4-diClPh SO₂ Single bond Sub-21 1-2230 Sub-38 3,4-diClPh SO₂ Single bond Sub-22 1-2231 Sub-38 3,4-diClPh SO₂ Single bond Sub-23 1-2232 Sub-38 3,4-diClPh SO₂ Single bond Sub-24 1-2233 Sub-38 3,4-diClPh SO₂ Single bond Sub-25 1-2234 Sub-38 3,4-diClPh SO₂ Single bond Sub-26 1-2235 Sub-38 3,4-diClPh SO₂ Single bond Sub-27 1-2236 Sub-38 3,4-diClPh SO₂ Single bond Sub-28 1-2237 Sub-38 3,4-diClPh SO₂ Single bond Sub-29 1-2238 Sub-38 3,4-diClPh SO₂ Single bond Sub-30 1-2239 Sub-38 3,4-diClPh SO₂ Single bond Sub-31 1-2240 Sub-38 3,4-diClPh SO₂ Single bond Sub-32 1-2241 Sub-39 3,4-diClPh SO₂ Single bond Sub-1  1-2242 Sub-39 3,4-diClPh SO₂ Single bond Sub-2  1-2243 Sub-39 3,4-diClPh SO₂ Single bond Sub-3  1-2244 Sub-39 3,4-diClPh SO₂ Single bond Sub-4  1-2245 Sub-39 3,4-diClPh SO₂ Single bond Sub-5  1-2246 Sub-39 3,4-diClPh SO₂ Single bond Sub-6  1-2247 Sub-39 3,4-diClPh SO₂ Single bond Sub-7  1-2248 Sub-39 3,4-diClPh SO₂ Single bond Sub-8  1-2249 Sub-39 3,4-diClPh SO₂ Single bond Sub-9  1-2250 Sub-39 3,4-diClPh SO₂ Single bond Sub-10 1-2251 Sub-39 3,4-diClPh SO₂ Single bond Sub-11 1-2252 Sub-39 3,4-diClPh SO₂ Single bond Sub-12 1-2253 Sub-39 3,4-diClPh SO₂ Single bond Sub-13 1-2254 Sub-39 3,4-diClPh SO₂ Single bond Sub-14 1-2255 Sub-39 3,4-diClPh SO₂ Single bond Sub-15 1-2256 Sub-39 3,4-diClPh SO₂ Single bond Sub-16 1-2257 Sub-39 3,4-diClPh SO₂ Single bond Sub-17 1-2258 Sub-39 3,4-diClPh SO₂ Single bond Sub-18 1-2259 Sub-39 3,4-diClPh SO₂ Single bond Sub-19 1-2260 Sub-39 3,4-diClPh SO₂ Single bond Sub-20 1-2261 Sub-39 3,4-diClPh SO₂ Single bond Sub-21 1-2262 Sub-39 3,4-diClPh SO₂ Single bond Sub-22 1-2263 Sub-39 3,4-diClPh SO₂ Single bond Sub-23 1-2264 Sub-39 3,4-diClPh SO₂ Single bond Sub-24 1-2265 Sub-39 3,4-diClPh SO₂ Single bond Sub-25 1-2266 Sub-39 3,4-diClPh SO₂ Single bond Sub-26 1-2267 Sub-39 3,4-diClPh SO₂ Single bond Sub-27 1-2268 Sub-39 3,4-diClPh SO₂ Single bond Sub-28 1-2269 Sub-39 3,4-diClPh SO₂ Single bond Sub-29 1-2270 Sub-39 3,4-diClPh SO₂ Single bond Sub-30 1-2271 Sub-39 3,4-diClPh SO₂ Single bond Sub-31 1-2272 Sub-39 3,4-diClPh SO₂ Single bond Sub-32 1-2273 Sub-40 3,4-diClPh SO₂ Single bond Sub-1  1-2274 Sub-40 3,4-diClPh SO₂ Single bond Sub-2  1-2275 Sub-40 3,4-diClPh SO₂ Single bond Sub-3  1-2276 Sub-40 3,4-diClPh SO₂ Single bond Sub-4  1-2277 Sub-40 3,4-diClPh SO₂ Single bond Sub-5  1-2278 Sub-40 3,4-diClPh SO₂ Single bond Sub-6  1-2279 Sub-40 3,4-diClPh SO₂ Single bond Sub-7  1-2280 Sub-40 3,4-diClPh SO₂ Single bond Sub-8  1-2281 Sub-40 3,4-diClPh SO₂ Single bond Sub-9  1-2282 Sub-40 3,4-diClPh SO₂ Single bond Sub-10 1-2283 Sub-40 3,4-diClPh SO₂ Single bond Sub-11 1-2284 Sub-40 3,4-diClPh SO₂ Single bond Sub-12 1-2285 Sub-40 3,4-diClPh SO₂ Single bond Sub-13 1-2286 Sub-40 3,4-diClPh SO₂ Single bond Sub-14 1-2287 Sub-40 3,4-diClPh SO₂ Single bond Sub-15 1-2288 Sub-40 3,4-diClPh SO₂ Single bond Sub-16 1-2289 Sub-40 3,4-diClPh SO₂ Single bond Sub-17 1-2290 Sub-40 3,4-diClPh SO₂ Single bond Sub-18 1-2291 Sub-40 3,4-diClPh SO₂ Single bond Sub-19 1-2292 Sub-40 3,4-diClPh SO₂ Single bond Sub-20 1-2293 Sub-40 3,4-diClPh SO₂ Single bond Sub-21 1-2294 Sub-40 3,4-diClPh SO₂ Single bond Sub-22 1-2295 Sub-40 3,4-diClPh SO₂ Single bond Sub-23 1-2296 Sub-40 3,4-diClPh SO₂ Single bond Sub-24 1-2297 Sub-40 3,4-diClPh SO₂ Single bond Sub-25 1-2298 Sub-40 3,4-diClPh SO₂ Single bond Sub-26 1-2299 Sub-40 3,4-diClPh SO₂ Single bond Sub-27 1-2300 Sub-40 3,4-diClPh SO₂ Single bond Sub-28 1-2301 Sub-40 3,4-diClPh SO₂ Single bond Sub-29 1-2302 Sub-40 3,4-diClPh SO₂ Single bond Sub-30 1-2303 Sub-40 3,4-diClPh SO₂ Single bond Sub-31 1-2304 Sub-40 3,4-diClPh SO₂ Single bond Sub-32 1-2305 Sub-41 3,4-diClPh SO₂ Single bond Sub-1  1-2306 Sub-41 3,4-diClPh SO₂ Single bond Sub-2  1-2307 Sub-41 3,4-diClPh SO₂ Single bond Sub-3  1-2308 Sub-41 3,4-diClPh SO₂ Single bond Sub-4  1-2309 Sub-41 3,4-diClPh SO₂ Single bond Sub-5  1-2310 Sub-41 3,4-diClPh SO₂ Single bond Sub-6  1-2311 Sub-41 3,4-diClPh SO₂ Single bond Sub-7  1-2312 Sub-41 3,4-diClPh SO₂ Single bond Sub-8  1-2313 Sub-41 3,4-diClPh SO₂ Single bond Sub-9  1-2314 Sub-41 3,4-diClPh SO₂ Single bond Sub-10 1-2315 Sub-41 3,4-diClPh SO₂ Single bond Sub-11 1-2316 Sub-41 3,4-diClPh SO₂ Single bond Sub-12 1-2317 Sub-41 3,4-diClPh SO₂ Single bond Sub-13 1-2318 Sub-41 3,4-diClPh SO₂ Single bond Sub-14 1-2319 Sub-41 3,4-diClPh SO₂ Single bond Sub-15 1-2321 Sub-41 3,4-diClPh SO₂ Single bond Sub-16 1-2321 Sub-41 3,4-diClPh SO₂ Single bond Sub-17 1-2322 Sub-41 3,4-diClPh SO₂ Single bond Sub-18 1-2323 Sub-41 3,4-diClPh SO₂ Single bond Sub-19 1-2324 Sub-41 3,4-diClPh SO₂ Single bond Sub-20 1-2325 Sub-41 3,4-diClPh SO₂ Single bond Sub-21 1-2326 Sub-41 3,4-diClPh SO₂ Single bond Sub-22 1-2327 Sub-41 3,4-diClPh SO₂ Single bond Sub-23 1-2328 Sub-41 3,4-diClPh SO₂ Single bond Sub-24 1-2329 Sub-41 3,4-diClPh SO₂ Single bond Sub-25 1-2330 Sub-41 3,4-diClPh SO₂ Single bond Sub-26 1-2331 Sub-41 3,4-diClPh SO₂ Single bond Sub-27 1-2332 Sub-41 3,4-diClPh SO₂ Single bond Sub-28 1-2333 Sub-41 3,4-diClPh SO₂ Single bond Sub-29 1-2334 Sub-41 3,4-diClPh SO₂ Single bond Sub-30 1-2335 Sub-41 3,4-diClPh SO₂ Single bond Sub-31 1-2336 Sub-41 3,4-diClPh SO₂ Single bond Sub-32 1-2337 Sub-42 3,4-diClPh SO₂ Single bond Sub-1  1-2338 Sub-42 3,4-diClPh SO₂ Single bond Sub-2  1-2339 Sub-42 3,4-diClPh SO₂ Single bond Sub-3  1-2340 Sub-42 3,4-diClPh SO₂ Single bond Sub-4  1-2341 Sub-42 3,4-diClPh SO₂ Single bond Sub-5  1-2342 Sub-42 3,4-diClPh SO₂ Single bond Sub-6  1-2343 Sub-42 3,4-diClPh SO₂ Single bond Sub-7  1-2344 Sub-42 3,4-diClPh SO₂ Single bond Sub-8  1-2345 Sub-42 3,4-diClPh SO₂ Single bond Sub-9  1-2346 Sub-42 3,4-diClPh SO₂ Single bond Sub-10 1-2347 Sub-42 3,4-diClPh SO₂ Single bond Sub-11 1-2348 Sub-42 3,4-diClPh SO₂ Single bond Sub-12 1-2349 Sub-42 3,4-diClPh SO₂ Single bond Sub-13 1-2350 Sub-42 3,4-diClPh SO₂ Single bond Sub-14 1-2351 Sub-42 3,4-diClPh SO₂ Single bond Sub-15 1-2352 Sub-42 3,4-diClPh SO₂ Single bond Sub-16 1-2353 Sub-42 3,4-diClPh SO₂ Single bond Sub-17 1-2354 Sub-42 3,4-diClPh SO₂ Single bond Sub-18 1-2355 Sub-42 3,4-diClPh SO₂ Single bond Sub-19 1-2356 Sub-42 3,4-diClPh SO₂ Single bond Sub-20 1-2357 Sub-42 3,4-diClPh SO₂ Single bond Sub-21 1-2358 Sub-42 3,4-diClPh SO₂ Single bond Sub-22 1-2359 Sub-42 3,4-diClPh SO₂ Single bond Sub-23 1-2360 Sub-42 3,4-diClPh SO₂ Single bond Sub-24 1-2361 Sub-42 3,4-diClPh SO₂ Single bond Sub-25 1-2362 Sub-42 3,4-diClPh SO₂ Single bond Sub-26 1-2363 Sub-42 3,4-diClPh SO₂ Single bond Sub-27 1-2364 Sub-42 3,4-diClPh SO₂ Single bond Sub-28 1-2365 Sub-42 3,4-diClPh SO₂ Single bond Sub-29 1-2366 Sub-42 3,4-diClPh SO₂ Single bond Sub-30 1-2367 Sub-42 3,4-diClPh SO₂ Single bond Sub-31 1-2368 Sub-42 3,4-diClPh SO₂ Single bond Sub-32 1-2369 Sub-43 3,4-diClPh SO₂ Single bond Sub-1  1-2370 Sub-43 3,4-diClPh SO₂ Single bond Sub-2  1-2371 Sub-43 3,4-diClPh SO₂ Single bond Sub-3  1-2372 Sub-43 3,4-diClPh SO₂ Single bond Sub-4  1-2373 Sub-43 3,4-diClPh SO₂ Single bond Sub-5  1-2374 Sub-43 3,4-diClPh SO₂ Single bond Sub-6  1-2375 Sub-43 3,4-diClPh SO₂ Single bond Sub-7  1-2376 Sub-43 3,4-diClPh SO₂ Single bond Sub-8  1-2377 Sub-43 3,4-diClPh SO₂ Single bond Sub-9  1-2378 Sub-43 3,4-diClPh SO₂ Single bond Sub-10 1-2379 Sub-43 3,4-diClPh SO₂ Single bond Sub-11 1-2380 Sub-43 3,4-diClPh SO₂ Single bond Sub-12 1-2381 Sub-43 3,4-diClPh SO₂ Single bond Sub-13 1-2382 Sub-43 3,4-diClPh SO₂ Single bond Sub-14 1-2383 Sub-43 3,4-diClPh SO₂ Single bond Sub-15 1-2384 Sub-43 3,4-diClPh SO₂ Single bond Sub-16 1-2385 Sub-43 3,4-diClPh SO₂ Single bond Sub-17 1-2386 Sub-43 3,4-diClPh SO₂ Single bond Sub-18 1-2387 Sub-43 3,4-diClPh SO₂ Single bond Sub-19 1-2388 Sub-43 3,4-diClPh SO₂ Single bond Sub-20 1-2389 Sub-43 3,4-diClPh SO₂ Single bond Sub-21 1-2390 Sub-43 3,4-diClPh SO₂ Single bond Sub-22 1-2391 Sub-43 3,4-diClPh SO₂ Single bond Sub-23 1-2392 Sub-43 3,4-diClPh SO₂ Single bond Sub-24 1-2393 Sub-43 3,4-diClPh SO₂ Single bond Sub-25 1-2394 Sub-43 3,4-diClPh SO₂ Single bond Sub-26 1-2395 Sub-43 3,4-diClPh SO₂ Single bond Sub-27 1-2396 Sub-43 3,4-diClPh SO₂ Single bond Sub-28 1-2397 Sub-43 3,4-diClPh SO₂ Single bond Sub-29 1-2398 Sub-43 3,4-diClPh SO₂ Single bond Sub-30 1-2399 Sub-43 3,4-diClPh SO₂ Single bond Sub-31 1-2400 Sub-43 3,4-diClPh SO₂ Single bond Sub-32 1-2401 Sub-44 3,4-diClPh SO₂ Single bond Sub-1  1-2402 Sub-44 3,4-diClPh SO₂ Single bond Sub-2  1-2403 Sub-44 3,4-diClPh SO₂ Single bond Sub-3  1-2404 Sub-44 3,4-diClPh SO₂ Single bond Sub-4  1-2405 Sub-44 3,4-diClPh SO₂ Single bond Sub-5  1-2406 Sub-44 3,4-diClPh SO₂ Single bond Sub-6  1-2407 Sub-44 3,4-diClPh SO₂ Single bond Sub-7  1-2408 Sub-44 3,4-diClPh SO₂ Single bond Sub-8  1-2409 Sub-44 3,4-diClPh SO₂ Single bond Sub-9  1-2410 Sub-44 3,4-diClPh SO₂ Single bond Sub-10 1-2411 Sub-44 3,4-diClPh SO₂ Single bond Sub-11 1-2412 Sub-44 3,4-diClPh SO₂ Single bond Sub-12 1-2413 Sub-44 3,4-diClPh SO₂ Single bond Sub-13 1-2414 Sub-44 3,4-diClPh SO₂ Single bond Sub-14 1-2415 Sub-44 3,4-diClPh SO₂ Single bond Sub-15 1-2416 Sub-44 3,4-diClPh SO₂ Single bond Sub-16 1-2417 Sub-44 3,4-diClPh SO₂ Single bond Sub-17 1-2418 Sub-44 3,4-diClPh SO₂ Single bond Sub-18 1-2419 Sub-44 3,4-diClPh SO₂ Single bond Sub-19 1-2420 Sub-44 3,4-diClPh SO₂ Single bond Sub-20 1-2421 Sub-44 3,4-diClPh SO₂ Single bond Sub-21 1-2422 Sub-44 3,4-diClPh SO₂ Single bond Sub-22 1-2423 Sub-44 3,4-diClPh SO₂ Single bond Sub-23 1-2424 Sub-44 3,4-diClPh SO₂ Single bond Sub-24 1-2425 Sub-44 3,4-diClPh SO₂ Single bond Sub-25 1-2426 Sub-44 3,4-diClPh SO₂ Single bond Sub-26 1-2427 Sub-44 3,4-diClPh SO₂ Single bond Sub-27 1-2428 Sub-44 3,4-diClPh SO₂ Single bond Sub-28 1-2429 Sub-44 3,4-diClPh SO₂ Single bond Sub-29 1-2430 Sub-44 3,4-diClPh SO₂ Single bond Sub-30 1-2431 Sub-44 3,4-diClPh SO₂ Single bond Sub-31 1-2432 Sub-44 3,4-diClPh SO₂ Single bond Sub-32 1-2433 Sub-45 3,4-diClPh SO₂ Single bond Sub-1  1-2434 Sub-45 3,4-diClPh SO₂ Single bond Sub-2  1-2435 Sub-45 3,4-diClPh SO₂ Single bond Sub-3  1-2436 Sub-45 3,4-diClPh SO₂ Single bond Sub-4  1-2437 Sub-45 3,4-diClPh SO₂ Single bond Sub-5  1-2438 Sub-45 3,4-diClPh SO₂ Single bond Sub-6  1-2439 Sub-45 3,4-diClPh SO₂ Single bond Sub-7  1-2440 Sub-45 3,4-diClPh SO₂ Single bond Sub-8  1-2441 Sub-45 3,4-diClPh SO₂ Single bond Sub-9  1-2442 Sub-45 3,4-diClPh SO₂ Single bond Sub-10 1-2443 Sub-45 3,4-diClPh SO₂ Single bond Sub-11 1-2444 Sub-45 3,4-diClPh SO₂ Single bond Sub-12 1-2445 Sub-45 3,4-diClPh SO₂ Single bond Sub-13 1-2446 Sub-45 3,4-diClPh SO₂ Single bond Sub-14 1-2447 Sub-45 3,4-diClPh SO₂ Single bond Sub-15 1-2448 Sub-45 3,4-diClPh SO₂ Single bond Sub-16 1-2449 Sub-45 3,4-diClPh SO₂ Single bond Sub-17 1-2450 Sub-45 3,4-diClPh SO₂ Single bond Sub-18 1-2451 Sub-45 3,4-diClPh SO₂ Single bond Sub-19 1-2452 Sub-45 3,4-diClPh SO₂ Single bond Sub-20 1-2453 Sub-45 3,4-diClPh SO₂ Single bond Sub-21 1-2454 Sub-45 3,4-diClPh SO₂ Single bond Sub-22 1-2455 Sub-45 3,4-diClPh SO₂ Single bond Sub-23 1-2456 Sub-45 3,4-diClPh SO₂ Single bond Sub-24 1-2457 Sub-45 3,4-diClPh SO₂ Single bond Sub-25 1-2458 Sub-45 3,4-diClPh SO₂ Single bond Sub-26 1-2459 Sub-45 3,4-diClPh SO₂ Single bond Sub-27 1-2460 Sub-45 3,4-diClPh SO₂ Single bond Sub-28 1-2461 Sub-45 3,4-diClPh SO₂ Single bond Sub-29 1-2462 Sub-45 3,4-diClPh SO₂ Single bond Sub-30 1-2463 Sub-45 3,4-diClPh SO₂ Single bond Sub-31 1-2464 Sub-45 3,4-diClPh SO₂ Single bond Sub-32 1-2465 Sub-46 3,4-diClPh SO₂ Single bond Sub-1  1-2466 Sub-46 3,4-diClPh SO₂ Single bond Sub-2  1-2467 Sub-46 3,4-diClPh SO₂ Single bond Sub-3  1-2468 Sub-46 3,4-diClPh SO₂ Single bond Sub-4  1-2469 Sub-46 3,4-diClPh SO₂ Single bond Sub-5  1-2470 Sub-46 3,4-diClPh SO₂ Single bond Sub-6  1-2471 Sub-46 3,4-diClPh SO₂ Single bond Sub-7  1-2472 Sub-46 3,4-diClPh SO₂ Single bond Sub-8  1-2473 Sub-46 3,4-diClPh SO₂ Single bond Sub-9  1-2474 Sub-46 3,4-diClPh SO₂ Single bond Sub-10 1-2475 Sub-46 3,4-diClPh SO₂ Single bond Sub-11 1-2476 Sub-46 3,4-diClPh SO₂ Single bond Sub-12 1-2477 Sub-46 3,4-diClPh SO₂ Single bond Sub-13 1-2478 Sub-46 3,4-diClPh SO₂ Single bond Sub-14 1-2479 Sub-46 3,4-diClPh SO₂ Single bond Sub-15 1-2480 Sub-46 3,4-diClPh SO₂ Single bond Sub-16 1-2481 Sub-46 3,4-diClPh SO₂ Single bond Sub-17 1-2482 Sub-46 3,4-diClPh SO₂ Single bond Sub-18 1-2483 Sub-46 3,4-diClPh SO₂ Single bond Sub-19 1-2484 Sub-46 3,4-diClPh SO₂ Single bond Sub-20 1-2485 Sub-46 3,4-diClPh SO₂ Single bond Sub-21 1-2486 Sub-46 3,4-diClPh SO₂ Single bond Sub-22 1-2487 Sub-46 3,4-diClPh SO₂ Single bond Sub-23 1-2488 Sub-46 3,4-diClPh SO₂ Single bond Sub-24 1-2489 Sub-46 3,4-diClPh SO₂ Single bond Sub-25 1-2490 Sub-46 3,4-diClPh SO₂ Single bond Sub-26 1-2491 Sub-46 3,4-diClPh SO₂ Single bond Sub-27 1-2492 Sub-46 3,4-diClPh SO₂ Single bond Sub-28 1-2493 Sub-46 3,4-diClPh SO₂ Single bond Sub-29 1-2494 Sub-46 3,4-diClPh SO₂ Single bond Sub-30 1-2495 Sub-46 3,4-diClPh SO₂ Single bond Sub-31 1-2496 Sub-46 3,4-diClPh SO₂ Single bond Sub-32 1-2497 Sub-47 3,4-diClPh SO₂ Single bond Sub-1  1-2498 Sub-47 3,4-diClPh SO₂ Single bond Sub-2  1-2499 Sub-47 3,4-diClPh SO₂ Single bond Sub-3  1-2500 Sub-47 3,4-diClPh SO₂ Single bond Sub-4  1-2501 Sub-47 3,4-diClPh SO₂ Single bond Sub-5  1-2502 Sub-47 3,4-diClPh SO₂ Single bond Sub-6  1-2503 Sub-47 3,4-diClPh SO₂ Single bond Sub-7  1-2504 Sub-47 3,4-diClPh SO₂ Single bond Sub-8  1-2505 Sub-47 3,4-diClPh SO₂ Single bond Sub-9  1-2506 Sub-47 3,4-diClPh SO₂ Single bond Sub-10 1-2507 Sub-47 3,4-diClPh SO₂ Single bond Sub-11 1-2508 Sub-47 3,4-diClPh SO₂ Single bond Sub-12 1-2509 Sub-47 3,4-diClPh SO₂ Single bond Sub-13 1-2510 Sub-47 3,4-diClPh SO₂ Single bond Sub-14 1-2511 Sub-47 3,4-diClPh SO₂ Single bond Sub-15 1-2512 Sub-47 3,4-diClPh SO₂ Single bond Sub-16 1-2513 Sub-47 3,4-diClPh SO₂ Single bond Sub-17 1-2514 Sub-47 3,4-diClPh SO₂ Single bond Sub-18 1-2515 Sub-47 3,4-diClPh SO₂ Single bond Sub-19 1-2516 Sub-47 3,4-diClPh SO₂ Single bond Sub-20 1-2517 Sub-47 3,4-diClPh SO₂ Single bond Sub-21 1-2518 Sub-47 3,4-diClPh SO₂ Single bond Sub-22 1-2519 Sub-47 3,4-diClPh SO₂ Single bond Sub-23 1-2521 Sub-47 3,4-diClPh SO₂ Single bond Sub-24 1-2521 Sub-47 3,4-diClPh SO₂ Single bond Sub-25 1-2522 Sub-47 3,4-diClPh SO₂ Single bond Sub-26 1-2523 Sub-47 3,4-diClPh SO₂ Single bond Sub-27 1-2524 Sub-47 3,4-diClPh SO₂ Single bond Sub-28 1-2525 Sub-47 3,4-diClPh SO₂ Single bond Sub-29 1-2526 Sub-47 3,4-diClPh SO₂ Single bond Sub-30 1-2527 Sub-47 3,4-diClPh SO₂ Single bond Sub-31 1-2528 Sub-47 3,4-diClPh SO₂ Single bond Sub-32 1-2529 Sub-48 3,4-diClPh SO₂ Single bond Sub-1  1-2530 Sub-48 3,4-diClPh SO₂ Single bond Sub-2  1-2531 Sub-48 3,4-diClPh SO₂ Single bond Sub-3  1-2532 Sub-48 3,4-diClPh SO₂ Single bond Sub-4  1-2533 Sub-48 3,4-diClPh SO₂ Single bond Sub-5  1-2534 Sub-48 3,4-diClPh SO₂ Single bond Sub-6  1-2535 Sub-48 3,4-diClPh SO₂ Single bond Sub-7  1-2536 Sub-48 3,4-diClPh SO₂ Single bond Sub-8  1-2537 Sub-48 3,4-diClPh SO₂ Single bond Sub-9  1-2538 Sub-48 3,4-diClPh SO₂ Single bond Sub-10 1-2539 Sub-48 3,4-diClPh SO₂ Single bond Sub-11 1-2540 Sub-48 3,4-diClPh SO₂ Single bond Sub-12 1-2541 Sub-48 3,4-diClPh SO₂ Single bond Sub-13 1-2542 Sub-48 3,4-diClPh SO₂ Single bond Sub-14 1-2543 Sub-48 3,4-diClPh SO₂ Single bond Sub-15 1-2544 Sub-48 3,4-diClPh SO₂ Single bond Sub-16 1-2545 Sub-48 3,4-diClPh SO₂ Single bond Sub-17 1-2546 Sub-48 3,4-diClPh SO₂ Single bond Sub-18 1-2547 Sub-48 3,4-diClPh SO₂ Single bond Sub-19 1-2548 Sub-48 3,4-diClPh SO₂ Single bond Sub-20 1-2549 Sub-48 3,4-diClPh SO₂ Single bond Sub-21 1-2550 Sub-48 3,4-diClPh SO₂ Single bond Sub-22 1-2551 Sub-48 3,4-diClPh SO₂ Single bond Sub-23 1-2552 Sub-48 3,4-diClPh SO₂ Single bond Sub-24 1-2553 Sub-48 3,4-diClPh SO₂ Single bond Sub-25 1-2554 Sub-48 3,4-diClPh SO₂ Single bond Sub-26 1-2555 Sub-48 3,4-diClPh SO₂ Single bond Sub-27 1-2556 Sub-48 3,4-diClPh SO₂ Single bond Sub-28 1-2557 Sub-48 3,4-diClPh SO₂ Single bond Sub-29 1-2558 Sub-48 3,4-diClPh SO₂ Single bond Sub-30 1-2559 Sub-48 3,4-diClPh SO₂ Single bond Sub-31 1-2560 Sub-48 3,4-diClPh SO₂ Single bond Sub-32 1-2561 Sub-49 3,4-diClPh SO₂ Single bond Sub-1  1-2562 Sub-49 3,4-diClPh SO₂ Single bond Sub-2  1-2563 Sub-49 3,4-diClPh SO₂ Single bond Sub-3  1-2564 Sub-49 3,4-diClPh SO₂ Single bond Sub-4  1-2565 Sub-49 3,4-diClPh SO₂ Single bond Sub-5  1-2566 Sub-49 3,4-diClPh SO₂ Single bond Sub-6  1-2567 Sub-49 3,4-diClPh SO₂ Single bond Sub-7  1-2568 Sub-49 3,4-diClPh SO₂ Single bond Sub-8  1-2569 Sub-49 3,4-diClPh SO₂ Single bond Sub-9  1-2570 Sub-49 3,4-diClPh SO₂ Single bond Sub-10 1-2571 Sub-49 3,4-diClPh SO₂ Single bond Sub-11 1-2572 Sub-49 3,4-diClPh SO₂ Single bond Sub-12 1-2573 Sub-49 3,4-diClPh SO₂ Single bond Sub-13 1-2574 Sub-49 3,4-diClPh SO₂ Single bond Sub-14 1-2575 Sub-49 3,4-diClPh SO₂ Single bond Sub-15 1-2576 Sub-49 3,4-diClPh SO₂ Single bond Sub-16 1-2577 Sub-49 3,4-diClPh SO₂ Single bond Sub-17 1-2578 Sub-49 3,4-diClPh SO₂ Single bond Sub-18 1-2579 Sub-49 3,4-diClPh SO₂ Single bond Sub-19 1-2580 Sub-49 3,4-diClPh SO₂ Single bond Sub-20 1-2581 Sub-49 3,4-diClPh SO₂ Single bond Sub-21 1-2582 Sub-49 3,4-diClPh SO₂ Single bond Sub-22 1-2583 Sub-49 3,4-diClPh SO₂ Single bond Sub-23 1-2584 Sub-49 3,4-diClPh SO₂ Single bond Sub-24 1-2585 Sub-49 3,4-diClPh SO₂ Single bond Sub-25 1-2586 Sub-49 3,4-diClPh SO₂ Single bond Sub-26 1-2587 Sub-49 3,4-diClPh SO₂ Single bond Sub-27 1-2588 Sub-49 3,4-diClPh SO₂ Single bond Sub-28 1-2589 Sub-49 3,4-diClPh SO₂ Single bond Sub-29 1-2590 Sub-49 3,4-diClPh SO₂ Single bond Sub-30 1-2591 Sub-49 3,4-diClPh SO₂ Single bond Sub-31 1-2592 Sub-49 3,4-diClPh SO₂ Single bond Sub-32 1-2593 Sub-50 3,4-diClPh SO₂ Single bond Sub-1  1-2594 Sub-50 3,4-diClPh SO₂ Single bond Sub-2  1-2595 Sub-50 3,4-diClPh SO₂ Single bond Sub-3  1-2596 Sub-50 3,4-diClPh SO₂ Single bond Sub-4  1-2597 Sub-50 3,4-diClPh SO₂ Single bond Sub-5  1-2598 Sub-50 3,4-diClPh SO₂ Single bond Sub-6  1-2599 Sub-50 3,4-diClPh SO₂ Single bond Sub-7  1-2600 Sub-50 3,4-diClPh SO₂ Single bond Sub-8  1-2601 Sub-50 3,4-diClPh SO₂ Single bond Sub-9  1-2602 Sub-50 3,4-diClPh SO₂ Single bond Sub-10 1-2603 Sub-50 3,4-diClPh SO₂ Single bond Sub-11 1-2604 Sub-50 3,4-diClPh SO₂ Single bond Sub-12 1-2605 Sub-50 3,4-diClPh SO₂ Single bond Sub-13 1-2606 Sub-50 3,4-diClPh SO₂ Single bond Sub-14 1-2607 Sub-50 3,4-diClPh SO₂ Single bond Sub-15 1-2608 Sub-50 3,4-diClPh SO₂ Single bond Sub-16 1-2609 Sub-50 3,4-diClPh SO₂ Single bond Sub-17 1-2610 Sub-50 3,4-diClPh SO₂ Single bond Sub-18 1-2611 Sub-50 3,4-diClPh SO₂ Single bond Sub-19 1-2612 Sub-50 3,4-diClPh SO₂ Single bond Sub-20 1-2613 Sub-50 3,4-diClPh SO₂ Single bond Sub-21 1-2614 Sub-50 3,4-diClPh SO₂ Single bond Sub-22 1-2615 Sub-50 3,4-diClPh SO₂ Single bond Sub-23 1-2616 Sub-50 3,4-diClPh SO₂ Single bond Sub-24 1-2617 Sub-50 3,4-diClPh SO₂ Single bond Sub-25 1-2618 Sub-50 3,4-diClPh SO₂ Single bond Sub-26 1-2619 Sub-50 3,4-diClPh SO₂ Single bond Sub-27 1-2621 Sub-50 3,4-diClPh SO₂ Single bond Sub-28 1-2621 Sub-50 3,4-diClPh SO₂ Single bond Sub-29 1-2622 Sub-50 3,4-diClPh SO₂ Single bond Sub-30 1-2623 Sub-50 3,4-diClPh SO₂ Single bond Sub-31 1-2624 Sub-50 3,4-diClPh SO₂ Single bond Sub-32 1-2625 Sub-51 3,4-diClPh SO₂ Single bond Sub-1  1-2626 Sub-51 3,4-diClPh SO₂ Single bond Sub-2  1-2627 Sub-51 3,4-diClPh SO₂ Single bond Sub-3  1-2628 Sub-51 3,4-diClPh SO₂ Single bond Sub-4  1-2629 Sub-51 3,4-diClPh SO₂ Single bond Sub-5  1-2630 Sub-51 3,4-diClPh SO₂ Single bond Sub-6  1-2631 Sub-51 3,4-diClPh SO₂ Single bond Sub-7  1-2632 Sub-51 3,4-diClPh SO₂ Single bond Sub-8  1-2633 Sub-51 3,4-diClPh SO₂ Single bond Sub-9  1-2634 Sub-51 3,4-diClPh SO₂ Single bond Sub-10 1-2635 Sub-51 3,4-diClPh SO₂ Single bond Sub-11 1-2636 Sub-51 3,4-diClPh SO₂ Single bond Sub-12 1-2637 Sub-51 3,4-diClPh SO₂ Single bond Sub-13 1-2638 Sub-51 3,4-diClPh SO₂ Single bond Sub-14 1-2639 Sub-51 3,4-diClPh SO₂ Single bond Sub-15 1-2640 Sub-51 3,4-diClPh SO₂ Single bond Sub-16 1-2641 Sub-51 3,4-diClPh SO₂ Single bond Sub-17 1-2642 Sub-51 3,4-diClPh SO₂ Single bond Sub-18 1-2643 Sub-51 3,4-diClPh SO₂ Single bond Sub-19 1-2644 Sub-51 3,4-diClPh SO₂ Single bond Sub-20 1-2645 Sub-51 3,4-diClPh SO₂ Single bond Sub-21 1-2646 Sub-51 3,4-diClPh SO₂ Single bond Sub-22 1-2647 Sub-51 3,4-diClPh SO₂ Single bond Sub-23 1-2648 Sub-51 3,4-diClPh SO₂ Single bond Sub-24 1-2649 Sub-51 3,4-diClPh SO₂ Single bond Sub-25 1-2650 Sub-51 3,4-diClPh SO₂ Single bond Sub-26 1-2651 Sub-51 3,4-diClPh SO₂ Single bond Sub-27 1-2652 Sub-51 3,4-diClPh SO₂ Single bond Sub-28 1-2653 Sub-51 3,4-diClPh SO₂ Single bond Sub-29 1-2654 Sub-51 3,4-diClPh SO₂ Single bond Sub-30 1-2655 Sub-51 3,4-diClPh SO₂ Single bond Sub-31 1-2656 Sub-51 3,4-diClPh SO₂ Single bond Sub-32 1-2657 Sub-52 3,4-diClPh SO₂ Single bond Sub-1  1-2658 Sub-52 3,4-diClPh SO₂ Single bond Sub-2  1-2659 Sub-52 3,4-diClPh SO₂ Single bond Sub-3  1-2660 Sub-52 3,4-diClPh SO₂ Single bond Sub-4  1-2661 Sub-52 3,4-diClPh SO₂ Single bond Sub-5  1-2662 Sub-52 3,4-diClPh SO₂ Single bond Sub-6  1-2663 Sub-52 3,4-diClPh SO₂ Single bond Sub-7  1-2664 Sub-52 3,4-diClPh SO₂ Single bond Sub-8  1-2665 Sub-52 3,4-diClPh SO₂ Single bond Sub-9  1-2666 Sub-52 3,4-diClPh SO₂ Single bond Sub-10 1-2667 Sub-52 3,4-diClPh SO₂ Single bond Sub-11 1-2668 Sub-52 3,4-diClPh SO₂ Single bond Sub-12 1-2669 Sub-52 3,4-diClPh SO₂ Single bond Sub-13 1-2670 Sub-52 3,4-diClPh SO₂ Single bond Sub-14 1-2671 Sub-52 3,4-diClPh SO₂ Single bond Sub-15 1-2672 Sub-52 3,4-diClPh SO₂ Single bond Sub-16 1-2673 Sub-52 3,4-diClPh SO₂ Single bond Sub-17 1-2674 Sub-52 3,4-diClPh SO₂ Single bond Sub-18 1-2675 Sub-52 3,4-diClPh SO₂ Single bond Sub-19 1-2676 Sub-52 3,4-diClPh SO₂ Single bond Sub-20 1-2677 Sub-52 3,4-diClPh SO₂ Single bond Sub-21 1-2678 Sub-52 3,4-diClPh SO₂ Single bond Sub-22 1-2679 Sub-52 3,4-diClPh SO₂ Single bond Sub-23 1-2680 Sub-52 3,4-diClPh SO₂ Single bond Sub-24 1-2681 Sub-52 3,4-diClPh SO₂ Single bond Sub-25 1-2682 Sub-52 3,4-diClPh SO₂ Single bond Sub-26 1-2683 Sub-52 3,4-diClPh SO₂ Single bond Sub-27 1-2684 Sub-52 3,4-diClPh SO₂ Single bond Sub-28 1-2685 Sub-52 3,4-diClPh SO₂ Single bond Sub-29 1-2686 Sub-52 3,4-diClPh SO₂ Single bond Sub-30 1-2687 Sub-52 3,4-diClPh SO₂ Single bond Sub-31 1-2688 Sub-52 3,4-diClPh SO₂ Single bond Sub-32 1-2689 Sub-53 3,4-diClPh SO₂ Single bond Sub-1  1-2690 Sub-53 3,4-diClPh SO₂ Single bond Sub-2  1-2691 Sub-53 3,4-diClPh SO₂ Single bond Sub-3  1-2692 Sub-53 3,4-diClPh SO₂ Single bond Sub-4  1-2693 Sub-53 3,4-diClPh SO₂ Single bond Sub-5  1-2694 Sub-53 3,4-diClPh SO₂ Single bond Sub-6  1-2695 Sub-53 3,4-diClPh SO₂ Single bond Sub-7  1-2696 Sub-53 3,4-diClPh SO₂ Single bond Sub-8  1-2697 Sub-53 3,4-diClPh SO₂ Single bond Sub-9  1-2698 Sub-53 3,4-diClPh SO₂ Single bond Sub-10 1-2699 Sub-53 3,4-diClPh SO₂ Single bond Sub-11 1-2700 Sub-53 3,4-diClPh SO₂ Single bond Sub-12 1-2701 Sub-53 3,4-diClPh SO₂ Single bond Sub-13 1-2702 Sub-53 3,4-diClPh SO₂ Single bond Sub-14 1-2703 Sub-53 3,4-diClPh SO₂ Single bond Sub-15 1-2704 Sub-53 3,4-diClPh SO₂ Single bond Sub-16 1-2705 Sub-53 3,4-diClPh SO₂ Single bond Sub-17 1-2706 Sub-53 3,4-diClPh SO₂ Single bond Sub-18 1-2707 Sub-53 3,4-diClPh SO₂ Single bond Sub-19 1-2708 Sub-53 3,4-diClPh SO₂ Single bond Sub-20 1-2709 Sub-53 3,4-diClPh SO₂ Single bond Sub-21 1-2710 Sub-53 3,4-diClPh SO₂ Single bond Sub-22 1-2711 Sub-53 3,4-diClPh SO₂ Single bond Sub-23 1-2712 Sub-53 3,4-diClPh SO₂ Single bond Sub-24 1-2713 Sub-53 3,4-diClPh SO₂ Single bond Sub-25 1-2714 Sub-53 3,4-diClPh SO₂ Single bond Sub-26 1-2715 Sub-53 3,4-diClPh SO₂ Single bond Sub-27 1-2716 Sub-53 3,4-diClPh SO₂ Single bond Sub-28 1-2717 Sub-53 3,4-diClPh SO₂ Single bond Sub-29 1-2718 Sub-53 3,4-diClPh SO₂ Single bond Sub-30 1-2719 Sub-53 3,4-diClPh SO₂ Single bond Sub-31 1-2721 Sub-53 3,4-diClPh SO₂ Single bond Sub-32 1-2721 Sub-54 3,4-diClPh SO₂ Single bond Sub-1  1-2722 Sub-54 3,4-diClPh SO₂ Single bond Sub-2  1-2723 Sub-54 3,4-diClPh SO₂ Single bond Sub-3  1-2724 Sub-54 3,4-diClPh SO₂ Single bond Sub-4  1-2725 Sub-54 3,4-diClPh SO₂ Single bond Sub-5  1-2726 Sub-54 3,4-diClPh SO₂ Single bond Sub-6  1-2727 Sub-54 3,4-diClPh SO₂ Single bond Sub-7  1-2728 Sub-54 3,4-diClPh SO₂ Single bond Sub-8  1-2729 Sub-54 3,4-diClPh SO₂ Single bond Sub-9  1-2730 Sub-54 3,4-diClPh SO₂ Single bond Sub-10 1-2731 Sub-54 3,4-diClPh SO₂ Single bond Sub-11 1-2732 Sub-54 3,4-diClPh SO₂ Single bond Sub-12 1-2733 Sub-54 3,4-diClPh SO₂ Single bond Sub-13 1-2734 Sub-54 3,4-diClPh SO₂ Single bond Sub-14 1-2735 Sub-54 3,4-diClPh SO₂ Single bond Sub-15 1-2736 Sub-54 3,4-diClPh SO₂ Single bond Sub-16 1-2737 Sub-54 3,4-diClPh SO₂ Single bond Sub-17 1-2738 Sub-54 3,4-diClPh SO₂ Single bond Sub-18 1-2739 Sub-54 3,4-diClPh SO₂ Single bond Sub-19 1-2740 Sub-54 3,4-diClPh SO₂ Single bond Sub-20 1-2741 Sub-54 3,4-diClPh SO₂ Single bond Sub-21 1-2742 Sub-54 3,4-diClPh SO₂ Single bond Sub-22 1-2743 Sub-54 3,4-diClPh SO₂ Single bond Sub-23 1-2744 Sub-54 3,4-diClPh SO₂ Single bond Sub-24 1-2745 Sub-54 3,4-diClPh SO₂ Single bond Sub-25 1-2746 Sub-54 3,4-diClPh SO₂ Single bond Sub-26 1-2747 Sub-54 3,4-diClPh SO₂ Single bond Sub-27 1-2748 Sub-54 3,4-diClPh SO₂ Single bond Sub-28 1-2749 Sub-54 3,4-diClPh SO₂ Single bond Sub-29 1-2750 Sub-54 3,4-diClPh SO₂ Single bond Sub-30 1-2751 Sub-54 3,4-diClPh SO₂ Single bond Sub-31 1-2752 Sub-54 3,4-diClPh SO₂ Single bond Sub-32 1-2753 Sub-55 3,4-diClPh SO₂ Single bond Sub-1  1-2754 Sub-55 3,4-diClPh SO₂ Single bond Sub-2  1-2755 Sub-55 3,4-diClPh SO₂ Single bond Sub-3  1-2756 Sub-55 3,4-diClPh SO₂ Single bond Sub-4  1-2757 Sub-55 3,4-diClPh SO₂ Single bond Sub-5  1-2758 Sub-55 3,4-diClPh SO₂ Single bond Sub-6  1-2759 Sub-55 3,4-diClPh SO₂ Single bond Sub-7  1-2760 Sub-55 3,4-diClPh SO₂ Single bond Sub-8  1-2761 Sub-55 3,4-diClPh SO₂ Single bond Sub-9  1-2762 Sub-55 3,4-diClPh SO₂ Single bond Sub-10 1-2763 Sub-55 3,4-diClPh SO₂ Single bond Sub-11 1-2764 Sub-55 3,4-diClPh SO₂ Single bond Sub-12 1-2765 Sub-55 3,4-diClPh SO₂ Single bond Sub-13 1-2766 Sub-55 3,4-diClPh SO₂ Single bond Sub-14 1-2767 Sub-55 3,4-diClPh SO₂ Single bond Sub-15 1-2768 Sub-55 3,4-diClPh SO₂ Single bond Sub-16 1-2769 Sub-55 3,4-diClPh SO₂ Single bond Sub-17 1-2770 Sub-55 3,4-diClPh SO₂ Single bond Sub-18 1-2771 Sub-55 3,4-diClPh SO₂ Single bond Sub-19 1-2772 Sub-55 3,4-diClPh SO₂ Single bond Sub-20 1-2773 Sub-55 3,4-diClPh SO₂ Single bond Sub-21 1-2774 Sub-55 3,4-diClPh SO₂ Single bond Sub-22 1-2775 Sub-55 3,4-diClPh SO₂ Single bond Sub-23 1-2776 Sub-55 3,4-diClPh SO₂ Single bond Sub-24 1-2777 Sub-55 3,4-diClPh SO₂ Single bond Sub-25 1-2778 Sub-55 3,4-diClPh SO₂ Single bond Sub-26 1-2779 Sub-55 3,4-diClPh SO₂ Single bond Sub-27 1-2780 Sub-55 3,4-diClPh SO₂ Single bond Sub-28 1-2781 Sub-55 3,4-diClPh SO₂ Single bond Sub-29 1-2782 Sub-55 3,4-diClPh SO₂ Single bond Sub-30 1-2783 Sub-55 3,4-diClPh SO₂ Single bond Sub-31 1-2784 Sub-55 3,4-diClPh SO₂ Single bond Sub-32 1-2785 Sub-56 3,4-diClPh SO₂ Single bond Sub-1  1-2786 Sub-56 3,4-diClPh SO₂ Single bond Sub-2  1-2787 Sub-56 3,4-diClPh SO₂ Single bond Sub-3  1-2788 Sub-56 3,4-diClPh SO₂ Single bond Sub-4  1-2789 Sub-56 3,4-diClPh SO₂ Single bond Sub-5  1-2790 Sub-56 3,4-diClPh SO₂ Single bond Sub-6  1-2791 Sub-56 3,4-diClPh SO₂ Single bond Sub-7  1-2792 Sub-56 3,4-diClPh SO₂ Single bond Sub-8  1-2793 Sub-56 3,4-diClPh SO₂ Single bond Sub-9  1-2794 Sub-56 3,4-diClPh SO₂ Single bond Sub-10 1-2795 Sub-56 3,4-diClPh SO₂ Single bond Sub-11 1-2796 Sub-56 3,4-diClPh SO₂ Single bond Sub-12 1-2797 Sub-56 3,4-diClPh SO₂ Single bond Sub-13 1-2798 Sub-56 3,4-diClPh SO₂ Single bond Sub-14 1-2799 Sub-56 3,4-diClPh SO₂ Single bond Sub-15 1-2800 Sub-56 3,4-diClPh SO₂ Single bond Sub-16 1-2801 Sub-56 3,4-diClPh SO₂ Single bond Sub-17 1-2802 Sub-56 3,4-diClPh SO₂ Single bond Sub-18 1-2803 Sub-56 3,4-diClPh SO₂ Single bond Sub-19 1-2804 Sub-56 3,4-diClPh SO₂ Single bond Sub-20 1-2805 Sub-56 3,4-diClPh SO₂ Single bond Sub-21 1-2806 Sub-56 3,4-diClPh SO₂ Single bond Sub-22 1-2807 Sub-56 3,4-diClPh SO₂ Single bond Sub-23 1-2808 Sub-56 3,4-diClPh SO₂ Single bond Sub-24 1-2809 Sub-56 3,4-diClPh SO₂ Single bond Sub-25 1-2810 Sub-56 3,4-diClPh SO₂ Single bond Sub-26 1-2811 Sub-56 3,4-diClPh SO₂ Single bond Sub-27 1-2812 Sub-56 3,4-diClPh SO₂ Single bond Sub-28 1-2813 Sub-56 3,4-diClPh SO₂ Single bond Sub-29 1-2814 Sub-56 3,4-diClPh SO₂ Single bond Sub-30 1-2815 Sub-56 3,4-diClPh SO₂ Single bond Sub-31 1-2816 Sub-56 3,4-diClPh SO₂ Single bond Sub-32 1-2817 Sub-57 3,4-diClPh SO₂ Single bond Sub-1  1-2818 Sub-57 3,4-diClPh SO₂ Single bond Sub-2  1-2819 Sub-57 3,4-diClPh SO₂ Single bond Sub-3  1-2821 Sub-57 3,4-diClPh SO₂ Single bond Sub-4  1-2821 Sub-57 3,4-diClPh SO₂ Single bond Sub-5  1-2822 Sub-57 3,4-diClPh SO₂ Single bond Sub-6  1-2823 Sub-57 3,4-diClPh SO₂ Single bond Sub-7  1-2824 Sub-57 3,4-diClPh SO₂ Single bond Sub-8  1-2825 Sub-57 3,4-diClPh SO₂ Single bond Sub-9  1-2826 Sub-57 3,4-diClPh SO₂ Single bond Sub-10 1-2827 Sub-57 3,4-diClPh SO₂ Single bond Sub-11 1-2828 Sub-57 3,4-diClPh SO₂ Single bond Sub-12 1-2829 Sub-57 3,4-diClPh SO₂ Single bond Sub-13 1-2830 Sub-57 3,4-diClPh SO₂ Single bond Sub-14 1-2831 Sub-57 3,4-diClPh SO₂ Single bond Sub-15 1-2832 Sub-57 3,4-diClPh SO₂ Single bond Sub-16 1-2833 Sub-57 3,4-diClPh SO₂ Single bond Sub-17 1-2834 Sub-57 3,4-diClPh SO₂ Single bond Sub-18 1-2835 Sub-57 3,4-diClPh SO₂ Single bond Sub-19 1-2836 Sub-57 3,4-diClPh SO₂ Single bond Sub-20 1-2837 Sub-57 3,4-diClPh SO₂ Single bond Sub-21 1-2838 Sub-57 3,4-diClPh SO₂ Single bond Sub-22 1-2839 Sub-57 3,4-diClPh SO₂ Single bond Sub-23 1-2840 Sub-57 3,4-diClPh SO₂ Single bond Sub-24 1-2841 Sub-57 3,4-diClPh SO₂ Single bond Sub-25 1-2842 Sub-57 3,4-diClPh SO₂ Single bond Sub-26 1-2843 Sub-57 3,4-diClPh SO₂ Single bond Sub-27 1-2844 Sub-57 3,4-diClPh SO₂ Single bond Sub-28 1-2845 Sub-57 3,4-diClPh SO₂ Single bond Sub-29 1-2846 Sub-57 3,4-diClPh SO₂ Single bond Sub-30 1-2847 Sub-57 3,4-diClPh SO₂ Single bond Sub-31 1-2848 Sub-57 3,4-diClPh SO₂ Single bond Sub-32 1-2849 Sub-58 3,4-diClPh SO₂ Single bond Sub-1  1-2850 Sub-58 3,4-diClPh SO₂ Single bond Sub-2  1-2851 Sub-58 3,4-diClPh SO₂ Single bond Sub-3  1-2852 Sub-58 3,4-diClPh SO₂ Single bond Sub-4  1-2853 Sub-58 3,4-diClPh SO₂ Single bond Sub-5  1-2854 Sub-58 3,4-diClPh SO₂ Single bond Sub-6  1-2855 Sub-58 3,4-diClPh SO₂ Single bond Sub-7  1-2856 Sub-58 3,4-diClPh SO₂ Single bond Sub-8  1-2857 Sub-58 3,4-diClPh SO₂ Single bond Sub-9  1-2858 Sub-58 3,4-diClPh SO₂ Single bond Sub-10 1-2859 Sub-58 3,4-diClPh SO₂ Single bond Sub-11 1-2860 Sub-58 3,4-diClPh SO₂ Single bond Sub-12 1-2861 Sub-58 3,4-diClPh SO₂ Single bond Sub-13 1-2862 Sub-58 3,4-diClPh SO₂ Single bond Sub-14 1-2863 Sub-58 3,4-diClPh SO₂ Single bond Sub-15 1-2864 Sub-58 3,4-diClPh SO₂ Single bond Sub-16 1-2865 Sub-58 3,4-diClPh SO₂ Single bond Sub-17 1-2866 Sub-58 3,4-diClPh SO₂ Single bond Sub-18 1-2867 Sub-58 3,4-diClPh SO₂ Single bond Sub-19 1-2868 Sub-58 3,4-diClPh SO₂ Single bond Sub-20 1-2869 Sub-58 3,4-diClPh SO₂ Single bond Sub-21 1-2870 Sub-58 3,4-diClPh SO₂ Single bond Sub-22 1-2871 Sub-58 3,4-diClPh SO₂ Single bond Sub-23 1-2872 Sub-58 3,4-diClPh SO₂ Single bond Sub-24 1-2873 Sub-58 3,4-diClPh SO₂ Single bond Sub-25 1-2874 Sub-58 3,4-diClPh SO₂ Single bond Sub-26 1-2875 Sub-58 3,4-diClPh SO₂ Single bond Sub-27 1-2876 Sub-58 3,4-diClPh SO₂ Single bond Sub-28 1-2877 Sub-58 3,4-diClPh SO₂ Single bond Sub-29 1-2878 Sub-58 3,4-diClPh SO₂ Single bond Sub-30 1-2879 Sub-58 3,4-diClPh SO₂ Single bond Sub-31 1-2880 Sub-58 3,4-diClPh SO₂ Single bond Sub-32 1-2881 Sub-59 3,4-diClPh SO₂ Single bond Sub-1  1-2882 Sub-59 3,4-diClPh SO₂ Single bond Sub-2  1-2883 Sub-59 3,4-diClPh SO₂ Single bond Sub-3  1-2884 Sub-59 3,4-diClPh SO₂ Single bond Sub-4  1-2885 Sub-59 3,4-diClPh SO₂ Single bond Sub-5  1-2886 Sub-59 3,4-diClPh SO₂ Single bond Sub-6  1-2887 Sub-59 3,4-diClPh SO₂ Single bond Sub-7  1-2888 Sub-59 3,4-diClPh SO₂ Single bond Sub-8  1-2889 Sub-59 3,4-diClPh SO₂ Single bond Sub-9  1-2890 Sub-59 3,4-diClPh SO₂ Single bond Sub-10 1-2891 Sub-59 3,4-diClPh SO₂ Single bond Sub-11 1-2892 Sub-59 3,4-diClPh SO₂ Single bond Sub-12 1-2893 Sub-59 3,4-diClPh SO₂ Single bond Sub-13 1-2894 Sub-59 3,4-diClPh SO₂ Single bond Sub-14 1-2895 Sub-59 3,4-diClPh SO₂ Single bond Sub-15 1-2896 Sub-59 3,4-diClPh SO₂ Single bond Sub-16 1-2897 Sub-59 3,4-diClPh SO₂ Single bond Sub-17 1-2898 Sub-59 3,4-diClPh SO₂ Single bond Sub-18 1-2899 Sub-59 3,4-diClPh SO₂ Single bond Sub-19 1-2900 Sub-59 3,4-diClPh SO₂ Single bond Sub-20 1-2901 Sub-59 3,4-diClPh SO₂ Single bond Sub-21 1-2902 Sub-59 3,4-diClPh SO₂ Single bond Sub-22 1-2903 Sub-59 3,4-diClPh SO₂ Single bond Sub-23 1-2904 Sub-59 3,4-diClPh SO₂ Single bond Sub-24 1-2905 Sub-59 3,4-diClPh SO₂ Single bond Sub-25 1-2906 Sub-59 3,4-diClPh SO₂ Single bond Sub-26 1-2907 Sub-59 3,4-diClPh SO₂ Single bond Sub-27 1-2908 Sub-59 3,4-diClPh SO₂ Single bond Sub-28 1-2909 Sub-59 3,4-diClPh SO₂ Single bond Sub-29 1-2910 Sub-59 3,4-diClPh SO₂ Single bond Sub-30 1-2911 Sub-59 3,4-diClPh SO₂ Single bond Sub-31 1-2912 Sub-59 3,4-diClPh SO₂ Single bond Sub-32 1-2913 Sub-60 3,4-diClPh SO₂ Single bond Sub-1  1-2914 Sub-60 3,4-diClPh SO₂ Single bond Sub-2  1-2915 Sub-60 3,4-diClPh SO₂ Single bond Sub-3  1-2916 Sub-60 3,4-diClPh SO₂ Single bond Sub-4  1-2917 Sub-60 3,4-diClPh SO₂ Single bond Sub-5  1-2918 Sub-60 3,4-diClPh SO₂ Single bond Sub-6  1-2919 Sub-60 3,4-diClPh SO₂ Single bond Sub-7  1-2921 Sub-60 3,4-diClPh SO₂ Single bond Sub-8  1-2921 Sub-60 3,4-diClPh SO₂ Single bond Sub-9  1-2922 Sub-60 3,4-diClPh SO₂ Single bond Sub-10 1-2923 Sub-60 3,4-diClPh SO₂ Single bond Sub-11 1-2924 Sub-60 3,4-diClPh SO₂ Single bond Sub-12 1-2925 Sub-60 3,4-diClPh SO₂ Single bond Sub-13 1-2926 Sub-60 3,4-diClPh SO₂ Single bond Sub-14 1-2927 Sub-60 3,4-diClPh SO₂ Single bond Sub-15 1-2928 Sub-60 3,4-diClPh SO₂ Single bond Sub-16 1-2929 Sub-60 3,4-diClPh SO₂ Single bond Sub-17 1-2930 Sub-60 3,4-diClPh SO₂ Single bond Sub-18 1-2931 Sub-60 3,4-diClPh SO₂ Single bond Sub-19 1-2932 Sub-60 3,4-diClPh SO₂ Single bond Sub-20 1-2933 Sub-60 3,4-diClPh SO₂ Single bond Sub-21 1-2934 Sub-60 3,4-diClPh SO₂ Single bond Sub-22 1-2935 Sub-60 3,4-diClPh SO₂ Single bond Sub-23 1-2936 Sub-60 3,4-diClPh SO₂ Single bond Sub-24 1-2937 Sub-60 3,4-diClPh SO₂ Single bond Sub-25 1-2938 Sub-60 3,4-diClPh SO₂ Single bond Sub-26 1-2939 Sub-60 3,4-diClPh SO₂ Single bond Sub-27 1-2940 Sub-60 3,4-diClPh SO₂ Single bond Sub-28 1-2941 Sub-60 3,4-diClPh SO₂ Single bond Sub-29 1-2942 Sub-60 3,4-diClPh SO₂ Single bond Sub-30 1-2943 Sub-60 3,4-diClPh SO₂ Single bond Sub-31 1-2944 Sub-60 3,4-diClPh SO₂ Single bond Sub-32 1-2945 Sub-61 3,4-diClPh SO₂ Single bond Sub-1  1-2946 Sub-61 3,4-diClPh SO₂ Single bond Sub-2  1-2947 Sub-61 3,4-diClPh SO₂ Single bond Sub-3  1-2948 Sub-61 3,4-diClPh SO₂ Single bond Sub-4  1-2949 Sub-61 3,4-diClPh SO₂ Single bond Sub-5  1-2950 Sub-61 3,4-diClPh SO₂ Single bond Sub-6  1-2951 Sub-61 3,4-diClPh SO₂ Single bond Sub-7  1-2952 Sub-61 3,4-diClPh SO₂ Single bond Sub-8  1-2953 Sub-61 3,4-diClPh SO₂ Single bond Sub-9  1-2954 Sub-61 3,4-diClPh SO₂ Single bond Sub-10 1-2955 Sub-61 3,4-diClPh SO₂ Single bond Sub-11 1-2956 Sub-61 3,4-diClPh SO₂ Single bond Sub-12 1-2957 Sub-61 3,4-diClPh SO₂ Single bond Sub-13 1-2958 Sub-61 3,4-diClPh SO₂ Single bond Sub-14 1-2959 Sub-61 3,4-diClPh SO₂ Single bond Sub-15 1-2960 Sub-61 3,4-diClPh SO₂ Single bond Sub-16 1-2961 Sub-61 3,4-diClPh SO₂ Single bond Sub-17 1-2962 Sub-61 3,4-diClPh SO₂ Single bond Sub-18 1-2963 Sub-61 3,4-diClPh SO₂ Single bond Sub-19 1-2964 Sub-61 3,4-diClPh SO₂ Single bond Sub-20 1-2965 Sub-61 3,4-diClPh SO₂ Single bond Sub-21 1-2966 Sub-61 3,4-diClPh SO₂ Single bond Sub-22 1-2967 Sub-61 3,4-diClPh SO₂ Single bond Sub-23 1-2968 Sub-61 3,4-diClPh SO₂ Single bond Sub-24 1-2969 Sub-61 3,4-diClPh SO₂ Single bond Sub-25 1-2970 Sub-61 3,4-diClPh SO₂ Single bond Sub-26 1-2971 Sub-61 3,4-diClPh SO₂ Single bond Sub-27 1-2972 Sub-61 3,4-diClPh SO₂ Single bond Sub-28 1-2973 Sub-61 3,4-diClPh SO₂ Single bond Sub-29 1-2974 Sub-61 3,4-diClPh SO₂ Single bond Sub-30 1-2975 Sub-61 3,4-diClPh SO₂ Single bond Sub-31 1-2976 Sub-61 3,4-diClPh SO₂ Single bond Sub-32 1-2977 Sub-62 3,4-diClPh SO₂ Single bond Sub-1  1-2978 Sub-62 3,4-diClPh SO₂ Single bond Sub-2  1-2979 Sub-62 3,4-diClPh SO₂ Single bond Sub-3  1-2980 Sub-62 3,4-diClPh SO₂ Single bond Sub-4  1-2981 Sub-62 3,4-diClPh SO₂ Single bond Sub-5  1-2982 Sub-62 3,4-diClPh SO₂ Single bond Sub-6  1-2983 Sub-62 3,4-diClPh SO₂ Single bond Sub-7  1-2984 Sub-62 3,4-diClPh SO₂ Single bond Sub-8  1-2985 Sub-62 3,4-diClPh SO₂ Single bond Sub-9  1-2986 Sub-62 3,4-diClPh SO₂ Single bond Sub-10 1-2987 Sub-62 3,4-diClPh SO₂ Single bond Sub-11 1-2988 Sub-62 3,4-diClPh SO₂ Single bond Sub-12 1-2989 Sub-62 3,4-diClPh SO₂ Single bond Sub-13 1-2990 Sub-62 3,4-diClPh SO₂ Single bond Sub-14 1-2991 Sub-62 3,4-diClPh SO₂ Single bond Sub-15 1-2992 Sub-62 3,4-diClPh SO₂ Single bond Sub-16 1-2993 Sub-62 3,4-diClPh SO₂ Single bond Sub-17 1-2994 Sub-62 3,4-diClPh SO₂ Single bond Sub-18 1-2995 Sub-62 3,4-diClPh SO₂ Single bond Sub-19 1-2996 Sub-62 3,4-diClPh SO₂ Single bond Sub-20 1-2997 Sub-62 3,4-diClPh SO₂ Single bond Sub-21 1-2998 Sub-62 3,4-diClPh SO₂ Single bond Sub-22 1-2999 Sub-62 3,4-diClPh SO₂ Single bond Sub-23 1-3000 Sub-62 3,4-diClPh SO₂ Single bond Sub-24 1-3001 Sub-62 3,4-diClPh SO₂ Single bond Sub-25 1-3002 Sub-62 3,4-diClPh SO₂ Single bond Sub-26 1-3003 Sub-62 3,4-diClPh SO₂ Single bond Sub-27 1-3004 Sub-62 3,4-diClPh SO₂ Single bond Sub-28 1-3005 Sub-62 3,4-diClPh SO₂ Single bond Sub-29 1-3006 Sub-62 3,4-diClPh SO₂ Single bond Sub-30 1-3007 Sub-62 3,4-diClPh SO₂ Single bond Sub-31 1-3008 Sub-62 3,4-diClPh SO₂ Single bond Sub-32 1-3009 Sub-63 3,4-diClPh SO₂ Single bond Sub-1  1-3010 Sub-63 3,4-diClPh SO₂ Single bond Sub-2  1-3011 Sub-63 3,4-diClPh SO₂ Single bond Sub-3  1-3012 Sub-63 3,4-diClPh SO₂ Single bond Sub-4  1-3013 Sub-63 3,4-diClPh SO₂ Single bond Sub-5  1-3014 Sub-63 3,4-diClPh SO₂ Single bond Sub-6  1-3015 Sub-63 3,4-diClPh SO₂ Single bond Sub-7  1-3016 Sub-63 3,4-diClPh SO₂ Single bond Sub-8  1-3017 Sub-63 3,4-diClPh SO₂ Single bond Sub-9  1-3018 Sub-63 3,4-diClPh SO₂ Single bond Sub-10 1-3019 Sub-63 3,4-diClPh SO₂ Single bond Sub-11 1-3020 Sub-63 3,4-diClPh SO₂ Single bond Sub-12 1-3021 Sub-63 3,4-diClPh SO₂ Single bond Sub-13 1-3022 Sub-63 3,4-diClPh SO₂ Single bond Sub-14 1-3023 Sub-63 3,4-diClPh SO₂ Single bond Sub-15 1-3024 Sub-63 3,4-diClPh SO₂ Single bond Sub-16 1-3025 Sub-63 3,4-diClPh SO₂ Single bond Sub-17 1-3026 Sub-63 3,4-diClPh SO₂ Single bond Sub-18 1-3027 Sub-63 3,4-diClPh SO₂ Single bond Sub-19 1-3028 Sub-63 3,4-diClPh SO₂ Single bond Sub-20 1-3029 Sub-63 3,4-diClPh SO₂ Single bond Sub-21 1-3030 Sub-63 3,4-diClPh SO₂ Single bond Sub-22 1-3031 Sub-63 3,4-diClPh SO₂ Single bond Sub-23 1-3032 Sub-63 3,4-diClPh SO₂ Single bond Sub-24 1-3033 Sub-63 3,4-diClPh SO₂ Single bond Sub-25 1-3034 Sub-63 3,4-diClPh SO₂ Single bond Sub-26 1-3035 Sub-63 3,4-diClPh SO₂ Single bond Sub-27 1-3036 Sub-63 3,4-diClPh SO₂ Single bond Sub-28 1-3037 Sub-63 3,4-diClPh SO₂ Single bond Sub-29 1-3038 Sub-63 3,4-diClPh SO₂ Single bond Sub-30 1-3039 Sub-63 3,4-diClPh SO₂ Single bond Sub-31 1-3040 Sub-63 3,4-diClPh SO₂ Single bond Sub-32 1-3041 Sub-64 3,4-diClPh SO₂ Single bond Sub-1  1-3042 Sub-64 3,4-diClPh SO₂ Single bond Sub-2  1-3043 Sub-64 3,4-diClPh SO₂ Single bond Sub-3  1-3044 Sub-64 3,4-diClPh SO₂ Single bond Sub-4  1-3045 Sub-64 3,4-diClPh SO₂ Single bond Sub-5  1-3046 Sub-64 3,4-diClPh SO₂ Single bond Sub-6  1-3047 Sub-64 3,4-diClPh SO₂ Single bond Sub-7  1-3048 Sub-64 3,4-diClPh SO₂ Single bond Sub-8  1-3049 Sub-64 3,4-diClPh SO₂ Single bond Sub-9  1-3050 Sub-64 3,4-diClPh SO₂ Single bond Sub-10 1-3051 Sub-64 3,4-diClPh SO₂ Single bond Sub-11 1-3052 Sub-64 3,4-diClPh SO₂ Single bond Sub-12 1-3053 Sub-64 3,4-diClPh SO₂ Single bond Sub-13 1-3054 Sub-64 3,4-diClPh SO₂ Single bond Sub-14 1-3055 Sub-64 3,4-diClPh SO₂ Single bond Sub-15 1-3056 Sub-64 3,4-diClPh SO₂ Single bond Sub-16 1-3057 Sub-64 3,4-diClPh SO₂ Single bond Sub-17 1-3058 Sub-64 3,4-diClPh SO₂ Single bond Sub-18 1-3059 Sub-64 3,4-diClPh SO₂ Single bond Sub-19 1-3060 Sub-64 3,4-diClPh SO₂ Single bond Sub-20 1-3061 Sub-64 3,4-diClPh SO₂ Single bond Sub-21 1-3062 Sub-64 3,4-diClPh SO₂ Single bond Sub-22 1-3063 Sub-64 3,4-diClPh SO₂ Single bond Sub-23 1-3064 Sub-64 3,4-diClPh SO₂ Single bond Sub-24 1-3065 Sub-64 3,4-diClPh SO₂ Single bond Sub-25 1-3066 Sub-64 3,4-diClPh SO₂ Single bond Sub-26 1-3067 Sub-64 3,4-diClPh SO₂ Single bond Sub-27 1-3068 Sub-64 3,4-diClPh SO₂ Single bond Sub-28 1-3069 Sub-64 3,4-diClPh SO₂ Single bond Sub-29 1-3070 Sub-64 3,4-diClPh SO₂ Single bond Sub-30 1-3071 Sub-64 3,4-diClPh SO₂ Single bond Sub-31 1-3072 Sub-64 3,4-diClPh SO₂ Single bond Sub-32 1-3073 Sub-33 3,4-diClPh CO CH₂ Sub-1  1-3074 Sub-33 3,4-diClPh CO CH₂ Sub-2  1-3075 Sub-33 3,4-diClPh CO CH₂ Sub-3  1-3076 Sub-33 3,4-diClPh CO CH₂ Sub-4  1-3077 Sub-33 3,4-diClPh CO CH₂ Sub-5  1-3078 Sub-33 3,4-diClPh CO CH₂ Sub-6  1-3079 Sub-33 3,4-diClPh CO CH₂ Sub-7  1-3080 Sub-33 3,4-diClPh CO CH₂ Sub-8  1-3081 Sub-33 3,4-diClPh CO CH₂ Sub-9  1-3082 Sub-33 3,4-diClPh CO CH₂ Sub-10 1-3083 Sub-33 3,4-diClPh CO CH₂ Sub-11 1-3084 Sub-33 3,4-diClPh CO CH₂ Sub-12 1-3085 Sub-33 3,4-diClPh CO CH₂ Sub-13 1-3086 Sub-33 3,4-diClPh CO CH₂ Sub-14 1-3087 Sub-33 3,4-diClPh CO CH₂ Sub-15 1-3088 Sub-33 3,4-diClPh CO CH₂ Sub-16 1-3089 Sub-33 3,4-diClPh CO CH₂ Sub-17 1-3090 Sub-33 3,4-diClPh CO CH₂ Sub-18 1-3091 Sub-33 3,4-diClPh CO CH₂ Sub-19 1-3092 Sub-33 3,4-diClPh CO CH₂ Sub-20 1-3093 Sub-33 3,4-diClPh CO CH₂ Sub-21 1-3094 Sub-33 3,4-diClPh CO CH₂ Sub-22 1-3095 Sub-33 3,4-diClPh CO CH₂ Sub-23 1-3096 Sub-33 3,4-diClPh CO CH₂ Sub-24 1-3097 Sub-33 3,4-diClPh CO CH₂ Sub-25 1-3098 Sub-33 3,4-diClPh CO CH₂ Sub-26 1-3099 Sub-33 3,4-diClPh CO CH₂ Sub-27 1-3100 Sub-33 3,4-diClPh CO CH₂ Sub-28 1-3101 Sub-33 3,4-diClPh CO CH₂ Sub-29 1-3102 Sub-33 3,4-diClPh CO CH₂ Sub-30 1-3103 Sub-33 3,4-diClPh CO CH₂ Sub-31 1-3104 Sub-33 3,4-diClPh CO CH₂ Sub-32 1-3105 Sub-34 3,4-diClPh CO CH₂ Sub-1  1-3106 Sub-34 3,4-diClPh CO CH₂ Sub-2  1-3107 Sub-34 3,4-diClPh CO CH₂ Sub-3  1-3108 Sub-34 3,4-diClPh CO CH₂ Sub-4  1-3109 Sub-34 3,4-diClPh CO CH₂ Sub-5  1-3110 Sub-34 3,4-diClPh CO CH₂ Sub-6  1-3111 Sub-34 3,4-diClPh CO CH₂ Sub-7  1-3112 Sub-34 3,4-diClPh CO CH₂ Sub-8  1-3113 Sub-34 3,4-diClPh CO CH₂ Sub-9  1-3114 Sub-34 3,4-diClPh CO CH₂ Sub-10 1-3115 Sub-34 3,4-diClPh CO CH₂ Sub-11 1-3116 Sub-34 3,4-diClPh CO CH₂ Sub-12 1-3117 Sub-34 3,4-diClPh CO CH₂ Sub-13 1-3118 Sub-34 3,4-diClPh CO CH₂ Sub-14 1-3119 Sub-34 3,4-diClPh CO CH₂ Sub-15 1-3120 Sub-34 3,4-diClPh CO CH₂ Sub-16 1-3121 Sub-34 3,4-diClPh CO CH₂ Sub-17 1-3122 Sub-34 3,4-diClPh CO CH₂ Sub-18 1-3123 Sub-34 3,4-diClPh CO CH₂ Sub-19 1-3124 Sub-34 3,4-diClPh CO CH₂ Sub-20 1-3125 Sub-34 3,4-diClPh CO CH₂ Sub-21 1-3126 Sub-34 3,4-diClPh CO CH₂ Sub-22 1-3127 Sub-34 3,4-diClPh CO CH₂ Sub-23 1-3128 Sub-34 3,4-diClPh CO CH₂ Sub-24 1-3129 Sub-34 3,4-diClPh CO CH₂ Sub-25 1-3130 Sub-34 3,4-diClPh CO CH₂ Sub-26 1-3131 Sub-34 3,4-diClPh CO CH₂ Sub-27 1-3132 Sub-34 3,4-diClPh CO CH₂ Sub-28 1-3133 Sub-34 3,4-diClPh CO CH₂ Sub-29 1-3134 Sub-34 3,4-diClPh CO CH₂ Sub-30 1-3135 Sub-34 3,4-diClPh CO CH₂ Sub-31 1-3136 Sub-34 3,4-diClPh CO CH₂ Sub-32 1-3137 Sub-35 3,4-diClPh CO CH₂ Sub-1  1-3138 Sub-35 3,4-diClPh CO CH₂ Sub-2  1-3139 Sub-35 3,4-diClPh CO CH₂ Sub-3  1-3140 Sub-35 3,4-diClPh CO CH₂ Sub-4  1-3141 Sub-35 3,4-diClPh CO CH₂ Sub-5  1-3142 Sub-35 3,4-diClPh CO CH₂ Sub-6  1-3143 Sub-35 3,4-diClPh CO CH₂ Sub-7  1-3144 Sub-35 3,4-diClPh CO CH₂ Sub-8  1-3145 Sub-35 3,4-diClPh CO CH₂ Sub-9  1-3146 Sub-35 3,4-diClPh CO CH₂ Sub-10 1-3147 Sub-35 3,4-diClPh CO CH₂ Sub-11 1-3148 Sub-35 3,4-diClPh CO CH₂ Sub-12 1-3149 Sub-35 3,4-diClPh CO CH₂ Sub-13 1-3150 Sub-35 3,4-diClPh CO CH₂ Sub-14 1-3151 Sub-35 3,4-diClPh CO CH₂ Sub-15 1-3152 Sub-35 3,4-diClPh CO CH₂ Sub-16 1-3153 Sub-35 3,4-diClPh CO CH₂ Sub-17 1-3154 Sub-35 3,4-diClPh CO CH₂ Sub-18 1-3155 Sub-35 3,4-diClPh CO CH₂ Sub-19 1-3156 Sub-35 3,4-diClPh CO CH₂ Sub-20 1-3157 Sub-35 3,4-diClPh CO CH₂ Sub-21 1-3158 Sub-35 3,4-diClPh CO CH₂ Sub-22 1-3159 Sub-35 3,4-diClPh CO CH₂ Sub-23 1-3160 Sub-35 3,4-diClPh CO CH₂ Sub-24 1-3161 Sub-35 3,4-diClPh CO CH₂ Sub-25 1-3162 Sub-35 3,4-diClPh CO CH₂ Sub-26 1-3163 Sub-35 3,4-diClPh CO CH₂ Sub-27 1-3164 Sub-35 3,4-diClPh CO CH₂ Sub-28 1-3165 Sub-35 3,4-diClPh CO CH₂ Sub-29 1-3166 Sub-35 3,4-diClPh CO CH₂ Sub-30 1-3167 Sub-35 3,4-diClPh CO CH₂ Sub-31 1-3168 Sub-35 3,4-diClPh CO CH₂ Sub-32 1-3169 Sub-36 3,4-diClPh CO CH₂ Sub-1  1-3170 Sub-36 3,4-diClPh CO CH₂ Sub-2  1-3171 Sub-36 3,4-diClPh CO CH₂ Sub-3  1-3172 Sub-36 3,4-diClPh CO CH₂ Sub-4  1-3173 Sub-36 3,4-diClPh CO CH₂ Sub-5  1-3174 Sub-36 3,4-diClPh CO CH₂ Sub-6  1-3175 Sub-36 3,4-diClPh CO CH₂ Sub-7  1-3176 Sub-36 3,4-diClPh CO CH₂ Sub-8  1-3177 Sub-36 3,4-diClPh CO CH₂ Sub-9  1-3178 Sub-36 3,4-diClPh CO CH₂ Sub-10 1-3179 Sub-36 3,4-diClPh CO CH₂ Sub-11 1-3180 Sub-36 3,4-diClPh CO CH₂ Sub-12 1-3181 Sub-36 3,4-diClPh CO CH₂ Sub-13 1-3182 Sub-36 3,4-diClPh CO CH₂ Sub-14 1-3183 Sub-36 3,4-diClPh CO CH₂ Sub-15 1-3184 Sub-36 3,4-diClPh CO CH₂ Sub-16 1-3185 Sub-36 3,4-diClPh CO CH₂ Sub-17 1-3186 Sub-36 3,4-diClPh CO CH₂ Sub-18 1-3187 Sub-36 3,4-diClPh CO CH₂ Sub-19 1-3188 Sub-36 3,4-diClPh CO CH₂ Sub-20 1-3189 Sub-36 3,4-diClPh CO CH₂ Sub-21 1-3190 Sub-36 3,4-diClPh CO CH₂ Sub-22 1-3191 Sub-36 3,4-diClPh CO CH₂ Sub-23 1-3192 Sub-36 3,4-diClPh CO CH₂ Sub-24 1-3193 Sub-36 3,4-diClPh CO CH₂ Sub-25 1-3194 Sub-36 3,4-diClPh CO CH₂ Sub-26 1-3195 Sub-36 3,4-diClPh CO CH₂ Sub-27 1-3196 Sub-36 3,4-diClPh CO CH₂ Sub-28 1-3197 Sub-36 3,4-diClPh CO CH₂ Sub-29 1-3198 Sub-36 3,4-diClPh CO CH₂ Sub-30 1-3199 Sub-36 3,4-diClPh CO CH₂ Sub-31 1-3200 Sub-36 3,4-diClPh CO CH₂ Sub-32 1-3201 Sub-37 3,4-diClPh CO CH₂ Sub-1  1-3202 Sub-37 3,4-diClPh CO CH₂ Sub-2  1-3203 Sub-37 3,4-diClPh CO CH₂ Sub-3  1-3204 Sub-37 3,4-diClPh CO CH₂ Sub-4  1-3205 Sub-37 3,4-diClPh CO CH₂ Sub-5  1-3206 Sub-37 3,4-diClPh CO CH₂ Sub-6  1-3207 Sub-37 3,4-diClPh CO CH₂ Sub-7  1-3208 Sub-37 3,4-diClPh CO CH₂ Sub-8  1-3209 Sub-37 3,4-diClPh CO CH₂ Sub-9  1-3210 Sub-37 3,4-diClPh CO CH₂ Sub-10 1-3211 Sub-37 3,4-diClPh CO CH₂ Sub-11 1-3212 Sub-37 3,4-diClPh CO CH₂ Sub-12 1-3213 Sub-37 3,4-diClPh CO CH₂ Sub-13 1-3214 Sub-37 3,4-diClPh CO CH₂ Sub-14 1-3215 Sub-37 3,4-diClPh CO CH₂ Sub-15 1-3216 Sub-37 3,4-diClPh CO CH₂ Sub-16 1-3217 Sub-37 3,4-diClPh CO CH₂ Sub-17 1-3218 Sub-37 3,4-diClPh CO CH₂ Sub-18 1-3219 Sub-37 3,4-diClPh CO CH₂ Sub-19 1-3220 Sub-37 3,4-diClPh CO CH₂ Sub-20 1-3221 Sub-37 3,4-diClPh CO CH₂ Sub-21 1-3222 Sub-37 3,4-diClPh CO CH₂ Sub-22 1-3223 Sub-37 3,4-diClPh CO CH₂ Sub-23 1-3224 Sub-37 3,4-diClPh CO CH₂ Sub-24 1-3225 Sub-37 3,4-diClPh CO CH₂ Sub-25 1-3226 Sub-37 3,4-diClPh CO CH₂ Sub-26 1-3227 Sub-37 3,4-diClPh CO CH₂ Sub-27 1-3228 Sub-37 3,4-diClPh CO CH₂ Sub-28 1-3229 Sub-37 3,4-diClPh CO CH₂ Sub-29 1-3230 Sub-37 3,4-diClPh CO CH₂ Sub-30 1-3231 Sub-37 3,4-diClPh CO CH₂ Sub-31 1-3232 Sub-37 3,4-diClPh CO CH₂ Sub-32 1-3233 Sub-38 3,4-diClPh CO CH₂ Sub-1  1-3234 Sub-38 3,4-diClPh CO CH₂ Sub-2  1-3235 Sub-38 3,4-diClPh CO CH₂ Sub-3  1-3236 Sub-38 3,4-diClPh CO CH₂ Sub-4  1-3237 Sub-38 3,4-diClPh CO CH₂ Sub-5  1-3238 Sub-38 3,4-diClPh CO CH₂ Sub-6  1-3239 Sub-38 3,4-diClPh CO CH₂ Sub-7  1-3240 Sub-38 3,4-diClPh CO CH₂ Sub-8  1-3241 Sub-38 3,4-diClPh CO CH₂ Sub-9  1-3242 Sub-38 3,4-diClPh CO CH₂ Sub-10 1-3243 Sub-38 3,4-diClPh CO CH₂ Sub-11 1-3244 Sub-38 3,4-diClPh CO CH₂ Sub-12 1-3245 Sub-38 3,4-diClPh CO CH₂ Sub-13 1-3246 Sub-38 3,4-diClPh CO CH₂ Sub-14 1-3247 Sub-38 3,4-diClPh CO CH₂ Sub-15 1-3248 Sub-38 3,4-diClPh CO CH₂ Sub-16 1-3249 Sub-38 3,4-diClPh CO CH₂ Sub-17 1-3250 Sub-38 3,4-diClPh CO CH₂ Sub-18 1-3251 Sub-38 3,4-diClPh CO CH₂ Sub-19 1-3252 Sub-38 3,4-diClPh CO CH₂ Sub-20 1-3253 Sub-38 3,4-diClPh CO CH₂ Sub-21 1-3254 Sub-38 3,4-diClPh CO CH₂ Sub-22 1-3255 Sub-38 3,4-diClPh CO CH₂ Sub-23 1-3256 Sub-38 3,4-diClPh CO CH₂ Sub-24 1-3257 Sub-38 3,4-diClPh CO CH₂ Sub-25 1-3258 Sub-38 3,4-diClPh CO CH₂ Sub-26 1-3259 Sub-38 3,4-diClPh CO CH₂ Sub-27 1-3260 Sub-38 3,4-diClPh CO CH₂ Sub-28 1-3261 Sub-38 3,4-diClPh CO CH₂ Sub-29 1-3262 Sub-38 3,4-diClPh CO CH₂ Sub-30 1-3263 Sub-38 3,4-diClPh CO CH₂ Sub-31 1-3264 Sub-38 3,4-diClPh CO CH₂ Sub-32 1-3265 Sub-39 3,4-diClPh CO CH₂ Sub-1  1-3266 Sub-39 3,4-diClPh CO CH₂ Sub-2  1-3267 Sub-39 3,4-diClPh CO CH₂ Sub-3  1-3268 Sub-39 3,4-diClPh CO CH₂ Sub-4  1-3269 Sub-39 3,4-diClPh CO CH₂ Sub-5  1-3270 Sub-39 3,4-diClPh CO CH₂ Sub-6  1-3271 Sub-39 3,4-diClPh CO CH₂ Sub-7  1-3272 Sub-39 3,4-diClPh CO CH₂ Sub-8  1-3273 Sub-39 3,4-diClPh CO CH₂ Sub-9  1-3274 Sub-39 3,4-diClPh CO CH₂ Sub-10 1-3275 Sub-39 3,4-diClPh CO CH₂ Sub-11 1-3276 Sub-39 3,4-diClPh CO CH₂ Sub-12 1-3277 Sub-39 3,4-diClPh CO CH₂ Sub-13 1-3278 Sub-39 3,4-diClPh CO CH₂ Sub-14 1-3279 Sub-39 3,4-diClPh CO CH₂ Sub-15 1-3280 Sub-39 3,4-diClPh CO CH₂ Sub-16 1-3281 Sub-39 3,4-diClPh CO CH₂ Sub-17 1-3282 Sub-39 3,4-diClPh CO CH₂ Sub-18 1-3283 Sub-39 3,4-diClPh CO CH₂ Sub-19 1-3284 Sub-39 3,4-diClPh CO CH₂ Sub-20 1-3285 Sub-39 3,4-diClPh CO CH₂ Sub-21 1-3286 Sub-39 3,4-diClPh CO CH₂ Sub-22 1-3287 Sub-39 3,4-diClPh CO CH₂ Sub-23 1-3288 Sub-39 3,4-diClPh CO CH₂ Sub-24 1-3289 Sub-39 3,4-diClPh CO CH₂ Sub-25 1-3290 Sub-39 3,4-diClPh CO CH₂ Sub-26 1-3291 Sub-39 3,4-diClPh CO CH₂ Sub-27 1-3292 Sub-39 3,4-diClPh CO CH₂ Sub-28 1-3293 Sub-39 3,4-diClPh CO CH₂ Sub-29 1-3294 Sub-39 3,4-diClPh CO CH₂ Sub-30 1-3295 Sub-39 3,4-diClPh CO CH₂ Sub-31 1-3296 Sub-39 3,4-diClPh CO CH₂ Sub-32 1-3297 Sub-40 3,4-diClPh CO CH₂ Sub-1  1-3298 Sub-40 3,4-diClPh CO CH₂ Sub-2  1-3299 Sub-40 3,4-diClPh CO CH₂ Sub-3  1-3300 Sub-40 3,4-diClPh CO CH₂ Sub-4  1-3301 Sub-40 3,4-diClPh CO CH₂ Sub-5  1-3302 Sub-40 3,4-diClPh CO CH₂ Sub-6  1-3303 Sub-40 3,4-diClPh CO CH₂ Sub-7  1-3304 Sub-40 3,4-diClPh CO CH₂ Sub-8  1-3305 Sub-40 3,4-diClPh CO CH₂ Sub-9  1-3306 Sub-40 3,4-diClPh CO CH₂ Sub-10 1-3307 Sub-40 3,4-diClPh CO CH₂ Sub-11 1-3308 Sub-40 3,4-diClPh CO CH₂ Sub-12 1-3309 Sub-40 3,4-diClPh CO CH₂ Sub-13 1-3310 Sub-40 3,4-diClPh CO CH₂ Sub-14 1-3311 Sub-40 3,4-diClPh CO CH₂ Sub-15 1-3312 Sub-40 3,4-diClPh CO CH₂ Sub-16 1-3313 Sub-40 3,4-diClPh CO CH₂ Sub-17 1-3314 Sub-40 3,4-diClPh CO CH₂ Sub-18 1-3315 Sub-40 3,4-diClPh CO CH₂ Sub-19 1-3316 Sub-40 3,4-diClPh CO CH₂ Sub-20 1-3317 Sub-40 3,4-diClPh CO CH₂ Sub-21 1-3318 Sub-40 3,4-diClPh CO CH₂ Sub-22 1-3319 Sub-40 3,4-diClPh CO CH₂ Sub-23 1-3320 Sub-40 3,4-diClPh CO CH₂ Sub-24 1-3321 Sub-40 3,4-diClPh CO CH₂ Sub-25 1-3322 Sub-40 3,4-diClPh CO CH₂ Sub-26 1-3323 Sub-40 3,4-diClPh CO CH₂ Sub-27 1-3324 Sub-40 3,4-diClPh CO CH₂ Sub-28 1-3325 Sub-40 3,4-diClPh CO CH₂ Sub-29 1-3326 Sub-40 3,4-diClPh CO CH₂ Sub-30 1-3327 Sub-40 3,4-diClPh CO CH₂ Sub-31 1-3328 Sub-40 3,4-diClPh CO CH₂ Sub-32 1-3329 Sub-41 3,4-diClPh CO CH₂ Sub-1  1-3330 Sub-41 3,4-diClPh CO CH₂ Sub-2  1-3331 Sub-41 3,4-diClPh CO CH₂ Sub-3  1-3332 Sub-41 3,4-diClPh CO CH₂ Sub-4  1-3333 Sub-41 3,4-diClPh CO CH₂ Sub-5  1-3334 Sub-41 3,4-diClPh CO CH₂ Sub-6  1-3335 Sub-41 3,4-diClPh CO CH₂ Sub-7  1-3336 Sub-41 3,4-diClPh CO CH₂ Sub-8  1-3337 Sub-41 3,4-diClPh CO CH₂ Sub-9  1-3338 Sub-41 3,4-diClPh CO CH₂ Sub-10 1-3339 Sub-41 3,4-diClPh CO CH₂ Sub-11 1-3340 Sub-41 3,4-diClPh CO CH₂ Sub-12 1-3341 Sub-41 3,4-diClPh CO CH₂ Sub-13 1-3342 Sub-41 3,4-diClPh CO CH₂ Sub-14 1-3343 Sub-41 3,4-diClPh CO CH₂ Sub-15 1-3344 Sub-41 3,4-diClPh CO CH₂ Sub-16 1-3345 Sub-41 3,4-diClPh CO CH₂ Sub-17 1-3346 Sub-41 3,4-diClPh CO CH₂ Sub-18 1-3347 Sub-41 3,4-diClPh CO CH₂ Sub-19 1-3348 Sub-41 3,4-diClPh CO CH₂ Sub-20 1-3349 Sub-41 3,4-diClPh CO CH₂ Sub-21 1-3350 Sub-41 3,4-diClPh CO CH₂ Sub-22 1-3351 Sub-41 3,4-diClPh CO CH₂ Sub-23 1-3352 Sub-41 3,4-diClPh CO CH₂ Sub-24 1-3353 Sub-41 3,4-diClPh CO CH₂ Sub-25 1-3354 Sub-41 3,4-diClPh CO CH₂ Sub-26 1-3355 Sub-41 3,4-diClPh CO CH₂ Sub-27 1-3356 Sub-41 3,4-diClPh CO CH₂ Sub-28 1-3357 Sub-41 3,4-diClPh CO CH₂ Sub-29 1-3358 Sub-41 3,4-diClPh CO CH₂ Sub-30 1-3359 Sub-41 3,4-diClPh CO CH₂ Sub-31 1-3360 Sub-41 3,4-diClPh CO CH₂ Sub-32 1-3361 Sub-42 3,4-diClPh CO CH₂ Sub-1  1-3362 Sub-42 3,4-diClPh CO CH₂ Sub-2  1-3363 Sub-42 3,4-diClPh CO CH₂ Sub-3  1-3364 Sub-42 3,4-diClPh CO CH₂ Sub-4  1-3365 Sub-42 3,4-diClPh CO CH₂ Sub-5  1-3366 Sub-42 3,4-diClPh CO CH₂ Sub-6  1-3367 Sub-42 3,4-diClPh CO CH₂ Sub-7  1-3368 Sub-42 3,4-diClPh CO CH₂ Sub-8  1-3369 Sub-42 3,4-diClPh CO CH₂ Sub-9  1-3370 Sub-42 3,4-diClPh CO CH₂ Sub-10 1-3371 Sub-42 3,4-diClPh CO CH₂ Sub-11 1-3372 Sub-42 3,4-diClPh CO CH₂ Sub-12 1-3373 Sub-42 3,4-diClPh CO CH₂ Sub-13 1-3374 Sub-42 3,4-diClPh CO CH₂ Sub-14 1-3375 Sub-42 3,4-diClPh CO CH₂ Sub-15 1-3376 Sub-42 3,4-diClPh CO CH₂ Sub-16 1-3377 Sub-42 3,4-diClPh CO CH₂ Sub-17 1-3378 Sub-42 3,4-diClPh CO CH₂ Sub-18 1-3379 Sub-42 3,4-diClPh CO CH₂ Sub-19 1-3380 Sub-42 3,4-diClPh CO CH₂ Sub-20 1-3381 Sub-42 3,4-diClPh CO CH₂ Sub-21 1-3382 Sub-42 3,4-diClPh CO CH₂ Sub-22 1-3383 Sub-42 3,4-diClPh CO CH₂ Sub-23 1-3384 Sub-42 3,4-diClPh CO CH₂ Sub-24 1-3385 Sub-42 3,4-diClPh CO CH₂ Sub-25 1-3386 Sub-42 3,4-diClPh CO CH₂ Sub-26 1-3387 Sub-42 3,4-diClPh CO CH₂ Sub-27 1-3388 Sub-42 3,4-diClPh CO CH₂ Sub-28 1-3389 Sub-42 3,4-diClPh CO CH₂ Sub-29 1-3390 Sub-42 3,4-diClPh CO CH₂ Sub-30 1-3391 Sub-42 3,4-diClPh CO CH₂ Sub-31 1-3392 Sub-42 3,4-diClPh CO CH₂ Sub-32 1-3393 Sub-43 3,4-diClPh CO CH₂ Sub-1  1-3394 Sub-43 3,4-diClPh CO CH₂ Sub-2  1-3395 Sub-43 3,4-diClPh CO CH₂ Sub-3  1-3396 Sub-43 3,4-diClPh CO CH₂ Sub-4  1-3397 Sub-43 3,4-diClPh CO CH₂ Sub-5  1-3398 Sub-43 3,4-diClPh CO CH₂ Sub-6  1-3399 Sub-43 3,4-diClPh CO CH₂ Sub-7  1-3400 Sub-43 3,4-diClPh CO CH₂ Sub-8  1-3401 Sub-43 3,4-diClPh CO CH₂ Sub-9  1-3402 Sub-43 3,4-diClPh CO CH₂ Sub-10 1-3403 Sub-43 3,4-diClPh CO CH₂ Sub-11 1-3404 Sub-43 3,4-diClPh CO CH₂ Sub-12 1-3405 Sub-43 3,4-diClPh CO CH₂ Sub-13 1-3406 Sub-43 3,4-diClPh CO CH₂ Sub-14 1-3407 Sub-43 3,4-diClPh CO CH₂ Sub-15 1-3408 Sub-43 3,4-diClPh CO CH₂ Sub-16 1-3409 Sub-43 3,4-diClPh CO CH₂ Sub-17 1-3410 Sub-43 3,4-diClPh CO CH₂ Sub-18 1-3411 Sub-43 3,4-diClPh CO CH₂ Sub-19 1-3412 Sub-43 3,4-diClPh CO CH₂ Sub-20 1-3413 Sub-43 3,4-diClPh CO CH₂ Sub-21 1-3414 Sub-43 3,4-diClPh CO CH₂ Sub-22 1-3415 Sub-43 3,4-diClPh CO CH₂ Sub-23 1-3416 Sub-43 3,4-diClPh CO CH₂ Sub-24 1-3417 Sub-43 3,4-diClPh CO CH₂ Sub-25 1-3418 Sub-43 3,4-diClPh CO CH₂ Sub-26 1-3419 Sub-43 3,4-diClPh CO CH₂ Sub-27 1-3420 Sub-43 3,4-diClPh CO CH₂ Sub-28 1-3421 Sub-43 3,4-diClPh CO CH₂ Sub-29 1-3422 Sub-43 3,4-diClPh CO CH₂ Sub-30 1-3423 Sub-43 3,4-diClPh CO CH₂ Sub-31 1-3424 Sub-43 3,4-diClPh CO CH₂ Sub-32 1-3425 Sub-44 3,4-diClPh CO CH₂ Sub-1  1-3426 Sub-44 3,4-diClPh CO CH₂ Sub-2  1-3427 Sub-44 3,4-diClPh CO CH₂ Sub-3  1-3428 Sub-44 3,4-diClPh CO CH₂ Sub-4  1-3429 Sub-44 3,4-diClPh CO CH₂ Sub-5  1-3430 Sub-44 3,4-diClPh CO CH₂ Sub-6  1-3431 Sub-44 3,4-diClPh CO CH₂ Sub-7  1-3432 Sub-44 3,4-diClPh CO CH₂ Sub-8  1-3433 Sub-44 3,4-diClPh CO CH₂ Sub-9  1-3434 Sub-44 3,4-diClPh CO CH₂ Sub-10 1-3435 Sub-44 3,4-diClPh CO CH₂ Sub-11 1-3436 Sub-44 3,4-diClPh CO CH₂ Sub-12 1-3437 Sub-44 3,4-diClPh CO CH₂ Sub-13 1-3438 Sub-44 3,4-diClPh CO CH₂ Sub-14 1-3439 Sub-44 3,4-diClPh CO CH₂ Sub-15 1-3440 Sub-44 3,4-diClPh CO CH₂ Sub-16 1-3441 Sub-44 3,4-diClPh CO CH₂ Sub-17 1-3442 Sub-44 3,4-diClPh CO CH₂ Sub-18 1-3443 Sub-44 3,4-diClPh CO CH₂ Sub-19 1-3444 Sub-44 3,4-diClPh CO CH₂ Sub-20 1-3445 Sub-44 3,4-diClPh CO CH₂ Sub-21 1-3446 Sub-44 3,4-diClPh CO CH₂ Sub-22 1-3447 Sub-44 3,4-diClPh CO CH₂ Sub-23 1-3448 Sub-44 3,4-diClPh CO CH₂ Sub-24 1-3449 Sub-44 3,4-diClPh CO CH₂ Sub-25 1-3450 Sub-44 3,4-diClPh CO CH₂ Sub-26 1-3451 Sub-44 3,4-diClPh CO CH₂ Sub-27 1-3452 Sub-44 3,4-diClPh CO CH₂ Sub-28 1-3453 Sub-44 3,4-diClPh CO CH₂ Sub-29 1-3454 Sub-44 3,4-diClPh CO CH₂ Sub-30 1-3455 Sub-44 3,4-diClPh CO CH₂ Sub-31 1-3456 Sub-44 3,4-diClPh CO CH₂ Sub-32 1-3457 Sub-45 3,4-diClPh CO CH₂ Sub-1  1-3458 Sub-45 3,4-diClPh CO CH₂ Sub-2  1-3459 Sub-45 3,4-diClPh CO CH₂ Sub-3  1-3460 Sub-45 3,4-diClPh CO CH₂ Sub-4  1-3461 Sub-45 3,4-diClPh CO CH₂ Sub-5  1-3462 Sub-45 3,4-diClPh CO CH₂ Sub-6  1-3463 Sub-45 3,4-diClPh CO CH₂ Sub-7  1-3464 Sub-45 3,4-diClPh CO CH₂ Sub-8  1-3465 Sub-45 3,4-diClPh CO CH₂ Sub-9  1-3466 Sub-45 3,4-diClPh CO CH₂ Sub-10 1-3467 Sub-45 3,4-diClPh CO CH₂ Sub-11 1-3468 Sub-45 3,4-diClPh CO CH₂ Sub-12 1-3469 Sub-45 3,4-diClPh CO CH₂ Sub-13 1-3470 Sub-45 3,4-diClPh CO CH₂ Sub-14 1-3471 Sub-45 3,4-diClPh CO CH₂ Sub-15 1-3472 Sub-45 3,4-diClPh CO CH₂ Sub-16 1-3473 Sub-45 3,4-diClPh CO CH₂ Sub-17 1-3474 Sub-45 3,4-diClPh CO CH₂ Sub-18 1-3475 Sub-45 3,4-diClPh CO CH₂ Sub-19 1-3476 Sub-45 3,4-diClPh CO CH₂ Sub-20 1-3477 Sub-45 3,4-diClPh CO CH₂ Sub-21 1-3478 Sub-45 3,4-diClPh CO CH₂ Sub-22 1-3479 Sub-45 3,4-diClPh CO CH₂ Sub-23 1-3480 Sub-45 3,4-diClPh CO CH₂ Sub-24 1-3481 Sub-45 3,4-diClPh CO CH₂ Sub-25 1-3482 Sub-45 3,4-diClPh CO CH₂ Sub-26 1-3483 Sub-45 3,4-diClPh CO CH₂ Sub-27 1-3484 Sub-45 3,4-diClPh CO CH₂ Sub-28 1-3485 Sub-45 3,4-diClPh CO CH₂ Sub-29 1-3486 Sub-45 3,4-diClPh CO CH₂ Sub-30 1-3487 Sub-45 3,4-diClPh CO CH₂ Sub-31 1-3488 Sub-45 3,4-diClPh CO CH₂ Sub-32 1-3489 Sub-46 3,4-diClPh CO CH₂ Sub-1  1-3490 Sub-46 3,4-diClPh CO CH₂ Sub-2  1-3491 Sub-46 3,4-diClPh CO CH₂ Sub-3  1-3492 Sub-46 3,4-diClPh CO CH₂ Sub-4  1-3493 Sub-46 3,4-diClPh CO CH₂ Sub-5  1-3494 Sub-46 3,4-diClPh CO CH₂ Sub-6  1-3495 Sub-46 3,4-diClPh CO CH₂ Sub-7  1-3496 Sub-46 3,4-diClPh CO CH₂ Sub-8  1-3497 Sub-46 3,4-diClPh CO CH₂ Sub-9  1-3498 Sub-46 3,4-diClPh CO CH₂ Sub-10 1-3499 Sub-46 3,4-diClPh CO CH₂ Sub-11 1-3500 Sub-46 3,4-diClPh CO CH₂ Sub-12 1-3501 Sub-46 3,4-diClPh CO CH₂ Sub-13 1-3502 Sub-46 3,4-diClPh CO CH₂ Sub-14 1-3503 Sub-46 3,4-diClPh CO CH₂ Sub-15 1-3504 Sub-46 3,4-diClPh CO CH₂ Sub-16 1-3505 Sub-46 3,4-diClPh CO CH₂ Sub-17 1-3506 Sub-46 3,4-diClPh CO CH₂ Sub-18 1-3507 Sub-46 3,4-diClPh CO CH₂ Sub-19 1-3508 Sub-46 3,4-diClPh CO CH₂ Sub-20 1-3509 Sub-46 3,4-diClPh CO CH₂ Sub-21 1-3510 Sub-46 3,4-diClPh CO CH₂ Sub-22 1-3511 Sub-46 3,4-diClPh CO CH₂ Sub-23 1-3512 Sub-46 3,4-diClPh CO CH₂ Sub-24 1-3513 Sub-46 3,4-diClPh CO CH₂ Sub-25 1-3514 Sub-46 3,4-diClPh CO CH₂ Sub-26 1-3515 Sub-46 3,4-diClPh CO CH₂ Sub-27 1-3516 Sub-46 3,4-diClPh CO CH₂ Sub-28 1-3517 Sub-46 3,4-diClPh CO CH₂ Sub-29 1-3518 Sub-46 3,4-diClPh CO CH₂ Sub-30 1-3519 Sub-46 3,4-diClPh CO CH₂ Sub-31 1-3520 Sub-46 3,4-diClPh CO CH₂ Sub-32 1-3521 Sub-47 3,4-diClPh CO CH₂ Sub-1  1-3522 Sub-47 3,4-diClPh CO CH₂ Sub-2  1-3523 Sub-47 3,4-diClPh CO CH₂ Sub-3  1-3524 Sub-47 3,4-diClPh CO CH₂ Sub-4  1-3525 Sub-47 3,4-diClPh CO CH₂ Sub-5  1-3526 Sub-47 3,4-diClPh CO CH₂ Sub-6  1-3527 Sub-47 3,4-diClPh CO CH₂ Sub-7  1-3528 Sub-47 3,4-diClPh CO CH₂ Sub-8  1-3529 Sub-47 3,4-diClPh CO CH₂ Sub-9  1-3530 Sub-47 3,4-diClPh CO CH₂ Sub-10 1-3531 Sub-47 3,4-diClPh CO CH₂ Sub-11 1-3532 Sub-47 3,4-diClPh CO CH₂ Sub-12 1-3533 Sub-47 3,4-diClPh CO CH₂ Sub-13 1-3534 Sub-47 3,4-diClPh CO CH₂ Sub-14 1-3535 Sub-47 3,4-diClPh CO CH₂ Sub-15 1-3536 Sub-47 3,4-diClPh CO CH₂ Sub-16 1-3537 Sub-47 3,4-diClPh CO CH₂ Sub-17 1-3538 Sub-47 3,4-diClPh CO CH₂ Sub-18 1-3539 Sub-47 3,4-diClPh CO CH₂ Sub-19 1-3540 Sub-47 3,4-diClPh CO CH₂ Sub-20 1-3541 Sub-47 3,4-diClPh CO CH₂ Sub-21 1-3542 Sub-47 3,4-diClPh CO CH₂ Sub-22 1-3543 Sub-47 3,4-diClPh CO CH₂ Sub-23 1-3544 Sub-47 3,4-diClPh CO CH₂ Sub-24 1-3545 Sub-47 3,4-diClPh CO CH₂ Sub-25 1-3546 Sub-47 3,4-diClPh CO CH₂ Sub-26 1-3547 Sub-47 3,4-diClPh CO CH₂ Sub-27 1-3548 Sub-47 3,4-diClPh CO CH₂ Sub-28 1-3549 Sub-47 3,4-diClPh CO CH₂ Sub-29 1-3550 Sub-47 3,4-diClPh CO CH₂ Sub-30 1-3551 Sub-47 3,4-diClPh CO CH₂ Sub-31 1-3552 Sub-47 3,4-diClPh CO CH₂ Sub-32 1-3553 Sub-48 3,4-diClPh CO CH₂ Sub-1  1-3554 Sub-48 3,4-diClPh CO CH₂ Sub-2  1-3555 Sub-48 3,4-diClPh CO CH₂ Sub-3  1-3556 Sub-48 3,4-diClPh CO CH₂ Sub-4  1-3557 Sub-48 3,4-diClPh CO CH₂ Sub-5  1-3558 Sub-48 3,4-diClPh CO CH₂ Sub-6  1-3559 Sub-48 3,4-diClPh CO CH₂ Sub-7  1-3560 Sub-48 3,4-diClPh CO CH₂ Sub-8  1-3561 Sub-48 3,4-diClPh CO CH₂ Sub-9  1-3562 Sub-48 3,4-diClPh CO CH₂ Sub-10 1-3563 Sub-48 3,4-diClPh CO CH₂ Sub-11 1-3564 Sub-48 3,4-diClPh CO CH₂ Sub-12 1-3565 Sub-48 3,4-diClPh CO CH₂ Sub-13 1-3566 Sub-48 3,4-diClPh CO CH₂ Sub-14 1-3567 Sub-48 3,4-diClPh CO CH₂ Sub-15 1-3568 Sub-48 3,4-diClPh CO CH₂ Sub-16 1-3569 Sub-48 3,4-diClPh CO CH₂ Sub-17 1-3570 Sub-48 3,4-diClPh CO CH₂ Sub-18 1-3571 Sub-48 3,4-diClPh CO CH₂ Sub-19 1-3572 Sub-48 3,4-diClPh CO CH₂ Sub-20 1-3573 Sub-48 3,4-diClPh CO CH₂ Sub-21 1-3574 Sub-48 3,4-diClPh CO CH₂ Sub-22 1-3575 Sub-48 3,4-diClPh CO CH₂ Sub-23 1-3576 Sub-48 3,4-diClPh CO CH₂ Sub-24 1-3577 Sub-48 3,4-diClPh CO CH₂ Sub-25 1-3578 Sub-48 3,4-diClPh CO CH₂ Sub-26 1-3579 Sub-48 3,4-diClPh CO CH₂ Sub-27 1-3580 Sub-48 3,4-diClPh CO CH₂ Sub-28 1-3581 Sub-48 3,4-diClPh CO CH₂ Sub-29 1-3582 Sub-48 3,4-diClPh CO CH₂ Sub-30 1-3583 Sub-48 3,4-diClPh CO CH₂ Sub-31 1-3584 Sub-48 3,4-diClPh CO CH₂ Sub-32 1-3585 Sub-49 3,4-diClPh CO CH₂ Sub-1  1-3586 Sub-49 3,4-diClPh CO CH₂ Sub-2  1-3587 Sub-49 3,4-diClPh CO CH₂ Sub-3  1-3588 Sub-49 3,4-diClPh CO CH₂ Sub-4  1-3589 Sub-49 3,4-diClPh CO CH₂ Sub-5  1-3590 Sub-49 3,4-diClPh CO CH₂ Sub-6  1-3591 Sub-49 3,4-diClPh CO CH₂ Sub-7  1-3592 Sub-49 3,4-diClPh CO CH₂ Sub-8  1-3593 Sub-49 3,4-diClPh CO CH₂ Sub-9  1-3594 Sub-49 3,4-diClPh CO CH₂ Sub-10 1-3595 Sub-49 3,4-diClPh CO CH₂ Sub-11 1-3596 Sub-49 3,4-diClPh CO CH₂ Sub-12 1-3597 Sub-49 3,4-diClPh CO CH₂ Sub-13 1-3598 Sub-49 3,4-diClPh CO CH₂ Sub-14 1-3599 Sub-49 3,4-diClPh CO CH₂ Sub-15 1-3600 Sub-49 3,4-diClPh CO CH₂ Sub-16 1-3601 Sub-49 3,4-diClPh CO CH₂ Sub-17 1-3602 Sub-49 3,4-diClPh CO CH₂ Sub-18 1-3603 Sub-49 3,4-diClPh CO CH₂ Sub-19 1-3604 Sub-49 3,4-diClPh CO CH₂ Sub-20 1-3605 Sub-49 3,4-diClPh CO CH₂ Sub-21 1-3606 Sub-49 3,4-diClPh CO CH₂ Sub-22 1-3607 Sub-49 3,4-diClPh CO CH₂ Sub-23 1-3608 Sub-49 3,4-diClPh CO CH₂ Sub-24 1-3609 Sub-49 3,4-diClPh CO CH₂ Sub-25 1-3610 Sub-49 3,4-diClPh CO CH₂ Sub-26 1-3611 Sub-49 3,4-diClPh CO CH₂ Sub-27 1-3612 Sub-49 3,4-diClPh CO CH₂ Sub-28 1-3613 Sub-49 3,4-diClPh CO CH₂ Sub-29 1-3614 Sub-49 3,4-diClPh CO CH₂ Sub-30 1-3615 Sub-49 3,4-diClPh CO CH₂ Sub-31 1-3616 Sub-49 3,4-diClPh CO CH₂ Sub-32 1-3617 Sub-50 3,4-diClPh CO CH₂ Sub-1  1-3618 Sub-50 3,4-diClPh CO CH₂ Sub-2  1-3619 Sub-50 3,4-diClPh CO CH₂ Sub-3  1-3620 Sub-50 3,4-diClPh CO CH₂ Sub-4  1-3621 Sub-50 3,4-diClPh CO CH₂ Sub-5  1-3622 Sub-50 3,4-diClPh CO CH₂ Sub-6  1-3623 Sub-50 3,4-diClPh CO CH₂ Sub-7  1-3624 Sub-50 3,4-diClPh CO CH₂ Sub-8  1-3625 Sub-50 3,4-diClPh CO CH₂ Sub-9  1-3626 Sub-50 3,4-diClPh CO CH₂ Sub-10 1-3627 Sub-50 3,4-diClPh CO CH₂ Sub-11 1-3628 Sub-50 3,4-diClPh CO CH₂ Sub-12 1-3629 Sub-50 3,4-diClPh CO CH₂ Sub-13 1-3630 Sub-50 3,4-diClPh CO CH₂ Sub-14 1-3631 Sub-50 3,4-diClPh CO CH₂ Sub-15 1-3632 Sub-50 3,4-diClPh CO CH₂ Sub-16 1-3633 Sub-50 3,4-diClPh CO CH₂ Sub-17 1-3634 Sub-50 3,4-diClPh CO CH₂ Sub-18 1-3635 Sub-50 3,4-diClPh CO CH₂ Sub-19 1-3636 Sub-50 3,4-diClPh CO CH₂ Sub-20 1-3637 Sub-50 3,4-diClPh CO CH₂ Sub-21 1-3638 Sub-50 3,4-diClPh CO CH₂ Sub-22 1-3639 Sub-50 3,4-diClPh CO CH₂ Sub-23 1-3640 Sub-50 3,4-diClPh CO CH₂ Sub-24 1-3641 Sub-50 3,4-diClPh CO CH₂ Sub-25 1-3642 Sub-50 3,4-diClPh CO CH₂ Sub-26 1-3643 Sub-50 3,4-diClPh CO CH₂ Sub-27 1-3644 Sub-50 3,4-diClPh CO CH₂ Sub-28 1-3645 Sub-50 3,4-diClPh CO CH₂ Sub-29 1-3646 Sub-50 3,4-diClPh CO CH₂ Sub-30 1-3647 Sub-50 3,4-diClPh CO CH₂ Sub-31 1-3648 Sub-50 3,4-diClPh CO CH₂ Sub-32 1-3649 Sub-51 3,4-diClPh CO CH₂ Sub-1  1-3650 Sub-51 3,4-diClPh CO CH₂ Sub-2  1-3651 Sub-51 3,4-diClPh CO CH₂ Sub-3  1-3652 Sub-51 3,4-diClPh CO CH₂ Sub-4  1-3653 Sub-51 3,4-diClPh CO CH₂ Sub-5  1-3654 Sub-51 3,4-diClPh CO CH₂ Sub-6  1-3655 Sub-51 3,4-diClPh CO CH₂ Sub-7  1-3656 Sub-51 3,4-diClPh CO CH₂ Sub-8  1-3657 Sub-51 3,4-diClPh CO CH₂ Sub-9  1-3658 Sub-51 3,4-diClPh CO CH₂ Sub-10 1-3659 Sub-51 3,4-diClPh CO CH₂ Sub-11 1-3660 Sub-51 3,4-diClPh CO CH₂ Sub-12 1-3661 Sub-51 3,4-diClPh CO CH₂ Sub-13 1-3662 Sub-51 3,4-diClPh CO CH₂ Sub-14 1-3663 Sub-51 3,4-diClPh CO CH₂ Sub-15 1-3664 Sub-51 3,4-diClPh CO CH₂ Sub-16 1-3665 Sub-51 3,4-diClPh CO CH₂ Sub-17 1-3666 Sub-51 3,4-diClPh CO CH₂ Sub-18 1-3667 Sub-51 3,4-diClPh CO CH₂ Sub-19 1-3668 Sub-51 3,4-diClPh CO CH₂ Sub-20 1-3669 Sub-51 3,4-diClPh CO CH₂ Sub-21 1-3670 Sub-51 3,4-diClPh CO CH₂ Sub-22 1-3671 Sub-51 3,4-diClPh CO CH₂ Sub-23 1-3672 Sub-51 3,4-diClPh CO CH₂ Sub-24 1-3673 Sub-51 3,4-diClPh CO CH₂ Sub-25 1-3674 Sub-51 3,4-diClPh CO CH₂ Sub-26 1-3675 Sub-51 3,4-diClPh CO CH₂ Sub-27 1-3676 Sub-51 3,4-diClPh CO CH₂ Sub-28 1-3677 Sub-51 3,4-diClPh CO CH₂ Sub-29 1-3678 Sub-51 3,4-diClPh CO CH₂ Sub-30 1-3679 Sub-51 3,4-diClPh CO CH₂ Sub-31 1-3680 Sub-51 3,4-diClPh CO CH₂ Sub-32 1-3681 Sub-52 3,4-diClPh CO CH₂ Sub-1  1-3682 Sub-52 3,4-diClPh CO CH₂ Sub-2  1-3683 Sub-52 3,4-diClPh CO CH₂ Sub-3  1-3684 Sub-52 3,4-diClPh CO CH₂ Sub-4  1-3685 Sub-52 3,4-diClPh CO CH₂ Sub-5  1-3686 Sub-52 3,4-diClPh CO CH₂ Sub-6  1-3687 Sub-52 3,4-diClPh CO CH₂ Sub-7  1-3688 Sub-52 3,4-diClPh CO CH₂ Sub-8  1-3689 Sub-52 3,4-diClPh CO CH₂ Sub-9  1-3690 Sub-52 3,4-diClPh CO CH₂ Sub-10 1-3691 Sub-52 3,4-diClPh CO CH₂ Sub-11 1-3692 Sub-52 3,4-diClPh CO CH₂ Sub-12 1-3693 Sub-52 3,4-diClPh CO CH₂ Sub-13 1-3694 Sub-52 3,4-diClPh CO CH₂ Sub-14 1-3695 Sub-52 3,4-diClPh CO CH₂ Sub-15 1-3696 Sub-52 3,4-diClPh CO CH₂ Sub-16 1-3697 Sub-52 3,4-diClPh CO CH₂ Sub-17 1-3698 Sub-52 3,4-diClPh CO CH₂ Sub-18 1-3699 Sub-52 3,4-diClPh CO CH₂ Sub-19 1-3700 Sub-52 3,4-diClPh CO CH₂ Sub-20 1-3701 Sub-52 3,4-diClPh CO CH₂ Sub-21 1-3702 Sub-52 3,4-diClPh CO CH₂ Sub-22 1-3703 Sub-52 3,4-diClPh CO CH₂ Sub-23 1-3704 Sub-52 3,4-diClPh CO CH₂ Sub-24 1-3705 Sub-52 3,4-diClPh CO CH₂ Sub-25 1-3706 Sub-52 3,4-diClPh CO CH₂ Sub-26 1-3707 Sub-52 3,4-diClPh CO CH₂ Sub-27 1-3708 Sub-52 3,4-diClPh CO CH₂ Sub-28 1-3709 Sub-52 3,4-diClPh CO CH₂ Sub-29 1-3710 Sub-52 3,4-diClPh CO CH₂ Sub-30 1-3711 Sub-52 3,4-diClPh CO CH₂ Sub-31 1-3712 Sub-52 3,4-diClPh CO CH₂ Sub-32 1-3713 Sub-53 3,4-diClPh CO CH₂ Sub-1  1-3714 Sub-53 3,4-diClPh CO CH₂ Sub-2  1-3715 Sub-53 3,4-diClPh CO CH₂ Sub-3  1-3716 Sub-53 3,4-diClPh CO CH₂ Sub-4  1-3717 Sub-53 3,4-diClPh CO CH₂ Sub-5  1-3718 Sub-53 3,4-diClPh CO CH₂ Sub-6  1-3719 Sub-53 3,4-diClPh CO CH₂ Sub-7  1-3720 Sub-53 3,4-diClPh CO CH₂ Sub-8  1-3721 Sub-53 3,4-diClPh CO CH₂ Sub-9  1-3722 Sub-53 3,4-diClPh CO CH₂ Sub-10 1-3723 Sub-53 3,4-diClPh CO CH₂ Sub-11 1-3724 Sub-53 3,4-diClPh CO CH₂ Sub-12 1-3725 Sub-53 3,4-diClPh CO CH₂ Sub-13 1-3726 Sub-53 3,4-diClPh CO CH₂ Sub-14 1-3727 Sub-53 3,4-diClPh CO CH₂ Sub-15 1-3728 Sub-53 3,4-diClPh CO CH₂ Sub-16 1-3729 Sub-53 3,4-diClPh CO CH₂ Sub-17 1-3730 Sub-53 3,4-diClPh CO CH₂ Sub-18 1-3731 Sub-53 3,4-diClPh CO CH₂ Sub-19 1-3732 Sub-53 3,4-diClPh CO CH₂ Sub-20 1-3733 Sub-53 3,4-diClPh CO CH₂ Sub-21 1-3734 Sub-53 3,4-diClPh CO CH₂ Sub-22 1-3735 Sub-53 3,4-diClPh CO CH₂ Sub-23 1-3736 Sub-53 3,4-diClPh CO CH₂ Sub-24 1-3737 Sub-53 3,4-diClPh CO CH₂ Sub-25 1-3738 Sub-53 3,4-diClPh CO CH₂ Sub-26 1-3739 Sub-53 3,4-diClPh CO CH₂ Sub-27 1-3740 Sub-53 3,4-diClPh CO CH₂ Sub-28 1-3741 Sub-53 3,4-diClPh CO CH₂ Sub-29 1-3742 Sub-53 3,4-diClPh CO CH₂ Sub-30 1-3743 Sub-53 3,4-diClPh CO CH₂ Sub-31 1-3744 Sub-53 3,4-diClPh CO CH₂ Sub-32 1-3745 Sub-54 3,4-diClPh CO CH₂ Sub-1  1-3746 Sub-54 3,4-diClPh CO CH₂ Sub-2  1-3747 Sub-54 3,4-diClPh CO CH₂ Sub-3  1-3748 Sub-54 3,4-diClPh CO CH₂ Sub-4  1-3749 Sub-54 3,4-diClPh CO CH₂ Sub-5  1-3750 Sub-54 3,4-diClPh CO CH₂ Sub-6  1-3751 Sub-54 3,4-diClPh CO CH₂ Sub-7  1-3752 Sub-54 3,4-diClPh CO CH₂ Sub-8  1-3753 Sub-54 3,4-diClPh CO CH₂ Sub-9  1-3754 Sub-54 3,4-diClPh CO CH₂ Sub-10 1-3755 Sub-54 3,4-diClPh CO CH₂ Sub-11 1-3756 Sub-54 3,4-diClPh CO CH₂ Sub-12 1-3757 Sub-54 3,4-diClPh CO CH₂ Sub-13 1-3758 Sub-54 3,4-diClPh CO CH₂ Sub-14 1-3759 Sub-54 3,4-diClPh CO CH₂ Sub-15 1-3760 Sub-54 3,4-diClPh CO CH₂ Sub-16 1-3761 Sub-54 3,4-diClPh CO CH₂ Sub-17 1-3762 Sub-54 3,4-diClPh CO CH₂ Sub-18 1-3763 Sub-54 3,4-diClPh CO CH₂ Sub-19 1-3764 Sub-54 3,4-diClPh CO CH₂ Sub-20 1-3765 Sub-54 3,4-diClPh CO CH₂ Sub-21 1-3766 Sub-54 3,4-diClPh CO CH₂ Sub-22 1-3767 Sub-54 3,4-diClPh CO CH₂ Sub-23 1-3768 Sub-54 3,4-diClPh CO CH₂ Sub-24 1-3769 Sub-54 3,4-diClPh CO CH₂ Sub-25 1-3770 Sub-54 3,4-diClPh CO CH₂ Sub-26 1-3771 Sub-54 3,4-diClPh CO CH₂ Sub-27 1-3772 Sub-54 3,4-diClPh CO CH₂ Sub-28 1-3773 Sub-54 3,4-diClPh CO CH₂ Sub-29 1-3774 Sub-54 3,4-diClPh CO CH₂ Sub-30 1-3775 Sub-54 3,4-diClPh CO CH₂ Sub-31 1-3776 Sub-54 3,4-diClPh CO CH₂ Sub-32 1-3777 Sub-55 3,4-diClPh CO CH₂ Sub-1  1-3778 Sub-55 3,4-diClPh CO CH₂ Sub-2  1-3779 Sub-55 3,4-diClPh CO CH₂ Sub-3  1-3780 Sub-55 3,4-diClPh CO CH₂ Sub-4  1-3781 Sub-55 3,4-diClPh CO CH₂ Sub-5  1-3782 Sub-55 3,4-diClPh CO CH₂ Sub-6  1-3783 Sub-55 3,4-diClPh CO CH₂ Sub-7  1-3784 Sub-55 3,4-diClPh CO CH₂ Sub-8  1-3785 Sub-55 3,4-diClPh CO CH₂ Sub-9  1-3786 Sub-55 3,4-diClPh CO CH₂ Sub-10 1-3787 Sub-55 3,4-diClPh CO CH₂ Sub-11 1-3788 Sub-55 3,4-diClPh CO CH₂ Sub-12 1-3789 Sub-55 3,4-diClPh CO CH₂ Sub-13 1-3790 Sub-55 3,4-diClPh CO CH₂ Sub-14 1-3791 Sub-55 3,4-diClPh CO CH₂ Sub-15 1-3792 Sub-55 3,4-diClPh CO CH₂ Sub-16 1-3793 Sub-55 3,4-diClPh CO CH₂ Sub-17 1-3794 Sub-55 3,4-diClPh CO CH₂ Sub-18 1-3795 Sub-55 3,4-diClPh CO CH₂ Sub-19 1-3796 Sub-55 3,4-diClPh CO CH₂ Sub-20 1-3797 Sub-55 3,4-diClPh CO CH₂ Sub-21 1-3798 Sub-55 3,4-diClPh CO CH₂ Sub-22 1-3799 Sub-55 3,4-diClPh CO CH₂ Sub-23 1-3800 Sub-55 3,4-diClPh CO CH₂ Sub-24 1-3801 Sub-55 3,4-diClPh CO CH₂ Sub-25 1-3802 Sub-55 3,4-diClPh CO CH₂ Sub-26 1-3803 Sub-55 3,4-diClPh CO CH₂ Sub-27 1-3804 Sub-55 3,4-diClPh CO CH₂ Sub-28 1-3805 Sub-55 3,4-diClPh CO CH₂ Sub-29 1-3806 Sub-55 3,4-diClPh CO CH₂ Sub-30 1-3807 Sub-55 3,4-diClPh CO CH₂ Sub-31 1-3808 Sub-55 3,4-diClPh CO CH₂ Sub-32 1-3809 Sub-56 3,4-diClPh CO CH₂ Sub-1  1-3810 Sub-56 3,4-diClPh CO CH₂ Sub-2  1-3811 Sub-56 3,4-diClPh CO CH₂ Sub-3  1-3812 Sub-56 3,4-diClPh CO CH₂ Sub-4  1-3813 Sub-56 3,4-diClPh CO CH₂ Sub-5  1-3814 Sub-56 3,4-diClPh CO CH₂ Sub-6  1-3815 Sub-56 3,4-diClPh CO CH₂ Sub-7  1-3816 Sub-56 3,4-diClPh CO CH₂ Sub-8  1-3817 Sub-56 3,4-diClPh CO CH₂ Sub-9  1-3818 Sub-56 3,4-diClPh CO CH₂ Sub-10 1-3819 Sub-56 3,4-diClPh CO CH₂ Sub-11 1-3820 Sub-56 3,4-diClPh CO CH₂ Sub-12 1-3821 Sub-56 3,4-diClPh CO CH₂ Sub-13 1-3822 Sub-56 3,4-diClPh CO CH₂ Sub-14 1-3823 Sub-56 3,4-diClPh CO CH₂ Sub-15 1-3824 Sub-56 3,4-diClPh CO CH₂ Sub-16 1-3825 Sub-56 3,4-diClPh CO CH₂ Sub-17 1-3826 Sub-56 3,4-diClPh CO CH₂ Sub-18 1-3827 Sub-56 3,4-diClPh CO CH₂ Sub-19 1-3828 Sub-56 3,4-diClPh CO CH₂ Sub-20 1-3829 Sub-56 3,4-diClPh CO CH₂ Sub-21 1-3830 Sub-56 3,4-diClPh CO CH₂ Sub-22 1-3831 Sub-56 3,4-diClPh CO CH₂ Sub-23 1-3832 Sub-56 3,4-diClPh CO CH₂ Sub-24 1-3833 Sub-56 3,4-diClPh CO CH₂ Sub-25 1-3834 Sub-56 3,4-diClPh CO CH₂ Sub-26 1-3835 Sub-56 3,4-diClPh CO CH₂ Sub-27 1-3836 Sub-56 3,4-diClPh CO CH₂ Sub-28 1-3837 Sub-56 3,4-diClPh CO CH₂ Sub-29 1-3838 Sub-56 3,4-diClPh CO CH₂ Sub-30 1-3839 Sub-56 3,4-diClPh CO CH₂ Sub-31 1-3840 Sub-56 3,4-diClPh CO CH₂ Sub-32 1-3841 Sub-57 3,4-diClPh CO CH₂ Sub-1  1-3842 Sub-57 3,4-diClPh CO CH₂ Sub-2  1-3843 Sub-57 3,4-diClPh CO CH₂ Sub-3  1-3844 Sub-57 3,4-diClPh CO CH₂ Sub-4  1-3845 Sub-57 3,4-diClPh CO CH₂ Sub-5  1-3846 Sub-57 3,4-diClPh CO CH₂ Sub-6  1-3847 Sub-57 3,4-diClPh CO CH₂ Sub-7  1-3848 Sub-57 3,4-diClPh CO CH₂ Sub-8  1-3849 Sub-57 3,4-diClPh CO CH₂ Sub-9  1-3850 Sub-57 3,4-diClPh CO CH₂ Sub-10 1-3851 Sub-57 3,4-diClPh CO CH₂ Sub-11 1-3852 Sub-57 3,4-diClPh CO CH₂ Sub-12 1-3853 Sub-57 3,4-diClPh CO CH₂ Sub-13 1-3854 Sub-57 3,4-diClPh CO CH₂ Sub-14 1-3855 Sub-57 3,4-diClPh CO CH₂ Sub-15 1-3856 Sub-57 3,4-diClPh CO CH₂ Sub-16 1-3857 Sub-57 3,4-diClPh CO CH₂ Sub-17 1-3858 Sub-57 3,4-diClPh CO CH₂ Sub-18 1-3859 Sub-57 3,4-diClPh CO CH₂ Sub-19 1-3860 Sub-57 3,4-diClPh CO CH₂ Sub-20 1-3861 Sub-57 3,4-diClPh CO CH₂ Sub-21 1-3862 Sub-57 3,4-diClPh CO CH₂ Sub-22 1-3863 Sub-57 3,4-diClPh CO CH₂ Sub-23 1-3864 Sub-57 3,4-diClPh CO CH₂ Sub-24 1-3865 Sub-57 3,4-diClPh CO CH₂ Sub-25 1-3866 Sub-57 3,4-diClPh CO CH₂ Sub-26 1-3867 Sub-57 3,4-diClPh CO CH₂ Sub-27 1-3868 Sub-57 3,4-diClPh CO CH₂ Sub-28 1-3869 Sub-57 3,4-diClPh CO CH₂ Sub-29 1-3870 Sub-57 3,4-diClPh CO CH₂ Sub-30 1-3871 Sub-57 3,4-diClPh CO CH₂ Sub-31 1-3872 Sub-57 3,4-diClPh CO CH₂ Sub-32 1-3873 Sub-58 3,4-diClPh CO CH₂ Sub-1  1-3874 Sub-58 3,4-diClPh CO CH₂ Sub-2  1-3875 Sub-58 3,4-diClPh CO CH₂ Sub-3  1-3876 Sub-58 3,4-diClPh CO CH₂ Sub-4  1-3877 Sub-58 3,4-diClPh CO CH₂ Sub-5  1-3878 Sub-58 3,4-diClPh CO CH₂ Sub-6  1-3879 Sub-58 3,4-diClPh CO CH₂ Sub-7  1-3880 Sub-58 3,4-diClPh CO CH₂ Sub-8  1-3881 Sub-58 3,4-diClPh CO CH₂ Sub-9  1-3882 Sub-58 3,4-diClPh CO CH₂ Sub-10 1-3883 Sub-58 3,4-diClPh CO CH₂ Sub-11 1-3884 Sub-58 3,4-diClPh CO CH₂ Sub-12 1-3885 Sub-58 3,4-diClPh CO CH₂ Sub-13 1-3886 Sub-58 3,4-diClPh CO CH₂ Sub-14 1-3887 Sub-58 3,4-diClPh CO CH₂ Sub-15 1-3888 Sub-58 3,4-diClPh CO CH₂ Sub-16 1-3889 Sub-58 3,4-diClPh CO CH₂ Sub-17 1-3890 Sub-58 3,4-diClPh CO CH₂ Sub-18 1-3891 Sub-58 3,4-diClPh CO CH₂ Sub-19 1-3892 Sub-58 3,4-diClPh CO CH₂ Sub-20 1-3893 Sub-58 3,4-diClPh CO CH₂ Sub-21 1-3894 Sub-58 3,4-diClPh CO CH₂ Sub-22 1-3895 Sub-58 3,4-diClPh CO CH₂ Sub-23 1-3896 Sub-58 3,4-diClPh CO CH₂ Sub-24 1-3897 Sub-58 3,4-diClPh CO CH₂ Sub-25 1-3898 Sub-58 3,4-diClPh CO CH₂ Sub-26 1-3899 Sub-58 3,4-diClPh CO CH₂ Sub-27 1-3900 Sub-58 3,4-diClPh CO CH₂ Sub-28 1-3901 Sub-58 3,4-diClPh CO CH₂ Sub-29 1-3902 Sub-58 3,4-diClPh CO CH₂ Sub-30 1-3903 Sub-58 3,4-diClPh CO CH₂ Sub-31 1-3904 Sub-58 3,4-diClPh CO CH₂ Sub-32 1-3905 Sub-59 3,4-diClPh CO CH₂ Sub-1  1-3906 Sub-59 3,4-diClPh CO CH₂ Sub-2  1-3907 Sub-59 3,4-diClPh CO CH₂ Sub-3  1-3908 Sub-59 3,4-diClPh CO CH₂ Sub-4  1-3909 Sub-59 3,4-diClPh CO CH₂ Sub-5  1-3910 Sub-59 3,4-diClPh CO CH₂ Sub-6  1-3911 Sub-59 3,4-diClPh CO CH₂ Sub-7  1-3912 Sub-59 3,4-diClPh CO CH₂ Sub-8  1-3913 Sub-59 3,4-diClPh CO CH₂ Sub-9  1-3914 Sub-59 3,4-diClPh CO CH₂ Sub-10 1-3915 Sub-59 3,4-diClPh CO CH₂ Sub-11 1-3916 Sub-59 3,4-diClPh CO CH₂ Sub-12 1-3917 Sub-59 3,4-diClPh CO CH₂ Sub-13 1-3918 Sub-59 3,4-diClPh CO CH₂ Sub-14 1-3919 Sub-59 3,4-diClPh CO CH₂ Sub-15 1-3920 Sub-59 3,4-diClPh CO CH₂ Sub-16 1-3921 Sub-59 3,4-diClPh CO CH₂ Sub-17 1-3922 Sub-59 3,4-diClPh CO CH₂ Sub-18 1-3923 Sub-59 3,4-diClPh CO CH₂ Sub-19 1-3924 Sub-59 3,4-diClPh CO CH₂ Sub-20 1-3925 Sub-59 3,4-diClPh CO CH₂ Sub-21 1-3926 Sub-59 3,4-diClPh CO CH₂ Sub-22 1-3927 Sub-59 3,4-diClPh CO CH₂ Sub-23 1-3928 Sub-59 3,4-diClPh CO CH₂ Sub-24 1-3929 Sub-59 3,4-diClPh CO CH₂ Sub-25 1-3930 Sub-59 3,4-diClPh CO CH₂ Sub-26 1-3931 Sub-59 3,4-diClPh CO CH₂ Sub-27 1-3932 Sub-59 3,4-diClPh CO CH₂ Sub-28 1-3933 Sub-59 3,4-diClPh CO CH₂ Sub-29 1-3934 Sub-59 3,4-diClPh CO CH₂ Sub-30 1-3935 Sub-59 3,4-diClPh CO CH₂ Sub-31 1-3936 Sub-59 3,4-diClPh CO CH₂ Sub-32 1-3937 Sub-60 3,4-diClPh CO CH₂ Sub-1  1-3938 Sub-60 3,4-diClPh CO CH₂ Sub-2  1-3939 Sub-60 3,4-diClPh CO CH₂ Sub-3  1-3940 Sub-60 3,4-diClPh CO CH₂ Sub-4  1-3941 Sub-60 3,4-diClPh CO CH₂ Sub-5  1-3942 Sub-60 3,4-diClPh CO CH₂ Sub-6  1-3943 Sub-60 3,4-diClPh CO CH₂ Sub-7  1-3944 Sub-60 3,4-diClPh CO CH₂ Sub-8  1-3945 Sub-60 3,4-diClPh CO CH₂ Sub-9  1-3946 Sub-60 3,4-diClPh CO CH₂ Sub-10 1-3947 Sub-60 3,4-diClPh CO CH₂ Sub-11 1-3948 Sub-60 3,4-diClPh CO CH₂ Sub-12 1-3949 Sub-60 3,4-diClPh CO CH₂ Sub-13 1-3950 Sub-60 3,4-diClPh CO CH₂ Sub-14 1-3951 Sub-60 3,4-diClPh CO CH₂ Sub-15 1-3952 Sub-60 3,4-diClPh CO CH₂ Sub-16 1-3953 Sub-60 3,4-diClPh CO CH₂ Sub-17 1-3954 Sub-60 3,4-diClPh CO CH₂ Sub-18 1-3955 Sub-60 3,4-diClPh CO CH₂ Sub-19 1-3956 Sub-60 3,4-diClPh CO CH₂ Sub-20 1-3957 Sub-60 3,4-diClPh CO CH₂ Sub-21 1-3958 Sub-60 3,4-diClPh CO CH₂ Sub-22 1-3959 Sub-60 3,4-diClPh CO CH₂ Sub-23 1-3960 Sub-60 3,4-diClPh CO CH₂ Sub-24 1-3961 Sub-60 3,4-diClPh CO CH₂ Sub-25 1-3962 Sub-60 3,4-diClPh CO CH₂ Sub-26 1-3963 Sub-60 3,4-diClPh CO CH₂ Sub-27 1-3964 Sub-60 3,4-diClPh CO CH₂ Sub-28 1-3965 Sub-60 3,4-diClPh CO CH₂ Sub-29 1-3966 Sub-60 3,4-diClPh CO CH₂ Sub-30 1-3967 Sub-60 3,4-diClPh CO CH₂ Sub-31 1-3968 Sub-60 3,4-diClPh CO CH₂ Sub-32 1-3969 Sub-61 3,4-diClPh CO CH₂ Sub-1  1-3970 Sub-61 3,4-diClPh CO CH₂ Sub-2  1-3971 Sub-61 3,4-diClPh CO CH₂ Sub-3  1-3972 Sub-61 3,4-diClPh CO CH₂ Sub-4  1-3973 Sub-61 3,4-diClPh CO CH₂ Sub-5  1-3974 Sub-61 3,4-diClPh CO CH₂ Sub-6  1-3975 Sub-61 3,4-diClPh CO CH₂ Sub-7  1-3976 Sub-61 3,4-diClPh CO CH₂ Sub-8  1-3977 Sub-61 3,4-diClPh CO CH₂ Sub-9  1-3978 Sub-61 3,4-diClPh CO CH₂ Sub-10 1-3979 Sub-61 3,4-diClPh CO CH₂ Sub-11 1-3980 Sub-61 3,4-diClPh CO CH₂ Sub-12 1-3981 Sub-61 3,4-diClPh CO CH₂ Sub-13 1-3982 Sub-61 3,4-diClPh CO CH₂ Sub-14 1-3983 Sub-61 3,4-diClPh CO CH₂ Sub-15 1-3984 Sub-61 3,4-diClPh CO CH₂ Sub-16 1-3985 Sub-61 3,4-diClPh CO CH₂ Sub-17 1-3986 Sub-61 3,4-diClPh CO CH₂ Sub-18 1-3987 Sub-61 3,4-diClPh CO CH₂ Sub-19 1-3988 Sub-61 3,4-diClPh CO CH₂ Sub-20 1-3989 Sub-61 3,4-diClPh CO CH₂ Sub-21 1-3990 Sub-61 3,4-diClPh CO CH₂ Sub-22 1-3991 Sub-61 3,4-diClPh CO CH₂ Sub-23 1-3992 Sub-61 3,4-diClPh CO CH₂ Sub-24 1-3993 Sub-61 3,4-diClPh CO CH₂ Sub-25 1-3994 Sub-61 3,4-diClPh CO CH₂ Sub-26 1-3995 Sub-61 3,4-diClPh CO CH₂ Sub-27 1-3996 Sub-61 3,4-diClPh CO CH₂ Sub-28 1-3997 Sub-61 3,4-diClPh CO CH₂ Sub-29 1-3998 Sub-61 3,4-diClPh CO CH₂ Sub-30 1-3999 Sub-61 3,4-diClPh CO CH₂ Sub-31 1-4000 Sub-61 3,4-diClPh CO CH₂ Sub-32 1-4001 Sub-62 3,4-diClPh CO CH₂ Sub-1  1-4002 Sub-62 3,4-diClPh CO CH₂ Sub-2  1-4003 Sub-62 3,4-diClPh CO CH₂ Sub-3  1-4004 Sub-62 3,4-diClPh CO CH₂ Sub-4  1-4005 Sub-62 3,4-diClPh CO CH₂ Sub-5  1-4006 Sub-62 3,4-diClPh CO CH₂ Sub-6  1-4007 Sub-62 3,4-diClPh CO CH₂ Sub-7  1-4008 Sub-62 3,4-diClPh CO CH₂ Sub-8  1-4009 Sub-62 3,4-diClPh CO CH₂ Sub-9  1-4010 Sub-62 3,4-diClPh CO CH₂ Sub-10 1-4011 Sub-62 3,4-diClPh CO CH₂ Sub-11 1-4012 Sub-62 3,4-diClPh CO CH₂ Sub-12 1-4013 Sub-62 3,4-diClPh CO CH₂ Sub-13 1-4014 Sub-62 3,4-diClPh CO CH₂ Sub-14 1-4015 Sub-62 3,4-diClPh CO CH₂ Sub-15 1-4016 Sub-62 3,4-diClPh CO CH₂ Sub-16 1-4017 Sub-62 3,4-diClPh CO CH₂ Sub-17 1-4018 Sub-62 3,4-diClPh CO CH₂ Sub-18 1-4019 Sub-62 3,4-diClPh CO CH₂ Sub-19 1-4020 Sub-62 3,4-diClPh CO CH₂ Sub-20 1-4021 Sub-62 3,4-diClPh CO CH₂ Sub-21 1-4022 Sub-62 3,4-diClPh CO CH₂ Sub-22 1-4023 Sub-62 3,4-diClPh CO CH₂ Sub-23 1-4024 Sub-62 3,4-diClPh CO CH₂ Sub-24 1-4025 Sub-62 3,4-diClPh CO CH₂ Sub-25 1-4026 Sub-62 3,4-diClPh CO CH₂ Sub-26 1-4027 Sub-62 3,4-diClPh CO CH₂ Sub-27 1-4028 Sub-62 3,4-diClPh CO CH₂ Sub-28 1-4029 Sub-62 3,4-diClPh CO CH₂ Sub-29 1-4030 Sub-62 3,4-diClPh CO CH₂ Sub-30 1-4031 Sub-62 3,4-diClPh CO CH₂ Sub-31 1-4032 Sub-62 3,4-diClPh CO CH₂ Sub-32 1-4033 Sub-63 3,4-diClPh CO CH₂ Sub-1  1-4034 Sub-63 3,4-diClPh CO CH₂ Sub-2  1-4035 Sub-63 3,4-diClPh CO CH₂ Sub-3  1-4036 Sub-63 3,4-diClPh CO CH₂ Sub-4  1-4037 Sub-63 3,4-diClPh CO CH₂ Sub-5  1-4038 Sub-63 3,4-diClPh CO CH₂ Sub-6  1-4039 Sub-63 3,4-diClPh CO CH₂ Sub-7  1-4040 Sub-63 3,4-diClPh CO CH₂ Sub-8  1-4041 Sub-63 3,4-diClPh CO CH₂ Sub-9  1-4042 Sub-63 3,4-diClPh CO CH₂ Sub-10 1-4043 Sub-63 3,4-diClPh CO CH₂ Sub-11 1-4044 Sub-63 3,4-diClPh CO CH₂ Sub-12 1-4045 Sub-63 3,4-diClPh CO CH₂ Sub-13 1-4046 Sub-63 3,4-diClPh CO CH₂ Sub-14 1-4047 Sub-63 3,4-diClPh CO CH₂ Sub-15 1-4048 Sub-63 3,4-diClPh CO CH₂ Sub-16 1-4049 Sub-63 3,4-diClPh CO CH₂ Sub-17 1-4050 Sub-63 3,4-diClPh CO CH₂ Sub-18 1-4051 Sub-63 3,4-diClPh CO CH₂ Sub-19 1-4052 Sub-63 3,4-diClPh CO CH₂ Sub-20 1-4053 Sub-63 3,4-diClPh CO CH₂ Sub-21 1-4054 Sub-63 3,4-diClPh CO CH₂ Sub-22 1-4055 Sub-63 3,4-diClPh CO CH₂ Sub-23 1-4056 Sub-63 3,4-diClPh CO CH₂ Sub-24 1-4057 Sub-63 3,4-diClPh CO CH₂ Sub-25 1-4058 Sub-63 3,4-diClPh CO CH₂ Sub-26 1-4059 Sub-63 3,4-diClPh CO CH₂ Sub-27 1-4060 Sub-63 3,4-diClPh CO CH₂ Sub-28 1-4061 Sub-63 3,4-diClPh CO CH₂ Sub-29 1-4062 Sub-63 3,4-diClPh CO CH₂ Sub-30 1-4063 Sub-63 3,4-diClPh CO CH₂ Sub-31 1-4064 Sub-63 3,4-diClPh CO CH₂ Sub-32 1-4065 Sub-64 3,4-diClPh CO CH₂ Sub-1  1-4066 Sub-64 3,4-diClPh CO CH₂ Sub-2  1-4067 Sub-64 3,4-diClPh CO CH₂ Sub-3  1-4068 Sub-64 3,4-diClPh CO CH₂ Sub-4  1-4069 Sub-64 3,4-diClPh CO CH₂ Sub-5  1-4070 Sub-64 3,4-diClPh CO CH₂ Sub-6  1-4071 Sub-64 3,4-diClPh CO CH₂ Sub-7  1-4072 Sub-64 3,4-diClPh CO CH₂ Sub-8  1-4073 Sub-64 3,4-diClPh CO CH₂ Sub-9  1-4074 Sub-64 3,4-diClPh CO CH₂ Sub-10 1-4075 Sub-64 3,4-diClPh CO CH₂ Sub-11 1-4076 Sub-64 3,4-diClPh CO CH₂ Sub-12 1-4077 Sub-64 3,4-diClPh CO CH₂ Sub-13 1-4078 Sub-64 3,4-diClPh CO CH₂ Sub-14 1-4079 Sub-64 3,4-diClPh CO CH₂ Sub-15 1-4080 Sub-64 3,4-diClPh CO CH₂ Sub-16 1-4081 Sub-64 3,4-diClPh CO CH₂ Sub-17 1-4082 Sub-64 3,4-diClPh CO CH₂ Sub-18 1-4083 Sub-64 3,4-diClPh CO CH₂ Sub-19 1-4084 Sub-64 3,4-diClPh CO CH₂ Sub-20 1-4085 Sub-64 3,4-diClPh CO CH₂ Sub-21 1-4086 Sub-64 3,4-diClPh CO CH₂ Sub-22 1-4087 Sub-64 3,4-diClPh CO CH₂ Sub-23 1-4088 Sub-64 3,4-diClPh CO CH₂ Sub-24 1-4089 Sub-64 3,4-diClPh CO CH₂ Sub-25 1-4090 Sub-64 3,4-diClPh CO CH₂ Sub-26 1-4091 Sub-64 3,4-diClPh CO CH₂ Sub-27 1-4092 Sub-64 3,4-diClPh CO CH₂ Sub-28 1-4093 Sub-64 3,4-diClPh CO CH₂ Sub-29 1-4094 Sub-64 3,4-diClPh CO CH₂ Sub-30 1-4095 Sub-64 3,4-diClPh CO CH₂ Sub-31 1-4096 Sub-64 3,4-diClPh CO CH₂ Sub-32

TABLE 2 Cpd. No. R¹ R² A B Z 2-1   Sub-33 3,4-diClPh CH₂ Single bond Sub-1  2-2   Sub-33 3,4-diClPh CH₂ Single bond Sub-2  2-3   Sub-33 3,4-diClPh CH₂ Single bond Sub-3  2-4   Sub-33 3,4-diClPh CH₂ Single bond Sub-4  2-5   Sub-33 3,4-diClPh CH₂ Single bond Sub-5  2-6   Sub-33 3,4-diClPh CH₂ Single bond Sub-6  2-7   Sub-33 3,4-diClPh CH₂ Single bond Sub-7  2-8   Sub-33 3,4-diClPh CH₂ Single bond Sub-8  2-9   Sub-33 3,4-diClPh CH₂ Single bond Sub-9  2-10  Sub-33 3,4-diClPh CH₂ Single bond Sub-10 2-11  Sub-33 3,4-diClPh CH₂ Single bond Sub-11 2-12  Sub-33 3,4-diClPh CH₂ Single bond Sub-12 2-13  Sub-33 3,4-diClPh CH₂ Single bond Sub-13 2-14  Sub-33 3,4-diClPh CH₂ Single bond Sub-14 2-15  Sub-33 3,4-diClPh CH₂ Single bond Sub-15 2-16  Sub-33 3,4-diClPh CH₂ Single bond Sub-16 2-17  Sub-33 3,4-diClPh CH₂ Single bond Sub-17 2-18  Sub-33 3,4-diClPh CH₂ Single bond Sub-18 2-19  Sub-33 3,4-diClPh CH₂ Single bond Sub-19 2-20  Sub-33 3,4-diClPh CH₂ Single bond Sub-20 2-21  Sub-33 3,4-diClPh CH₂ Single bond Sub-21 2-22  Sub-33 3,4-diClPh CH₂ Single bond Sub-22 2-23  Sub-33 3,4-diClPh CH₂ Single bond Sub-23 2-24  Sub-33 3,4-diClPh CH₂ Single bond Sub-24 2-25  Sub-33 3,4-diClPh CH₂ Single bond Sub-25 2-26  Sub-33 3,4-diClPh CH₂ Single bond Sub-26 2-27  Sub-33 3,4-diClPh CH₂ Single bond Sub-27 2-28  Sub-33 3,4-diClPh CH₂ Single bond Sub-28 2-29  Sub-33 3,4-diClPh CH₂ Single bond Sub-29 2-30  Sub-33 3,4-diClPh CH₂ Single bond Sub-30 2-31  Sub-33 3,4-diClPh CH₂ Single bond Sub-31 2-32  Sub-33 3,4-diClPh CH₂ Single bond Sub-32 2-33  Sub-33 3,4-diClPh CH₂ Single bond Sub-65 2-34  Sub-33 3,4-diClPh CH₂ Single bond Sub-66 2-35  Sub-33 3,4-diClPh CH₂ Single bond Sub-67 2-36  Sub-33 3,4-diClPh CH₂ Single bond Sub-68 2-37  Sub-33 3,4-diClPh CH₂ Single bond Sub-69 2-38  Sub-33 3,4-diClPh CH₂ Single bond Sub-70 2-39  Sub-33 3,4-diClPh CH₂ Single bond Sub-71 2-40  Sub-33 3,4-diClPh CH₂ Single bond Sub-72 2-41  Sub-33 3,4-diClPh CH₂ Single bond Sub-73 2-42  Sub-33 3,4-diClPh CH₂ Single bond Sub-74 2-43  Sub-33 3,4-diClPh CH₂ Single bond Sub-75 2-44  Sub-33 3,4-diClPh CH₂ Single bond Sub-76 2-45  Sub-33 3,4-diClPh CH₂ Single bond Sub-77 2-46  Sub-33 3,4-diClPh CH₂ Single bond Sub-78 2-47  Sub-33 3,4-diClPh CH₂ Single bond Sub-79 2-48  Sub-33 3,4-diClPh CH₂ Single bond Sub-80 2-49  Sub-34 3,4-diClPh CH₂ Single bond Sub-1  2-50  Sub-34 3,4-diClPh CH₂ Single bond Sub-2  2-51  Sub-34 3,4-diClPh CH₂ Single bond Sub-3  2-52  Sub-34 3,4-diClPh CH₂ Single bond Sub-4  2-53  Sub-34 3,4-diClPh CH₂ Single bond Sub-5  2-54  Sub-34 3,4-diClPh CH₂ Single bond Sub-6  2-55  Sub-34 3,4-diClPh CH₂ Single bond Sub-7  2-56  Sub-34 3,4-diClPh CH₂ Single bond Sub-8  2-57  Sub-34 3,4-diClPh CH₂ Single bond Sub-9  2-58  Sub-34 3,4-diClPh CH₂ Single bond Sub-10 2-59  Sub-34 3,4-diClPh CH₂ Single bond Sub-11 2-60  Sub-34 3,4-diClPh CH₂ Single bond Sub-12 2-61  Sub-34 3,4-diClPh CH₂ Single bond Sub-13 2-62  Sub-34 3,4-diClPh CH₂ Single bond Sub-14 2-63  Sub-34 3,4-diClPh CH₂ Single bond Sub-15 2-64  Sub-34 3,4-diClPh CH₂ Single bond Sub-16 2-65  Sub-34 3,4-diClPh CH₂ Single bond Sub-17 2-66  Sub-34 3,4-diClPh CH₂ Single bond Sub-18 2-67  Sub-34 3,4-diClPh CH₂ Single bond Sub-19 2-68  Sub-34 3,4-diClPh CH₂ Single bond Sub-20 2-69  Sub-34 3,4-diClPh CH₂ Single bond Sub-21 2-70  Sub-34 3,4-diClPh CH₂ Single bond Sub-22 2-71  Sub-34 3,4-diClPh CH₂ Single bond Sub-23 2-72  Sub-34 3,4-diClPh CH₂ Single bond Sub-24 2-73  Sub-34 3,4-diClPh CH₂ Single bond Sub-25 2-74  Sub-34 3,4-diClPh CH₂ Single bond Sub-26 2-75  Sub-34 3,4-diClPh CH₂ Single bond Sub-27 2-76  Sub-34 3,4-diClPh CH₂ Single bond Sub-28 2-77  Sub-34 3,4-diClPh CH₂ Single bond Sub-29 2-78  Sub-34 3,4-diClPh CH₂ Single bond Sub-30 2-79  Sub-34 3,4-diClPh CH₂ Single bond Sub-31 2-80  Sub-34 3,4-diClPh CH₂ Single bond Sub-32 2-81  Sub-34 3,4-diClPh CH₂ Single bond Sub-65 2-82  Sub-34 3,4-diClPh CH₂ Single bond Sub-66 2-83  Sub-34 3,4-diClPh CH₂ Single bond Sub-67 2-84  Sub-34 3,4-diClPh CH₂ Single bond Sub-68 2-85  Sub-34 3,4-diClPh CH₂ Single bond Sub-69 2-86  Sub-34 3,4-diClPh CH₂ Single bond Sub-70 2-87  Sub-34 3,4-diClPh CH₂ Single bond Sub-71 2-88  Sub-34 3,4-diClPh CH₂ Single bond Sub-72 2-89  Sub-34 3,4-diClPh CH₂ Single bond Sub-73 2-90  Sub-34 3,4-diClPh CH₂ Single bond Sub-74 2-91  Sub-34 3,4-diClPh CH₂ Single bond Sub-75 2-92  Sub-34 3,4-diClPh CH₂ Single bond Sub-76 2-93  Sub-34 3,4-diClPh CH₂ Single bond Sub-77 2-94  Sub-34 3,4-diClPh CH₂ Single bond Sub-78 2-95  Sub-34 3,4-diClPh CH₂ Single bond Sub-79 2-96  Sub-34 3,4-diClPh CH₂ Single bond Sub-80 2-97  Sub-35 3,4-diClPh CH₂ Single bond Sub-1  2-98  Sub-35 3,4-diClPh CH₂ Single bond Sub-2  2-99  Sub-35 3,4-diClPh CH₂ Single bond Sub-3  2-100  Sub-35 3,4-diClPh CH₂ Single bond Sub-4  2-101  Sub-35 3,4-diClPh CH₂ Single bond Sub-5  2-102  Sub-35 3,4-diClPh CH₂ Single bond Sub-6  2-103  Sub-35 3,4-diClPh CH₂ Single bond Sub-7  2-104  Sub-35 3,4-diClPh CH₂ Single bond Sub-8  2-105  Sub-35 3,4-diClPh CH₂ Single bond Sub-9  2-106  Sub-35 3,4-diClPh CH₂ Single bond Sub-10 2-107  Sub-35 3,4-diClPh CH₂ Single bond Sub-11 2-108  Sub-35 3,4-diClPh CH₂ Single bond Sub-12 2-109  Sub-35 3,4-diClPh CH₂ Single bond Sub-13 2-110  Sub-35 3,4-diClPh CH₂ Single bond Sub-14 2-111  Sub-35 3,4-diClPh CH₂ Single bond Sub-15 2-112  Sub-35 3,4-diClPh CH₂ Single bond Sub-16 2-113  Sub-35 3,4-diClPh CH₂ Single bond Sub-17 2-114  Sub-35 3,4-diClPh CH₂ Single bond Sub-18 2-115  Sub-35 3,4-diClPh CH₂ Single bond Sub-19 2-116  Sub-35 3,4-diClPh CH₂ Single bond Sub-20 2-117  Sub-35 3,4-diClPh CH₂ Single bond Sub-21 2-118  Sub-35 3,4-diClPh CH₂ Single bond Sub-22 2-119  Sub-35 3,4-diClPh CH₂ Single bond Sub-23 2-120  Sub-35 3,4-diClPh CH₂ Single bond Sub-24 2-121  Sub-35 3,4-diClPh CH₂ Single bond Sub-25 2-122  Sub-35 3,4-diClPh CH₂ Single bond Sub-26 2-123  Sub-35 3,4-diClPh CH₂ Single bond Sub-27 2-124  Sub-35 3,4-diClPh CH₂ Single bond Sub-28 2-125  Sub-35 3,4-diClPh CH₂ Single bond Sub-29 2-126  Sub-35 3,4-diClPh CH₂ Single bond Sub-30 2-127  Sub-35 3,4-diClPh CH₂ Single bond Sub-31 2-128  Sub-35 3,4-diClPh CH₂ Single bond Sub-32 2-129  Sub-35 3,4-diClPh CH₂ Single bond Sub-65 2-130  Sub-35 3,4-diClPh CH₂ Single bond Sub-66 2-131  Sub-35 3,4-diClPh CH₂ Single bond Sub-67 2-132  Sub-35 3,4-diClPh CH₂ Single bond Sub-68 2-133  Sub-35 3,4-diClPh CH₂ Single bond Sub-69 2-134  Sub-35 3,4-diClPh CH₂ Single bond Sub-70 2-135  Sub-35 3,4-diClPh CH₂ Single bond Sub-71 2-136  Sub-35 3,4-diClPh CH₂ Single bond Sub-72 2-137  Sub-35 3,4-diClPh CH₂ Single bond Sub-73 2-138  Sub-35 3,4-diClPh CH₂ Single bond Sub-74 2-139  Sub-35 3,4-diClPh CH₂ Single bond Sub-75 2-140  Sub-35 3,4-diClPh CH₂ Single bond Sub-76 2-141  Sub-35 3,4-diClPh CH₂ Single bond Sub-77 2-142  Sub-35 3,4-diClPh CH₂ Single bond Sub-78 2-143  Sub-35 3,4-diClPh CH₂ Single bond Sub-79 2-144  Sub-35 3,4-diClPh CH₂ Single bond Sub-80 2-145  Sub-36 3,4-diClPh CH₂ Single bond Sub-1  2-146  Sub-36 3,4-diClPh CH₂ Single bond Sub-2  2-147  Sub-36 3,4-diClPh CH₂ Single bond Sub-3  2-148  Sub-36 3,4-diClPh CH₂ Single bond Sub-4  2-149  Sub-36 3,4-diClPh CH₂ Single bond Sub-5  2-150  Sub-36 3,4-diClPh CH₂ Single bond Sub-6  2-151  Sub-36 3,4-diClPh CH₂ Single bond Sub-7  2-152  Sub-36 3,4-diClPh CH₂ Single bond Sub-8  2-153  Sub-36 3,4-diClPh CH₂ Single bond Sub-9  2-154  Sub-36 3,4-diClPh CH₂ Single bond Sub-10 2-155  Sub-36 3,4-diClPh CH₂ Single bond Sub-11 2-156  Sub-36 3,4-diClPh CH₂ Single bond Sub-12 2-157  Sub-36 3,4-diClPh CH₂ Single bond Sub-13 2-158  Sub-36 3,4-diClPh CH₂ Single bond Sub-14 2-159  Sub-36 3,4-diClPh CH₂ Single bond Sub-15 2-160  Sub-36 3,4-diClPh CH₂ Single bond Sub-16 2-161  Sub-36 3,4-diClPh CH₂ Single bond Sub-17 2-162  Sub-36 3,4-diClPh CH₂ Single bond Sub-18 2-163  Sub-36 3,4-diClPh CH₂ Single bond Sub-19 2-164  Sub-36 3,4-diClPh CH₂ Single bond Sub-20 2-165  Sub-36 3,4-diClPh CH₂ Single bond Sub-21 2-166  Sub-36 3,4-diClPh CH₂ Single bond Sub-22 2-167  Sub-36 3,4-diClPh CH₂ Single bond Sub-23 2-168  Sub-36 3,4-diClPh CH₂ Single bond Sub-24 2-169  Sub-36 3,4-diClPh CH₂ Single bond Sub-25 2-170  Sub-36 3,4-diClPh CH₂ Single bond Sub-26 2-171  Sub-36 3,4-diClPh CH₂ Single bond Sub-27 2-172  Sub-36 3,4-diClPh CH₂ Single bond Sub-28 2-173  Sub-36 3,4-diClPh CH₂ Single bond Sub-29 2-174  Sub-36 3,4-diClPh CH₂ Single bond Sub-30 2-175  Sub-36 3,4-diClPh CH₂ Single bond Sub-31 2-176  Sub-36 3,4-diClPh CH₂ Single bond Sub-32 2-177  Sub-36 3,4-diClPh CH₂ Single bond Sub-65 2-178  Sub-36 3,4-diClPh CH₂ Single bond Sub-66 2-179  Sub-36 3,4-diClPh CH₂ Single bond Sub-67 2-180  Sub-36 3,4-diClPh CH₂ Single bond Sub-68 2-181  Sub-36 3,4-diClPh CH₂ Single bond Sub-69 2-182  Sub-36 3,4-diClPh CH₂ Single bond Sub-70 2-183  Sub-36 3,4-diClPh CH₂ Single bond Sub-71 2-184  Sub-36 3,4-diClPh CH₂ Single bond Sub-72 2-185  Sub-36 3,4-diClPh CH₂ Single bond Sub-73 2-186  Sub-36 3,4-diClPh CH₂ Single bond Sub-74 2-187  Sub-36 3,4-diClPh CH₂ Single bond Sub-75 2-188  Sub-36 3,4-diClPh CH₂ Single bond Sub-76 2-189  Sub-36 3,4-diClPh CH₂ Single bond Sub-77 2-190  Sub-36 3,4-diClPh CH₂ Single bond Sub-78 2-191  Sub-36 3,4-diClPh CH₂ Single bond Sub-79 2-192  Sub-36 3,4-diClPh CH₂ Single bond Sub-80 2-193  Sub-37 3,4-diClPh CH₂ Single bond Sub-1  2-194  Sub-37 3,4-diClPh CH₂ Single bond Sub-2  2-195  Sub-37 3,4-diClPh CH₂ Single bond Sub-3  2-196  Sub-37 3,4-diClPh CH₂ Single bond Sub-4  2-197  Sub-37 3,4-diClPh CH₂ Single bond Sub-5  2-198  Sub-37 3,4-diClPh CH₂ Single bond Sub-6  2-199  Sub-37 3,4-diClPh CH₂ Single bond Sub-7  2-200  Sub-37 3,4-diClPh CH₂ Single bond Sub-8  2-201  Sub-37 3,4-diClPh CH₂ Single bond Sub-9  2-202  Sub-37 3,4-diClPh CH₂ Single bond Sub-10 2-203  Sub-37 3,4-diClPh CH₂ Single bond Sub-11 2-204  Sub-37 3,4-diClPh CH₂ Single bond Sub-12 2-205  Sub-37 3,4-diClPh CH₂ Single bond Sub-13 2-206  Sub-37 3,4-diClPh CH₂ Single bond Sub-14 2-207  Sub-37 3,4-diClPh CH₂ Single bond Sub-15 2-208  Sub-37 3,4-diClPh CH₂ Single bond Sub-16 2-209  Sub-37 3,4-diClPh CH₂ Single bond Sub-17 2-210  Sub-37 3,4-diClPh CH₂ Single bond Sub-18 2-211  Sub-37 3,4-diClPh CH₂ Single bond Sub-19 2-212  Sub-37 3,4-diClPh CH₂ Single bond Sub-20 2-213  Sub-37 3,4-diClPh CH₂ Single bond Sub-21 2-214  Sub-37 3,4-diClPh CH₂ Single bond Sub-22 2-215  Sub-37 3,4-diClPh CH₂ Single bond Sub-23 2-216  Sub-37 3,4-diClPh CH₂ Single bond Sub-24 2-217  Sub-37 3,4-diClPh CH₂ Single bond Sub-25 2-218  Sub-37 3,4-diClPh CH₂ Single bond Sub-26 2-219  Sub-37 3,4-diClPh CH₂ Single bond Sub-27 2-220  Sub-37 3,4-diClPh CH₂ Single bond Sub-28 2-221  Sub-37 3,4-diClPh CH₂ Single bond Sub-29 2-222  Sub-37 3,4-diClPh CH₂ Single bond Sub-30 2-223  Sub-37 3,4-diClPh CH₂ Single bond Sub-31 2-224  Sub-37 3,4-diClPh CH₂ Single bond Sub-32 2-225  Sub-37 3,4-diClPh CH₂ Single bond Sub-65 2-226  Sub-37 3,4-diClPh CH₂ Single bond Sub-66 2-227  Sub-37 3,4-diClPh CH₂ Single bond Sub-67 2-228  Sub-37 3,4-diClPh CH₂ Single bond Sub-68 2-229  Sub-37 3,4-diClPh CH₂ Single bond Sub-69 2-230  Sub-37 3,4-diClPh CH₂ Single bond Sub-70 2-231  Sub-37 3,4-diClPh CH₂ Single bond Sub-71 2-232  Sub-37 3,4-diClPh CH₂ Single bond Sub-72 2-233  Sub-37 3,4-diClPh CH₂ Single bond Sub-73 2-234  Sub-37 3,4-diClPh CH₂ Single bond Sub-74 2-235  Sub-37 3,4-diClPh CH₂ Single bond Sub-75 2-236  Sub-37 3,4-diClPh CH₂ Single bond Sub-76 2-237  Sub-37 3,4-diClPh CH₂ Single bond Sub-77 2-238  Sub-37 3,4-diClPh CH₂ Single bond Sub-78 2-239  Sub-37 3,4-diClPh CH₂ Single bond Sub-79 2-240  Sub-37 3,4-diClPh CH₂ Single bond Sub-80 2-241  Sub-38 3,4-diClPh CH₂ Single bond Sub-1  2-242  Sub-38 3,4-diClPh CH₂ Single bond Sub-2  2-243  Sub-38 3,4-diClPh CH₂ Single bond Sub-3  2-244  Sub-38 3,4-diClPh CH₂ Single bond Sub-4  2-245  Sub-38 3,4-diClPh CH₂ Single bond Sub-5  2-246  Sub-38 3,4-diClPh CH₂ Single bond Sub-6  2-247  Sub-38 3,4-diClPh CH₂ Single bond Sub-7  2-248  Sub-38 3,4-diClPh CH₂ Single bond Sub-8  2-249  Sub-38 3,4-diClPh CH₂ Single bond Sub-9  2-250  Sub-38 3,4-diClPh CH₂ Single bond Sub-10 2-251  Sub-38 3,4-diClPh CH₂ Single bond Sub-11 2-252  Sub-38 3,4-diClPh CH₂ Single bond Sub-12 2-253  Sub-38 3,4-diClPh CH₂ Single bond Sub-13 2-254  Sub-38 3,4-diClPh CH₂ Single bond Sub-14 2-255  Sub-38 3,4-diClPh CH₂ Single bond Sub-15 2-256  Sub-38 3,4-diClPh CH₂ Single bond Sub-16 2-257  Sub-38 3,4-diClPh CH₂ Single bond Sub-17 2-258  Sub-38 3,4-diClPh CH₂ Single bond Sub-18 2-259  Sub-38 3,4-diClPh CH₂ Single bond Sub-19 2-260  Sub-38 3,4-diClPh CH₂ Single bond Sub-20 2-261  Sub-38 3,4-diClPh CH₂ Single bond Sub-21 2-262  Sub-38 3,4-diClPh CH₂ Single bond Sub-22 2-263  Sub-38 3,4-diClPh CH₂ Single bond Sub-23 2-264  Sub-38 3,4-diClPh CH₂ Single bond Sub-24 2-265  Sub-38 3,4-diClPh CH₂ Single bond Sub-25 2-266  Sub-38 3,4-diClPh CH₂ Single bond Sub-26 2-267  Sub-38 3,4-diClPh CH₂ Single bond Sub-27 2-268  Sub-38 3,4-diClPh CH₂ Single bond Sub-28 2-269  Sub-38 3,4-diClPh CH₂ Single bond Sub-29 2-270  Sub-38 3,4-diClPh CH₂ Single bond Sub-30 2-271  Sub-38 3,4-diClPh CH₂ Single bond Sub-31 2-272  Sub-38 3,4-diClPh CH₂ Single bond Sub-32 2-273  Sub-38 3,4-diClPh CH₂ Single bond Sub-65 2-274  Sub-38 3,4-diClPh CH₂ Single bond Sub-66 2-275  Sub-38 3,4-diClPh CH₂ Single bond Sub-67 2-276  Sub-38 3,4-diClPh CH₂ Single bond Sub-68 2-277  Sub-38 3,4-diClPh CH₂ Single bond Sub-69 2-278  Sub-38 3,4-diClPh CH₂ Single bond Sub-70 2-279  Sub-38 3,4-diClPh CH₂ Single bond Sub-71 2-280  Sub-38 3,4-diClPh CH₂ Single bond Sub-72 2-281  Sub-38 3,4-diClPh CH₂ Single bond Sub-73 2-282  Sub-38 3,4-diClPh CH₂ Single bond Sub-74 2-283  Sub-38 3,4-diClPh CH₂ Single bond Sub-75 2-284  Sub-38 3,4-diClPh CH₂ Single bond Sub-76 2-285  Sub-38 3,4-diClPh CH₂ Single bond Sub-77 2-286  Sub-38 3,4-diClPh CH₂ Single bond Sub-78 2-287  Sub-38 3,4-diClPh CH₂ Single bond Sub-79 2-288  Sub-38 3,4-diClPh CH₂ Single bond Sub-80 2-289  Sub-39 3,4-diClPh CH₂ Single bond Sub-1  2-290  Sub-39 3,4-diClPh CH₂ Single bond Sub-2  2-291  Sub-39 3,4-diClPh CH₂ Single bond Sub-3  2-292  Sub-39 3,4-diClPh CH₂ Single bond Sub-4  2-293  Sub-39 3,4-diClPh CH₂ Single bond Sub-5  2-294  Sub-39 3,4-diClPh CH₂ Single bond Sub-6  2-295  Sub-39 3,4-diClPh CH₂ Single bond Sub-7  2-296  Sub-39 3,4-diClPh CH₂ Single bond Sub-8  2-297  Sub-39 3,4-diClPh CH₂ Single bond Sub-9  2-298  Sub-39 3,4-diClPh CH₂ Single bond Sub-10 2-299  Sub-39 3,4-diClPh CH₂ Single bond Sub-11 2-300  Sub-39 3,4-diClPh CH₂ Single bond Sub-12 2-301  Sub-39 3,4-diClPh CH₂ Single bond Sub-13 2-302  Sub-39 3,4-diClPh CH₂ Single bond Sub-14 2-303  Sub-39 3,4-diClPh CH₂ Single bond Sub-15 2-304  Sub-39 3,4-diClPh CH₂ Single bond Sub-16 2-305  Sub-39 3,4-diClPh CH₂ Single bond Sub-17 2-306  Sub-39 3,4-diClPh CH₂ Single bond Sub-18 2-307  Sub-39 3,4-diClPh CH₂ Single bond Sub-19 2-308  Sub-39 3,4-diClPh CH₂ Single bond Sub-20 2-309  Sub-39 3,4-diClPh CH₂ Single bond Sub-21 2-310  Sub-39 3,4-diClPh CH₂ Single bond Sub-22 2-311  Sub-39 3,4-diClPh CH₂ Single bond Sub-23 2-312  Sub-39 3,4-diClPh CH₂ Single bond Sub-24 2-313  Sub-39 3,4-diClPh CH₂ Single bond Sub-25 2-314  Sub-39 3,4-diClPh CH₂ Single bond Sub-26 2-315  Sub-39 3,4-diClPh CH₂ Single bond Sub-27 2-316  Sub-39 3,4-diClPh CH₂ Single bond Sub-28 2-317  Sub-39 3,4-diClPh CH₂ Single bond Sub-29 2-318  Sub-39 3,4-diClPh CH₂ Single bond Sub-30 2-319  Sub-39 3,4-diClPh CH₂ Single bond Sub-31 2-320  Sub-39 3,4-diClPh CH₂ Single bond Sub-32 2-321  Sub-39 3,4-diClPh CH₂ Single bond Sub-65 2-322  Sub-39 3,4-diClPh CH₂ Single bond Sub-66 2-323  Sub-39 3,4-diClPh CH₂ Single bond Sub-67 2-324  Sub-39 3,4-diClPh CH₂ Single bond Sub-68 2-325  Sub-39 3,4-diClPh CH₂ Single bond Sub-69 2-326  Sub-39 3,4-diClPh CH₂ Single bond Sub-70 2-327  Sub-39 3,4-diClPh CH₂ Single bond Sub-71 2-328  Sub-39 3,4-diClPh CH₂ Single bond Sub-72 2-329  Sub-39 3,4-diClPh CH₂ Single bond Sub-73 2-330  Sub-39 3,4-diClPh CH₂ Single bond Sub-74 2-331  Sub-39 3,4-diClPh CH₂ Single bond Sub-75 2-332  Sub-39 3,4-diClPh CH₂ Single bond Sub-76 2-333  Sub-39 3,4-diClPh CH₂ Single bond Sub-77 2-334  Sub-39 3,4-diClPh CH₂ Single bond Sub-78 2-335  Sub-39 3,4-diClPh CH₂ Single bond Sub-79 2-336  Sub-39 3,4-diClPh CH₂ Single bond Sub-80 2-337  Sub-40 3,4-diClPh CH₂ Single bond Sub-1  2-338  Sub-40 3,4-diClPh CH₂ Single bond Sub-2  2-339  Sub-40 3,4-diClPh CH₂ Single bond Sub-3  2-340  Sub-40 3,4-diClPh CH₂ Single bond Sub-4  2-341  Sub-40 3,4-diClPh CH₂ Single bond Sub-5  2-342  Sub-40 3,4-diClPh CH₂ Single bond Sub-6  2-343  Sub-40 3,4-diClPh CH₂ Single bond Sub-7  2-344  Sub-40 3,4-diClPh CH₂ Single bond Sub-8  2-345  Sub-40 3,4-diClPh CH₂ Single bond Sub-9  2-346  Sub-40 3,4-diClPh CH₂ Single bond Sub-10 2-347  Sub-40 3,4-diClPh CH₂ Single bond Sub-11 2-348  Sub-40 3,4-diClPh CH₂ Single bond Sub-12 2-349  Sub-40 3,4-diClPh CH₂ Single bond Sub-13 2-350  Sub-40 3,4-diClPh CH₂ Single bond Sub-14 2-351  Sub-40 3,4-diClPh CH₂ Single bond Sub-15 2-352  Sub-40 3,4-diClPh CH₂ Single bond Sub-16 2-353  Sub-40 3,4-diClPh CH₂ Single bond Sub-17 2-354  Sub-40 3,4-diClPh CH₂ Single bond Sub-18 2-355  Sub-40 3,4-diClPh CH₂ Single bond Sub-19 2-356  Sub-40 3,4-diClPh CH₂ Single bond Sub-20 2-357  Sub-40 3,4-diClPh CH₂ Single bond Sub-21 2-358  Sub-40 3,4-diClPh CH₂ Single bond Sub-22 2-359  Sub-40 3,4-diClPh CH₂ Single bond Sub-23 2-360  Sub-40 3,4-diClPh CH₂ Single bond Sub-24 2-361  Sub-40 3,4-diClPh CH₂ Single bond Sub-25 2-362  Sub-40 3,4-diClPh CH₂ Single bond Sub-26 2-363  Sub-40 3,4-diClPh CH₂ Single bond Sub-27 2-364  Sub-40 3,4-diClPh CH₂ Single bond Sub-28 2-365  Sub-40 3,4-diClPh CH₂ Single bond Sub-29 2-366  Sub-40 3,4-diClPh CH₂ Single bond Sub-30 2-367  Sub-40 3,4-diClPh CH₂ Single bond Sub-31 2-368  Sub-40 3,4-diClPh CH₂ Single bond Sub-32 2-369  Sub-40 3,4-diClPh CH₂ Single bond Sub-65 2-370  Sub-40 3,4-diClPh CH₂ Single bond Sub-66 2-371  Sub-40 3,4-diClPh CH₂ Single bond Sub-67 2-372  Sub-40 3,4-diClPh CH₂ Single bond Sub-68 2-373  Sub-40 3,4-diClPh CH₂ Single bond Sub-69 2-374  Sub-40 3,4-diClPh CH₂ Single bond Sub-70 2-375  Sub-40 3,4-diClPh CH₂ Single bond Sub-71 2-376  Sub-40 3,4-diClPh CH₂ Single bond Sub-72 2-377  Sub-40 3,4-diClPh CH₂ Single bond Sub-73 2-378  Sub-40 3,4-diClPh CH₂ Single bond Sub-74 2-379  Sub-40 3,4-diClPh CH₂ Single bond Sub-75 2-380  Sub-40 3,4-diClPh CH₂ Single bond Sub-76 2-381  Sub-40 3,4-diClPh CH₂ Single bond Sub-77 2-382  Sub-40 3,4-diClPh CH₂ Single bond Sub-78 2-383  Sub-40 3,4-diClPh CH₂ Single bond Sub-79 2-384  Sub-40 3,4-diClPh CH₂ Single bond Sub-80 2-385  Sub-41 3,4-diClPh CH₂ Single bond Sub-1  2-386  Sub-41 3,4-diClPh CH₂ Single bond Sub-2  2-387  Sub-41 3,4-diClPh CH₂ Single bond Sub-3  2-388  Sub-41 3,4-diClPh CH₂ Single bond Sub-4  2-389  Sub-41 3,4-diClPh CH₂ Single bond Sub-5  2-390  Sub-41 3,4-diClPh CH₂ Single bond Sub-6  2-391  Sub-41 3,4-diClPh CH₂ Single bond Sub-7  2-392  Sub-41 3,4-diClPh CH₂ Single bond Sub-8  2-393  Sub-41 3,4-diClPh CH₂ Single bond Sub-9  2-394  Sub-41 3,4-diClPh CH₂ Single bond Sub-10 2-395  Sub-41 3,4-diClPh CH₂ Single bond Sub-11 2-396  Sub-41 3,4-diClPh CH₂ Single bond Sub-12 2-397  Sub-41 3,4-diClPh CH₂ Single bond Sub-13 2-398  Sub-41 3,4-diClPh CH₂ Single bond Sub-14 2-399  Sub-41 3,4-diClPh CH₂ Single bond Sub-15 2-400  Sub-41 3,4-diClPh CH₂ Single bond Sub-16 2-401  Sub-41 3,4-diClPh CH₂ Single bond Sub-17 2-402  Sub-41 3,4-diClPh CH₂ Single bond Sub-18 2-403  Sub-41 3,4-diClPh CH₂ Single bond Sub-19 2-404  Sub-41 3,4-diClPh CH₂ Single bond Sub-20 2-405  Sub-41 3,4-diClPh CH₂ Single bond Sub-21 2-406  Sub-41 3,4-diClPh CH₂ Single bond Sub-22 2-407  Sub-41 3,4-diClPh CH₂ Single bond Sub-23 2-408  Sub-41 3,4-diClPh CH₂ Single bond Sub-24 2-409  Sub-41 3,4-diClPh CH₂ Single bond Sub-25 2-410  Sub-41 3,4-diClPh CH₂ Single bond Sub-26 2-411  Sub-41 3,4-diClPh CH₂ Single bond Sub-27 2-412  Sub-41 3,4-diClPh CH₂ Single bond Sub-28 2-413  Sub-41 3,4-diClPh CH₂ Single bond Sub-29 2-414  Sub-41 3,4-diClPh CH₂ Single bond Sub-30 2-415  Sub-41 3,4-diClPh CH₂ Single bond Sub-31 2-416  Sub-41 3,4-diClPh CH₂ Single bond Sub-32 2-417  Sub-41 3,4-diClPh CH₂ Single bond Sub-65 2-418  Sub-41 3,4-diClPh CH₂ Single bond Sub-66 2-419  Sub-41 3,4-diClPh CH₂ Single bond Sub-67 2-420  Sub-41 3,4-diClPh CH₂ Single bond Sub-68 2-421  Sub-41 3,4-diClPh CH₂ Single bond Sub-69 2-422  Sub-41 3,4-diClPh CH₂ Single bond Sub-70 2-423  Sub-41 3,4-diClPh CH₂ Single bond Sub-71 2-424  Sub-41 3,4-diClPh CH₂ Single bond Sub-72 2-425  Sub-41 3,4-diClPh CH₂ Single bond Sub-73 2-426  Sub-41 3,4-diClPh CH₂ Single bond Sub-74 2-427  Sub-41 3,4-diClPh CH₂ Single bond Sub-75 2-428  Sub-41 3,4-diClPh CH₂ Single bond Sub-76 2-429  Sub-41 3,4-diClPh CH₂ Single bond Sub-77 2-430  Sub-41 3,4-diClPh CH₂ Single bond Sub-78 2-431  Sub-41 3,4-diClPh CH₂ Single bond Sub-79 2-432  Sub-41 3,4-diClPh CH₂ Single bond Sub-80 2-433  Sub-42 3,4-diClPh CH₂ Single bond Sub-1  2-434  Sub-42 3,4-diClPh CH₂ Single bond Sub-2  2-435  Sub-42 3,4-diClPh CH₂ Single bond Sub-3  2-436  Sub-42 3,4-diClPh CH₂ Single bond Sub-4  2-437  Sub-42 3,4-diClPh CH₂ Single bond Sub-5  2-438  Sub-42 3,4-diClPh CH₂ Single bond Sub-6  2-439  Sub-42 3,4-diClPh CH₂ Single bond Sub-7  2-440  Sub-42 3,4-diClPh CH₂ Single bond Sub-8  2-441  Sub-42 3,4-diClPh CH₂ Single bond Sub-9  2-442  Sub-42 3,4-diClPh CH₂ Single bond Sub-10 2-443  Sub-42 3,4-diClPh CH₂ Single bond Sub-11 2-444  Sub-42 3,4-diClPh CH₂ Single bond Sub-12 2-445  Sub-42 3,4-diClPh CH₂ Single bond Sub-13 2-446  Sub-42 3,4-diClPh CH₂ Single bond Sub-14 2-447  Sub-42 3,4-diClPh CH₂ Single bond Sub-15 2-448  Sub-42 3,4-diClPh CH₂ Single bond Sub-16 2-449  Sub-42 3,4-diClPh CH₂ Single bond Sub-17 2-450  Sub-42 3,4-diClPh CH₂ Single bond Sub-18 2-451  Sub-42 3,4-diClPh CH₂ Single bond Sub-19 2-452  Sub-42 3,4-diClPh CH₂ Single bond Sub-20 2-453  Sub-42 3,4-diClPh CH₂ Single bond Sub-21 2-454  Sub-42 3,4-diClPh CH₂ Single bond Sub-22 2-455  Sub-42 3,4-diClPh CH₂ Single bond Sub-23 2-456  Sub-42 3,4-diClPh CH₂ Single bond Sub-24 2-457  Sub-42 3,4-diClPh CH₂ Single bond Sub-25 2-458  Sub-42 3,4-diClPh CH₂ Single bond Sub-26 2-459  Sub-42 3,4-diClPh CH₂ Single bond Sub-27 2-460  Sub-42 3,4-diClPh CH₂ Single bond Sub-28 2-461  Sub-42 3,4-diClPh CH₂ Single bond Sub-29 2-462  Sub-42 3,4-diClPh CH₂ Single bond Sub-30 2-463  Sub-42 3,4-diClPh CH₂ Single bond Sub-31 2-464  Sub-42 3,4-diClPh CH₂ Single bond Sub-32 2-465  Sub-42 3,4-diClPh CH₂ Single bond Sub-65 2-466  Sub-42 3,4-diClPh CH₂ Single bond Sub-66 2-467  Sub-42 3,4-diClPh CH₂ Single bond Sub-67 2-468  Sub-42 3,4-diClPh CH₂ Single bond Sub-68 2-469  Sub-42 3,4-diClPh CH₂ Single bond Sub-69 2-470  Sub-42 3,4-diClPh CH₂ Single bond Sub-70 2-471  Sub-42 3,4-diClPh CH₂ Single bond Sub-71 2-472  Sub-42 3,4-diClPh CH₂ Single bond Sub-72 2-473  Sub-42 3,4-diClPh CH₂ Single bond Sub-73 2-474  Sub-42 3,4-diClPh CH₂ Single bond Sub-74 2-475  Sub-42 3,4-diClPh CH₂ Single bond Sub-75 2-476  Sub-42 3,4-diClPh CH₂ Single bond Sub-76 2-477  Sub-42 3,4-diClPh CH₂ Single bond Sub-77 2-478  Sub-42 3,4-diClPh CH₂ Single bond Sub-78 2-479  Sub-42 3,4-diClPh CH₂ Single bond Sub-79 2-480  Sub-42 3,4-diClPh CH₂ Single bond Sub-80 2-481  Sub-43 3,4-diClPh CH₂ Single bond Sub-1  2-482  Sub-43 3,4-diClPh CH₂ Single bond Sub-2  2-483  Sub-43 3,4-diClPh CH₂ Single bond Sub-3  2-484  Sub-43 3,4-diClPh CH₂ Single bond Sub-4  2-485  Sub-43 3,4-diClPh CH₂ Single bond Sub-5  2-486  Sub-43 3,4-diClPh CH₂ Single bond Sub-6  2-487  Sub-43 3,4-diClPh CH₂ Single bond Sub-7  2-488  Sub-43 3,4-diClPh CH₂ Single bond Sub-8  2-489  Sub-43 3,4-diClPh CH₂ Single bond Sub-9  2-490  Sub-43 3,4-diClPh CH₂ Single bond Sub-10 2-491  Sub-43 3,4-diClPh CH₂ Single bond Sub-11 2-492  Sub-43 3,4-diClPh CH₂ Single bond Sub-12 2-493  Sub-43 3,4-diClPh CH₂ Single bond Sub-13 2-494  Sub-43 3,4-diClPh CH₂ Single bond Sub-14 2-495  Sub-43 3,4-diClPh CH₂ Single bond Sub-15 2-496  Sub-43 3,4-diClPh CH₂ Single bond Sub-16 2-497  Sub-43 3,4-diClPh CH₂ Single bond Sub-17 2-498  Sub-43 3,4-diClPh CH₂ Single bond Sub-18 2-499  Sub-43 3,4-diClPh CH₂ Single bond Sub-19 2-500  Sub-43 3,4-diClPh CH₂ Single bond Sub-20 2-501  Sub-43 3,4-diClPh CH₂ Single bond Sub-21 2-502  Sub-43 3,4-diClPh CH₂ Single bond Sub-22 2-503  Sub-43 3,4-diClPh CH₂ Single bond Sub-23 2-504  Sub-43 3,4-diClPh CH₂ Single bond Sub-24 2-505  Sub-43 3,4-diClPh CH₂ Single bond Sub-25 2-506  Sub-43 3,4-diClPh CH₂ Single bond Sub-26 2-507  Sub-43 3,4-diClPh CH₂ Single bond Sub-27 2-508  Sub-43 3,4-diClPh CH₂ Single bond Sub-28 2-509  Sub-43 3,4-diClPh CH₂ Single bond Sub-29 2-510  Sub-43 3,4-diClPh CH₂ Single bond Sub-30 2-511  Sub-43 3,4-diClPh CH₂ Single bond Sub-31 2-512  Sub-43 3,4-diClPh CH₂ Single bond Sub-32 2-513  Sub-43 3,4-diClPh CH₂ Single bond Sub-65 2-514  Sub-43 3,4-diClPh CH₂ Single bond Sub-66 2-515  Sub-43 3,4-diClPh CH₂ Single bond Sub-67 2-516  Sub-43 3,4-diClPh CH₂ Single bond Sub-68 2-517  Sub-43 3,4-diClPh CH₂ Single bond Sub-69 2-518  Sub-43 3,4-diClPh CH₂ Single bond Sub-70 2-519  Sub-43 3,4-diClPh CH₂ Single bond Sub-71 2-520  Sub-43 3,4-diClPh CH₂ Single bond Sub-72 2-521  Sub-43 3,4-diClPh CH₂ Single bond Sub-73 2-522  Sub-43 3,4-diClPh CH₂ Single bond Sub-74 2-523  Sub-43 3,4-diClPh CH₂ Single bond Sub-75 2-524  Sub-43 3,4-diClPh CH₂ Single bond Sub-76 2-525  Sub-43 3,4-diClPh CH₂ Single bond Sub-77 2-526  Sub-43 3,4-diClPh CH₂ Single bond Sub-78 2-527  Sub-43 3,4-diClPh CH₂ Single bond Sub-79 2-528  Sub-43 3,4-diClPh CH₂ Single bond Sub-80 2-529  Sub-44 3,4-diClPh CH₂ Single bond Sub-1  2-530  Sub-44 3,4-diClPh CH₂ Single bond Sub-2  2-531  Sub-44 3,4-diClPh CH₂ Single bond Sub-3  2-532  Sub-44 3,4-diClPh CH₂ Single bond Sub-4  2-533  Sub-44 3,4-diClPh CH₂ Single bond Sub-5  2-534  Sub-44 3,4-diClPh CH₂ Single bond Sub-6  2-535  Sub-44 3,4-diClPh CH₂ Single bond Sub-7  2-536  Sub-44 3,4-diClPh CH₂ Single bond Sub-8  2-537  Sub-44 3,4-diClPh CH₂ Single bond Sub-9  2-538  Sub-44 3,4-diClPh CH₂ Single bond Sub-10 2-539  Sub-44 3,4-diClPh CH₂ Single bond Sub-11 2-540  Sub-44 3,4-diClPh CH₂ Single bond Sub-12 2-541  Sub-44 3,4-diClPh CH₂ Single bond Sub-13 2-542  Sub-44 3,4-diClPh CH₂ Single bond Sub-14 2-543  Sub-44 3,4-diClPh CH₂ Single bond Sub-15 2-544  Sub-44 3,4-diClPh CH₂ Single bond Sub-16 2-545  Sub-44 3,4-diClPh CH₂ Single bond Sub-17 2-546  Sub-44 3,4-diClPh CH₂ Single bond Sub-18 2-547  Sub-44 3,4-diClPh CH₂ Single bond Sub-19 2-548  Sub-44 3,4-diClPh CH₂ Single bond Sub-20 2-549  Sub-44 3,4-diClPh CH₂ Single bond Sub-21 2-550  Sub-44 3,4-diClPh CH₂ Single bond Sub-22 2-551  Sub-44 3,4-diClPh CH₂ Single bond Sub-23 2-552  Sub-44 3,4-diClPh CH₂ Single bond Sub-24 2-553  Sub-44 3,4-diClPh CH₂ Single bond Sub-25 2-554  Sub-44 3,4-diClPh CH₂ Single bond Sub-26 2-555  Sub-44 3,4-diClPh CH₂ Single bond Sub-27 2-556  Sub-44 3,4-diClPh CH₂ Single bond Sub-28 2-557  Sub-44 3,4-diClPh CH₂ Single bond Sub-29 2-558  Sub-44 3,4-diClPh CH₂ Single bond Sub-30 2-559  Sub-44 3,4-diClPh CH₂ Single bond Sub-31 2-560  Sub-44 3,4-diClPh CH₂ Single bond Sub-32 2-561  Sub-44 3,4-diClPh CH₂ Single bond Sub-65 2-562  Sub-44 3,4-diClPh CH₂ Single bond Sub-66 2-563  Sub-44 3,4-diClPh CH₂ Single bond Sub-67 2-564  Sub-44 3,4-diClPh CH₂ Single bond Sub-68 2-565  Sub-44 3,4-diClPh CH₂ Single bond Sub-69 2-566  Sub-44 3,4-diClPh CH₂ Single bond Sub-70 2-567  Sub-44 3,4-diClPh CH₂ Single bond Sub-71 2-568  Sub-44 3,4-diClPh CH₂ Single bond Sub-72 2-569  Sub-44 3,4-diClPh CH₂ Single bond Sub-73 2-570  Sub-44 3,4-diClPh CH₂ Single bond Sub-74 2-571  Sub-44 3,4-diClPh CH₂ Single bond Sub-75 2-572  Sub-44 3,4-diClPh CH₂ Single bond Sub-76 2-573  Sub-44 3,4-diClPh CH₂ Single bond Sub-77 2-574  Sub-44 3,4-diClPh CH₂ Single bond Sub-78 2-575  Sub-44 3,4-diClPh CH₂ Single bond Sub-79 2-576  Sub-44 3,4-diClPh CH₂ Single bond Sub-80 2-577  Sub-45 3,4-diClPh CH₂ Single bond Sub-1  2-578  Sub-45 3,4-diClPh CH₂ Single bond Sub-2  2-579  Sub-45 3,4-diClPh CH₂ Single bond Sub-3  2-580  Sub-45 3,4-diClPh CH₂ Single bond Sub-4  2-581  Sub-45 3,4-diClPh CH₂ Single bond Sub-5  2-582  Sub-45 3,4-diClPh CH₂ Single bond Sub-6  2-583  Sub-45 3,4-diClPh CH₂ Single bond Sub-7  2-584  Sub-45 3,4-diClPh CH₂ Single bond Sub-8  2-585  Sub-45 3,4-diClPh CH₂ Single bond Sub-9  2-586  Sub-45 3,4-diClPh CH₂ Single bond Sub-10 2-587  Sub-45 3,4-diClPh CH₂ Single bond Sub-11 2-588  Sub-45 3,4-diClPh CH₂ Single bond Sub-12 2-589  Sub-45 3,4-diClPh CH₂ Single bond Sub-13 2-590  Sub-45 3,4-diClPh CH₂ Single bond Sub-14 2-591  Sub-45 3,4-diClPh CH₂ Single bond Sub-15 2-592  Sub-45 3,4-diClPh CH₂ Single bond Sub-16 2-593  Sub-45 3,4-diClPh CH₂ Single bond Sub-17 2-594  Sub-45 3,4-diClPh CH₂ Single bond Sub-18 2-595  Sub-45 3,4-diClPh CH₂ Single bond Sub-19 2-596  Sub-45 3,4-diClPh CH₂ Single bond Sub-20 2-597  Sub-45 3,4-diClPh CH₂ Single bond Sub-21 2-598  Sub-45 3,4-diClPh CH₂ Single bond Sub-22 2-599  Sub-45 3,4-diClPh CH₂ Single bond Sub-23 2-600  Sub-45 3,4-diClPh CH₂ Single bond Sub-24 2-601  Sub-45 3,4-diClPh CH₂ Single bond Sub-25 2-602  Sub-45 3,4-diClPh CH₂ Single bond Sub-26 2-603  Sub-45 3,4-diClPh CH₂ Single bond Sub-27 2-604  Sub-45 3,4-diClPh CH₂ Single bond Sub-28 2-605  Sub-45 3,4-diClPh CH₂ Single bond Sub-29 2-606  Sub-45 3,4-diClPh CH₂ Single bond Sub-30 2-607  Sub-45 3,4-diClPh CH₂ Single bond Sub-31 2-608  Sub-45 3,4-diClPh CH₂ Single bond Sub-32 2-609  Sub-45 3,4-diClPh CH₂ Single bond Sub-65 2-610  Sub-45 3,4-diClPh CH₂ Single bond Sub-66 2-611  Sub-45 3,4-diClPh CH₂ Single bond Sub-67 2-612  Sub-45 3,4-diClPh CH₂ Single bond Sub-68 2-613  Sub-45 3,4-diClPh CH₂ Single bond Sub-69 2-614  Sub-45 3,4-diClPh CH₂ Single bond Sub-70 2-615  Sub-45 3,4-diClPh CH₂ Single bond Sub-71 2-616  Sub-45 3,4-diClPh CH₂ Single bond Sub-72 2-617  Sub-45 3,4-diClPh CH₂ Single bond Sub-73 2-618  Sub-45 3,4-diClPh CH₂ Single bond Sub-74 2-619  Sub-45 3,4-diClPh CH₂ Single bond Sub-75 2-620  Sub-45 3,4-diClPh CH₂ Single bond Sub-76 2-621  Sub-45 3,4-diClPh CH₂ Single bond Sub-77 2-622  Sub-45 3,4-diClPh CH₂ Single bond Sub-78 2-623  Sub-45 3,4-diClPh CH₂ Single bond Sub-79 2-624  Sub-45 3,4-diClPh CH₂ Single bond Sub-80 2-625  Sub-46 3,4-diClPh CH₂ Single bond Sub-1  2-626  Sub-46 3,4-diClPh CH₂ Single bond Sub-2  2-627  Sub-46 3,4-diClPh CH₂ Single bond Sub-3  2-628  Sub-46 3,4-diClPh CH₂ Single bond Sub-4  2-629  Sub-46 3,4-diClPh CH₂ Single bond Sub-5  2-630  Sub-46 3,4-diClPh CH₂ Single bond Sub-6  2-631  Sub-46 3,4-diClPh CH₂ Single bond Sub-7  2-632  Sub-46 3,4-diClPh CH₂ Single bond Sub-8  2-633  Sub-46 3,4-diClPh CH₂ Single bond Sub-9  2-634  Sub-46 3,4-diClPh CH₂ Single bond Sub-10 2-635  Sub-46 3,4-diClPh CH₂ Single bond Sub-11 2-636  Sub-46 3,4-diClPh CH₂ Single bond Sub-12 2-637  Sub-46 3,4-diClPh CH₂ Single bond Sub-13 2-638  Sub-46 3,4-diClPh CH₂ Single bond Sub-14 2-639  Sub-46 3,4-diClPh CH₂ Single bond Sub-15 2-640  Sub-46 3,4-diClPh CH₂ Single bond Sub-16 2-641  Sub-46 3,4-diClPh CH₂ Single bond Sub-17 2-642  Sub-46 3,4-diClPh CH₂ Single bond Sub-18 2-643  Sub-46 3,4-diClPh CH₂ Single bond Sub-19 2-644  Sub-46 3,4-diClPh CH₂ Single bond Sub-20 2-645  Sub-46 3,4-diClPh CH₂ Single bond Sub-21 2-646  Sub-46 3,4-diClPh CH₂ Single bond Sub-22 2-647  Sub-46 3,4-diClPh CH₂ Single bond Sub-23 2-648  Sub-46 3,4-diClPh CH₂ Single bond Sub-24 2-649  Sub-46 3,4-diClPh CH₂ Single bond Sub-25 2-650  Sub-46 3,4-diClPh CH₂ Single bond Sub-26 2-651  Sub-46 3,4-diClPh CH₂ Single bond Sub-27 2-652  Sub-46 3,4-diClPh CH₂ Single bond Sub-28 2-653  Sub-46 3,4-diClPh CH₂ Single bond Sub-29 2-654  Sub-46 3,4-diClPh CH₂ Single bond Sub-30 2-655  Sub-46 3,4-diClPh CH₂ Single bond Sub-31 2-656  Sub-46 3,4-diClPh CH₂ Single bond Sub-32 2-657  Sub-46 3,4-diClPh CH₂ Single bond Sub-65 2-658  Sub-46 3,4-diClPh CH₂ Single bond Sub-66 2-659  Sub-46 3,4-diClPh CH₂ Single bond Sub-67 2-660  Sub-46 3,4-diClPh CH₂ Single bond Sub-68 2-661  Sub-46 3,4-diClPh CH₂ Single bond Sub-69 2-662  Sub-46 3,4-diClPh CH₂ Single bond Sub-70 2-663  Sub-46 3,4-diClPh CH₂ Single bond Sub-71 2-664  Sub-46 3,4-diClPh CH₂ Single bond Sub-72 2-665  Sub-46 3,4-diClPh CH₂ Single bond Sub-73 2-666  Sub-46 3,4-diClPh CH₂ Single bond Sub-74 2-667  Sub-46 3,4-diClPh CH₂ Single bond Sub-75 2-668  Sub-46 3,4-diClPh CH₂ Single bond Sub-76 2-669  Sub-46 3,4-diClPh CH₂ Single bond Sub-77 2-670  Sub-46 3,4-diClPh CH₂ Single bond Sub-78 2-671  Sub-46 3,4-diClPh CH₂ Single bond Sub-79 2-672  Sub-46 3,4-diClPh CH₂ Single bond Sub-80 2-673  Sub-47 3,4-diClPh CH₂ Single bond Sub-1  2-674  Sub-47 3,4-diClPh CH₂ Single bond Sub-2  2-675  Sub-47 3,4-diClPh CH₂ Single bond Sub-3  2-676  Sub-47 3,4-diClPh CH₂ Single bond Sub-4  2-677  Sub-47 3,4-diClPh CH₂ Single bond Sub-5  2-678  Sub-47 3,4-diClPh CH₂ Single bond Sub-6  2-679  Sub-47 3,4-diClPh CH₂ Single bond Sub-7  2-680  Sub-47 3,4-diClPh CH₂ Single bond Sub-8  2-681  Sub-47 3,4-diClPh CH₂ Single bond Sub-9  2-682  Sub-47 3,4-diClPh CH₂ Single bond Sub-10 2-683  Sub-47 3,4-diClPh CH₂ Single bond Sub-11 2-684  Sub-47 3,4-diClPh CH₂ Single bond Sub-12 2-685  Sub-47 3,4-diClPh CH₂ Single bond Sub-13 2-686  Sub-47 3,4-diClPh CH₂ Single bond Sub-14 2-687  Sub-47 3,4-diClPh CH₂ Single bond Sub-15 2-688  Sub-47 3,4-diClPh CH₂ Single bond Sub-16 2-689  Sub-47 3,4-diClPh CH₂ Single bond Sub-17 2-690  Sub-47 3,4-diClPh CH₂ Single bond Sub-18 2-691  Sub-47 3,4-diClPh CH₂ Single bond Sub-19 2-692  Sub-47 3,4-diClPh CH₂ Single bond Sub-20 2-693  Sub-47 3,4-diClPh CH₂ Single bond Sub-21 2-694  Sub-47 3,4-diClPh CH₂ Single bond Sub-22 2-695  Sub-47 3,4-diClPh CH₂ Single bond Sub-23 2-696  Sub-47 3,4-diClPh CH₂ Single bond Sub-24 2-697  Sub-47 3,4-diClPh CH₂ Single bond Sub-25 2-698  Sub-47 3,4-diClPh CH₂ Single bond Sub-26 2-699  Sub-47 3,4-diClPh CH₂ Single bond Sub-27 2-700  Sub-47 3,4-diClPh CH₂ Single bond Sub-28 2-701  Sub-47 3,4-diClPh CH₂ Single bond Sub-29 2-702  Sub-47 3,4-diClPh CH₂ Single bond Sub-30 2-703  Sub-47 3,4-diClPh CH₂ Single bond Sub-31 2-704  Sub-47 3,4-diClPh CH₂ Single bond Sub-32 2-705  Sub-47 3,4-diClPh CH₂ Single bond Sub-65 2-706  Sub-47 3,4-diClPh CH₂ Single bond Sub-66 2-707  Sub-47 3,4-diClPh CH₂ Single bond Sub-67 2-708  Sub-47 3,4-diClPh CH₂ Single bond Sub-68 2-709  Sub-47 3,4-diClPh CH₂ Single bond Sub-69 2-710  Sub-47 3,4-diClPh CH₂ Single bond Sub-70 2-711  Sub-47 3,4-diClPh CH₂ Single bond Sub-71 2-712  Sub-47 3,4-diClPh CH₂ Single bond Sub-72 2-713  Sub-47 3,4-diClPh CH₂ Single bond Sub-73 2-714  Sub-47 3,4-diClPh CH₂ Single bond Sub-74 2-715  Sub-47 3,4-diClPh CH₂ Single bond Sub-75 2-716  Sub-47 3,4-diClPh CH₂ Single bond Sub-76 2-717  Sub-47 3,4-diClPh CH₂ Single bond Sub-77 2-718  Sub-47 3,4-diClPh CH₂ Single bond Sub-78 2-719  Sub-47 3,4-diClPh CH₂ Single bond Sub-79 2-720  Sub-47 3,4-diClPh CH₂ Single bond Sub-80 2-721  Sub-81 3,4-diClPh CH₂ Single bond Sub-1  2-722  Sub-81 3,4-diClPh CH₂ Single bond Sub-2  2-723  Sub-81 3,4-diClPh CH₂ Single bond Sub-3  2-724  Sub-81 3,4-diClPh CH₂ Single bond Sub-4  2-725  Sub-81 3,4-diClPh CH₂ Single bond Sub-5  2-726  Sub-81 3,4-diClPh CH₂ Single bond Sub-6  2-727  Sub-81 3,4-diClPh CH₂ Single bond Sub-7  2-728  Sub-81 3,4-diClPh CH₂ Single bond Sub-8  2-729  Sub-81 3,4-diClPh CH₂ Single bond Sub-9  2-730  Sub-81 3,4-diClPh CH₂ Single bond Sub-10 2-731  Sub-81 3,4-diClPh CH₂ Single bond Sub-11 2-732  Sub-81 3,4-diClPh CH₂ Single bond Sub-12 2-733  Sub-81 3,4-diClPh CH₂ Single bond Sub-13 2-734  Sub-81 3,4-diClPh CH₂ Single bond Sub-14 2-735  Sub-81 3,4-diClPh CH₂ Single bond Sub-15 2-736  Sub-81 3,4-diClPh CH₂ Single bond Sub-16 2-737  Sub-81 3,4-diClPh CH₂ Single bond Sub-17 2-738  Sub-81 3,4-diClPh CH₂ Single bond Sub-18 2-739  Sub-81 3,4-diClPh CH₂ Single bond Sub-19 2-740  Sub-81 3,4-diClPh CH₂ Single bond Sub-20 2-741  Sub-81 3,4-diClPh CH₂ Single bond Sub-21 2-742  Sub-81 3,4-diClPh CH₂ Single bond Sub-22 2-743  Sub-81 3,4-diClPh CH₂ Single bond Sub-23 2-744  Sub-81 3,4-diClPh CH₂ Single bond Sub-24 2-745  Sub-81 3,4-diClPh CH₂ Single bond Sub-25 2-746  Sub-81 3,4-diClPh CH₂ Single bond Sub-26 2-747  Sub-81 3,4-diClPh CH₂ Single bond Sub-27 2-748  Sub-81 3,4-diClPh CH₂ Single bond Sub-28 2-749  Sub-81 3,4-diClPh CH₂ Single bond Sub-29 2-750  Sub-81 3,4-diClPh CH₂ Single bond Sub-30 2-751  Sub-81 3,4-diClPh CH₂ Single bond Sub-31 2-752  Sub-81 3,4-diClPh CH₂ Single bond Sub-32 2-753  Sub-81 3,4-diClPh CH₂ Single bond Sub-65 2-754  Sub-81 3,4-diClPh CH₂ Single bond Sub-66 2-755  Sub-81 3,4-diClPh CH₂ Single bond Sub-67 2-756  Sub-81 3,4-diClPh CH₂ Single bond Sub-68 2-757  Sub-81 3,4-diClPh CH₂ Single bond Sub-69 2-758  Sub-81 3,4-diClPh CH₂ Single bond Sub-70 2-759  Sub-81 3,4-diClPh CH₂ Single bond Sub-71 2-760  Sub-81 3,4-diClPh CH₂ Single bond Sub-72 2-761  Sub-81 3,4-diClPh CH₂ Single bond Sub-73 2-762  Sub-81 3,4-diClPh CH₂ Single bond Sub-74 2-763  Sub-81 3,4-diClPh CH₂ Single bond Sub-75 2-764  Sub-81 3,4-diClPh CH₂ Single bond Sub-76 2-765  Sub-81 3,4-diClPh CH₂ Single bond Sub-77 2-766  Sub-81 3,4-diClPh CH₂ Single bond Sub-78 2-767  Sub-81 3,4-diClPh CH₂ Single bond Sub-79 2-768  Sub-81 3,4-diClPh CH₂ Single bond Sub-80 2-769  Sub-48 3,4-diClPh CH₂ Single bond Sub-1  2-770  Sub-48 3,4-diClPh CH₂ Single bond Sub-2  2-771  Sub-48 3,4-diClPh CH₂ Single bond Sub-3  2-772  Sub-48 3,4-diClPh CH₂ Single bond Sub-4  2-773  Sub-48 3,4-diClPh CH₂ Single bond Sub-5  2-774  Sub-48 3,4-diClPh CH₂ Single bond Sub-6  2-775  Sub-48 3,4-diClPh CH₂ Single bond Sub-7  2-776  Sub-48 3,4-diClPh CH₂ Single bond Sub-8  2-777  Sub-48 3,4-diClPh CH₂ Single bond Sub-9  2-778  Sub-48 3,4-diClPh CH₂ Single bond Sub-10 2-779  Sub-48 3,4-diClPh CH₂ Single bond Sub-11 2-780  Sub-48 3,4-diClPh CH₂ Single bond Sub-12 2-781  Sub-48 3,4-diClPh CH₂ Single bond Sub-13 2-782  Sub-48 3,4-diClPh CH₂ Single bond Sub-14 2-783  Sub-48 3,4-diClPh CH₂ Single bond Sub-15 2-784  Sub-48 3,4-diClPh CH₂ Single bond Sub-16 2-785  Sub-48 3,4-diClPh CH₂ Single bond Sub-17 2-786  Sub-48 3,4-diClPh CH₂ Single bond Sub-18 2-787  Sub-48 3,4-diClPh CH₂ Single bond Sub-19 2-788  Sub-48 3,4-diClPh CH₂ Single bond Sub-20 2-789  Sub-48 3,4-diClPh CH₂ Single bond Sub-21 2-790  Sub-48 3,4-diClPh CH₂ Single bond Sub-22 2-791  Sub-48 3,4-diClPh CH₂ Single bond Sub-23 2-792  Sub-48 3,4-diClPh CH₂ Single bond Sub-24 2-793  Sub-48 3,4-diClPh CH₂ Single bond Sub-25 2-794  Sub-48 3,4-diClPh CH₂ Single bond Sub-26 2-795  Sub-48 3,4-diClPh CH₂ Single bond Sub-27 2-796  Sub-48 3,4-diClPh CH₂ Single bond Sub-28 2-797  Sub-48 3,4-diClPh CH₂ Single bond Sub-29 2-798  Sub-48 3,4-diClPh CH₂ Single bond Sub-30 2-799  Sub-48 3,4-diClPh CH₂ Single bond Sub-31 2-800  Sub-48 3,4-diClPh CH₂ Single bond Sub-32 2-801  Sub-48 3,4-diClPh CH₂ Single bond Sub-65 2-802  Sub-48 3,4-diClPh CH₂ Single bond Sub-66 2-803  Sub-48 3,4-diClPh CH₂ Single bond Sub-67 2-804  Sub-48 3,4-diClPh CH₂ Single bond Sub-68 2-805  Sub-48 3,4-diClPh CH₂ Single bond Sub-69 2-806  Sub-48 3,4-diClPh CH₂ Single bond Sub-70 2-807  Sub-48 3,4-diClPh CH₂ Single bond Sub-71 2-808  Sub-48 3,4-diClPh CH₂ Single bond Sub-72 2-809  Sub-48 3,4-diClPh CH₂ Single bond Sub-73 2-810  Sub-48 3,4-diClPh CH₂ Single bond Sub-74 2-811  Sub-48 3,4-diClPh CH₂ Single bond Sub-75 2-812  Sub-48 3,4-diClPh CH₂ Single bond Sub-76 2-813  Sub-48 3,4-diClPh CH₂ Single bond Sub-77 2-814  Sub-48 3,4-diClPh CH₂ Single bond Sub-78 2-815  Sub-48 3,4-diClPh CH₂ Single bond Sub-79 2-816  Sub-48 3,4-diClPh CH₂ Single bond Sub-80 2-817  Sub-49 3,4-diClPh CH₂ Single bond Sub-1  2-818  Sub-49 3,4-diClPh CH₂ Single bond Sub-2  2-819  Sub-49 3,4-diClPh CH₂ Single bond Sub-3  2-820  Sub-49 3,4-diClPh CH₂ Single bond Sub-4  2-821  Sub-49 3,4-diClPh CH₂ Single bond Sub-5  2-822  Sub-49 3,4-diClPh CH₂ Single bond Sub-6  2-823  Sub-49 3,4-diClPh CH₂ Single bond Sub-7  2-824  Sub-49 3,4-diClPh CH₂ Single bond Sub-8  2-825  Sub-49 3,4-diClPh CH₂ Single bond Sub-9  2-826  Sub-49 3,4-diClPh CH₂ Single bond Sub-10 2-827  Sub-49 3,4-diClPh CH₂ Single bond Sub-11 2-828  Sub-49 3,4-diClPh CH₂ Single bond Sub-12 2-829  Sub-49 3,4-diClPh CH₂ Single bond Sub-13 2-830  Sub-49 3,4-diClPh CH₂ Single bond Sub-14 2-831  Sub-49 3,4-diClPh CH₂ Single bond Sub-15 2-832  Sub-49 3,4-diClPh CH₂ Single bond Sub-16 2-833  Sub-49 3,4-diClPh CH₂ Single bond Sub-17 2-834  Sub-49 3,4-diClPh CH₂ Single bond Sub-18 2-835  Sub-49 3,4-diClPh CH₂ Single bond Sub-19 2-836  Sub-49 3,4-diClPh CH₂ Single bond Sub-20 2-837  Sub-49 3,4-diClPh CH₂ Single bond Sub-21 2-838  Sub-49 3,4-diClPh CH₂ Single bond Sub-22 2-839  Sub-49 3,4-diClPh CH₂ Single bond Sub-23 2-840  Sub-49 3,4-diClPh CH₂ Single bond Sub-24 2-841  Sub-49 3,4-diClPh CH₂ Single bond Sub-25 2-842  Sub-49 3,4-diClPh CH₂ Single bond Sub-26 2-843  Sub-49 3,4-diClPh CH₂ Single bond Sub-27 2-844  Sub-49 3,4-diClPh CH₂ Single bond Sub-28 2-845  Sub-49 3,4-diClPh CH₂ Single bond Sub-29 2-846  Sub-49 3,4-diClPh CH₂ Single bond Sub-30 2-847  Sub-49 3,4-diClPh CH₂ Single bond Sub-31 2-848  Sub-49 3,4-diClPh CH₂ Single bond Sub-32 2-849  Sub-49 3,4-diClPh CH₂ Single bond Sub-65 2-850  Sub-49 3,4-diClPh CH₂ Single bond Sub-66 2-851  Sub-49 3,4-diClPh CH₂ Single bond Sub-67 2-852  Sub-49 3,4-diClPh CH₂ Single bond Sub-68 2-853  Sub-49 3,4-diClPh CH₂ Single bond Sub-69 2-854  Sub-49 3,4-diClPh CH₂ Single bond Sub-70 2-855  Sub-49 3,4-diClPh CH₂ Single bond Sub-71 2-856  Sub-49 3,4-diClPh CH₂ Single bond Sub-72 2-857  Sub-49 3,4-diClPh CH₂ Single bond Sub-73 2-858  Sub-49 3,4-diClPh CH₂ Single bond Sub-74 2-859  Sub-49 3,4-diClPh CH₂ Single bond Sub-75 2-860  Sub-49 3,4-diClPh CH₂ Single bond Sub-76 2-861  Sub-49 3,4-diClPh CH₂ Single bond Sub-77 2-862  Sub-49 3,4-diClPh CH₂ Single bond Sub-78 2-863  Sub-49 3,4-diClPh CH₂ Single bond Sub-79 2-864  Sub-49 3,4-diClPh CH₂ Single bond Sub-80 2-865  Sub-50 3,4-diClPh CH₂ Single bond Sub-1  2-866  Sub-50 3,4-diClPh CH₂ Single bond Sub-2  2-867  Sub-50 3,4-diClPh CH₂ Single bond Sub-3  2-868  Sub-50 3,4-diClPh CH₂ Single bond Sub-4  2-869  Sub-50 3,4-diClPh CH₂ Single bond Sub-5  2-870  Sub-50 3,4-diClPh CH₂ Single bond Sub-6  2-871  Sub-50 3,4-diClPh CH₂ Single bond Sub-7  2-872  Sub-50 3,4-diClPh CH₂ Single bond Sub-8  2-873  Sub-50 3,4-diClPh CH₂ Single bond Sub-9  2-874  Sub-50 3,4-diClPh CH₂ Single bond Sub-10 2-875  Sub-50 3,4-diClPh CH₂ Single bond Sub-11 2-876  Sub-50 3,4-diClPh CH₂ Single bond Sub-12 2-877  Sub-50 3,4-diClPh CH₂ Single bond Sub-13 2-878  Sub-50 3,4-diClPh CH₂ Single bond Sub-14 2-879  Sub-50 3,4-diClPh CH₂ Single bond Sub-15 2-880  Sub-50 3,4-diClPh CH₂ Single bond Sub-16 2-881  Sub-50 3,4-diClPh CH₂ Single bond Sub-17 2-882  Sub-50 3,4-diClPh CH₂ Single bond Sub-18 2-883  Sub-50 3,4-diClPh CH₂ Single bond Sub-19 2-884  Sub-50 3,4-diClPh CH₂ Single bond Sub-20 2-885  Sub-50 3,4-diClPh CH₂ Single bond Sub-21 2-886  Sub-50 3,4-diClPh CH₂ Single bond Sub-22 2-887  Sub-50 3,4-diClPh CH₂ Single bond Sub-23 2-888  Sub-50 3,4-diClPh CH₂ Single bond Sub-24 2-889  Sub-50 3,4-diClPh CH₂ Single bond Sub-25 2-890  Sub-50 3,4-diClPh CH₂ Single bond Sub-26 2-891  Sub-50 3,4-diClPh CH₂ Single bond Sub-27 2-892  Sub-50 3,4-diClPh CH₂ Single bond Sub-28 2-893  Sub-50 3,4-diClPh CH₂ Single bond Sub-29 2-894  Sub-50 3,4-diClPh CH₂ Single bond Sub-30 2-895  Sub-50 3,4-diClPh CH₂ Single bond Sub-31 2-896  Sub-50 3,4-diClPh CH₂ Single bond Sub-32 2-897  Sub-50 3,4-diClPh CH₂ Single bond Sub-65 2-898  Sub-50 3,4-diClPh CH₂ Single bond Sub-66 2-899  Sub-50 3,4-diClPh CH₂ Single bond Sub-67 2-900  Sub-50 3,4-diClPh CH₂ Single bond Sub-68 2-901  Sub-50 3,4-diClPh CH₂ Single bond Sub-69 2-902  Sub-50 3,4-diClPh CH₂ Single bond Sub-70 2-903  Sub-50 3,4-diClPh CH₂ Single bond Sub-71 2-904  Sub-50 3,4-diClPh CH₂ Single bond Sub-72 2-905  Sub-50 3,4-diClPh CH₂ Single bond Sub-73 2-906  Sub-50 3,4-diClPh CH₂ Single bond Sub-74 2-907  Sub-50 3,4-diClPh CH₂ Single bond Sub-75 2-908  Sub-50 3,4-diClPh CH₂ Single bond Sub-76 2-909  Sub-50 3,4-diClPh CH₂ Single bond Sub-77 2-910  Sub-50 3,4-diClPh CH₂ Single bond Sub-78 2-911  Sub-50 3,4-diClPh CH₂ Single bond Sub-79 2-912  Sub-50 3,4-diClPh CH₂ Single bond Sub-80 2-913  Sub-51 3,4-diClPh CH₂ Single bond Sub-1  2-914  Sub-51 3,4-diClPh CH₂ Single bond Sub-2  2-915  Sub-51 3,4-diClPh CH₂ Single bond Sub-3  2-916  Sub-51 3,4-diClPh CH₂ Single bond Sub-4  2-917  Sub-51 3,4-diClPh CH₂ Single bond Sub-5  2-918  Sub-51 3,4-diClPh CH₂ Single bond Sub-6  2-919  Sub-51 3,4-diClPh CH₂ Single bond Sub-7  2-920  Sub-51 3,4-diClPh CH₂ Single bond Sub-8  2-921  Sub-51 3,4-diClPh CH₂ Single bond Sub-9  2-922  Sub-51 3,4-diClPh CH₂ Single bond Sub-10 2-923  Sub-51 3,4-diClPh CH₂ Single bond Sub-11 2-924  Sub-51 3,4-diClPh CH₂ Single bond Sub-12 2-925  Sub-51 3,4-diClPh CH₂ Single bond Sub-13 2-926  Sub-51 3,4-diClPh CH₂ Single bond Sub-14 2-927  Sub-51 3,4-diClPh CH₂ Single bond Sub-15 2-928  Sub-51 3,4-diClPh CH₂ Single bond Sub-16 2-929  Sub-51 3,4-diClPh CH₂ Single bond Sub-17 2-930  Sub-51 3,4-diClPh CH₂ Single bond Sub-18 2-931  Sub-51 3,4-diClPh CH₂ Single bond Sub-19 2-932  Sub-51 3,4-diClPh CH₂ Single bond Sub-20 2-933  Sub-51 3,4-diClPh CH₂ Single bond Sub-21 2-934  Sub-51 3,4-diClPh CH₂ Single bond Sub-22 2-935  Sub-51 3,4-diClPh CH₂ Single bond Sub-23 2-936  Sub-51 3,4-diClPh CH₂ Single bond Sub-24 2-937  Sub-51 3,4-diClPh CH₂ Single bond Sub-25 2-938  Sub-51 3,4-diClPh CH₂ Single bond Sub-26 2-939  Sub-51 3,4-diClPh CH₂ Single bond Sub-27 2-940  Sub-51 3,4-diClPh CH₂ Single bond Sub-28 2-941  Sub-51 3,4-diClPh CH₂ Single bond Sub-29 2-942  Sub-51 3,4-diClPh CH₂ Single bond Sub-30 2-943  Sub-51 3,4-diClPh CH₂ Single bond Sub-31 2-944  Sub-51 3,4-diClPh CH₂ Single bond Sub-32 2-945  Sub-51 3,4-diClPh CH₂ Single bond Sub-65 2-946  Sub-51 3,4-diClPh CH₂ Single bond Sub-66 2-947  Sub-51 3,4-diClPh CH₂ Single bond Sub-67 2-948  Sub-51 3,4-diClPh CH₂ Single bond Sub-68 2-949  Sub-51 3,4-diClPh CH₂ Single bond Sub-69 2-950  Sub-51 3,4-diClPh CH₂ Single bond Sub-70 2-951  Sub-51 3,4-diClPh CH₂ Single bond Sub-71 2-952  Sub-51 3,4-diClPh CH₂ Single bond Sub-72 2-953  Sub-51 3,4-diClPh CH₂ Single bond Sub-73 2-954  Sub-51 3,4-diClPh CH₂ Single bond Sub-74 2-955  Sub-51 3,4-diClPh CH₂ Single bond Sub-75 2-956  Sub-51 3,4-diClPh CH₂ Single bond Sub-76 2-957  Sub-51 3,4-diClPh CH₂ Single bond Sub-77 2-958  Sub-51 3,4-diClPh CH₂ Single bond Sub-78 2-959  Sub-51 3,4-diClPh CH₂ Single bond Sub-79 2-960  Sub-51 3,4-diClPh CH₂ Single bond Sub-80 2-961  Sub-52 3,4-diClPh CH₂ Single bond Sub-1  2-962  Sub-52 3,4-diClPh CH₂ Single bond Sub-2  2-963  Sub-52 3,4-diClPh CH₂ Single bond Sub-3  2-964  Sub-52 3,4-diClPh CH₂ Single bond Sub-4  2-965  Sub-52 3,4-diClPh CH₂ Single bond Sub-5  2-966  Sub-52 3,4-diClPh CH₂ Single bond Sub-6  2-967  Sub-52 3,4-diClPh CH₂ Single bond Sub-7  2-968  Sub-52 3,4-diClPh CH₂ Single bond Sub-8  2-969  Sub-52 3,4-diClPh CH₂ Single bond Sub-9  2-970  Sub-52 3,4-diClPh CH₂ Single bond Sub-10 2-971  Sub-52 3,4-diClPh CH₂ Single bond Sub-11 2-972  Sub-52 3,4-diClPh CH₂ Single bond Sub-12 2-973  Sub-52 3,4-diClPh CH₂ Single bond Sub-13 2-974  Sub-52 3,4-diClPh CH₂ Single bond Sub-14 2-975  Sub-52 3,4-diClPh CH₂ Single bond Sub-15 2-976  Sub-52 3,4-diClPh CH₂ Single bond Sub-16 2-977  Sub-52 3,4-diClPh CH₂ Single bond Sub-17 2-978  Sub-52 3,4-diClPh CH₂ Single bond Sub-18 2-979  Sub-52 3,4-diClPh CH₂ Single bond Sub-19 2-980  Sub-52 3,4-diClPh CH₂ Single bond Sub-20 2-981  Sub-52 3,4-diClPh CH₂ Single bond Sub-21 2-982  Sub-52 3,4-diClPh CH₂ Single bond Sub-22 2-983  Sub-52 3,4-diClPh CH₂ Single bond Sub-23 2-984  Sub-52 3,4-diClPh CH₂ Single bond Sub-24 2-985  Sub-52 3,4-diClPh CH₂ Single bond Sub-25 2-986  Sub-52 3,4-diClPh CH₂ Single bond Sub-26 2-987  Sub-52 3,4-diClPh CH₂ Single bond Sub-27 2-988  Sub-52 3,4-diClPh CH₂ Single bond Sub-28 2-989  Sub-52 3,4-diClPh CH₂ Single bond Sub-29 2-990  Sub-52 3,4-diClPh CH₂ Single bond Sub-30 2-991  Sub-52 3,4-diClPh CH₂ Single bond Sub-31 2-992  Sub-52 3,4-diClPh CH₂ Single bond Sub-32 2-993  Sub-52 3,4-diClPh CH₂ Single bond Sub-65 2-994  Sub-52 3,4-diClPh CH₂ Single bond Sub-66 2-995  Sub-52 3,4-diClPh CH₂ Single bond Sub-67 2-996  Sub-52 3,4-diClPh CH₂ Single bond Sub-68 2-997  Sub-52 3,4-diClPh CH₂ Single bond Sub-69 2-998  Sub-52 3,4-diClPh CH₂ Single bond Sub-70 2-999  Sub-52 3,4-diClPh CH₂ Single bond Sub-71 2-1000 Sub-52 3,4-diClPh CH₂ Single bond Sub-72 2-1001 Sub-52 3,4-diClPh CH₂ Single bond Sub-73 2-1002 Sub-52 3,4-diClPh CH₂ Single bond Sub-74 2-1003 Sub-52 3,4-diClPh CH₂ Single bond Sub-75 2-1004 Sub-52 3,4-diClPh CH₂ Single bond Sub-76 2-1005 Sub-52 3,4-diClPh CH₂ Single bond Sub-77 2-1006 Sub-52 3,4-diClPh CH₂ Single bond Sub-78 2-1007 Sub-52 3,4-diClPh CH₂ Single bond Sub-79 2-1008 Sub-52 3,4-diClPh CH₂ Single bond Sub-80 2-1009 Sub-53 3,4-diClPh CH₂ Single bond Sub-1  2-1010 Sub-53 3,4-diClPh CH₂ Single bond Sub-2  2-1011 Sub-53 3,4-diClPh CH₂ Single bond Sub-3  2-1012 Sub-53 3,4-diClPh CH₂ Single bond Sub-4  2-1013 Sub-53 3,4-diClPh CH₂ Single bond Sub-5  2-1014 Sub-53 3,4-diClPh CH₂ Single bond Sub-6  2-1015 Sub-53 3,4-diClPh CH₂ Single bond Sub-7  2-1016 Sub-53 3,4-diClPh CH₂ Single bond Sub-8  2-1017 Sub-53 3,4-diClPh CH₂ Single bond Sub-9  2-1018 Sub-53 3,4-diClPh CH₂ Single bond Sub-10 2-1019 Sub-53 3,4-diClPh CH₂ Single bond Sub-11 2-1020 Sub-53 3,4-diClPh CH₂ Single bond Sub-12 2-1021 Sub-53 3,4-diClPh CH₂ Single bond Sub-13 2-1022 Sub-53 3,4-diClPh CH₂ Single bond Sub-14 2-1023 Sub-53 3,4-diClPh CH₂ Single bond Sub-15 2-1024 Sub-53 3,4-diClPh CH₂ Single bond Sub-16 2-1025 Sub-53 3,4-diClPh CH₂ Single bond Sub-17 2-1026 Sub-53 3,4-diClPh CH₂ Single bond Sub-18 2-1027 Sub-53 3,4-diClPh CH₂ Single bond Sub-19 2-1028 Sub-53 3,4-diClPh CH₂ Single bond Sub-20 2-1029 Sub-53 3,4-diClPh CH₂ Single bond Sub-21 2-1030 Sub-53 3,4-diClPh CH₂ Single bond Sub-22 2-1031 Sub-53 3,4-diClPh CH₂ Single bond Sub-23 2-1032 Sub-53 3,4-diClPh CH₂ Single bond Sub-24 2-1033 Sub-53 3,4-diClPh CH₂ Single bond Sub-25 2-1034 Sub-53 3,4-diClPh CH₂ Single bond Sub-26 2-1035 Sub-53 3,4-diClPh CH₂ Single bond Sub-27 2-1036 Sub-53 3,4-diClPh CH₂ Single bond Sub-28 2-1037 Sub-53 3,4-diClPh CH₂ Single bond Sub-29 2-1038 Sub-53 3,4-diClPh CH₂ Single bond Sub-30 2-1039 Sub-53 3,4-diClPh CH₂ Single bond Sub-31 2-1040 Sub-53 3,4-diClPh CH₂ Single bond Sub-32 2-1041 Sub-53 3,4-diClPh CH₂ Single bond Sub-65 2-1042 Sub-53 3,4-diClPh CH₂ Single bond Sub-66 2-1043 Sub-53 3,4-diClPh CH₂ Single bond Sub-67 2-1044 Sub-53 3,4-diClPh CH₂ Single bond Sub-68 2-1045 Sub-53 3,4-diClPh CH₂ Single bond Sub-69 2-1046 Sub-53 3,4-diClPh CH₂ Single bond Sub-70 2-1047 Sub-53 3,4-diClPh CH₂ Single bond Sub-71 2-1048 Sub-53 3,4-diClPh CH₂ Single bond Sub-72 2-1049 Sub-53 3,4-diClPh CH₂ Single bond Sub-73 2-1050 Sub-53 3,4-diClPh CH₂ Single bond Sub-74 2-1051 Sub-53 3,4-diClPh CH₂ Single bond Sub-75 2-1052 Sub-53 3,4-diClPh CH₂ Single bond Sub-76 2-1053 Sub-53 3,4-diClPh CH₂ Single bond Sub-77 2-1054 Sub-53 3,4-diClPh CH₂ Single bond Sub-78 2-1055 Sub-53 3,4-diClPh CH₂ Single bond Sub-79 2-1056 Sub-53 3,4-diClPh CH₂ Single bond Sub-80 2-1057 Sub-54 3,4-diClPh CH₂ Single bond Sub-1  2-1058 Sub-54 3,4-diClPh CH₂ Single bond Sub-2  2-1059 Sub-54 3,4-diClPh CH₂ Single bond Sub-3  2-1060 Sub-54 3,4-diClPh CH₂ Single bond Sub-4  2-1061 Sub-54 3,4-diClPh CH₂ Single bond Sub-5  2-1062 Sub-54 3,4-diClPh CH₂ Single bond Sub-6  2-1063 Sub-54 3,4-diClPh CH₂ Single bond Sub-7  2-1064 Sub-54 3,4-diClPh CH₂ Single bond Sub-8  2-1065 Sub-54 3,4-diClPh CH₂ Single bond Sub-9  2-1066 Sub-54 3,4-diClPh CH₂ Single bond Sub-10 2-1067 Sub-54 3,4-diClPh CH₂ Single bond Sub-11 2-1068 Sub-54 3,4-diClPh CH₂ Single bond Sub-12 2-1069 Sub-54 3,4-diClPh CH₂ Single bond Sub-13 2-1070 Sub-54 3,4-diClPh CH₂ Single bond Sub-14 2-1071 Sub-54 3,4-diClPh CH₂ Single bond Sub-15 2-1072 Sub-54 3,4-diClPh CH₂ Single bond Sub-16 2-1073 Sub-54 3,4-diClPh CH₂ Single bond Sub-17 2-1074 Sub-54 3,4-diClPh CH₂ Single bond Sub-18 2-1075 Sub-54 3,4-diClPh CH₂ Single bond Sub-19 2-1076 Sub-54 3,4-diClPh CH₂ Single bond Sub-20 2-1077 Sub-54 3,4-diClPh CH₂ Single bond Sub-21 2-1078 Sub-54 3,4-diClPh CH₂ Single bond Sub-22 2-1079 Sub-54 3,4-diClPh CH₂ Single bond Sub-23 2-1080 Sub-54 3,4-diClPh CH₂ Single bond Sub-24 2-1081 Sub-54 3,4-diClPh CH₂ Single bond Sub-25 2-1082 Sub-54 3,4-diClPh CH₂ Single bond Sub-26 2-1083 Sub-54 3,4-diClPh CH₂ Single bond Sub-27 2-1084 Sub-54 3,4-diClPh CH₂ Single bond Sub-28 2-1085 Sub-54 3,4-diClPh CH₂ Single bond Sub-29 2-1086 Sub-54 3,4-diClPh CH₂ Single bond Sub-30 2-1087 Sub-54 3,4-diClPh CH₂ Single bond Sub-31 2-1088 Sub-54 3,4-diClPh CH₂ Single bond Sub-32 2-1089 Sub-54 3,4-diClPh CH₂ Single bond Sub-65 2-1090 Sub-54 3,4-diClPh CH₂ Single bond Sub-66 2-1091 Sub-54 3,4-diCiPh CH₂ Single bond Sub-67 2-1092 Sub-54 3,4-diClPh CH₂ Single bond Sub-68 2-1093 Sub-54 3,4-diClPh CH₂ Single bond Sub-69 2-1094 Sub-54 3,4-diClPh CH₂ Single bond Sub-70 2-1095 Sub-54 3,4-diClPh CH₂ Single bond Sub-71 2-1096 Sub-54 3,4-diClPh CH₂ Single bond Sub-72 2-1097 Sub-54 3,4-diClPh CH₂ Single bond Sub-73 2-1098 Sub-54 3,4-diClPh CH₂ Single bond Sub-74 2-1099 Sub-54 3,4-diClPh CH₂ Single bond Sub-75 2-1100 Sub-54 3,4-diClPh CH₂ Single bond Sub-76 2-1101 Sub-54 3,4-diClPh CH₂ Single bond Sub-77 2-1102 Sub-54 3,4-diClPh CH₂ Single bond Sub-78 2-1103 Sub-54 3,4-diClPh CH₂ Single bond Sub-79 2-1104 Sub-54 3,4-diClPh CH₂ Single bond Sub-80 2-1105 Sub-55 3,4-diClPh CH₂ Single bond Sub-1  2-1106 Sub-55 3,4-diClPh CH₂ Single bond Sub-2  2-1107 Sub-55 3,4-diClPh CH₂ Single bond Sub-3  2-1108 Sub-55 3,4-diClPh CH₂ Single bond Sub-4  2-1109 Sub-55 3,4-diClPh CH₂ Single bond Sub-5  2-1110 Sub-55 3,4-diClPh CH₂ Single bond Sub-6  2-1111 Sub-55 3,4-diClPh CH₂ Single bond Sub-7  2-1112 Sub-55 3,4-diClPh CH₂ Single bond Sub-8  2-1113 Sub-55 3,4-diClPh CH₂ Single bond Sub-9  2-1114 Sub-55 3,4-diClPh CH₂ Single bond Sub-10 2-1115 Sub-55 3,4-diClPh CH₂ Single bond Sub-11 2-1116 Sub-55 3,4-diClPh CH₂ Single bond Sub-12 2-1117 Sub-55 3,4-diClPh CH₂ Single bond Sub-13 2-1118 Sub-55 3,4-diClPh CH₂ Single bond Sub-14 2-1119 Sub-55 3,4-diClPh CH₂ Single bond Sub-15 2-1120 Sub-55 3,4-diClPh CH₂ Single bond Sub-16 2-1121 Sub-55 3,4-diClPh CH₂ Single bond Sub-17 2-1122 Sub-55 3,4-diClPh CH₂ Single bond Sub-18 2-1123 Sub-55 3,4-diClPh CH₂ Single bond Sub-19 2-1124 Sub-55 3,4-diClPh CH₂ Single bond Sub-20 2-1125 Sub-55 3,4-diClPh CH₂ Single bond Sub-21 2-1126 Sub-55 3,4-diClPh CH₂ Single bond Sub-22 2-1127 Sub-55 3,4-diClPh CH₂ Single bond Sub-23 2-1128 Sub-55 3,4-diClPh CH₂ Single bond Sub-24 2-1129 Sub-55 3,4-diClPh CH₂ Single bond Sub-25 2-1130 Sub-55 3,4-diClPh CH₂ Single bond Sub-26 2-1131 Sub-55 3,4-diClPh CH₂ Single bond Sub-27 2-1132 Sub-55 3,4-diClPh CH₂ Single bond Sub-28 2-1133 Sub-55 3,4-diClPh CH₂ Single bond Sub-29 2-1134 Sub-55 3,4-diClPh CH₂ Single bond Sub-30 2-1135 Sub-55 3,4-diClPh CH₂ Single bond Sub-31 2-1136 Sub-55 3,4-diClPh CH₂ Single bond Sub-32 2-1137 Sub-55 3,4-diClPh CH₂ Single bond Sub-65 2-1138 Sub-55 3,4-diClPh CH₂ Single bond Sub-66 2-1139 Sub-55 3,4-diClPh CH₂ Single bond Sub-67 2-1140 Sub-55 3,4-diClPh CH₂ Single bond Sub-68 2-1141 Sub-55 3,4-diClPh CH₂ Single bond Sub-69 2-1142 Sub-55 3,4-diClPh CH₂ Single bond Sub-70 2-1143 Sub-55 3,4-diClPh CH₂ Single bond Sub-71 2-1144 Sub-55 3,4-diClPh CH₂ Single bond Sub-72 2-1145 Sub-55 3,4-diClPh CH₂ Single bond Sub-73 2-1146 Sub-55 3,4-diClPh CH₂ Single bond Sub-74 2-1147 Sub-55 3,4-diClPh CH₂ Single bond Sub-75 2-1148 Sub-55 3,4-diClPh CH₂ Single bond Sub-76 2-1149 Sub-55 3,4-diClPh CH₂ Single bond Sub-77 2-1150 Sub-55 3,4-diClPh CH₂ Single bond Sub-78 2-1151 Sub-55 3,4-diClPh CH₂ Single bond Sub-79 2-1152 Sub-55 3,4-diClPh CH₂ Single bond Sub-80 2-1153 Sub-56 3,4-diClPh CH₂ Single bond Sub-1  2-1154 Sub-56 3,4-diClPh CH₂ Single bond Sub-2  2-1155 Sub-56 3,4-diClPh CH₂ Single bond Sub-3  2-1156 Sub-56 3,4-diClPh CH₂ Single bond Sub-4  2-1157 Sub-56 3,4-diClPh CH₂ Single bond Sub-5  2-1158 Sub-56 3,4-diClPh CH₂ Single bond Sub-6  2-1159 Sub-56 3,4-diClPh CH₂ Single bond Sub-7  2-1160 Sub-56 3,4-diClPh CH₂ Single bond Sub-8  2-1161 Sub-56 3,4-diClPh CH₂ Single bond Sub-9  2-1162 Sub-56 3,4-diClPh CH₂ Single bond Sub-10 2-1163 Sub-56 3,4-diClPh CH₂ Single bond Sub-11 2-1164 Sub-56 3,4-diClPh CH₂ Single bond Sub-12 2-1165 Sub-56 3,4-diClPh CH₂ Single bond Sub-13 2-1166 Sub-56 3,4-diClPh CH₂ Single bond Sub-14 2-1167 Sub-56 3,4-diClPh CH₂ Single bond Sub-15 2-1168 Sub-56 3,4-diClPh CH₂ Single bond Sub-16 2-1169 Sub-56 3,4-diClPh CH₂ Single bond Sub-17 2-1170 Sub-56 3,4-diClPh CH₂ Single bond Sub-18 2-1171 Sub-56 3,4-diClPh CH₂ Single bond Sub-19 2-1172 Sub-56 3,4-diClPh CH₂ Single bond Sub-20 2-1173 Sub-56 3,4-diClPh CH₂ Single bond Sub-21 2-1174 Sub-56 3,4-diClPh CH₂ Single bond Sub-22 2-1175 Sub-56 3,4-diClPh CH₂ Single bond Sub-23 2-1176 Sub-56 3,4-diClPh CH₂ Single bond Sub-24 2-1177 Sub-56 3,4-diClPh CH₂ Single bond Sub-25 2-1178 Sub-56 3,4-diClPh CH₂ Single bond Sub-26 2-1179 Sub-56 3,4-diClPh CH₂ Single bond Sub-27 2-1180 Sub-56 3,4-diClPh CH₂ Single bond Sub-28 2-1181 Sub-56 3,4-diClPh CH₂ Single bond Sub-29 2-1182 Sub-56 3,4-diClPh CH₂ Single bond Sub-30 2-1183 Sub-56 3,4-diClPh CH₂ Single bond Sub-31 2-1184 Sub-56 3,4-diClPh CH₂ Single bond Sub-32 2-1185 Sub-56 3,4-diClPh CH₂ Single bond Sub-65 2-1186 Sub-56 3,4-diClPh CH₂ Single bond Sub-66 2-1187 Sub-56 3,4-diClPh CH₂ Single bond Sub-67 2-1188 Sub-56 3,4-diClPh CH₂ Single bond Sub-68 2-1189 Sub-56 3,4-diClPh CH₂ Single bond Sub-69 2-1190 Sub-56 3,4-diClPh CH₂ Single bond Sub-70 2-1191 Sub-56 3,4-diClPh CH₂ Single bond Sub-71 2-1192 Sub-56 3,4-diClPh CH₂ Single bond Sub-72 2-1193 Sub-56 3,4-diClPh CH₂ Single bond Sub-73 2-1194 Sub-56 3,4-diClPh CH₂ Single bond Sub-74 2-1195 Sub-56 3,4-diClPh CH₂ Single bond Sub-75 2-1196 Sub-56 3,4-diClPh CH₂ Single bond Sub-76 2-1197 Sub-56 3,4-diClPh CH₂ Single bond Sub-77 2-1198 Sub-56 3,4-diClPh CH₂ Single bond Sub-78 2-1199 Sub-56 3,4-diClPh CH₂ Single bond Sub-79 2-1200 Sub-56 3,4-diClPh CH₂ Single bond Sub-80 2-1201 Sub-57 3,4-diClPh CH₂ Single bond Sub-1  2-1202 Sub-57 3,4-diClPh CH₂ Single bond Sub-2  2-1203 Sub-57 3,4-diClPh CH₂ Single bond Sub-3  2-1204 Sub-57 3,4-diClPh CH₂ Single bond Sub-4  2-1205 Sub-57 3,4-diClPh CH₂ Single bond Sub-5  2-1206 Sub-57 3,4-diClPh CH₂ Single bond Sub-6  2-1207 Sub-57 3,4-diClPh CH₂ Single bond Sub-7  2-1208 Sub-57 3,4-diClPh CH₂ Single bond Sub-8  2-1209 Sub-57 3,4-diClPh CH₂ Single bond Sub-9  2-1210 Sub-57 3,4-diClPh CH₂ Single bond Sub-10 2-1211 Sub-57 3,4-diClPh CH₂ Single bond Sub-11 2-1212 Sub-57 3,4-diClPh CH₂ Single bond Sub-12 2-1213 Sub-57 3,4-diClPh CH₂ Single bond Sub-13 2-1214 Sub-57 3,4-diClPh CH₂ Single bond Sub-14 2-1215 Sub-57 3,4-diClPh CH₂ Single bond Sub-15 2-1216 Sub-57 3,4-diClPh CH₂ Single bond Sub-16 2-1217 Sub-57 3,4-diClPh CH₂ Single bond Sub-17 2-1218 Sub-57 3,4-diClPh CH₂ Single bond Sub-18 2-1219 Sub-57 3,4-diClPh CH₂ Single bond Sub-19 2-1220 Sub-57 3,4-diClPh CH₂ Single bond Sub-20 2-1221 Sub-57 3,4-diClPh CH₂ Single bond Sub-21 2-1222 Sub-57 3,4-diClPh CH₂ Single bond Sub-22 2-1223 Sub-57 3,4-diClPh CH₂ Single bond Sub-23 2-1224 Sub-57 3,4-diClPh CH₂ Single bond Sub-24 2-1225 Sub-57 3,4-diClPh CH₂ Single bond Sub-25 2-1226 Sub-57 3,4-diClPh CH₂ Single bond Sub-26 2-1227 Sub-57 3,4-diClPh CH₂ Single bond Sub-27 2-1228 Sub-57 3,4-diClPh CH₂ Single bond Sub-28 2-1229 Sub-57 3,4-diClPh CH₂ Single bond Sub-29 2-1230 Sub-57 3,4-diClPh CH₂ Single bond Sub-30 2-1231 Sub-57 3,4-diClPh CH₂ Single bond Sub-31 2-1232 Sub-57 3,4-diClPh CH₂ Single bond Sub-32 2-1233 Sub-57 3,4-diClPh CH₂ Single bond Sub-65 2-1234 Sub-57 3,4-diClPh CH₂ Single bond Sub-66 2-1235 Sub-57 3,4-diClPh CH₂ Single bond Sub-67 2-1236 Sub-57 3,4-diClPh CH₂ Single bond Sub-68 2-1237 Sub-57 3,4-diClPh CH₂ Single bond Sub-69 2-1238 Sub-57 3,4-diClPh CH₂ Single bond Sub-70 2-1239 Sub-57 3,4-diClPh CH₂ Single bond Sub-71 2-1240 Sub-57 3,4-diClPh CH₂ Single bond Sub-72 2-1241 Sub-57 3,4-diClPh CH₂ Single bond Sub-73 2-1242 Sub-57 3,4-diClPh CH₂ Single bond Sub-74 2-1243 Sub-57 3,4-diClPh CH₂ Single bond Sub-75 2-1244 Sub-57 3,4-diClPh CH₂ Single bond Sub-76 2-1245 Sub-57 3,4-diClPh CH₂ Single bond Sub-77 2-1246 Sub-57 3,4-diClPh CH₂ Single bond Sub-78 2-1247 Sub-57 3,4-diClPh CH₂ Single bond Sub-79 2-1248 Sub-57 3,4-diClPh CH₂ Single bond Sub-80 2-1249 Sub-58 3,4-diClPh CH₂ Single bond Sub-1  2-1250 Sub-58 3,4-diClPh CH₂ Single bond Sub-2  2-1251 Sub-58 3,4-diClPh CH₂ Single bond Sub-3  2-1252 Sub-58 3,4-diClPh CH₂ Single bond Sub-4  2-1253 Sub-58 3,4-diClPh CH₂ Single bond Sub-5  2-1254 Sub-58 3,4-diClPh CH₂ Single bond Sub-6  2-1255 Sub-58 3,4-diClPh CH₂ Single bond Sub-7  2-1256 Sub-58 3,4-diClPh CH₂ Single bond Sub-8  2-1257 Sub-58 3,4-diClPh CH₂ Single bond Sub-9  2-1258 Sub-58 3,4-diClPh CH₂ Single bond Sub-10 2-1259 Sub-58 3,4-diClPh CH₂ Single bond Sub-11 2-1260 Sub-58 3,4-diClPh CH₂ Single bond Sub-12 2-1261 Sub-58 3,4-diClPh CH₂ Single bond Sub-13 2-1262 Sub-58 3,4-diClPh CH₂ Single bond Sub-14 2-1263 Sub-58 3,4-diClPh CH₂ Single bond Sub-15 2-1264 Sub-58 3,4-diClPh CH₂ Single bond Sub-16 2-1265 Sub-58 3,4-diClPh CH₂ Single bond Sub-17 2-1266 Sub-58 3,4-diClPh CH₂ Single bond Sub-18 2-1267 Sub-58 3,4-diClPh CH₂ Single bond Sub-19 2-1268 Sub-58 3,4-diClPh CH₂ Single bond Sub-20 2-1269 Sub-58 3,4-diClPh CH₂ Single bond Sub-21 2-1270 Sub-58 3,4-diClPh CH₂ Single bond Sub-22 2-1271 Sub-58 3,4-diClPh CH₂ Single bond Sub-23 2-1272 Sub-58 3,4-diClPh CH₂ Single bond Sub-24 2-1273 Sub-58 3,4-diClPh CH₂ Single bond Sub-25 2-1274 Sub-58 3,4-diClPh CH₂ Single bond Sub-26 2-1275 Sub-58 3,4-diClPh CH₂ Single bond Sub-27 2-1276 Sub-58 3,4-diClPh CH₂ Single bond Sub-28 2-1277 Sub-58 3,4-diClPh CH₂ Single bond Sub-29 2-1278 Sub-58 3,4-diClPh CH₂ Single bond Sub-30 2-1279 Sub-58 3,4-diClPh CH₂ Single bond Sub-31 2-1280 Sub-58 3,4-diClPh CH₂ Single bond Sub-32 2-1281 Sub-58 3,4-diClPh CH₂ Single bond Sub-65 2-1282 Sub-58 3,4-diClPh CH₂ Single bond Sub-66 2-1283 Sub-58 3,4-diClPh CH₂ Single bond Sub-67 2-1284 Sub-58 3,4-diClPh CH₂ Single bond Sub-68 2-1285 Sub-58 3,4-diClPh CH₂ Single bond Sub-69 2-1286 Sub-58 3,4-diClPh CH₂ Single bond Sub-70 2-1287 Sub-58 3,4-diClPh CH₂ Single bond Sub-71 2-1288 Sub-58 3,4-diClPh CH₂ Single bond Sub-72 2-1289 Sub-58 3,4-diClPh CH₂ Single bond Sub-73 2-1290 Sub-58 3,4-diClPh CH₂ Single bond Sub-74 2-1291 Sub-58 3,4-diClPh CH₂ Single bond Sub-75 2-1292 Sub-58 3,4-diClPh CH₂ Single bond Sub-76 2-1293 Sub-58 3,4-diClPh CH₂ Single bond Sub-77 2-1294 Sub-58 3,4-diClPh CH₂ Single bond Sub-78 2-1295 Sub-58 3,4-diClPh CH₂ Single bond Sub-79 2-1296 Sub-58 3,4-diClPh CH₂ Single bond Sub-80 2-1297 Sub-59 3,4-diClPh CH₂ Single bond Sub-1  2-1298 Sub-59 3,4-diClPh CH₂ Single bond Sub-2  2-1299 Sub-59 3,4-diClPh CH₂ Single bond Sub-3  2-1300 Sub-59 3,4-diClPh CH₂ Single bond Sub-4  2-1301 Sub-59 3,4-diClPh CH₂ Single bond Sub-5  2-1302 Sub-59 3,4-diClPh CH₂ Single bond Sub-6  2-1303 Sub-59 3,4-diClPh CH₂ Single bond Sub-7  2-1304 Sub-59 3,4-diClPh CH₂ Single bond Sub-8  2-1305 Sub-59 3,4-diClPh CH₂ Single bond Sub-9  2-1306 Sub-59 3,4-diClPh CH₂ Single bond Sub-10 2-1307 Sub-59 3,4-diClPh CH₂ Single bond Sub-11 2-1308 Sub-59 3,4-diClPh CH₂ Single bond Sub-12 2-1309 Sub-59 3,4-diClPh CH₂ Single bond Sub-13 2-1310 Sub-59 3,4-diClPh CH₂ Single bond Sub-14 2-1311 Sub-59 3,4-diClPh CH₂ Single bond Sub-15 2-1312 Sub-59 3,4-diClPh CH₂ Single bond Sub-16 2-1313 Sub-59 3,4-diClPh CH₂ Single bond Sub-17 2-1314 Sub-59 3,4-diClPh CH₂ Single bond Sub-18 2-1315 Sub-59 3,4-diClPh CH₂ Single bond Sub-19 2-1316 Sub-59 3,4-diClPh CH₂ Single bond Sub-20 2-1317 Sub-59 3,4-diClPh CH₂ Single bond Sub-21 2-1318 Sub-59 3,4-diClPh CH₂ Single bond Sub-22 2-1319 Sub-59 3,4-diClPh CH₂ Single bond Sub-23 2-1320 Sub-59 3,4-diClPh CH₂ Single bond Sub-24 2-1321 Sub-59 3,4-diClPh CH₂ Single bond Sub-25 2-1322 Sub-59 3,4-diClPh CH₂ Single bond Sub-26 2-1323 Sub-59 3,4-diClPh CH₂ Single bond Sub-27 2-1324 Sub-59 3,4-diClPh CH₂ Single bond Sub-28 2-1325 Sub-59 3,4-diClPh CH₂ Single bond Sub-29 2-1326 Sub-59 3,4-diClPh CH₂ Single bond Sub-30 2-1327 Sub-59 3,4-diClPh CH₂ Single bond Sub-31 2-1328 Sub-59 3,4-diClPh CH₂ Single bond Sub-32 2-1329 Sub-59 3,4-diClPh CH₂ Single bond Sub-65 2-1330 Sub-59 3,4-diClPh CH₂ Single bond Sub-66 2-1331 Sub-59 3,4-diClPh CH₂ Single bond Sub-67 2-1332 Sub-59 3,4-diClPh CH₂ Single bond Sub-68 2-1333 Sub-59 3,4-diClPh CH₂ Single bond Sub-69 2-1334 Sub-59 3,4-diClPh CH₂ Single bond Sub-70 2-1335 Sub-59 3,4-diClPh CH₂ Single bond Sub-71 2-1336 Sub-59 3,4-diClPh CH₂ Single bond Sub-72 2-1337 Sub-59 3,4-diClPh CH₂ Single bond Sub-73 2-1338 Sub-59 3,4-diClPh CH₂ Single bond Sub-74 2-1339 Sub-59 3,4-diClPh CH₂ Single bond Sub-75 2-1340 Sub-59 3,4-diClPh CH₂ Single bond Sub-76 2-1341 Sub-59 3,4-diClPh CH₂ Single bond Sub-77 2-1342 Sub-59 3,4-diClPh CH₂ Single bond Sub-78 2-1343 Sub-59 3,4-diClPh CH₂ Single bond Sub-79 2-1344 Sub-59 3,4-diClPh CH₂ Single bond Sub-80 2-1345 Sub-82 3,4-diClPh CH₂ Single bond Sub-1  2-1346 Sub-82 3,4-diClPh CH₂ Single bond Sub-2  2-1347 Sub-82 3,4-diClPh CH₂ Single bond Sub-3  2-1348 Sub-82 3,4-diClPh CH₂ Single bond Sub-4  2-1349 Sub-82 3,4-diClPh CH₂ Single bond Sub-5  2-1350 Sub-82 3,4-diClPh CH₂ Single bond Sub-6  2-1351 Sub-82 3,4-diClPh CH₂ Single bond Sub-7  2-1352 Sub-82 3,4-diClPh CH₂ Single bond Sub-8  2-1353 Sub-82 3,4-diClPh CH₂ Single bond Sub-9  2-1354 Sub-82 3,4-diClPh CH₂ Single bond Sub-10 2-1355 Sub-82 3,4-diClPh CH₂ Single bond Sub-11 2-1356 Sub-82 3,4-diClPh CH₂ Single bond Sub-12 2-1357 Sub-82 3,4-diClPh CH₂ Single bond Sub-13 2-1358 Sub-82 3,4-diClPh CH₂ Single bond Sub-14 2-1359 Sub-82 3,4-diClPh CH₂ Single bond Sub-15 2-1360 Sub-82 3,4-diClPh CH₂ Single bond Sub-16 2-1361 Sub-82 3,4-diClPh CH₂ Single bond Sub-17 2-1362 Sub-82 3,4-diClPh CH₂ Single bond Sub-18 2-1363 Sub-82 3,4-diClPh CH₂ Single bond Sub-19 2-1364 Sub-82 3,4-diClPh CH₂ Single bond Sub-20 2-1365 Sub-82 3,4-diClPh CH₂ Single bond Sub-21 2-1366 Sub-82 3,4-diClPh CH₂ Single bond Sub-22 2-1367 Sub-82 3,4-diClPh CH₂ Single bond Sub-23 2-1368 Sub-82 3,4-diClPh CH₂ Single bond Sub-24 2-1369 Sub-82 3,4-diClPh CH₂ Single bond Sub-25 2-1370 Sub-82 3,4-diClPh CH₂ Single bond Sub-26 2-1371 Sub-82 3,4-diClPh CH₂ Single bond Sub-27 2-1372 Sub-82 3,4-diClPh CH₂ Single bond Sub-28 2-1373 Sub-82 3,4-diClPh CH₂ Single bond Sub-29 2-1374 Sub-82 3,4-diClPh CH₂ Single bond Sub-30 2-1375 Sub-82 3,4-diClPh CH₂ Single bond Sub-31 2-1376 Sub-82 3,4-diClPh CH₂ Single bond Sub-32 2-1377 Sub-82 3,4-diClPh CH₂ Single bond Sub-65 2-1378 Sub-82 3,4-diClPh CH₂ Single bond Sub-66 2-1379 Sub-82 3,4-diClPh CH₂ Single bond Sub-67 2-1380 Sub-82 3,4-diClPh CH₂ Single bond Sub-68 2-1381 Sub-82 3,4-diClPh CH₂ Single bond Sub-69 2-1382 Sub-82 3,4-diClPh CH₂ Single bond Sub-70 2-1383 Sub-82 3,4-diClPh CH₂ Single bond Sub-71 2-1384 Sub-82 3,4-diClPh CH₂ Single bond Sub-72 2-1385 Sub-82 3,4-diClPh CH₂ Single bond Sub-73 2-1386 Sub-82 3,4-diClPh CH₂ Single bond Sub-74 2-1387 Sub-82 3,4-diClPh CH₂ Single bond Sub-75 2-1388 Sub-82 3,4-diClPh CH₂ Single bond Sub-76 2-1389 Sub-82 3,4-diClPh CH₂ Single bond Sub-77 2-1390 Sub-82 3,4-diClPh CH₂ Single bond Sub-78 2-1391 Sub-82 3,4-diClPh CH₂ Single bond Sub-79 2-1392 Sub-82 3,4-diClPh CH₂ Single bond Sub-80 2-1393 Sub-83 3,4-diClPh CH₂ Single bond Sub-1  2-1394 Sub-83 3,4-diClPh CH₂ Single bond Sub-2  2-1395 Sub-83 3,4-diClPh CH₂ Single bond Sub-3  2-1396 Sub-83 3,4-diClPh CH₂ Single bond Sub-4  2-1397 Sub-83 3,4-diClPh CH₂ Single bond Sub-5  2-1398 Sub-83 3,4-diClPh CH₂ Single bond Sub-6  2-1399 Sub-83 3,4-diClPh CH₂ Single bond Sub-7  2-1400 Sub-83 3,4-diClPh CH₂ Single bond Sub-8  2-1401 Sub-83 3,4-diClPh CH₂ Single bond Sub-9  2-1402 Sub-83 3,4-diClPh CH₂ Single bond Sub-10 2-1403 Sub-83 3,4-diClPh CH₂ Single bond Sub-11 2-1404 Sub-83 3,4-diClPh CH₂ Single bond Sub-12 2-1405 Sub-83 3,4-diClPh CH₂ Single bond Sub-13 2-1406 Sub-83 3,4-diClPh CH₂ Single bond Sub-14 2-1407 Sub-83 3,4-diClPh CH₂ Single bond Sub-15 2-1408 Sub-83 3,4-diClPh CH₂ Single bond Sub-16 2-1409 Sub-83 3,4-diClPh CH₂ Single bond Sub-17 2-1410 Sub-83 3,4-diClPh CH₂ Single bond Sub-18 2-1411 Sub-83 3,4-diClPh CH₂ Single bond Sub-19 2-1412 Sub-83 3,4-diClPh CH₂ Single bond Sub-20 2-1413 Sub-83 3,4-diClPh CH₂ Single bond Sub-21 2-1414 Sub-83 3,4-diClPh CH₂ Single bond Sub-22 2-1415 Sub-83 3,4-diClPh CH₂ Single bond Sub-23 2-1416 Sub-83 3,4-diClPh CH₂ Single bond Sub-24 2-1417 Sub-83 3,4-diClPh CH₂ Single bond Sub-25 2-1418 Sub-83 3,4-diClPh CH₂ Single bond Sub-26 2-1419 Sub-83 3,4-diClPh CH₂ Single bond Sub-27 2-1420 Sub-83 3,4-diClPh CH₂ Single bond Sub-28 2-1421 Sub-83 3,4-diClPh CH₂ Single bond Sub-29 2-1422 Sub-83 3,4-diClPh CH₂ Single bond Sub-30 2-1423 Sub-83 3,4-diClPh CH₂ Single bond Sub-31 2-1424 Sub-83 3,4-diClPh CH₂ Single bond Sub-32 2-1425 Sub-83 3,4-diClPh CH₂ Single bond Sub-65 2-1426 Sub-83 3,4-diClPh CH₂ Single bond Sub-66 2-1427 Sub-83 3,4-diClPh CH₂ Single bond Sub-67 2-1428 Sub-83 3,4-diClPh CH₂ Single bond Sub-68 2-1429 Sub-83 3,4-diClPh CH₂ Single bond Sub-69 2-1430 Sub-83 3,4-diClPh CH₂ Single bond Sub-70 2-1431 Sub-83 3,4-diClPh CH₂ Single bond Sub-71 2-1432 Sub-83 3,4-diClPh CH₂ Single bond Sub-72 2-1433 Sub-83 3,4-diClPh CH₂ Single bond Sub-73 2-1434 Sub-83 3,4-diClPh CH₂ Single bond Sub-74 2-1435 Sub-83 3,4-diClPh CH₂ Single bond Sub-75 2-1436 Sub-83 3,4-diClPh CH₂ Single bond Sub-76 2-1437 Sub-83 3,4-diClPh CH₂ Single bond Sub-77 2-1438 Sub-83 3,4-diClPh CH₂ Single bond Sub-78 2-1439 Sub-83 3,4-diClPh CH₂ Single bond Sub-79 2-1440 Sub-83 3,4-diClPh CH₂ Single bond Sub-80 2-1441 Sub-61 3,4-diClPh CH₂ Single bond Sub-1  2-1442 Sub-61 3,4-diClPh CH₂ Single bond Sub-2  2-1443 Sub-61 3,4-diClPh CH₂ Single bond Sub-3  2-1444 Sub-61 3,4-diClPh CH₂ Single bond Sub-4  2-1445 Sub-61 3,4-diClPh CH₂ Single bond Sub-5  2-1446 Sub-61 3,4-diClPh CH₂ Single bond Sub-6  2-1447 Sub-61 3,4-diClPh CH₂ Single bond Sub-7  2-1448 Sub-61 3,4-diClPh CH₂ Single bond Sub-8  2-1449 Sub-61 3,4-diClPh CH₂ Single bond Sub-9  2-1450 Sub-61 3,4-diClPh CH₂ Single bond Sub-10 2-1451 Sub-61 3,4-diClPh CH₂ Single bond Sub-11 2-1452 Sub-61 3,4-diClPh CH₂ Single bond Sub-12 2-1453 Sub-61 3,4-diClPh CH₂ Single bond Sub-13 2-1454 Sub-61 3,4-diClPh CH₂ Single bond Sub-14 2-1455 Sub-61 3,4-diClPh CH₂ Single bond Sub-15 2-1456 Sub-61 3,4-diClPh CH₂ Single bond Sub-16 2-1457 Sub-61 3,4-diClPh CH₂ Single bond Sub-17 2-1458 Sub-61 3,4-diClPh CH₂ Single bond Sub-18 2-1459 Sub-61 3,4-diClPh CH₂ Single bond Sub-19 2-1460 Sub-61 3,4-diClPh CH₂ Single bond Sub-20 2-1461 Sub-61 3,4-diClPh CH₂ Single bond Sub-21 2-1462 Sub-61 3,4-diClPh CH₂ Single bond Sub-22 2-1463 Sub-61 3,4-diClPh CH₂ Single bond Sub-23 2-1464 Sub-61 3,4-diClPh CH₂ Single bond Sub-24 2-1465 Sub-61 3,4-diClPh CH₂ Single bond Sub-25 2-1466 Sub-61 3,4-diClPh CH₂ Single bond Sub-26 2-1467 Sub-61 3,4-diClPh CH₂ Single bond Sub-27 2-1468 Sub-61 3,4-diClPh CH₂ Single bond Sub-28 2-1469 Sub-61 3,4-diClPh CH₂ Single bond Sub-29 2-1470 Sub-61 3,4-diClPh CH₂ Single bond Sub-30 2-1471 Sub-61 3,4-diClPh CH₂ Single bond Sub-31 2-1472 Sub-61 3,4-diClPh CH₂ Single bond Sub-32 2-1473 Sub-61 3,4-diClPh CH₂ Single bond Sub-65 2-1474 Sub-61 3,4-diClPh CH₂ Single bond Sub-66 2-1475 Sub-61 3,4-diClPh CH₂ Single bond Sub-67 2-1476 Sub-61 3,4-diClPh CH₂ Single bond Sub-68 2-1477 Sub-61 3,4-diClPh CH₂ Single bond Sub-69 2-1478 Sub-61 3,4-diClPh CH₂ Single bond Sub-70 2-1479 Sub-61 3,4-diClPh CH₂ Single bond Sub-71 2-1480 Sub-61 3,4-diClPh CH₂ Single bond Sub-72 2-1481 Sub-61 3,4-diClPh CH₂ Single bond Sub-73 2-1482 Sub-61 3,4-diClPh CH₂ Single bond Sub-74 2-1483 Sub-61 3,4-diClPh CH₂ Single bond Sub-75 2-1484 Sub-61 3,4-diClPh CH₂ Single bond Sub-76 2-1485 Sub-61 3,4-diClPh CH₂ Single bond Sub-77 2-1486 Sub-61 3,4-diClPh CH₂ Single bond Sub-78 2-1487 Sub-61 3,4-diClPh CH₂ Single bond Sub-79 2-1488 Sub-61 3,4-diClPh CH₂ Single bond Sub-80 2-1489 Sub-60 3,4-diClPh CH₂ Single bond Sub-1  2-1490 Sub-60 3,4-diClPh CH₂ Single bond Sub-2  2-1491 Sub-60 3,4-diClPh CH₂ Single bond Sub-3  2-1492 Sub-60 3,4-diClPh CH₂ Single bond Sub-4  2-1493 Sub-60 3,4-diClPh CH₂ Single bond Sub-5  2-1494 Sub-60 3,4-diClPh CH₂ Single bond Sub-6  2-1495 Sub-60 3,4-diClPh CH₂ Single bond Sub-7  2-1496 Sub-60 3,4-diClPh CH₂ Single bond Sub-8  2-1497 Sub-60 3,4-diClPh CH₂ Single bond Sub-9  2-1498 Sub-60 3,4-diClPh CH₂ Single bond Sub-10 2-1499 Sub-60 3,4-diClPh CH₂ Single bond Sub-11 2-1500 Sub-60 3,4-diClPh CH₂ Single bond Sub-12 2-1501 Sub-60 3,4-diClPh CH₂ Single bond Sub-13 2-1502 Sub-60 3,4-diClPh CH₂ Single bond Sub-14 2-1503 Sub-60 3,4-diClPh CH₂ Single bond Sub-15 2-1504 Sub-60 3,4-diClPh CH₂ Single bond Sub-16 2-1505 Sub-60 3,4-diClPh CH₂ Single bond Sub-17 2-1506 Sub-60 3,4-diClPh CH₂ Single bond Sub-18 2-1507 Sub-60 3,4-diClPh CH₂ Single bond Sub-19 2-1508 Sub-60 3,4-diClPh CH₂ Single bond Sub-20 2-1509 Sub-60 3,4-diClPh CH₂ Single bond Sub-21 2-1510 Sub-60 3,4-diClPh CH₂ Single bond Sub-22 2-1511 Sub-60 3,4-diClPh CH₂ Single bond Sub-23 2-1512 Sub-60 3,4-diClPh CH₂ Single bond Sub-24 2-1513 Sub-60 3,4-diClPh CH₂ Single bond Sub-25 2-1514 Sub-60 3,4-diClPh CH₂ Single bond Sub-26 2-1515 Sub-60 3,4-diClPh CH₂ Single bond Sub-27 2-1516 Sub-60 3,4-diClPh CH₂ Single bond Sub-28 2-1517 Sub-60 3,4-diClPh CH₂ Single bond Sub-29 2-1518 Sub-60 3,4-diClPh CH₂ Single bond Sub-30 2-1519 Sub-60 3,4-diClPh CH₂ Single bond Sub-31 2-1520 Sub-60 3,4-diClPh CH₂ Single bond Sub-32 2-1521 Sub-60 3,4-diClPh CH₂ Single bond Sub-65 2-1522 Sub-60 3,4-diClPh CH₂ Single bond Sub-66 2-1523 Sub-60 3,4-diClPh CH₂ Single bond Sub-67 2-1524 Sub-60 3,4-diClPh CH₂ Single bond Sub-68 2-1525 Sub-60 3,4-diClPh CH₂ Single bond Sub-69 2-1526 Sub-60 3,4-diClPh CH₂ Single bond Sub-70 2-1527 Sub-60 3,4-diClPh CH₂ Single bond Sub-71 2-1528 Sub-60 3,4-diClPh CH₂ Single bond Sub-72 2-1529 Sub-60 3,4-diClPh CH₂ Single bond Sub-73 2-1530 Sub-60 3,4-diClPh CH₂ Single bond Sub-74 2-1531 Sub-60 3,4-diClPh CH₂ Single bond Sub-75 2-1532 Sub-60 3,4-diClPh CH₂ Single bond Sub-76 2-1533 Sub-60 3,4-diClPh CH₂ Single bond Sub-77 2-1534 Sub-60 3,4-diClPh CH₂ Single bond Sub-78 2-1535 Sub-60 3,4-diClPh CH₂ Single bond Sub-79 2-1536 Sub-60 3,4-diClPh CH₂ Single bond Sub-80 2-1537 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1538 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1539 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1540 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1541 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1542 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1543 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1544 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1545 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1546 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1547 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1548 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1549 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1550 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1551 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1552 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1553 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1554 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1555 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1556 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1557 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1558 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1559 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1560 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1561 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1562 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1563 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1564 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1565 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1566 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1567 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1568 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1569 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1570 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1571 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1572 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1573 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1574 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1575 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1576 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1577 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1578 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1579 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1580 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1581 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1582 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1583 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1584 Sub-33 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1585 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1586 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1587 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1588 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1589 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1590 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1591 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1592 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1593 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1594 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1595 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1596 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1597 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1598 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1599 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1600 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1601 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1602 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1603 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1604 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1605 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1606 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1607 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1608 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1609 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1610 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1611 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1612 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1613 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1614 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1615 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1616 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1617 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1618 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1619 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1620 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1621 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1622 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1623 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1624 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1625 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1626 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1627 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1628 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1629 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1630 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1631 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1632 Sub-34 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1633 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1634 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1635 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1636 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1637 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1638 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1639 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1640 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1641 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1642 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1643 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1644 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1645 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1646 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1647 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1648 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1649 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1650 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1651 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1652 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1653 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1654 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1655 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1656 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1657 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1658 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1659 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1660 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1661 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1662 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1663 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1664 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1665 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1666 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1667 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1668 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1669 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1670 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1671 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1672 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1673 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1674 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1675 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1676 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1677 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1678 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1679 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1680 Sub-35 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1681 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1682 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1683 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1684 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1685 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1686 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1687 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1688 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1689 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1690 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1691 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1692 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1693 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1694 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1695 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1696 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1697 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1698 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1699 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1700 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1701 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1702 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1703 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1704 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1705 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1706 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1707 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1708 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1709 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1710 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1711 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1712 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1713 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1714 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1715 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1716 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1717 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1718 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1719 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1720 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1721 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1722 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1723 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1724 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1725 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1726 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1727 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1728 Sub-36 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1729 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1730 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1731 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1732 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1733 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1734 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1735 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1736 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1737 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1738 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1739 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1740 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1741 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1742 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1743 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1744 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1745 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1746 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1747 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1748 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1749 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1750 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1751 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1752 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1753 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1754 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1755 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1756 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1757 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1758 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1759 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1760 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1761 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1762 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1763 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1764 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1765 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1766 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1767 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1768 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1769 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1770 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1771 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1772 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1773 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1774 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1775 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1776 Sub-37 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1777 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1778 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1779 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1780 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1781 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1782 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1783 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1784 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1785 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1786 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1787 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1788 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1789 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1790 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1791 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1792 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1793 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1794 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1795 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1796 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1797 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1798 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1799 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1800 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1801 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1802 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1803 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1804 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1805 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1806 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1807 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1808 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1809 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1810 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1811 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1812 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1813 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1814 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1815 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1816 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1817 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1818 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1819 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1820 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1821 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1822 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1823 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1824 Sub-38 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1825 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1826 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1827 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1828 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1829 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1830 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1831 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1832 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1833 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1834 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1835 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1836 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1837 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1838 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1839 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1840 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1841 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1842 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1843 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1844 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1845 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1846 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1847 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1848 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1849 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1850 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1851 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1852 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1853 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1854 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1855 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1856 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1857 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1858 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1859 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1860 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1861 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1862 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1863 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1864 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1865 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1866 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1867 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1868 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1869 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1870 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1871 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1872 Sub-39 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1873 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1874 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1875 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1876 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1877 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1878 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1879 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1880 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1881 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1882 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1883 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1884 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1885 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1886 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1887 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1888 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1889 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1890 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1891 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1892 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1893 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1894 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1895 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1896 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1897 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1898 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1899 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1900 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1901 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1902 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1903 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1904 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1905 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1906 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1907 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1908 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1909 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1910 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1911 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1912 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1913 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1914 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1915 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1916 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1917 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1918 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1919 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1920 Sub-40 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1921 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1922 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1923 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1924 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1925 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1926 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1927 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1928 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1929 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1930 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1931 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1932 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1933 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1934 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1935 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1936 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1937 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1938 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1939 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1940 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1941 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1942 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1943 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1944 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1945 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1946 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1947 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1948 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1949 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1950 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1951 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-31 2-1952 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-32 2-1953 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-65 2-1954 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-66 2-1955 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-67 2-1956 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-68 2-1957 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-69 2-1958 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-70 2-1959 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-71 2-1960 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-72 2-1961 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-73 2-1962 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-74 2-1963 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-75 2-1964 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-76 2-1965 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-77 2-1966 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-78 2-1967 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-79 2-1968 Sub-41 3,4-diClPh CO Single bond or CH₂ Sub-80 2-1969 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-1  2-1970 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-2  2-1971 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-3  2-1972 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-4  2-1973 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-5  2-1974 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-6  2-1975 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-7  2-1976 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-8  2-1977 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-9  2-1978 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-10 2-1979 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-11 2-1980 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-12 2-1981 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-13 2-1982 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-14 2-1983 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-15 2-1984 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-16 2-1985 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-17 2-1986 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-18 2-1987 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-19 2-1988 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-20 2-1989 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-21 2-1990 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-22 2-1991 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-23 2-1992 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-24 2-1993 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-25 2-1994 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-26 2-1995 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-27 2-1996 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-28 2-1997 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-29 2-1998 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-30 2-1999 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2000 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2001 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2002 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2003 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2004 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2005 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2006 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2007 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2008 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2009 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2010 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2011 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2012 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2013 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2014 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2015 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2016 Sub-42 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2017 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2018 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2019 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2020 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2021 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2022 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2023 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2024 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2025 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2026 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2027 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2028 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2029 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2030 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2031 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2032 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2033 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2034 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2035 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2036 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2037 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2038 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2039 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2040 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2041 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2042 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2043 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2044 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2045 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2046 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2047 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2048 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2049 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2050 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2051 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2052 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2053 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2054 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2055 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2056 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2057 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2058 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2059 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2060 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2061 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2062 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2063 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2064 Sub-43 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2065 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2066 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2067 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2068 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2069 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2070 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2071 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2072 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2073 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2074 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2075 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2076 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2077 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2078 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2079 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2080 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2081 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2082 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2083 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2084 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2085 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2086 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2087 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2088 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2089 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2090 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2091 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2092 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2093 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2094 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2095 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2096 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2097 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2098 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2099 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2100 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2101 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2102 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2103 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2104 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2105 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2106 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2107 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2108 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2109 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2110 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2111 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2112 Sub-44 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2113 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2114 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2115 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2116 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2117 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2118 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2119 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2120 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2121 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2122 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2123 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2124 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2125 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2126 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2127 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2128 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2129 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2130 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2131 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2132 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2133 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2134 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2135 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2136 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2137 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2138 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2139 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2140 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2141 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2142 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2143 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2144 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2145 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2146 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2147 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2148 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2149 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2150 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2151 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2152 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2153 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2154 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2155 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2156 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2157 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2158 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2159 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2160 Sub-45 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2161 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2162 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2163 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2164 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2165 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2166 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2167 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2168 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2169 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2170 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2171 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2172 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2173 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2174 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2175 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2176 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2177 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2178 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2179 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2180 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2181 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2182 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2183 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2184 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2185 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2186 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2187 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2188 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2189 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2190 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2191 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2192 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2193 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2194 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2195 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2196 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2197 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2198 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2199 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2200 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2201 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2202 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2203 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2204 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2205 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2206 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2207 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2208 Sub-46 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2209 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2210 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2211 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2212 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2213 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2214 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2215 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2216 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2217 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2218 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2219 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2220 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2221 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2222 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2223 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2224 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2225 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2226 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2227 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2228 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2229 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2230 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2231 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2232 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2233 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2234 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2235 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2236 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2237 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2238 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2239 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2240 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2241 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2242 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2243 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2244 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2245 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2246 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2247 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2248 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2249 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2250 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2251 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2252 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2253 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2254 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2255 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2256 Sub-47 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2257 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2258 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2259 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2260 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2261 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2262 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2263 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2264 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2265 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2266 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2267 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2268 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2269 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2270 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2271 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2272 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2273 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2274 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2275 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2276 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2277 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2278 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2279 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2280 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2281 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2282 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2283 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2284 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2285 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2286 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2287 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2288 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2289 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2290 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2291 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2292 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2293 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2294 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2295 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2296 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2297 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2298 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2299 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2300 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2301 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2302 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2303 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2304 Sub-81 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2305 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2306 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2307 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2308 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2309 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2310 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2311 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2312 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2313 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2314 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2315 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2316 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2317 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2318 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2319 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2320 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2321 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2322 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2323 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2324 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2325 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2326 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2327 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2328 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2329 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2330 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2331 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2332 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2333 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2334 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2335 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2336 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2337 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2338 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2339 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2340 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2341 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2342 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2343 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2344 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2345 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2346 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2347 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2348 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2349 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2350 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2351 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2352 Sub-48 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2353 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2354 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2355 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2356 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2357 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2358 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2359 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2360 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2361 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2362 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2363 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2364 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2365 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2366 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2367 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2368 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2369 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2370 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2371 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2372 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2373 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2374 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2375 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2376 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2377 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2378 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2379 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2380 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2381 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2382 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2383 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2384 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2385 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2386 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2387 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2388 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2389 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2390 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2391 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2392 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2393 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2394 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2395 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2396 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2397 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2398 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2399 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2400 Sub-49 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2401 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2402 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2403 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2404 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2405 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2406 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2407 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2408 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2409 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2410 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2411 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2412 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2413 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2414 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2415 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2416 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2417 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2418 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2419 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2420 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2421 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2422 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2423 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2424 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2425 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2426 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2427 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2428 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2429 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2430 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2431 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2432 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2433 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2434 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2435 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2436 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2437 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2438 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2439 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2440 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2441 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2442 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2443 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2444 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2445 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2446 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2447 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2448 Sub-50 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2449 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2450 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2451 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2452 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2453 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2454 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2455 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2456 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2457 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2458 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2459 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2460 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2461 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2462 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2463 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2464 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2465 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2466 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2467 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2468 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2469 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2470 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2471 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2472 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2473 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2474 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2475 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2476 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2477 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2478 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2479 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2480 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2481 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2482 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2483 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2484 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2485 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2486 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2487 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2488 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2489 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2490 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2491 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2492 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2493 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2494 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2495 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2496 Sub-51 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2497 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2498 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2499 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2500 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2501 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2502 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2503 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2504 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2505 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2506 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2507 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2508 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2509 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2510 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2511 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2512 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2513 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2514 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2515 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2516 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2517 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2518 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2519 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2520 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2521 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2522 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2523 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2524 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2525 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2526 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2527 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2528 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2529 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2530 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2531 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2532 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2533 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2534 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2535 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2536 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2537 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2538 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2539 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2540 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2541 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2542 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2543 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2544 Sub-52 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2545 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2546 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2547 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2548 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2549 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2550 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2551 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2552 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2553 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2554 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2555 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2556 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2557 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2558 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2559 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2560 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2561 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2562 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2563 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2564 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2565 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2566 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2567 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2568 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2569 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2570 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2571 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2572 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2573 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2574 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2575 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2576 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2577 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2578 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2579 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2580 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2581 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2582 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2583 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2584 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2585 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2586 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2587 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2588 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2589 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2590 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2591 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2592 Sub-53 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2593 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2594 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2595 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2596 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2597 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2598 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2599 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2600 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2601 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2602 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2603 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2604 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2605 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2606 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2607 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2608 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2609 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2610 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2611 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2612 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2613 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2614 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2615 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2616 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2617 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2618 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2619 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2620 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2621 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2622 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2623 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2624 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2625 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2626 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2627 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2628 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2629 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2630 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2631 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2632 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2633 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2634 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2635 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2636 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2637 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2638 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2639 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2640 Sub-54 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2641 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2642 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2643 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2644 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2645 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2646 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2647 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2648 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2649 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2650 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2651 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2652 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2653 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2654 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2655 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2656 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2657 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2658 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2659 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2660 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2661 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2662 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2663 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2664 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2665 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2666 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2667 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2668 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2669 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2670 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2671 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2672 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2673 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2674 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2675 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2676 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2677 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2678 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2679 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2680 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2681 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2682 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2683 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2684 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2685 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2686 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2687 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2688 Sub-55 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2689 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2690 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2691 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2692 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2693 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2694 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2695 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2696 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2697 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2698 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2699 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2700 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2701 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2702 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2703 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2704 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2705 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2706 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2707 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2708 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2709 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2710 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2711 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2712 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2713 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2714 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2715 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2716 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2717 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2718 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2719 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2720 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2721 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2722 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2723 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2724 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2725 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2726 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2727 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2728 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2729 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2730 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2731 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2732 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2733 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2734 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2735 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2736 Sub-56 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2737 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2738 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2739 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2740 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2741 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2742 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2743 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2744 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2745 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2746 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2747 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2748 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2749 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2750 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2751 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2752 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2753 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2754 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2755 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2756 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2757 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2758 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2759 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2760 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2761 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2762 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2763 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2764 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2765 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2766 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2767 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2768 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2769 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2770 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2771 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2772 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2773 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2774 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2775 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2776 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2777 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2778 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2779 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2780 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2781 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2782 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2783 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2784 Sub-57 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2785 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2786 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2787 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2788 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2789 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2790 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2791 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2792 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2793 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2794 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2795 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2796 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2797 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2798 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2799 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2800 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2801 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2802 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2803 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2804 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2805 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2806 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2807 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2808 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2809 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2810 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2811 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2812 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2813 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2814 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2815 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2816 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2817 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2818 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2819 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2820 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2821 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2822 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2823 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2824 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2825 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2826 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2827 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2828 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2829 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2830 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2831 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2832 Sub-58 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2833 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2834 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2835 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2836 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2837 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2838 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2839 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2840 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2841 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2842 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2843 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2844 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2845 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2846 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2847 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2848 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2849 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2850 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2851 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2852 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2853 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2854 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2855 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2856 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2857 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2858 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2859 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2860 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2861 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2862 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2863 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2864 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2865 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2866 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2867 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2868 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2869 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2870 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2871 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2872 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2873 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2874 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2875 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2876 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2877 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2878 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2879 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2880 Sub-59 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2881 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2882 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2883 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2884 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2885 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2886 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2887 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2888 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2889 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2890 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2891 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2892 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2893 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2894 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2895 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2896 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2897 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2898 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2899 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2900 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2901 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2902 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2903 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2904 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2905 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2906 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2907 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2908 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2909 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2910 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2911 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2912 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2913 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2914 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2915 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2916 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2917 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2918 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2919 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2920 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2921 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2922 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2923 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2924 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2925 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2926 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2927 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2928 Sub-82 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2929 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2930 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2931 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2932 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2933 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2934 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2935 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2936 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2937 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2938 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2939 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2940 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2941 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2942 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2943 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2944 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2945 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2946 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2947 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2948 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2949 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2950 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2951 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-23 2-2952 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-24 2-2953 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-25 2-2954 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-26 2-2955 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-27 2-2956 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-28 2-2957 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-29 2-2958 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-30 2-2959 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-31 2-2960 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-32 2-2961 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-65 2-2962 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-66 2-2963 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-67 2-2964 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-68 2-2965 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-69 2-2966 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-70 2-2967 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-71 2-2968 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-72 2-2969 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-73 2-2970 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-74 2-2971 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-75 2-2972 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-76 2-2973 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-77 2-2974 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-78 2-2975 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-79 2-2976 Sub-83 3,4-diClPh CO Single bond or CH₂ Sub-80 2-2977 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-1  2-2978 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-2  2-2979 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-3  2-2980 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-4  2-2981 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-5  2-2982 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-6  2-2983 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-7  2-2984 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-8  2-2985 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-9  2-2986 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-10 2-2987 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-11 2-2988 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-12 2-2989 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-13 2-2990 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-14 2-2991 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-15 2-2992 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-16 2-2993 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-17 2-2994 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-18 2-2995 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-19 2-2996 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-20 2-2997 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-21 2-2998 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-22 2-2999 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-23 2-3000 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-24 2-3001 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-25 2-3002 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-26 2-3003 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-27 2-3004 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-28 2-3005 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-29 2-3006 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-30 2-3007 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-31 2-3008 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-32 2-3009 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-65 2-3010 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-66 2-3011 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-67 2-3012 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-68 2-3013 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-69 2-3014 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-70 2-3015 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-71 2-3016 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-72 2-3017 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-73 2-3018 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-74 2-3019 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-75 2-3020 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-76 2-3021 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-77 2-3022 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-78 2-3023 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-79 2-3024 Sub-61 3,4-diClPh CO Single bond or CH₂ Sub-80 2-3025 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-1  2-3026 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-2  2-3027 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-3  2-3028 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-4  2-3029 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-5  2-3030 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-6  2-3031 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-7  2-3032 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-8  2-3033 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-9  2-3034 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-10 2-3035 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-11 2-3036 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-12 2-3037 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-13 2-3038 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-14 2-3039 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-15 2-3040 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-16 2-3041 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-17 2-3042 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-18 2-3043 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-19 2-3044 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-20 2-3045 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-21 2-3046 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-22 2-3047 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-23 2-3048 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-24 2-3049 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-25 2-3050 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-26 2-3051 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-27 2-3052 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-28 2-3053 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-29 2-3054 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-30 2-3055 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-31 2-3056 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-32 2-3057 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-65 2-3058 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-66 2-3059 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-67 2-3060 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-68 2-3061 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-69 2-3062 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-70 2-3063 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-71 2-3064 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-72 2-3065 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-73 2-3066 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-74 2-3067 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-75 2-3068 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-76 2-3069 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-77 2-3070 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-78 2-3071 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-79 2-3072 Sub-60 3,4-diClPh CO Single bond or CH₂ Sub-80 2-3073 Sub-33 3,4-diClPh SO₂ Single bond Sub-1  2-3074 Sub-33 3,4-diClPh SO₂ Single bond Sub-2  2-3075 Sub-33 3,4-diClPh SO₂ Single bond Sub-3  2-3076 Sub-33 3,4-diClPh SO₂ Single bond Sub-4  2-3077 Sub-33 3,4-diClPh SO₂ Single bond Sub-5  2-3078 Sub-33 3,4-diClPh SO₂ Single bond Sub-6  2-3079 Sub-33 3,4-diClPh SO₂ Single bond Sub-7  2-3080 Sub-33 3,4-diClPh SO₂ Single bond Sub-8  2-3081 Sub-33 3,4-diClPh SO₂ Single bond Sub-9  2-3082 Sub-33 3,4-diClPh SO₂ Single bond Sub-10 2-3083 Sub-33 3,4-diClPh SO₂ Single bond Sub-11 2-3084 Sub-33 3,4-diClPh SO₂ Single bond Sub-12 2-3085 Sub-33 3,4-diClPh SO₂ Single bond Sub-13 2-3086 Sub-33 3,4-diClPh SO₂ Single bond Sub-14 2-3087 Sub-33 3,4-diClPh SO₂ Single bond Sub-15 2-3088 Sub-33 3,4-diClPh SO₂ Single bond Sub-16 2-3089 Sub-33 3,4-diClPh SO₂ Single bond Sub-17 2-3090 Sub-33 3,4-diClPh SO₂ Single bond Sub-18 2-3091 Sub-33 3,4-diClPh SO₂ Single bond Sub-19 2-3092 Sub-33 3,4-diClPh SO₂ Single bond Sub-20 2-3093 Sub-33 3,4-diClPh SO₂ Single bond Sub-21 2-3094 Sub-33 3,4-diClPh SO₂ Single bond Sub-22 2-3095 Sub-33 3,4-diClPh SO₂ Single bond Sub-23 2-3096 Sub-33 3,4-diClPh SO₂ Single bond Sub-24 2-3097 Sub-33 3,4-diClPh SO₂ Single bond Sub-25 2-3098 Sub-33 3,4-diClPh SO₂ Single bond Sub-26 2-3099 Sub-33 3,4-diClPh SO₂ Single bond Sub-27 2-3100 Sub-33 3,4-diClPh SO₂ Single bond Sub-28 2-3101 Sub-33 3,4-diClPh SO₂ Single bond Sub-29 2-3102 Sub-33 3,4-diClPh SO₂ Single bond Sub-30 2-3103 Sub-33 3,4-diClPh SO₂ Single bond Sub-31 2-3104 Sub-33 3,4-diClPh SO₂ Single bond Sub-32 2-3105 Sub-33 3,4-diClPh SO₂ Single bond Sub-65 2-3106 Sub-33 3,4-diClPh SO₂ Single bond Sub-66 2-3107 Sub-33 3,4-diClPh SO₂ Single bond Sub-67 2-3108 Sub-33 3,4-diClPh SO₂ Single bond Sub-68 2-3109 Sub-33 3,4-diClPh SO₂ Single bond Sub-69 2-3110 Sub-33 3,4-diClPh SO₂ Single bond Sub-70 2-3111 Sub-33 3,4-diClPh SO₂ Single bond Sub-71 2-3112 Sub-33 3,4-diClPh SO₂ Single bond Sub-72 2-3113 Sub-33 3,4-diClPh SO₂ Single bond Sub-73 2-3114 Sub-33 3,4-diClPh SO₂ Single bond Sub-74 2-3115 Sub-33 3,4-diClPh SO₂ Single bond Sub-75 2-3116 Sub-33 3,4-diClPh SO₂ Single bond Sub-76 2-3117 Sub-33 3,4-diClPh SO₂ Single bond Sub-77 2-3118 Sub-33 3,4-diClPh SO₂ Single bond Sub-78 2-3119 Sub-33 3,4-diClPh SO₂ Single bond Sub-79 2-3120 Sub-33 3,4-diClPh SO₂ Single bond Sub-80 2-3121 Sub-34 3,4-diClPh SO₂ Single bond Sub-1  2-3122 Sub-34 3,4-diClPh SO₂ Single bond Sub-2  2-3123 Sub-34 3,4-diClPh SO₂ Single bond Sub-3  2-3124 Sub-34 3,4-diClPh SO₂ Single bond Sub-4  2-3125 Sub-34 3,4-diClPh SO₂ Single bond Sub-5  2-3126 Sub-34 3,4-diClPh SO₂ Single bond Sub-6  2-3127 Sub-34 3,4-diClPh SO₂ Single bond Sub-7  2-3128 Sub-34 3,4-diClPh SO₂ Single bond Sub-8  2-3129 Sub-34 3,4-diClPh SO₂ Single bond Sub-9  2-3130 Sub-34 3,4-diClPh SO₂ Single bond Sub-10 2-3131 Sub-34 3,4-diClPh SO₂ Single bond Sub-11 2-3132 Sub-34 3,4-diClPh SO₂ Single bond Sub-12 2-3133 Sub-34 3,4-diClPh SO₂ Single bond Sub-13 2-3134 Sub-34 3,4-diClPh SO₂ Single bond Sub-14 2-3135 Sub-34 3,4-diClPh SO₂ Single bond Sub-15 2-3136 Sub-34 3,4-diClPh SO₂ Single bond Sub-16 2-3137 Sub-34 3,4-diClPh SO₂ Single bond Sub-17 2-3138 Sub-34 3,4-diClPh SO₂ Single bond Sub-18 2-3139 Sub-34 3,4-diClPh SO₂ Single bond Sub-19 2-3140 Sub-34 3,4-diClPh SO₂ Single bond Sub-20 2-3141 Sub-34 3,4-diClPh SO₂ Single bond Sub-21 2-3142 Sub-34 3,4-diClPh SO₂ Single bond Sub-22 2-3143 Sub-34 3,4-diClPh SO₂ Single bond Sub-23 2-3144 Sub-34 3,4-diClPh SO₂ Single bond Sub-24 2-3145 Sub-34 3,4-diClPh SO₂ Single bond Sub-25 2-3146 Sub-34 3,4-diClPh SO₂ Single bond Sub-26 2-3147 Sub-34 3,4-diClPh SO₂ Single bond Sub-27 2-3148 Sub-34 3,4-diClPh SO₂ Single bond Sub-28 2-3149 Sub-34 3,4-diClPh SO₂ Single bond Sub-29 2-3150 Sub-34 3,4-diClPh SO₂ Single bond Sub-30 2-3151 Sub-34 3,4-diClPh SO₂ Single bond Sub-31 2-3152 Sub-34 3,4-diClPh SO₂ Single bond Sub-32 2-3153 Sub-34 3,4-diClPh SO₂ Single bond Sub-65 2-3154 Sub-34 3,4-diClPh SO₂ Single bond Sub-66 2-3155 Sub-34 3,4-diClPh SO₂ Single bond Sub-67 2-3156 Sub-34 3,4-diClPh SO₂ Single bond Sub-68 2-3157 Sub-34 3,4-diClPh SO₂ Single bond Sub-69 2-3158 Sub-34 3,4-diClPh SO₂ Single bond Sub-70 2-3159 Sub-34 3,4-diClPh SO₂ Single bond Sub-71 2-3160 Sub-34 3,4-diClPh SO₂ Single bond Sub-72 2-3161 Sub-34 3,4-diClPh SO₂ Single bond Sub-73 2-3162 Sub-34 3,4-diClPh SO₂ Single bond Sub-74 2-3163 Sub-34 3,4-diClPh SO₂ Single bond Sub-75 2-3164 Sub-34 3,4-diClPh SO₂ Single bond Sub-76 2-3165 Sub-34 3,4-diClPh SO₂ Single bond Sub-77 2-3166 Sub-34 3,4-diClPh SO₂ Single bond Sub-78 2-3167 Sub-34 3,4-diClPh SO₂ Single bond Sub-79 2-3168 Sub-34 3,4-diClPh SO₂ Single bond Sub-80 2-3169 Sub-35 3,4-diClPh SO₂ Single bond Sub-1  2-3170 Sub-35 3,4-diClPh SO₂ Single bond Sub-2  2-3171 Sub-35 3,4-diClPh SO₂ Single bond Sub-3  2-3172 Sub-35 3,4-diClPh SO₂ Single bond Sub-4  2-3173 Sub-35 3,4-diClPh SO₂ Single bond Sub-5  2-3174 Sub-35 3,4-diClPh SO₂ Single bond Sub-6  2-3175 Sub-35 3,4-diClPh SO₂ Single bond Sub-7  2-3176 Sub-35 3,4-diClPh SO₂ Single bond Sub-8  2-3177 Sub-35 3,4-diClPh SO₂ Single bond Sub-9  2-3178 Sub-35 3,4-diClPh SO₂ Single bond Sub-10 2-3179 Sub-35 3,4-diClPh SO₂ Single bond Sub-11 2-3180 Sub-35 3,4-diClPh SO₂ Single bond Sub-12 2-3181 Sub-35 3,4-diClPh SO₂ Single bond Sub-13 2-3182 Sub-35 3,4-diCiPh SO₂ Single bond Sub-14 2-3183 Sub-35 3,4-diClPh SO₂ Single bond Sub-15 2-3184 Sub-35 3,4-diClPh SO₂ Single bond Sub-16 2-3185 Sub-35 3,4-diClPh SO₂ Single bond Sub-17 2-3186 Sub-35 3,4-diClPh SO₂ Single bond Sub-18 2-3187 Sub-35 3,4-diClPh SO₂ Single bond Sub-19 2-3188 Sub-35 3,4-diClPh SO₂ Single bond Sub-20 2-3189 Sub-35 3,4-diClPh SO₂ Single bond Sub-21 2-3190 Sub-35 3,4-diClPh SO₂ Single bond Sub-22 2-3191 Sub-35 3,4-diClPh SO₂ Single bond Sub-23 2-3192 Sub-35 3,4-diClPh SO₂ Single bond Sub-24 2-3193 Sub-35 3,4-diClPh SO₂ Single bond Sub-25 2-3194 Sub-35 3,4-diClPh SO₂ Single bond Sub-26 2-3195 Sub-35 3,4-diClPh SO₂ Single bond Sub-27 2-3196 Sub-35 3,4-diClPh SO₂ Single bond Sub-28 2-3197 Sub-35 3,4-diClPh SO₂ Single bond Sub-29 2-3198 Sub-35 3,4-diClPh SO₂ Single bond Sub-30 2-3199 Sub-35 3,4-diClPh SO₂ Single bond Sub-31 2-3200 Sub-35 3,4-diClPh SO₂ Single bond Sub-32 2-3201 Sub-35 3,4-diClPh SO₂ Single bond Sub-65 2-3202 Sub-35 3,4-diClPh SO₂ Single bond Sub-66 2-3203 Sub-35 3,4-diClPh SO₂ Single bond Sub-67 2-3204 Sub-35 3,4-diClPh SO₂ Single bond Sub-68 2-3205 Sub-35 3,4-diClPh SO₂ Single bond Sub-69 2-3206 Sub-35 3,4-diClPh SO₂ Single bond Sub-70 2-3207 Sub-35 3,4-diClPh SO₂ Single bond Sub-71 2-3208 Sub-35 3,4-diClPh SO₂ Single bond Sub-72 2-3209 Sub-35 3,4-diClPh SO₂ Single bond Sub-73 2-3210 Sub-35 3,4-diClPh SO₂ Single bond Sub-74 2-3211 Sub-35 3,4-diClPh SO₂ Single bond Sub-75 2-3212 Sub-35 3,4-diClPh SO₂ Single bond Sub-76 2-3213 Sub-35 3,4-diClPh SO₂ Single bond Sub-77 2-3214 Sub-35 3,4-diClPh SO₂ Single bond Sub-78 2-3215 Sub-35 3,4-diClPh SO₂ Single bond Sub-79 2-3216 Sub-35 3,4-diClPh SO₂ Single bond Sub-80 2-3217 Sub-36 3,4-diClPh SO₂ Single bond Sub-1  2-3218 Sub-36 3,4-diClPh SO₂ Single bond Sub-2  2-3219 Sub-36 3,4-diClPh SO₂ Single bond Sub-3  2-3220 Sub-36 3,4-diClPh SO₂ Single bond Sub-4  2-3221 Sub-36 3,4-diClPh SO₂ Single bond Sub-5  2-3222 Sub-36 3,4-diClPh SO₂ Single bond Sub-6  2-3223 Sub-36 3,4-diClPh SO₂ Single bond Sub-7  2-3224 Sub-36 3,4-diClPh SO₂ Single bond Sub-8  2-3225 Sub-36 3,4-diClPh SO₂ Single bond Sub-9  2-3226 Sub-36 3,4-diClPh SO₂ Single bond Sub-10 2-3227 Sub-36 3,4-diClPh SO₂ Single bond Sub-11 2-3228 Sub-36 3,4-diClPh SO₂ Single bond Sub-12 2-3229 Sub-36 3,4-diClPh SO₂ Single bond Sub-13 2-3230 Sub-36 3,4-diClPh SO₂ Single bond Sub-14 2-3231 Sub-36 3,4-diClPh SO₂ Single bond Sub-15 2-3232 Sub-36 3,4-diClPh SO₂ Single bond Sub-16 2-3233 Sub-36 3,4-diClPh SO₂ Single bond Sub-17 2-3234 Sub-36 3,4-diClPh SO₂ Single bond Sub-18 2-3235 Sub-36 3,4-diClPh SO₂ Single bond Sub-19 2-3236 Sub-36 3,4-diClPh SO₂ Single bond Sub-20 2-3237 Sub-36 3,4-diClPh SO₂ Single bond Sub-21 2-3238 Sub-36 3,4-diClPh SO₂ Single bond Sub-22 2-3239 Sub-36 3,4-diClPh SO₂ Single bond Sub-23 2-3240 Sub-36 3,4-diClPh SO₂ Single bond Sub-24 2-3241 Sub-36 3,4-diClPh SO₂ Single bond Sub-25 2-3242 Sub-36 3,4-diClPh SO₂ Single bond Sub-26 2-3243 Sub-36 3,4-diClPh SO₂ Single bond Sub-27 2-3244 Sub-36 3,4-diClPh SO₂ Single bond Sub-28 2-3245 Sub-36 3,4-diClPh SO₂ Single bond Sub-29 2-3246 Sub-36 3,4-diClPh SO₂ Single bond Sub-30 2-3247 Sub-36 3,4-diClPh SO₂ Single bond Sub-31 2-3248 Sub-36 3,4-diClPh SO₂ Single bond Sub-32 2-3249 Sub-36 3,4-diClPh SO₂ Single bond Sub-65 2-3250 Sub-36 3,4-diClPh SO₂ Single bond Sub-66 2-3251 Sub-36 3,4-diClPh SO₂ Single bond Sub-67 2-3252 Sub-36 3,4-diClPh SO₂ Single bond Sub-68 2-3253 Sub-36 3,4-diClPh SO₂ Single bond Sub-69 2-3254 Sub-36 3,4-diClPh SO₂ Single bond Sub-70 2-3255 Sub-36 3,4-diClPh SO₂ Single bond Sub-71 2-3256 Sub-36 3,4-diClPh SO₂ Single bond Sub-72 2-3257 Sub-36 3,4-diClPh SO₂ Single bond Sub-73 2-3258 Sub-36 3,4-diClPh SO₂ Single bond Sub-74 2-3259 Sub-36 3,4-diClPh SO₂ Single bond Sub-75 2-3260 Sub-36 3,4-diClPh SO₂ Single bond Sub-76 2-3261 Sub-36 3,4-diClPh SO₂ Single bond Sub-77 2-3262 Sub-36 3,4-diClPh SO₂ Single bond Sub-78 2-3263 Sub-36 3,4-diClPh SO₂ Single bond Sub-79 2-3264 Sub-36 3,4-diClPh SO₂ Single bond Sub-80 2-3265 Sub-37 3,4-diClPh SO₂ Single bond Sub-1  2-3266 Sub-37 3,4-diClPh SO₂ Single bond Sub-2  2-3267 Sub-37 3,4-diClPh SO₂ Single bond Sub-3  2-3268 Sub-37 3,4-diClPh SO₂ Single bond Sub-4  2-3269 Sub-37 3,4-diClPh SO₂ Single bond Sub-5  2-3270 Sub-37 3,4-diClPh SO₂ Single bond Sub-6  2-3271 Sub-37 3,4-diClPh SO₂ Single bond Sub-7  2-3272 Sub-37 3,4-diClPh SO₂ Single bond Sub-8  2-3273 Sub-37 3,4-diClPh SO₂ Single bond Sub-9  2-3274 Sub-37 3,4-diClPh SO₂ Single bond Sub-10 2-3275 Sub-37 3,4-diClPh SO₂ Single bond Sub-11 2-3276 Sub-37 3,4-diClPh SO₂ Single bond Sub-12 2-3277 Sub-37 3,4-diClPh SO₂ Single bond Sub-13 2-3278 Sub-37 3,4-diClPh SO₂ Single bond Sub-14 2-3279 Sub-37 3,4-diClPh SO₂ Single bond Sub-15 2-3280 Sub-37 3,4-diClPh SO₂ Single bond Sub-16 2-3281 Sub-37 3,4-diClPh SO₂ Single bond Sub-17 2-3282 Sub-37 3,4-diClPh SO₂ Single bond Sub-18 2-3283 Sub-37 3,4-diClPh SO₂ Single bond Sub-19 2-3284 Sub-37 3,4-diClPh SO₂ Single bond Sub-20 2-3285 Sub-37 3,4-diClPh SO₂ Single bond Sub-21 2-3286 Sub-37 3,4-diClPh SO₂ Single bond Sub-22 2-3287 Sub-37 3,4-diClPh SO₂ Single bond Sub-23 2-3288 Sub-37 3,4-diClPh SO₂ Single bond Sub-24 2-3289 Sub-37 3,4-diClPh SO₂ Single bond Sub-25 2-3290 Sub-37 3,4-diClPh SO₂ Single bond Sub-26 2-3291 Sub-37 3,4-diClPh SO₂ Single bond Sub-27 2-3292 Sub-37 3,4-diClPh SO₂ Single bond Sub-28 2-3293 Sub-37 3,4-diClPh SO₂ Single bond Sub-29 2-3294 Sub-37 3,4-diClPh SO₂ Single bond Sub-30 2-3295 Sub-37 3,4-diClPh SO₂ Single bond Sub-31 2-3296 Sub-37 3,4-diClPh SO₂ Single bond Sub-32 2-3297 Sub-37 3,4-diClPh SO₂ Single bond Sub-65 2-3298 Sub-37 3,4-diClPh SO₂ Single bond Sub-66 2-3299 Sub-37 3,4-diClPh SO₂ Single bond Sub-67 2-3300 Sub-37 3,4-diClPh SO₂ Single bond Sub-68 2-3301 Sub-37 3,4-diClPh SO₂ Single bond Sub-69 2-3302 Sub-37 3,4-diClPh SO₂ Single bond Sub-70 2-3303 Sub-37 3,4-diClPh SO₂ Single bond Sub-71 2-3304 Sub-37 3,4-diClPh SO₂ Single bond Sub-72 2-3305 Sub-37 3,4-diClPh SO₂ Single bond Sub-73 2-3306 Sub-37 3,4-diClPh SO₂ Single bond Sub-74 2-3307 Sub-37 3,4-diClPh SO₂ Single bond Sub-75 2-3308 Sub-37 3,4-diClPh SO₂ Single bond Sub-76 2-3309 Sub-37 3,4-diClPh SO₂ Single bond Sub-77 2-3310 Sub-37 3,4-diClPh SO₂ Single bond Sub-78 2-3311 Sub-37 3,4-diClPh SO₂ Single bond Sub-79 2-3312 Sub-37 3,4-diClPh SO₂ Single bond Sub-80 2-3313 Sub-38 3,4-diClPh SO₂ Single bond Sub-1  2-3314 Sub-38 3,4-diClPh SO₂ Single bond Sub-2  2-3315 Sub-38 3,4-diClPh SO₂ Single bond Sub-3  2-3316 Sub-38 3,4-diClPh SO₂ Single bond Sub-4  2-3317 Sub-38 3,4-diClPh SO₂ Single bond Sub-5  2-3318 Sub-38 3,4-diClPh SO₂ Single bond Sub-6  2-3319 Sub-38 3,4-diClPh SO₂ Single bond Sub-7  2-3320 Sub-38 3,4-diClPh SO₂ Single bond Sub-8  2-3321 Sub-38 3,4-diClPh SO₂ Single bond Sub-9  2-3322 Sub-38 3,4-diClPh SO₂ Single bond Sub-10 2-3323 Sub-38 3,4-diClPh SO₂ Single bond Sub-11 2-3324 Sub-38 3,4-diClPh SO₂ Single bond Sub-12 2-3325 Sub-38 3,4-diClPh SO₂ Single bond Sub-13 2-3326 Sub-38 3,4-diClPh SO₂ Single bond Sub-14 2-3327 Sub-38 3,4-diClPh SO₂ Single bond Sub-15 2-3328 Sub-38 3,4-diClPh SO₂ Single bond Sub-16 2-3329 Sub-38 3,4-diClPh SO₂ Single bond Sub-17 2-3330 Sub-38 3,4-diClPh SO₂ Single bond Sub-18 2-3331 Sub-38 3,4-diClPh SO₂ Single bond Sub-19 2-3332 Sub-38 3,4-diClPh SO₂ Single bond Sub-20 2-3333 Sub-38 3,4-diClPh SO₂ Single bond Sub-21 2-3334 Sub-38 3,4-diClPh SO₂ Single bond Sub-22 2-3335 Sub-38 3,4-diClPh SO₂ Single bond Sub-23 2-3336 Sub-38 3,4-diClPh SO₂ Single bond Sub-24 2-3337 Sub-38 3,4-diClPh SO₂ Single bond Sub-25 2-3338 Sub-38 3,4-diClPh SO₂ Single bond Sub-26 2-3339 Sub-38 3,4-diClPh SO₂ Single bond Sub-27 2-3340 Sub-38 3,4-diClPh SO₂ Single bond Sub-28 2-3341 Sub-38 3,4-diClPh SO₂ Single bond Sub-29 2-3342 Sub-38 3,4-diClPh SO₂ Single bond Sub-30 2-3343 Sub-38 3,4-diClPh SO₂ Single bond Sub-31 2-3344 Sub-38 3,4-diClPh SO₂ Single bond Sub-32 2-3345 Sub-38 3,4-diClPh SO₂ Single bond Sub-65 2-3346 Sub-38 3,4-diClPh SO₂ Single bond Sub-66 2-3347 Sub-38 3,4-diClPh SO₂ Single bond Sub-67 2-3348 Sub-38 3,4-diClPh SO₂ Single bond Sub-68 2-3349 Sub-38 3,4-diClPh SO₂ Single bond Sub-69 2-3350 Sub-38 3,4-diClPh SO₂ Single bond Sub-70 2-3351 Sub-38 3,4-diClPh SO₂ Single bond Sub-71 2-3352 Sub-38 3,4-diClPh SO₂ Single bond Sub-72 2-3353 Sub-38 3,4-diClPh SO₂ Single bond Sub-73 2-3354 Sub-38 3,4-diClPh SO₂ Single bond Sub-74 2-3355 Sub-38 3,4-diClPh SO₂ Single bond Sub-75 2-3356 Sub-38 3,4-diClPh SO₂ Single bond Sub-76 2-3357 Sub-38 3,4-diClPh SO₂ Single bond Sub-77 2-3358 Sub-38 3,4-diClPh SO₂ Single bond Sub-78 2-3359 Sub-38 3,4-diClPh SO₂ Single bond Sub-79 2-3360 Sub-38 3,4-diClPh SO₂ Single bond Sub-80 2-3361 Sub-39 3,4-diClPh SO₂ Single bond Sub-1  2-3362 Sub-39 3,4-diClPh SO₂ Single bond Sub-2  2-3363 Sub-39 3,4-diClPh SO₂ Single bond Sub-3  2-3364 Sub-39 3,4-diClPh SO₂ Single bond Sub-4  2-3365 Sub-39 3,4-diClPh SO₂ Single bond Sub-5  2-3366 Sub-39 3,4-diClPh SO₂ Single bond Sub-6  2-3367 Sub-39 3,4-diClPh SO₂ Single bond Sub-7  2-3368 Sub-39 3,4-diClPh SO₂ Single bond Sub-8  2-3369 Sub-39 3,4-diClPh SO₂ Single bond Sub-9  2-3370 Sub-39 3,4-diClPh SO₂ Single bond Sub-10 2-3371 Sub-39 3,4-diClPh SO₂ Single bond Sub-11 2-3372 Sub-39 3,4-diClPh SO₂ Single bond Sub-12 2-3373 Sub-39 3,4-diClPh SO₂ Single bond Sub-13 2-3374 Sub-39 3,4-diClPh SO₂ Single bond Sub-14 2-3375 Sub-39 3,4-diClPh SO₂ Single bond Sub-15 2-3376 Sub-39 3,4-diClPh SO₂ Single bond Sub-16 2-3377 Sub-39 3,4-diClPh SO₂ Single bond Sub-17 2-3378 Sub-39 3,4-diClPh SO₂ Single bond Sub-18 2-3379 Sub-39 3,4-diClPh SO₂ Single bond Sub-19 2-3380 Sub-39 3,4-diClPh SO₂ Single bond Sub-20 2-3381 Sub-39 3,4-diClPh SO₂ Single bond Sub-21 2-3382 Sub-39 3,4-diClPh SO₂ Single bond Sub-22 2-3383 Sub-39 3,4-diClPh SO₂ Single bond Sub-23 2-3384 Sub-39 3,4-diClPh SO₂ Single bond Sub-24 2-3385 Sub-39 3,4-diClPh SO₂ Single bond Sub-25 2-3386 Sub-39 3,4-diClPh SO₂ Single bond Sub-26 2-3387 Sub-39 3,4-diClPh SO₂ Single bond Sub-27 2-3388 Sub-39 3,4-diClPh SO₂ Single bond Sub-28 2-3389 Sub-39 3,4-diClPh SO₂ Single bond Sub-29 2-3390 Sub-39 3,4-diClPh SO₂ Single bond Sub-30 2-3391 Sub-39 3,4-diClPh SO₂ Single bond Sub-31 2-3392 Sub-39 3,4-diClPh SO₂ Single bond Sub-32 2-3393 Sub-39 3,4-diClPh SO₂ Single bond Sub-65 2-3394 Sub-39 3,4-diClPh SO₂ Single bond Sub-66 2-3395 Sub-39 3,4-diClPh SO₂ Single bond Sub-67 2-3396 Sub-39 3,4-diClPh SO₂ Single bond Sub-68 2-3397 Sub-39 3,4-diClPh SO₂ Single bond Sub-69 2-3398 Sub-39 3,4-diClPh SO₂ Single bond Sub-70 2-3399 Sub-39 3,4-diClPh SO₂ Single bond Sub-71 2-3400 Sub-39 3,4-diClPh SO₂ Single bond Sub-72 2-3401 Sub-39 3,4-diClPh SO₂ Single bond Sub-73 2-3402 Sub-39 3,4-diClPh SO₂ Single bond Sub-74 2-3403 Sub-39 3,4-diClPh SO₂ Single bond Sub-75 2-3404 Sub-39 3,4-diClPh SO₂ Single bond Sub-76 2-3405 Sub-39 3,4-diClPh SO₂ Single bond Sub-77 2-3406 Sub-39 3,4-diClPh SO₂ Single bond Sub-78 2-3407 Sub-39 3,4-diClPh SO₂ Single bond Sub-79 2-3408 Sub-39 3,4-diClPh SO₂ Single bond Sub-80 2-3409 Sub-40 3,4-diClPh SO₂ Single bond Sub-1  2-3410 Sub-40 3,4-diClPh SO₂ Single bond Sub-2  2-3411 Sub-40 3,4-diClPh SO₂ Single bond Sub-3  2-3412 Sub-40 3,4-diClPh SO₂ Single bond Sub-4  2-3413 Sub-40 3,4-diClPh SO₂ Single bond Sub-5  2-3414 Sub-40 3,4-diClPh SO₂ Single bond Sub-6  2-3415 Sub-40 3,4-diClPh SO₂ Single bond Sub-7  2-3416 Sub-40 3,4-diClPh SO₂ Single bond Sub-8  2-3417 Sub-40 3,4-diClPh SO₂ Single bond Sub-9  2-3418 Sub-40 3,4-diClPh SO₂ Single bond Sub-10 2-3419 Sub-40 3,4-diClPh SO₂ Single bond Sub-11 2-3420 Sub-40 3,4-diClPh SO₂ Single bond Sub-12 2-3421 Sub-40 3,4-diClPh SO₂ Single bond Sub-13 2-3422 Sub-40 3,4-diClPh SO₂ Single bond Sub-14 2-3423 Sub-40 3,4-diClPh SO₂ Single bond Sub-15 2-3424 Sub-40 3,4-diClPh SO₂ Single bond Sub-16 2-3425 Sub-40 3,4-diClPh SO₂ Single bond Sub-17 2-3426 Sub-40 3,4-diClPh SO₂ Single bond Sub-18 2-3427 Sub-40 3,4-diClPh SO₂ Single bond Sub-19 2-3428 Sub-40 3,4-diClPh SO₂ Single bond Sub-20 2-3429 Sub-40 3,4-diClPh SO₂ Single bond Sub-21 2-3430 Sub-40 3,4-diClPh SO₂ Single bond Sub-22 2-3431 Sub-40 3,4-diClPh SO₂ Single bond Sub-23 2-3432 Sub-40 3,4-diClPh SO₂ Single bond Sub-24 2-3433 Sub-40 3,4-diClPh SO₂ Single bond Sub-25 2-3434 Sub-40 3,4-diClPh SO₂ Single bond Sub-26 2-3435 Sub-40 3,4-diClPh SO₂ Single bond Sub-27 2-3436 Sub-40 3,4-diClPh SO₂ Single bond Sub-28 2-3437 Sub-40 3,4-diClPh SO₂ Single bond Sub-29 2-3438 Sub-40 3,4-diClPh SO₂ Single bond Sub-30 2-3439 Sub-40 3,4-diClPh SO₂ Single bond Sub-31 2-3440 Sub-40 3,4-diClPh SO₂ Single bond Sub-32 2-3441 Sub-40 3,4-diClPh SO₂ Single bond Sub-65 2-3442 Sub-40 3,4-diClPh SO₂ Single bond Sub-66 2-3443 Sub-40 3,4-diClPh SO₂ Single bond Sub-67 2-3444 Sub-40 3,4-diClPh SO₂ Single bond Sub-68 2-3445 Sub-40 3,4-diClPh SO₂ Single bond Sub-69 2-3446 Sub-40 3,4-diClPh SO₂ Single bond Sub-70 2-3447 Sub-40 3,4-diClPh SO₂ Single bond Sub-71 2-3448 Sub-40 3,4-diClPh SO₂ Single bond Sub-72 2-3449 Sub-40 3,4-diClPh SO₂ Single bond Sub-73 2-3450 Sub-40 3,4-diClPh SO₂ Single bond Sub-74 2-3451 Sub-40 3,4-diClPh SO₂ Single bond Sub-75 2-3452 Sub-40 3,4-diClPh SO₂ Single bond Sub-76 2-3453 Sub-40 3,4-diClPh SO₂ Single bond Sub-77 2-3454 Sub-40 3,4-diClPh SO₂ Single bond Sub-78 2-3455 Sub-40 3,4-diClPh SO₂ Single bond Sub-79 2-3456 Sub-40 3,4-diClPh SO₂ Single bond Sub-80 2-3457 Sub-41 3,4-diClPh SO₂ Single bond Sub-1  2-3458 Sub-41 3,4-diClPh SO₂ Single bond Sub-2  2-3459 Sub-41 3,4-diClPh SO₂ Single bond Sub-3  2-3460 Sub-41 3,4-diClPh SO₂ Single bond Sub-4  2-3461 Sub-41 3,4-diClPh SO₂ Single bond Sub-5  2-3462 Sub-41 3,4-diClPh SO₂ Single bond Sub-6  2-3463 Sub-41 3,4-diClPh SO₂ Single bond Sub-7  2-3464 Sub-41 3,4-diClPh SO₂ Single bond Sub-8  2-3465 Sub-41 3,4-diClPh SO₂ Single bond Sub-9  2-3466 Sub-41 3,4-diClPh SO₂ Single bond Sub-10 2-3467 Sub-41 3,4-diClPh SO₂ Single bond Sub-11 2-3468 Sub-41 3,4-diClPh SO₂ Single bond Sub-12 2-3469 Sub-41 3,4-diClPh SO₂ Single bond Sub-13 2-3470 Sub-41 3,4-diClPh SO₂ Single bond Sub-14 2-3471 Sub-41 3,4-diClPh SO₂ Single bond Sub-15 2-3472 Sub-41 3,4-diClPh SO₂ Single bond Sub-16 2-3473 Sub-41 3,4-diClPh SO₂ Single bond Sub-17 2-3474 Sub-41 3,4-diClPh SO₂ Single bond Sub-18 2-3475 Sub-41 3,4-diClPh SO₂ Single bond Sub-19 2-3476 Sub-41 3,4-diClPh SO₂ Single bond Sub-20 2-3477 Sub-41 3,4-diClPh SO₂ Single bond Sub-21 2-3478 Sub-41 3,4-diClPh SO₂ Single bond Sub-22 2-3479 Sub-41 3,4-diClPh SO₂ Single bond Sub-23 2-3480 Sub-41 3,4-diClPh SO₂ Single bond Sub-24 2-3481 Sub-41 3,4-diClPh SO₂ Single bond Sub-25 2-3482 Sub-41 3,4-diClPh SO₂ Single bond Sub-26 2-3483 Sub-41 3,4-diClPh SO₂ Single bond Sub-27 2-3484 Sub-41 3,4-diClPh SO₂ Single bond Sub-28 2-3485 Sub-41 3,4-diClPh SO₂ Single bond Sub-29 2-3486 Sub-41 3,4-diClPh SO₂ Single bond Sub-30 2-3487 Sub-41 3,4-diClPh SO₂ Single bond Sub-31 2-3488 Sub-41 3,4-diClPh SO₂ Single bond Sub-32 2-3489 Sub-41 3,4-diClPh SO₂ Single bond Sub-65 2-3490 Sub-41 3,4-diClPh SO₂ Single bond Sub-66 2-3491 Sub-41 3,4-diClPh SO₂ Single bond Sub-67 2-3492 Sub-41 3,4-diClPh SO₂ Single bond Sub-68 2-3493 Sub-41 3,4-diClPh SO₂ Single bond Sub-69 2-3494 Sub-41 3,4-diClPh SO₂ Single bond Sub-70 2-3495 Sub-41 3,4-diClPh SO₂ Single bond Sub-71 2-3496 Sub-41 3,4-diClPh SO₂ Single bond Sub-72 2-3497 Sub-41 3,4-diClPh SO₂ Single bond Sub-73 2-3498 Sub-41 3,4-diClPh SO₂ Single bond Sub-74 2-3499 Sub-41 3,4-diClPh SO₂ Single bond Sub-75 2-3500 Sub-41 3,4-diClPh SO₂ Single bond Sub-76 2-3501 Sub-41 3,4-diClPh SO₂ Single bond Sub-77 2-3502 Sub-41 3,4-diClPh SO₂ Single bond Sub-78 2-3503 Sub-41 3,4-diClPh SO₂ Single bond Sub-79 2-3504 Sub-41 3,4-diClPh SO₂ Single bond Sub-80 2-3505 Sub-42 3,4-diClPh SO₂ Single bond Sub-1  2-3506 Sub-42 3,4-diClPh SO₂ Single bond Sub-2  2-3507 Sub-42 3,4-diClPh SO₂ Single bond Sub-3  2-3508 Sub-42 3,4-diClPh SO₂ Single bond Sub-4  2-3509 Sub-42 3,4-diClPh SO₂ Single bond Sub-5  2-3510 Sub-42 3,4-diClPh SO₂ Single bond Sub-6  2-3511 Sub-42 3,4-diClPh SO₂ Single bond Sub-7  2-3512 Sub-42 3,4-diClPh SO₂ Single bond Sub-8  2-3513 Sub-42 3,4-diClPh SO₂ Single bond Sub-9  2-3514 Sub-42 3,4-diClPh SO₂ Single bond Sub-10 2-3515 Sub-42 3,4-diClPh SO₂ Single bond Sub-11 2-3516 Sub-42 3,4-diClPh SO₂ Single bond Sub-12 2-3517 Sub-42 3,4-diClPh SO₂ Single bond Sub-13 2-3518 Sub-42 3,4-diClPh SO₂ Single bond Sub-14 2-3519 Sub-42 3,4-diClPh SO₂ Single bond Sub-15 2-3520 Sub-42 3,4-diClPh SO₂ Single bond Sub-16 2-3521 Sub-42 3,4-diClPh SO₂ Single bond Sub-17 2-3522 Sub-42 3,4-diClPh SO₂ Single bond Sub-18 2-3523 Sub-42 3,4-diClPh SO₂ Single bond Sub-19 2-3524 Sub-42 3,4-diClPh SO₂ Single bond Sub-20 2-3525 Sub-42 3,4-diClPh SO₂ Single bond Sub-21 2-3526 Sub-42 3,4-diClPh SO₂ Single bond Sub-22 2-3527 Sub-42 3,4-diClPh SO₂ Single bond Sub-23 2-3528 Sub-42 3,4-diClPh SO₂ Single bond Sub-24 2-3529 Sub-42 3,4-diClPh SO₂ Single bond Sub-25 2-3530 Sub-42 3,4-diClPh SO₂ Single bond Sub-26 2-3531 Sub-42 3,4-diClPh SO₂ Single bond Sub-27 2-3532 Sub-42 3,4-diClPh SO₂ Single bond Sub-28 2-3533 Sub-42 3,4-diClPh SO₂ Single bond Sub-29 2-3534 Sub-42 3,4-diClPh SO₂ Single bond Sub-30 2-3535 Sub-42 3,4-diClPh SO₂ Single bond Sub-31 2-3536 Sub-42 3,4-diClPh SO₂ Single bond Sub-32 2-3537 Sub-42 3,4-diClPh SO₂ Single bond Sub-65 2-3538 Sub-42 3,4-diClPh SO₂ Single bond Sub-66 2-3539 Sub-42 3,4-diClPh SO₂ Single bond Sub-67 2-3540 Sub-42 3,4-diClPh SO₂ Single bond Sub-68 2-3541 Sub-42 3,4-diClPh SO₂ Single bond Sub-69 2-3542 Sub-42 3,4-diClPh SO₂ Single bond Sub-70 2-3543 Sub-42 3,4-diClPh SO₂ Single bond Sub-71 2-3544 Sub-42 3,4-diClPh SO₂ Single bond Sub-72 2-3545 Sub-42 3,4-diClPh SO₂ Single bond Sub-73 2-3546 Sub-42 3,4-diClPh SO₂ Single bond Sub-74 2-3547 Sub-42 3,4-diClPh SO₂ Single bond Sub-75 2-3548 Sub-42 3,4-diClPh SO₂ Single bond Sub-76 2-3549 Sub-42 3,4-diClPh SO₂ Single bond Sub-77 2-3550 Sub-42 3,4-diClPh SO₂ Single bond Sub-78 2-3551 Sub-42 3,4-diClPh SO₂ Single bond Sub-79 2-3552 Sub-42 3,4-diClPh SO₂ Single bond Sub-80 2-3553 Sub-43 3,4-diClPh SO₂ Single bond Sub-1  2-3554 Sub-43 3,4-diClPh SO₂ Single bond Sub-2  2-3555 Sub-43 3,4-diClPh SO₂ Single bond Sub-3  2-3556 Sub-43 3,4-diClPh SO₂ Single bond Sub-4  2-3557 Sub-43 3,4-diClPh SO₂ Single bond Sub-5  2-3558 Sub-43 3,4-diClPh SO₂ Single bond Sub-6  2-3559 Sub-43 3,4-diClPh SO₂ Single bond Sub-7  2-3560 Sub-43 3,4-diClPh SO₂ Single bond Sub-8  2-3561 Sub-43 3,4-diClPh SO₂ Single bond Sub-9  2-3562 Sub-43 3,4-diClPh SO₂ Single bond Sub-10 2-3563 Sub-43 3,4-diClPh SO₂ Single bond Sub-11 2-3564 Sub-43 3,4-diClPh SO₂ Single bond Sub-12 2-3565 Sub-43 3,4-diClPh SO₂ Single bond Sub-13 2-3566 Sub-43 3,4-diClPh SO₂ Single bond Sub-14 2-3567 Sub-43 3,4-diClPh SO₂ Single bond Sub-15 2-3568 Sub-43 3,4-diClPh SO₂ Single bond Sub-16 2-3569 Sub-43 3,4-diClPh SO₂ Single bond Sub-17 2-3570 Sub-43 3,4-diClPh SO₂ Single bond Sub-18 2-3571 Sub-43 3,4-diClPh SO₂ Single bond Sub-19 2-3572 Sub-43 3,4-diClPh SO₂ Single bond Sub-20 2-3573 Sub-43 3,4-diClPh SO₂ Single bond Sub-21 2-3574 Sub-43 3,4-diClPh SO₂ Single bond Sub-22 2-3575 Sub-43 3,4-diClPh SO₂ Single bond Sub-23 2-3576 Sub-43 3,4-diClPh SO₂ Single bond Sub-24 2-3577 Sub-43 3,4-diClPh SO₂ Single bond Sub-25 2-3578 Sub-43 3,4-diClPh SO₂ Single bond Sub-26 2-3579 Sub-43 3,4-diClPh SO₂ Single bond Sub-27 2-3580 Sub-43 3,4-diClPh SO₂ Single bond Sub-28 2-3581 Sub-43 3,4-diClPh SO₂ Single bond Sub-29 2-3582 Sub-43 3,4-diClPh SO₂ Single bond Sub-30 2-3583 Sub-43 3,4-diClPh SO₂ Single bond Sub-31 2-3584 Sub-43 3,4-diClPh SO₂ Single bond Sub-32 2-3585 Sub-43 3,4-diClPh SO₂ Single bond Sub-65 2-3586 Sub-43 3,4-diClPh SO₂ Single bond Sub-66 2-3587 Sub-43 3,4-diClPh SO₂ Single bond Sub-67 2-3588 Sub-43 3,4-diClPh SO₂ Single bond Sub-68 2-3589 Sub-43 3,4-diClPh SO₂ Single bond Sub-69 2-3590 Sub-43 3,4-diClPh SO₂ Single bond Sub-70 2-3591 Sub-43 3,4-diClPh SO₂ Single bond Sub-71 2-3592 Sub-43 3,4-diClPh SO₂ Single bond Sub-72 2-3593 Sub-43 3,4-diClPh SO₂ Single bond Sub-73 2-3594 Sub-43 3,4-diClPh SO₂ Single bond Sub-74 2-3595 Sub-43 3,4-diClPh SO₂ Single bond Sub-75 2-3596 Sub-43 3,4-diClPh SO₂ Single bond Sub-76 2-3597 Sub-43 3,4-diClPh SO₂ Single bond Sub-77 2-3598 Sub-43 3,4-diClPh SO₂ Single bond Sub-78 2-3599 Sub-43 3,4-diClPh SO₂ Single bond Sub-79 2-3600 Sub-43 3,4-diClPh SO₂ Single bond Sub-80 2-3601 Sub-44 3,4-diClPh SO₂ Single bond Sub-1  2-3602 Sub-44 3,4-diClPh SO₂ Single bond Sub-2  2-3603 Sub-44 3,4-diClPh SO₂ Single bond Sub-3  2-3604 Sub-44 3,4-diClPh SO₂ Single bond Sub-4  2-3605 Sub-44 3,4-diClPh SO₂ Single bond Sub-5  2-3606 Sub-44 3,4-diClPh SO₂ Single bond Sub-6  2-3607 Sub-44 3,4-diClPh SO₂ Single bond Sub-7  2-3608 Sub-44 3,4-diClPh SO₂ Single bond Sub-8  2-3609 Sub-44 3,4-diClPh SO₂ Single bond Sub-9  2-3610 Sub-44 3,4-diClPh SO₂ Single bond Sub-10 2-3611 Sub-44 3,4-diClPh SO₂ Single bond Sub-11 2-3612 Sub-44 3,4-diClPh SO₂ Single bond Sub-12 2-3613 Sub-44 3,4-diClPh SO₂ Single bond Sub-13 2-3614 Sub-44 3,4-diClPh SO₂ Single bond Sub-14 2-3615 Sub-44 3,4-diClPh SO₂ Single bond Sub-15 2-3616 Sub-44 3,4-diClPh SO₂ Single bond Sub-16 2-3617 Sub-44 3,4-diClPh SO₂ Single bond Sub-17 2-3618 Sub-44 3,4-diClPh SO₂ Single bond Sub-18 2-3619 Sub-44 3,4-diClPh SO₂ Single bond Sub-19 2-3620 Sub-44 3,4-diClPh SO₂ Single bond Sub-20 2-3621 Sub-44 3,4-diClPh SO₂ Single bond Sub-21 2-3622 Sub-44 3,4-diClPh SO₂ Single bond Sub-22 2-3623 Sub-44 3,4-diClPh SO₂ Single bond Sub-23 2-3624 Sub-44 3,4-diClPh SO₂ Single bond Sub-24 2-3625 Sub-44 3,4-diClPh SO₂ Single bond Sub-25 2-3626 Sub-44 3,4-diClPh SO₂ Single bond Sub-26 2-3627 Sub-44 3,4-diClPh SO₂ Single bond Sub-27 2-3628 Sub-44 3,4-diClPh SO₂ Single bond Sub-28 2-3629 Sub-44 3,4-diClPh SO₂ Single bond Sub-29 2-3630 Sub-44 3,4-diClPh SO₂ Single bond Sub-30 2-3631 Sub-44 3,4-diClPh SO₂ Single bond Sub-31 2-3632 Sub-44 3,4-diClPh SO₂ Single bond Sub-32 2-3633 Sub-44 3,4-diClPh SO₂ Single bond Sub-65 2-3634 Sub-44 3,4-diClPh SO₂ Single bond Sub-66 2-3635 Sub-44 3,4-diClPh SO₂ Single bond Sub-67 2-3636 Sub-44 3,4-diClPh SO₂ Single bond Sub-68 2-3637 Sub-44 3,4-diClPh SO₂ Single bond Sub-69 2-3638 Sub-44 3,4-diClPh SO₂ Single bond Sub-70 2-3639 Sub-44 3,4-diClPh SO₂ Single bond Sub-71 2-3640 Sub-44 3,4-diClPh SO₂ Single bond Sub-72 2-3641 Sub-44 3,4-diClPh SO₂ Single bond Sub-73 2-3642 Sub-44 3,4-diClPh SO₂ Single bond Sub-74 2-3643 Sub-44 3,4-diClPh SO₂ Single bond Sub-75 2-3644 Sub-44 3,4-diClPh SO₂ Single bond Sub-76 2-3645 Sub-44 3,4-diClPh SO₂ Single bond Sub-77 2-3646 Sub-44 3,4-diClPh SO₂ Single bond Sub-78 2-3647 Sub-44 3,4-diClPh SO₂ Single bond Sub-79 2-3648 Sub-44 3,4-diClPh SO₂ Single bond Sub-80 2-3649 Sub-45 3,4-diClPh SO₂ Single bond Sub-1  2-3650 Sub-45 3,4-diClPh SO₂ Single bond Sub-2  2-3651 Sub-45 3,4-diClPh SO₂ Single bond Sub-3  2-3652 Sub-45 3,4-diClPh SO₂ Single bond Sub-4  2-3653 Sub-45 3,4-diClPh SO₂ Single bond Sub-5  2-3654 Sub-45 3,4-diClPh SO₂ Single bond Sub-6  2-3655 Sub-45 3,4-diClPh SO₂ Single bond Sub-7  2-3656 Sub-45 3,4-diClPh SO₂ Single bond Sub-8  2-3657 Sub-45 3,4-diClPh SO₂ Single bond Sub-9  2-3658 Sub-45 3,4-diClPh SO₂ Single bond Sub-10 2-3659 Sub-45 3,4-diClPh SO₂ Single bond Sub-11 2-3660 Sub-45 3,4-diClPh SO₂ Single bond Sub-12 2-3661 Sub-45 3,4-diClPh SO₂ Single bond Sub-13 2-3662 Sub-45 3,4-diClPh SO₂ Single bond Sub-14 2-3663 Sub-45 3,4-diClPh SO₂ Single bond Sub-15 2-3664 Sub-45 3,4-diClPh SO₂ Single bond Sub-16 2-3665 Sub-45 3,4-diClPh SO₂ Single bond Sub-17 2-3666 Sub-45 3,4-diClPh SO₂ Single bond Sub-18 2-3667 Sub-45 3,4-diClPh SO₂ Single bond Sub-19 2-3668 Sub-45 3,4-diClPh SO₂ Single bond Sub-20 2-3669 Sub-45 3,4-diClPh SO₂ Single bond Sub-21 2-3670 Sub-45 3,4-diClPh SO₂ Single bond Sub-22 2-3671 Sub-45 3,4-diClPh SO₂ Single bond Sub-23 2-3672 Sub-45 3,4-diClPh SO₂ Single bond Sub-24 2-3673 Sub-45 3,4-diClPh SO₂ Single bond Sub-25 2-3674 Sub-45 3,4-diClPh SO₂ Single bond Sub-26 2-3675 Sub-45 3,4-diClPh SO₂ Single bond Sub-27 2-3676 Sub-45 3,4-diClPh SO₂ Single bond Sub-28 2-3677 Sub-45 3,4-diClPh SO₂ Single bond Sub-29 2-3678 Sub-45 3,4-diClPh SO₂ Single bond Sub-30 2-3679 Sub-45 3,4-diClPh SO₂ Single bond Sub-31 2-3680 Sub-45 3,4-diClPh SO₂ Single bond Sub-32 2-3681 Sub-45 3,4-diClPh SO₂ Single bond Sub-65 2-3682 Sub-45 3,4-diClPh SO₂ Single bond Sub-66 2-3683 Sub-45 3,4-diClPh SO₂ Single bond Sub-67 2-3684 Sub-45 3,4-diClPh SO₂ Single bond Sub-68 2-3685 Sub-45 3,4-diClPh SO₂ Single bond Sub-69 2-3686 Sub-45 3,4-diClPh SO₂ Single bond Sub-70 2-3687 Sub-45 3,4-diClPh SO₂ Single bond Sub-71 2-3688 Sub-45 3,4-diClPh SO₂ Single bond Sub-72 2-3689 Sub-45 3,4-diClPh SO₂ Single bond Sub-73 2-3690 Sub-45 3,4-diClPh SO₂ Single bond Sub-74 2-3691 Sub-45 3,4-diClPh SO₂ Single bond Sub-75 2-3692 Sub-45 3,4-diClPh SO₂ Single bond Sub-76 2-3693 Sub-45 3,4-diClPh SO₂ Single bond Sub-77 2-3694 Sub-45 3,4-diClPh SO₂ Single bond Sub-78 2-3695 Sub-45 3,4-diClPh SO₂ Single bond Sub-79 2-3696 Sub-45 3,4-diClPh SO₂ Single bond Sub-80 2-3697 Sub-46 3,4-diClPh SO₂ Single bond Sub-1  2-3698 Sub-46 3,4-diClPh SO₂ Single bond Sub-2  2-3699 Sub-46 3,4-diClPh SO₂ Single bond Sub-3  2-3700 Sub-46 3,4-diClPh SO₂ Single bond Sub-4  2-3701 Sub-46 3,4-diClPh SO₂ Single bond Sub-5  2-3702 Sub-46 3,4-diClPh SO₂ Single bond Sub-6  2-3703 Sub-46 3,4-diClPh SO₂ Single bond Sub-7  2-3704 Sub-46 3,4-diClPh SO₂ Single bond Sub-8  2-3705 Sub-46 3,4-diClPh SO₂ Single bond Sub-9  2-3706 Sub-46 3,4-diClPh SO₂ Single bond Sub-10 2-3707 Sub-46 3,4-diClPh SO₂ Single bond Sub-11 2-3708 Sub-46 3,4-diClPh SO₂ Single bond Sub-12 2-3709 Sub-46 3,4-diClPh SO₂ Single bond Sub-13 2-3710 Sub-46 3,4-diClPh SO₂ Single bond Sub-14 2-3711 Sub-46 3,4-diClPh SO₂ Single bond Sub-15 2-3712 Sub-46 3,4-diClPh SO₂ Single bond Sub-16 2-3713 Sub-46 3,4-diClPh SO₂ Single bond Sub-17 2-3714 Sub-46 3,4-diClPh SO₂ Single bond Sub-18 2-3715 Sub-46 3,4-diClPh SO₂ Single bond Sub-19 2-3716 Sub-46 3,4-diClPh SO₂ Single bond Sub-20 2-3717 Sub-46 3,4-diClPh SO₂ Single bond Sub-21 2-3718 Sub-46 3,4-diClPh SO₂ Single bond Sub-22 2-3719 Sub-46 3,4-diClPh SO₂ Single bond Sub-23 2-3720 Sub-46 3,4-diClPh SO₂ Single bond Sub-24 2-3721 Sub-46 3,4-diClPh SO₂ Single bond Sub-25 2-3722 Sub-46 3,4-diClPh SO₂ Single bond Sub-26 2-3723 Sub-46 3,4-diClPh SO₂ Single bond Sub-27 2-3724 Sub-46 3,4-diClPh SO₂ Single bond Sub-28 2-3725 Sub-46 3,4-diClPh SO₂ Single bond Sub-29 2-3726 Sub-46 3,4-diClPh SO₂ Single bond Sub-30 2-3727 Sub-46 3,4-diClPh SO₂ Single bond Sub-31 2-3728 Sub-46 3,4-diClPh SO₂ Single bond Sub-32 2-3729 Sub-46 3,4-diClPh SO₂ Single bond Sub-65 2-3730 Sub-46 3,4-diClPh SO₂ Single bond Sub-66 2-3731 Sub-46 3,4-diClPh SO₂ Single bond Sub-67 2-3732 Sub-46 3,4-diClPh SO₂ Single bond Sub-68 2-3733 Sub-46 3,4-diClPh SO₂ Single bond Sub-69 2-3734 Sub-46 3,4-diClPh SO₂ Single bond Sub-70 2-3735 Sub-46 3,4-diClPh SO₂ Single bond Sub-71 2-3736 Sub-46 3,4-diClPh SO₂ Single bond Sub-72 2-3737 Sub-46 3,4-diClPh SO₂ Single bond Sub-73 2-3738 Sub-46 3,4-diClPh SO₂ Single bond Sub-74 2-3739 Sub-46 3,4-diClPh SO₂ Single bond Sub-75 2-3740 Sub-46 3,4-diClPh SO₂ Single bond Sub-76 2-3741 Sub-46 3,4-diClPh SO₂ Single bond Sub-77 2-3742 Sub-46 3,4-diClPh SO₂ Single bond Sub-78 2-3743 Sub-46 3,4-diClPh SO₂ Single bond Sub-79 2-3744 Sub-46 3,4-diClPh SO₂ Single bond Sub-80 2-3745 Sub-47 3,4-diClPh SO₂ Single bond Sub-1  2-3746 Sub-47 3,4-diClPh SO₂ Single bond Sub-2  2-3747 Sub-47 3,4-diClPh SO₂ Single bond Sub-3  2-3748 Sub-47 3,4-diClPh SO₂ Single bond Sub-4  2-3749 Sub-47 3,4-diClPh SO₂ Single bond Sub-5  2-3750 Sub-47 3,4-diClPh SO₂ Single bond Sub-6  2-3751 Sub-47 3,4-diClPh SO₂ Single bond Sub-7  2-3752 Sub-47 3,4-diClPh SO₂ Single bond Sub-8  2-3753 Sub-47 3,4-diClPh SO₂ Single bond Sub-9  2-3754 Sub-47 3,4-diClPh SO₂ Single bond Sub-10 2-3755 Sub-47 3,4-diClPh SO₂ Single bond Sub-11 2-3756 Sub-47 3,4-diClPh SO₂ Single bond Sub-12 2-3757 Sub-47 3,4-diClPh SO₂ Single bond Sub-13 2-3758 Sub-47 3,4-diClPh SO₂ Single bond Sub-14 2-3759 Sub-47 3,4-diClPh SO₂ Single bond Sub-15 2-3760 Sub-47 3,4-diClPh SO₂ Single bond Sub-16 2-3761 Sub-47 3,4-diClPh SO₂ Single bond Sub-17 2-3762 Sub-47 3,4-diClPh SO₂ Single bond Sub-18 2-3763 Sub-47 3,4-diClPh SO₂ Single bond Sub-19 2-3764 Sub-47 3,4-diClPh SO₂ Single bond Sub-20 2-3765 Sub-47 3,4-diClPh SO₂ Single bond Sub-21 2-3766 Sub-47 3,4-diClPh SO₂ Single bond Sub-22 2-3767 Sub-47 3,4-diClPh SO₂ Single bond Sub-23 2-3768 Sub-47 3,4-diClPh SO₂ Single bond Sub-24 2-3769 Sub-47 3,4-diClPh SO₂ Single bond Sub-25 2-3770 Sub-47 3,4-diClPh SO₂ Single bond Sub-26 2-3771 Sub-47 3,4-diClPh SO₂ Single bond Sub-27 2-3772 Sub-47 3,4-diClPh SO₂ Single bond Sub-28 2-3773 Sub-47 3,4-diClPh SO₂ Single bond Sub-29 2-3774 Sub-47 3,4-diClPh SO₂ Single bond Sub-30 2-3775 Sub-47 3,4-diClPh SO₂ Single bond Sub-31 2-3776 Sub-47 3,4-diClPh SO₂ Single bond Sub-32 2-3777 Sub-47 3,4-diClPh SO₂ Single bond Sub-65 2-3778 Sub-47 3,4-diClPh SO₂ Single bond Sub-66 2-3779 Sub-47 3,4-diClPh SO₂ Single bond Sub-67 2-3780 Sub-47 3,4-diClPh SO₂ Single bond Sub-68 2-3781 Sub-47 3,4-diClPh SO₂ Single bond Sub-69 2-3782 Sub-47 3,4-diClPh SO₂ Single bond Sub-70 2-3783 Sub-47 3,4-diClPh SO₂ Single bond Sub-71 2-3784 Sub-47 3,4-diClPh SO₂ Single bond Sub-72 2-3785 Sub-47 3,4-diClPh SO₂ Single bond Sub-73 2-3786 Sub-47 3,4-diClPh SO₂ Single bond Sub-74 2-3787 Sub-47 3,4-diClPh SO₂ Single bond Sub-75 2-3788 Sub-47 3,4-diClPh SO₂ Single bond Sub-76 2-3789 Sub-47 3,4-diClPh SO₂ Single bond Sub-77 2-3790 Sub-47 3,4-diClPh SO₂ Single bond Sub-78 2-3791 Sub-47 3,4-diClPh SO₂ Single bond Sub-79 2-3792 Sub-47 3,4-diClPh SO₂ Single bond Sub-80 2-3793 Sub-81 3,4-diClPh SO₂ Single bond Sub-1  2-3794 Sub-81 3,4-diClPh SO₂ Single bond Sub-2  2-3795 Sub-81 3,4-diClPh SO₂ Single bond Sub-3  2-3796 Sub-81 3,4-diClPh SO₂ Single bond Sub-4  2-3797 Sub-81 3,4-diClPh SO₂ Single bond Sub-5  2-3798 Sub-81 3,4-diClPh SO₂ Single bond Sub-6  2-3799 Sub-81 3,4-diClPh SO₂ Single bond Sub-7  2-3800 Sub-81 3,4-diClPh SO₂ Single bond Sub-8  2-3801 Sub-81 3,4-diClPh SO₂ Single bond Sub-9  2-3802 Sub-81 3,4-diClPh SO₂ Single bond Sub-10 2-3803 Sub-81 3,4-diClPh SO₂ Single bond Sub-11 2-3804 Sub-81 3,4-diClPh SO₂ Single bond Sub-12 2-3805 Sub-81 3,4-diClPh SO₂ Single bond Sub-13 2-3806 Sub-81 3,4-diClPh SO₂ Single bond Sub-14 2-3807 Sub-81 3,4-diClPh SO₂ Single bond Sub-15 2-3808 Sub-81 3,4-diClPh SO₂ Single bond Sub-16 2-3809 Sub-81 3,4-diClPh SO₂ Single bond Sub-17 2-3810 Sub-81 3,4-diClPh SO₂ Single bond Sub-18 2-3811 Sub-81 3,4-diClPh SO₂ Single bond Sub-19 2-3812 Sub-81 3,4-diClPh SO₂ Single bond Sub-20 2-3813 Sub-81 3,4-diClPh SO₂ Single bond Sub-21 2-3814 Sub-81 3,4-diClPh SO₂ Single bond Sub-22 2-3815 Sub-81 3,4-diClPh SO₂ Single bond Sub-23 2-3816 Sub-81 3,4-diClPh SO₂ Single bond Sub-24 2-3817 Sub-81 3,4-diClPh SO₂ Single bond Sub-25 2-3818 Sub-81 3,4-diClPh SO₂ Single bond Sub-26 2-3819 Sub-81 3,4-diClPh SO₂ Single bond Sub-27 2-3820 Sub-81 3,4-diClPh SO₂ Single bond Sub-28 2-3821 Sub-81 3,4-diClPh SO₂ Single bond Sub-29 2-3822 Sub-81 3,4-diClPh SO₂ Single bond Sub-30 2-3823 Sub-81 3,4-diClPh SO₂ Single bond Sub-31 2-3824 Sub-81 3,4-diClPh SO₂ Single bond Sub-32 2-3825 Sub-81 3,4-diClPh SO₂ Single bond Sub-65 2-3826 Sub-81 3,4-diClPh SO₂ Single bond Sub-66 2-3827 Sub-81 3,4-diClPh SO₂ Single bond Sub-67 2-3828 Sub-81 3,4-diClPh SO₂ Single bond Sub-68 2-3829 Sub-81 3,4-diClPh SO₂ Single bond Sub-69 2-3830 Sub-81 3,4-diClPh SO₂ Single bond Sub-70 2-3831 Sub-81 3,4-diClPh SO₂ Single bond Sub-71 2-3832 Sub-81 3,4-diClPh SO₂ Single bond Sub-72 2-3833 Sub-81 3,4-diClPh SO₂ Single bond Sub-73 2-3834 Sub-81 3,4-diClPh SO₂ Single bond Sub-74 2-3835 Sub-81 3,4-diClPh SO₂ Single bond Sub-75 2-3836 Sub-81 3,4-diClPh SO₂ Single bond Sub-76 2-3837 Sub-81 3,4-diClPh SO₂ Single bond Sub-77 2-3838 Sub-81 3,4-diClPh SO₂ Single bond Sub-78 2-3839 Sub-81 3,4-diClPh SO₂ Single bond Sub-79 2-3840 Sub-81 3,4-diClPh SO₂ Single bond Sub-80 2-3841 Sub-48 3,4-diClPh SO₂ Single bond Sub-1  2-3842 Sub-48 3,4-diClPh SO₂ Single bond Sub-2  2-3843 Sub-48 3,4-diClPh SO₂ Single bond Sub-3  2-3844 Sub-48 3,4-diClPh SO₂ Single bond Sub-4  2-3845 Sub-48 3,4-diClPh SO₂ Single bond Sub-5  2-3846 Sub-48 3,4-diClPh SO₂ Single bond Sub-6  2-3847 Sub-48 3,4-diClPh SO₂ Single bond Sub-7  2-3848 Sub-48 3,4-diClPh SO₂ Single bond Sub-8  2-3849 Sub-48 3,4-diClPh SO₂ Single bond Sub-9  2-3850 Sub-48 3,4-diClPh SO₂ Single bond Sub-10 2-3851 Sub-48 3,4-diClPh SO₂ Single bond Sub-11 2-3852 Sub-48 3,4-diClPh SO₂ Single bond Sub-12 2-3853 Sub-48 3,4-diClPh SO₂ Single bond Sub-13 2-3854 Sub-48 3,4-diClPh SO₂ Single bond Sub-14 2-3855 Sub-48 3,4-diClPh SO₂ Single bond Sub-15 2-3856 Sub-48 3,4-diClPh SO₂ Single bond Sub-16 2-3857 Sub-48 3,4-diClPh SO₂ Single bond Sub-17 2-3858 Sub-48 3,4-diClPh SO₂ Single bond Sub-18 2-3859 Sub-48 3,4-diClPh SO₂ Single bond Sub-19 2-3860 Sub-48 3,4-diClPh SO₂ Single bond Sub-20 2-3861 Sub-48 3,4-diClPh SO₂ Single bond Sub-21 2-3862 Sub-48 3,4-diClPh SO₂ Single bond Sub-22 2-3863 Sub-48 3,4-diClPh SO₂ Single bond Sub-23 2-3864 Sub-48 3,4-diClPh SO₂ Single bond Sub-24 2-3865 Sub-48 3,4-diClPh SO₂ Single bond Sub-25 2-3866 Sub-48 3,4-diClPh SO₂ Single bond Sub-26 2-3867 Sub-48 3,4-diClPh SO₂ Single bond Sub-27 2-3868 Sub-48 3,4-diClPh SO₂ Single bond Sub-28 2-3869 Sub-48 3,4-diClPh SO₂ Single bond Sub-29 2-3870 Sub-48 3,4-diClPh SO₂ Single bond Sub-30 2-3871 Sub-48 3,4-diClPh SO₂ Single bond Sub-31 2-3872 Sub-48 3,4-diClPh SO₂ Single bond Sub-32 2-3873 Sub-48 3,4-diClPh SO₂ Single bond Sub-65 2-3874 Sub-48 3,4-diClPh SO₂ Single bond Sub-66 2-3875 Sub-48 3,4-diClPh SO₂ Single bond Sub-67 2-3876 Sub-48 3,4-diClPh SO₂ Single bond Sub-68 2-3877 Sub-48 3,4-diClPh SO₂ Single bond Sub-69 2-3878 Sub-48 3,4-diClPh SO₂ Single bond Sub-70 2-3879 Sub-48 3,4-diClPh SO₂ Single bond Sub-71 2-3880 Sub-48 3,4-diClPh SO₂ Single bond Sub-72 2-3881 Sub-48 3,4-diClPh SO₂ Single bond Sub-73 2-3882 Sub-48 3,4-diClPh SO₂ Single bond Sub-74 2-3883 Sub-48 3,4-diClPh SO₂ Single bond Sub-75 2-3884 Sub-48 3,4-diClPh SO₂ Single bond Sub-76 2-3885 Sub-48 3,4-diClPh SO₂ Single bond Sub-77 2-3886 Sub-48 3,4-diClPh SO₂ Single bond Sub-78 2-3887 Sub-48 3,4-diClPh SO₂ Single bond Sub-79 2-3888 Sub-48 3,4-diClPh SO₂ Single bond Sub-80 2-3889 Sub-49 3,4-diClPh SO₂ Single bond Sub-1  2-3890 Sub-49 3,4-diClPh SO₂ Single bond Sub-2  2-3891 Sub-49 3,4-diClPh SO₂ Single bond Sub-3  2-3892 Sub-49 3,4-diClPh SO₂ Single bond Sub-4  2-3893 Sub-49 3,4-diClPh SO₂ Single bond Sub-5  2-3894 Sub-49 3,4-diClPh SO₂ Single bond Sub-6  2-3895 Sub-49 3,4-diClPh SO₂ Single bond Sub-7  2-3896 Sub-49 3,4-diClPh SO₂ Single bond Sub-8  2-3897 Sub-49 3,4-diClPh SO₂ Single bond Sub-9  2-3898 Sub-49 3,4-diClPh SO₂ Single bond Sub-10 2-3899 Sub-49 3,4-diClPh SO₂ Single bond Sub-11 2-3900 Sub-49 3,4-diClPh SO₂ Single bond Sub-12 2-3901 Sub-49 3,4-diClPh SO₂ Single bond Sub-13 2-3902 Sub-49 3,4-diClPh SO₂ Single bond Sub-14 2-3903 Sub-49 3,4-diClPh SO₂ Single bond Sub-15 2-3904 Sub-49 3,4-diClPh SO₂ Single bond Sub-16 2-3905 Sub-49 3,4-diClPh SO₂ Single bond Sub-17 2-3906 Sub-49 3,4-diClPh SO₂ Single bond Sub-18 2-3907 Sub-49 3,4-diClPh SO₂ Single bond Sub-19 2-3908 Sub-49 3,4-diClPh SO₂ Single bond Sub-20 2-3909 Sub-49 3,4-diClPh SO₂ Single bond Sub-21 2-3910 Sub-49 3,4-diClPh SO₂ Single bond Sub-22 2-3911 Sub-49 3,4-diClPh SO₂ Single bond Sub-23 2-3912 Sub-49 3,4-diClPh SO₂ Single bond Sub-24 2-3913 Sub-49 3,4-diClPh SO₂ Single bond Sub-25 2-3914 Sub-49 3,4-diClPh SO₂ Single bond Sub-26 2-3915 Sub-49 3,4-diClPh SO₂ Single bond Sub-27 2-3916 Sub-49 3,4-diClPh SO₂ Single bond Sub-28 2-3917 Sub-49 3,4-diClPh SO₂ Single bond Sub-29 2-3918 Sub-49 3,4-diClPh SO₂ Single bond Sub-30 2-3919 Sub-49 3,4-diClPh SO₂ Single bond Sub-31 2-3920 Sub-49 3,4-diClPh SO₂ Single bond Sub-32 2-3921 Sub-49 3,4-diClPh SO₂ Single bond Sub-65 2-3922 Sub-49 3,4-diClPh SO₂ Single bond Sub-66 2-3923 Sub-49 3,4-diClPh SO₂ Single bond Sub-67 2-3924 Sub-49 3,4-diClPh SO₂ Single bond Sub-68 2-3925 Sub-49 3,4-diClPh SO₂ Single bond Sub-69 2-3926 Sub-49 3,4-diClPh SO₂ Single bond Sub-70 2-3927 Sub-49 3,4-diClPh SO₂ Single bond Sub-71 2-3928 Sub-49 3,4-diClPh SO₂ Single bond Sub-72 2-3929 Sub-49 3,4-diClPh SO₂ Single bond Sub-73 2-3930 Sub-49 3,4-diClPh SO₂ Single bond Sub-74 2-3931 Sub-49 3,4-diClPh SO₂ Single bond Sub-75 2-3932 Sub-49 3,4-diClPh SO₂ Single bond Sub-76 2-3933 Sub-49 3,4-diClPh SO₂ Single bond Sub-77 2-3934 Sub-49 3,4-diClPh SO₂ Single bond Sub-78 2-3935 Sub-49 3,4-diClPh SO₂ Single bond Sub-79 2-3936 Sub-49 3,4-diClPh SO₂ Single bond Sub-80 2-3937 Sub-50 3,4-diClPh SO₂ Single bond Sub-1  2-3938 Sub-50 3,4-diClPh SO₂ Single bond Sub-2  2-3939 Sub-50 3,4-diClPh SO₂ Single bond Sub-3  2-3940 Sub-50 3,4-diClPh SO₂ Single bond Sub-4  2-3941 Sub-50 3,4-diClPh SO₂ Single bond Sub-5  2-3942 Sub-50 3,4-diClPh SO₂ Single bond Sub-6  2-3943 Sub-50 3,4-diClPh SO₂ Single bond Sub-7  2-3944 Sub-50 3,4-diClPh SO₂ Single bond Sub-8  2-3945 Sub-50 3,4-diClPh SO₂ Single bond Sub-9  2-3946 Sub-50 3,4-diClPh SO₂ Single bond Sub-10 2-3947 Sub-50 3,4-diClPh SO₂ Single bond Sub-11 2-3948 Sub-50 3,4-diClPh SO₂ Single bond Sub-12 2-3949 Sub-50 3,4-diClPh SO₂ Single bond Sub-13 2-3950 Sub-50 3,4-diClPh SO₂ Single bond Sub-14 2-3951 Sub-50 3,4-diClPh SO₂ Single bond Sub-15 2-3952 Sub-50 3,4-diClPh SO₂ Single bond Sub-16 2-3953 Sub-50 3,4-diClPh SO₂ Single bond Sub-17 2-3954 Sub-50 3,4-diClPh SO₂ Single bond Sub-18 2-3955 Sub-50 3,4-diClPh SO₂ Single bond Sub-19 2-3956 Sub-50 3,4-diClPh SO₂ Single bond Sub-20 2-3957 Sub-50 3,4-diClPh SO₂ Single bond Sub-21 2-3958 Sub-50 3,4-diClPh SO₂ Single bond Sub-22 2-3959 Sub-50 3,4-diClPh SO₂ Single bond Sub-23 2-3960 Sub-50 3,4-diClPh SO₂ Single bond Sub-24 2-3961 Sub-50 3,4-diClPh SO₂ Single bond Sub-25 2-3962 Sub-50 3,4-diClPh SO₂ Single bond Sub-26 2-3963 Sub-50 3,4-diClPh SO₂ Single bond Sub-27 2-3964 Sub-50 3,4-diClPh SO₂ Single bond Sub-28 2-3965 Sub-50 3,4-diClPh SO₂ Single bond Sub-29 2-3966 Sub-50 3,4-diClPh SO₂ Single bond Sub-30 2-3967 Sub-50 3,4-diClPh SO₂ Single bond Sub-31 2-3968 Sub-50 3,4-diClPh SO₂ Single bond Sub-32 2-3969 Sub-50 3,4-diClPh SO₂ Single bond Sub-65 2-3970 Sub-50 3,4-diClPh SO₂ Single bond Sub-66 2-3971 Sub-50 3,4-diClPh SO₂ Single bond Sub-67 2-3972 Sub-50 3,4-diClPh SO₂ Single bond Sub-68 2-3973 Sub-50 3,4-diClPh SO₂ Single bond Sub-69 2-3974 Sub-50 3,4-diClPh SO₂ Single bond Sub-70 2-3975 Sub-50 3,4-diClPh SO₂ Single bond Sub-71 2-3976 Sub-50 3,4-diClPh SO₂ Single bond Sub-72 2-3977 Sub-50 3,4-diClPh SO₂ Single bond Sub-73 2-3978 Sub-50 3,4-diClPh SO₂ Single bond Sub-74 2-3979 Sub-50 3,4-diClPh SO₂ Single bond Sub-75 2-3980 Sub-50 3,4-diClPh SO₂ Single bond Sub-76 2-3981 Sub-50 3,4-diClPh SO₂ Single bond Sub-77 2-3982 Sub-50 3,4-diClPh SO₂ Single bond Sub-78 2-3983 Sub-50 3,4-diClPh SO₂ Single bond Sub-79 2-3984 Sub-50 3,4-diClPh SO₂ Single bond Sub-80 2-3985 Sub-51 3,4-diClPh SO₂ Single bond Sub-1  2-3986 Sub-51 3,4-diClPh SO₂ Single bond Sub-2  2-3987 Sub-51 3,4-diClPh SO₂ Single bond Sub-3  2-3988 Sub-51 3,4-diClPh SO₂ Single bond Sub-4  2-3989 Sub-51 3,4-diClPh SO₂ Single bond Sub-5  2-3990 Sub-51 3,4-diClPh SO₂ Single bond Sub-6  2-3991 Sub-51 3,4-diClPh SO₂ Single bond Sub-7  2-3992 Sub-51 3,4-diClPh SO₂ Single bond Sub-8  2-3993 Sub-51 3,4-diClPh SO₂ Single bond Sub-9  2-3994 Sub-51 3,4-diClPh SO₂ Single bond Sub-10 2-3995 Sub-51 3,4-diClPh SO₂ Single bond Sub-11 2-3996 Sub-51 3,4-diClPh SO₂ Single bond Sub-12 2-3997 Sub-51 3,4-diClPh SO₂ Single bond Sub-13 2-3998 Sub-51 3,4-diClPh SO₂ Single bond Sub-14 2-3999 Sub-51 3,4-diClPh SO₂ Single bond Sub-15 2-4000 Sub-51 3,4-diClPh SO₂ Single bond Sub-16 2-4001 Sub-51 3,4-diClPh SO₂ Single bond Sub-17 2-4002 Sub-51 3,4-diClPh SO₂ Single bond Sub-18 2-4003 Sub-51 3,4-diClPh SO₂ Single bond Sub-19 2-4004 Sub-51 3,4-diClPh SO₂ Single bond Sub-20 2-4005 Sub-51 3,4-diClPh SO₂ Single bond Sub-21 2-4006 Sub-51 3,4-diClPh SO₂ Single bond Sub-22 2-4007 Sub-51 3,4-diClPh SO₂ Single bond Sub-23 2-4008 Sub-51 3,4-diClPh SO₂ Single bond Sub-24 2-4009 Sub-51 3,4-diClPh SO₂ Single bond Sub-25 2-4010 Sub-51 3,4-diClPh SO₂ Single bond Sub-26 2-4011 Sub-51 3,4-diClPh SO₂ Single bond Sub-27 2-4012 Sub-51 3,4-diClPh SO₂ Single bond Sub-28 2-4013 Sub-51 3,4-diClPh SO₂ Single bond Sub-29 2-4014 Sub-51 3,4-diClPh SO₂ Single bond Sub-30 2-4015 Sub-51 3,4-diClPh SO₂ Single bond Sub-31 2-4016 Sub-51 3,4-diClPh SO₂ Single bond Sub-32 2-4017 Sub-51 3,4-diClPh SO₂ Single bond Sub-65 2-4018 Sub-51 3,4-diClPh SO₂ Single bond Sub-66 2-4019 Sub-51 3,4-diClPh SO₂ Single bond Sub-67 2-4020 Sub-51 3,4-diClPh SO₂ Single bond Sub-68 2-4021 Sub-51 3,4-diClPh SO₂ Single bond Sub-69 2-4022 Sub-51 3,4-diClPh SO₂ Single bond Sub-70 2-4023 Sub-51 3,4-diClPh SO₂ Single bond Sub-71 2-4024 Sub-51 3,4-diClPh SO₂ Single bond Sub-72 2-4025 Sub-51 3,4-diClPh SO₂ Single bond Sub-73 2-4026 Sub-51 3,4-diClPh SO₂ Single bond Sub-74 2-4027 Sub-51 3,4-diClPh SO₂ Single bond Sub-75 2-4028 Sub-51 3,4-diClPh SO₂ Single bond Sub-76 2-4029 Sub-51 3,4-diClPh SO₂ Single bond Sub-77 2-4030 Sub-51 3,4-diClPh SO₂ Single bond Sub-78 2-4031 Sub-51 3,4-diClPh SO₂ Single bond Sub-79 2-4032 Sub-51 3,4-diClPh SO₂ Single bond Sub-80 2-4033 Sub-52 3,4-diClPh SO₂ Single bond Sub-1  2-4034 Sub-52 3,4-diClPh SO₂ Single bond Sub-2  2-4035 Sub-52 3,4-diClPh SO₂ Single bond Sub-3  2-4036 Sub-52 3,4-diClPh SO₂ Single bond Sub-4  2-4037 Sub-52 3,4-diClPh SO₂ Single bond Sub-5  2-4038 Sub-52 3,4-diClPh SO₂ Single bond Sub-6  2-4039 Sub-52 3,4-diClPh SO₂ Single bond Sub-7  2-4040 Sub-52 3,4-diClPh SO₂ Single bond Sub-8  2-4041 Sub-52 3,4-diClPh SO₂ Single bond Sub-9  2-4042 Sub-52 3,4-diClPh SO₂ Single bond Sub-10 2-4043 Sub-52 3,4-diClPh SO₂ Single bond Sub-11 2-4044 Sub-52 3,4-diClPh SO₂ Single bond Sub-12 2-4045 Sub-52 3,4-diClPh SO₂ Single bond Sub-13 2-4046 Sub-52 3,4-diClPh SO₂ Single bond Sub-14 2-4047 Sub-52 3,4-diClPh SO₂ Single bond Sub-15 2-4048 Sub-52 3,4-diClPh SO₂ Single bond Sub-16 2-4049 Sub-52 3,4-diClPh SO₂ Single bond Sub-17 2-4050 Sub-52 3,4-diClPh SO₂ Single bond Sub-18 2-4051 Sub-52 3,4-diClPh SO₂ Single bond Sub-19 2-4052 Sub-52 3,4-diClPh SO₂ Single bond Sub-20 2-4053 Sub-52 3,4-diClPh SO₂ Single bond Sub-21 2-4054 Sub-52 3,4-diClPh SO₂ Single bond Sub-22 2-4055 Sub-52 3,4-diClPh SO₂ Single bond Sub-23 2-4056 Sub-52 3,4-diClPh SO₂ Single bond Sub-24 2-4057 Sub-52 3,4-diClPh SO₂ Single bond Sub-25 2-4058 Sub-52 3,4-diClPh SO₂ Single bond Sub-26 2-4059 Sub-52 3,4-diClPh SO₂ Single bond Sub-27 2-4060 Sub-52 3,4-diClPh SO₂ Single bond Sub-28 2-4061 Sub-52 3,4-diClPh SO₂ Single bond Sub-29 2-4062 Sub-52 3,4-diClPh SO₂ Single bond Sub-30 2-4063 Sub-52 3,4-diClPh SO₂ Single bond Sub-31 2-4064 Sub-52 3,4-diClPh SO₂ Single bond Sub-32 2-4065 Sub-52 3,4-diClPh SO₂ Single bond Sub-65 2-4066 Sub-52 3,4-diClPh SO₂ Single bond Sub-66 2-4067 Sub-52 3,4-diClPh SO₂ Single bond Sub-67 2-4068 Sub-52 3,4-diClPh SO₂ Single bond Sub-68 2-4069 Sub-52 3,4-diClPh SO₂ Single bond Sub-69 2-4070 Sub-52 3,4-diClPh SO₂ Single bond Sub-70 2-4071 Sub-52 3,4-diClPh SO₂ Single bond Sub-71 2-4072 Sub-52 3,4-diClPh SO₂ Single bond Sub-72 2-4073 Sub-52 3,4-diClPh SO₂ Single bond Sub-73 2-4074 Sub-52 3,4-diClPh SO₂ Single bond Sub-74 2-4075 Sub-52 3,4-diClPh SO₂ Single bond Sub-75 2-4076 Sub-52 3,4-diClPh SO₂ Single bond Sub-76 2-4077 Sub-52 3,4-diClPh SO₂ Single bond Sub-77 2-4078 Sub-52 3,4-diClPh SO₂ Single bond Sub-78 2-4079 Sub-52 3,4-diClPh SO₂ Single bond Sub-79 2-4080 Sub-52 3,4-diClPh SO₂ Single bond Sub-80 2-4081 Sub-53 3,4-diClPh SO₂ Single bond Sub-1  2-4082 Sub-53 3,4-diClPh SO₂ Single bond Sub-2  2-4083 Sub-53 3,4-diClPh SO₂ Single bond Sub-3  2-4084 Sub-53 3,4-diClPh SO₂ Single bond Sub-4  2-4085 Sub-53 3,4-diClPh SO₂ Single bond Sub-5  2-4086 Sub-53 3,4-diClPh SO₂ Single bond Sub-6  2-4087 Sub-53 3,4-diClPh SO₂ Single bond Sub-7  2-4088 Sub-53 3,4-diClPh SO₂ Single bond Sub-8  2-4089 Sub-53 3,4-diClPh SO₂ Single bond Sub-9  2-4090 Sub-53 3,4-diClPh SO₂ Single bond Sub-10 2-4091 Sub-53 3,4-diClPh SO₂ Single bond Sub-11 2-4092 Sub-53 3,4-diClPh SO₂ Single bond Sub-12 2-4093 Sub-53 3,4-diClPh SO₂ Single bond Sub-13 2-4094 Sub-53 3,4-diClPh SO₂ Single bond Sub-14 2-4095 Sub-53 3,4-diClPh SO₂ Single bond Sub-15 2-4096 Sub-53 3,4-diClPh SO₂ Single bond Sub-16 2-4097 Sub-53 3,4-diClPh SO₂ Single bond Sub-17 2-4098 Sub-53 3,4-diClPh SO₂ Single bond Sub-18 2-4099 Sub-53 3,4-diClPh SO₂ Single bond Sub-19 2-4100 Sub-53 3,4-diClPh SO₂ Single bond Sub-20 2-4101 Sub-53 3,4-diClPh SO₂ Single bond Sub-21 2-4102 Sub-53 3,4-diClPh SO₂ Single bond Sub-22 2-4103 Sub-53 3,4-diClPh SO₂ Single bond Sub-23 2-4104 Sub-53 3,4-diClPh SO₂ Single bond Sub-24 2-4105 Sub-53 3,4-diClPh SO₂ Single bond Sub-25 2-4106 Sub-53 3,4-diClPh SO₂ Single bond Sub-26 2-4107 Sub-53 3,4-diClPh SO₂ Single bond Sub-27 2-4108 Sub-53 3,4-diClPh SO₂ Single bond Sub-28 2-4109 Sub-53 3,4-diClPh SO₂ Single bond Sub-29 2-4110 Sub-53 3,4-diClPh SO₂ Single bond Sub-30 2-4111 Sub-53 3,4-diClPh SO₂ Single bond Sub-31 2-4112 Sub-53 3,4-diClPh SO₂ Single bond Sub-32 2-4113 Sub-53 3,4-diClPh SO₂ Single bond Sub-65 2-4114 Sub-53 3,4-diClPh SO₂ Single bond Sub-66 2-4115 Sub-53 3,4-diClPh SO₂ Single bond Sub-67 2-4116 Sub-53 3,4-diClPh SO₂ Single bond Sub-68 2-4117 Sub-53 3,4-diClPh SO₂ Single bond Sub-69 2-4118 Sub-53 3,4-diClPh SO₂ Single bond Sub-70 2-4119 Sub-53 3,4-diClPh SO₂ Single bond Sub-71 2-4120 Sub-53 3,4-diClPh SO₂ Single bond Sub-72 2-4121 Sub-53 3,4-diClPh SO₂ Single bond Sub-73 2-4122 Sub-53 3,4-diClPh SO₂ Single bond Sub-74 2-4123 Sub-53 3,4-diClPh SO₂ Single bond Sub-75 2-4124 Sub-53 3,4-diClPh SO₂ Single bond Sub-76 2-4125 Sub-53 3,4-diClPh SO₂ Single bond Sub-77 2-4126 Sub-53 3,4-diClPh SO₂ Single bond Sub-78 2-4127 Sub-53 3,4-diClPh SO₂ Single bond Sub-79 2-4128 Sub-53 3,4-diClPh SO₂ Single bond Sub-80 2-4129 Sub-54 3,4-diClPh SO₂ Single bond Sub-1  2-4130 Sub-54 3,4-diClPh SO₂ Single bond Sub-2  2-4131 Sub-54 3,4-diClPh SO₂ Single bond Sub-3  2-4132 Sub-54 3,4-diClPh SO₂ Single bond Sub-4  2-4133 Sub-54 3,4-diClPh SO₂ Single bond Sub-5  2-4134 Sub-54 3,4-diClPh SO₂ Single bond Sub-6  2-4135 Sub-54 3,4-diClPh SO₂ Single bond Sub-7  2-4136 Sub-54 3,4-diClPh SO₂ Single bond Sub-8  2-4137 Sub-54 3,4-diClPh SO₂ Single bond Sub-9  2-4138 Sub-54 3,4-diClPh SO₂ Single bond Sub-10 2-4139 Sub-54 3,4-diClPh SO₂ Single bond Sub-11 2-4140 Sub-54 3,4-diClPh SO₂ Single bond Sub-12 2-4141 Sub-54 3,4-diClPh SO₂ Single bond Sub-13 2-4142 Sub-54 3,4-diClPh SO₂ Single bond Sub-14 2-4143 Sub-54 3,4-diClPh SO₂ Single bond Sub-15 2-4144 Sub-54 3,4-diClPh SO₂ Single bond Sub-16 2-4145 Sub-54 3,4-diClPh SO₂ Single bond Sub-17 2-4146 Sub-54 3,4-diClPh SO₂ Single bond Sub-18 2-4147 Sub-54 3,4-diClPh SO₂ Single bond Sub-19 2-4148 Sub-54 3,4-diClPh SO₂ Single bond Sub-20 2-4149 Sub-54 3,4-diClPh SO₂ Single bond Sub-21 2-4150 Sub-54 3,4-diClPh SO₂ Single bond Sub-22 2-4151 Sub-54 3,4-diClPh SO₂ Single bond Sub-23 2-4152 Sub-54 3,4-diClPh SO₂ Single bond Sub-24 2-4153 Sub-54 3,4-diClPh SO₂ Single bond Sub-25 2-4154 Sub-54 3,4-diClPh SO₂ Single bond Sub-26 2-4155 Sub-54 3,4-diClPh SO₂ Single bond Sub-27 2-4156 Sub-54 3,4-diClPh SO₂ Single bond Sub-28 2-4157 Sub-54 3,4-diClPh SO₂ Single bond Sub-29 2-4158 Sub-54 3,4-diClPh SO₂ Single bond Sub-30 2-4159 Sub-54 3,4-diClPh SO₂ Single bond Sub-31 2-4160 Sub-54 3,4-diClPh SO₂ Single bond Sub-32 2-4161 Sub-54 3,4-diClPh SO₂ Single bond Sub-65 2-4162 Sub-54 3,4-diClPh SO₂ Single bond Sub-66 2-4163 Sub-54 3,4-diClPh SO₂ Single bond Sub-67 2-4164 Sub-54 3,4-diClPh SO₂ Single bond Sub-68 2-4165 Sub-54 3,4-diClPh SO₂ Single bond Sub-69 2-4166 Sub-54 3,4-diClPh SO₂ Single bond Sub-70 2-4167 Sub-54 3,4-diClPh SO₂ Single bond Sub-71 2-4168 Sub-54 3,4-diClPh SO₂ Single bond Sub-72 2-4169 Sub-54 3,4-diClPh SO₂ Single bond Sub-73 2-4170 Sub-54 3,4-diClPh SO₂ Single bond Sub-74 2-4171 Sub-54 3,4-diClPh SO₂ Single bond Sub-75 2-4172 Sub-54 3,4-diClPh SO₂ Single bond Sub-76 2-4173 Sub-54 3,4-diClPh SO₂ Single bond Sub-77 2-4174 Sub-54 3,4-diClPh SO₂ Single bond Sub-78 2-4175 Sub-54 3,4-diClPh SO₂ Single bond Sub-79 2-4176 Sub-54 3,4-diClPh SO₂ Single bond Sub-80 2-4177 Sub-55 3,4-diClPh SO₂ Single bond Sub-1  2-4178 Sub-55 3,4-diClPh SO₂ Single bond Sub-2  2-4179 Sub-55 3,4-diClPh SO₂ Single bond Sub-3  2-4180 Sub-55 3,4-diClPh SO₂ Single bond Sub-4  2-4181 Sub-55 3,4-diClPh SO₂ Single bond Sub-5  2-4182 Sub-55 3,4-diClPh SO₂ Single bond Sub-6  2-4183 Sub-55 3,4-diClPh SO₂ Single bond Sub-7  2-4184 Sub-55 3,4-diClPh SO₂ Single bond Sub-8  2-4185 Sub-55 3,4-diClPh SO₂ Single bond Sub-9  2-4186 Sub-55 3,4-diClPh SO₂ Single bond Sub-10 2-4187 Sub-55 3,4-diClPh SO₂ Single bond Sub-11 2-4188 Sub-55 3,4-diClPh SO₂ Single bond Sub-12 2-4189 Sub-55 3,4-diClPh SO₂ Single bond Sub-13 2-4190 Sub-55 3,4-diClPh SO₂ Single bond Sub-14 2-4191 Sub-55 3,4-diClPh SO₂ Single bond Sub-15 2-4192 Sub-55 3,4-diClPh SO₂ Single bond Sub-16 2-4193 Sub-55 3,4-diClPh SO₂ Single bond Sub-17 2-4194 Sub-55 3,4-diClPh SO₂ Single bond Sub-18 2-4195 Sub-55 3,4-diClPh SO₂ Single bond Sub-19 2-4196 Sub-55 3,4-diClPh SO₂ Single bond Sub-20 2-4197 Sub-55 3,4-diClPh SO₂ Single bond Sub-21 2-4198 Sub-55 3,4-diClPh SO₂ Single bond Sub-22 2-4199 Sub-55 3,4-diClPh SO₂ Single bond Sub-23 2-4200 Sub-55 3,4-diClPh SO₂ Single bond Sub-24 2-4201 Sub-55 3,4-diClPh SO₂ Single bond Sub-25 2-4202 Sub-55 3,4-diClPh SO₂ Single bond Sub-26 2-4203 Sub-55 3,4-diClPh SO₂ Single bond Sub-27 2-4204 Sub-55 3,4-diClPh SO₂ Single bond Sub-28 2-4205 Sub-55 3,4-diClPh SO₂ Single bond Sub-29 2-4206 Sub-55 3,4-diClPh SO₂ Single bond Sub-30 2-4207 Sub-55 3,4-diClPh SO₂ Single bond Sub-31 2-4208 Sub-55 3,4-diClPh SO₂ Single bond Sub-32 2-4209 Sub-55 3,4-diClPh SO₂ Single bond Sub-65 2-4210 Sub-55 3,4-diClPh SO₂ Single bond Sub-66 2-4211 Sub-55 3,4-diClPh SO₂ Single bond Sub-67 2-4212 Sub-55 3,4-diClPh SO₂ Single bond Sub-68 2-4213 Sub-55 3,4-diClPh SO₂ Single bond Sub-69 2-4214 Sub-55 3,4-diClPh SO₂ Single bond Sub-70 2-4215 Sub-55 3,4-diClPh SO₂ Single bond Sub-71 2-4216 Sub-55 3,4-diClPh SO₂ Single bond Sub-72 2-4217 Sub-55 3,4-diClPh SO₂ Single bond Sub-73 2-4218 Sub-55 3,4-diClPh SO₂ Single bond Sub-74 2-4219 Sub-55 3,4-diClPh SO₂ Single bond Sub-75 2-4220 Sub-55 3,4-diClPh SO₂ Single bond Sub-76 2-4221 Sub-55 3,4-diClPh SO₂ Single bond Sub-77 2-4222 Sub-55 3,4-diClPh SO₂ Single bond Sub-78 2-4223 Sub-55 3,4-diClPh SO₂ Single bond Sub-79 2-4224 Sub-55 3,4-diClPh SO₂ Single bond Sub-80 2-4225 Sub-56 3,4-diClPh SO₂ Single bond Sub-1  2-4226 Sub-56 3,4-diClPh SO₂ Single bond Sub-2  2-4227 Sub-56 3,4-diClPh SO₂ Single bond Sub-3  2-4228 Sub-56 3,4-diClPh SO₂ Single bond Sub-4  2-4229 Sub-56 3,4-diClPh SO₂ Single bond Sub-5  2-4230 Sub-56 3,4-diClPh SO₂ Single bond Sub-6  2-4231 Sub-56 3,4-diClPh SO₂ Single bond Sub-7  2-4232 Sub-56 3,4-diClPh SO₂ Single bond Sub-8  2-4233 Sub-56 3,4-diClPh SO₂ Single bond Sub-9  2-4234 Sub-56 3,4-diClPh SO₂ Single bond Sub-10 2-4235 Sub-56 3,4-diClPh SO₂ Single bond Sub-11 2-4236 Sub-56 3,4-diClPh SO₂ Single bond Sub-12 2-4237 Sub-56 3,4-diClPh SO₂ Single bond Sub-13 2-4238 Sub-56 3,4-diClPh SO₂ Single bond Sub-14 2-4239 Sub-56 3,4-diClPh SO₂ Single bond Sub-15 2-4240 Sub-56 3,4-diClPh SO₂ Single bond Sub-16 2-4241 Sub-56 3,4-diClPh SO₂ Single bond Sub-17 2-4242 Sub-56 3,4-diClPh SO₂ Single bond Sub-18 2-4243 Sub-56 3,4-diClPh SO₂ Single bond Sub-19 2-4244 Sub-56 3,4-diClPh SO₂ Single bond Sub-20 2-4245 Sub-56 3,4-diClPh SO₂ Single bond Sub-21 2-4246 Sub-56 3,4-diClPh SO₂ Single bond Sub-22 2-4247 Sub-56 3,4-diClPh SO₂ Single bond Sub-23 2-4248 Sub-56 3,4-diClPh SO₂ Single bond Sub-24 2-4249 Sub-56 3,4-diClPh SO₂ Single bond Sub-25 2-4250 Sub-56 3,4-diClPh SO₂ Single bond Sub-26 2-4251 Sub-56 3,4-diClPh SO₂ Single bond Sub-27 2-4252 Sub-56 3,4-diClPh SO₂ Single bond Sub-28 2-4253 Sub-56 3,4-diClPh SO₂ Single bond Sub-29 2-4254 Sub-56 3,4-diClPh SO₂ Single bond Sub-30 2-4255 Sub-56 3,4-diClPh SO₂ Single bond Sub-31 2-4256 Sub-56 3,4-diClPh SO₂ Single bond Sub-32 2-4257 Sub-56 3,4-diClPh SO₂ Single bond Sub-65 2-4258 Sub-56 3,4-diClPh SO₂ Single bond Sub-66 2-4259 Sub-56 3,4-diClPh SO₂ Single bond Sub-67 2-4260 Sub-56 3,4-diClPh SO₂ Single bond Sub-68 2-4261 Sub-56 3,4-diClPh SO₂ Single bond Sub-69 2-4262 Sub-56 3,4-diClPh SO₂ Single bond Sub-70 2-4263 Sub-56 3,4-diClPh SO₂ Single bond Sub-71 2-4264 Sub-56 3,4-diClPh SO₂ Single bond Sub-72 2-4265 Sub-56 3,4-diClPh SO₂ Single bond Sub-73 2-4266 Sub-56 3,4-diClPh SO₂ Single bond Sub-74 2-4267 Sub-56 3,4-diClPh SO₂ Single bond Sub-75 2-4268 Sub-56 3,4-diClPh SO₂ Single bond Sub-76 2-4269 Sub-56 3,4-diClPh SO₂ Single bond Sub-77 2-4270 Sub-56 3,4-diClPh SO₂ Single bond Sub-78 2-4271 Sub-56 3,4-diClPh SO₂ Single bond Sub-79 2-4272 Sub-56 3,4-diClPh SO₂ Single bond Sub-80 2-4273 Sub-57 3,4-diClPh SO₂ Single bond Sub-1  2-4274 Sub-57 3,4-diClPh SO₂ Single bond Sub-2  2-4275 Sub-57 3,4-diClPh SO₂ Single bond Sub-3  2-4276 Sub-57 3,4-diClPh SO₂ Single bond Sub-4  2-4277 Sub-57 3,4-diClPh SO₂ Single bond Sub-5  2-4278 Sub-57 3,4-diClPh SO₂ Single bond Sub-6  2-4279 Sub-57 3,4-diClPh SO₂ Single bond Sub-7  2-4280 Sub-57 3,4-diClPh SO₂ Single bond Sub-8  2-4281 Sub-57 3,4-diClPh SO₂ Single bond Sub-9  2-4282 Sub-57 3,4-diClPh SO₂ Single bond Sub-10 2-4283 Sub-57 3,4-diClPh SO₂ Single bond Sub-11 2-4284 Sub-57 3,4-diClPh SO₂ Single bond Sub-12 2-4285 Sub-57 3,4-diClPh SO₂ Single bond Sub-13 2-4286 Sub-57 3,4-diClPh SO₂ Single bond Sub-14 2-4287 Sub-57 3,4-diClPh SO₂ Single bond Sub-15 2-4288 Sub-57 3,4-diClPh SO₂ Single bond Sub-16 2-4289 Sub-57 3,4-diClPh SO₂ Single bond Sub-17 2-4290 Sub-57 3,4-diClPh SO₂ Single bond Sub-18 2-4291 Sub-57 3,4-diClPh SO₂ Single bond Sub-19 2-4292 Sub-57 3,4-diClPh SO₂ Single bond Sub-20 2-4293 Sub-57 3,4-diClPh SO₂ Single bond Sub-21 2-4294 Sub-57 3,4-diClPh SO₂ Single bond Sub-22 2-4295 Sub-57 3,4-diClPh SO₂ Single bond Sub-23 2-4296 Sub-57 3,4-diClPh SO₂ Single bond Sub-24 2-4297 Sub-57 3,4-diClPh SO₂ Single bond Sub-25 2-4298 Sub-57 3,4-diClPh SO₂ Single bond Sub-26 2-4299 Sub-57 3,4-diClPh SO₂ Single bond Sub-27 2-4300 Sub-57 3,4-diClPh SO₂ Single bond Sub-28 2-4301 Sub-57 3,4-diClPh SO₂ Single bond Sub-29 2-4302 Sub-57 3,4-diClPh SO₂ Single bond Sub-30 2-4303 Sub-57 3,4-diClPh SO₂ Single bond Sub-31 2-4304 Sub-57 3,4-diClPh SO₂ Single bond Sub-32 2-4305 Sub-57 3,4-diClPh SO₂ Single bond Sub-65 2-4306 Sub-57 3,4-diClPh SO₂ Single bond Sub-66 2-4307 Sub-57 3,4-diClPh SO₂ Single bond Sub-67 2-4308 Sub-57 3,4-diClPh SO₂ Single bond Sub-68 2-4309 Sub-57 3,4-diClPh SO₂ Single bond Sub-69 2-4310 Sub-57 3,4-diClPh SO₂ Single bond Sub-70 2-4311 Sub-57 3,4-diClPh SO₂ Single bond Sub-71 2-4312 Sub-57 3,4-diClPh SO₂ Single bond Sub-72 2-4313 Sub-57 3,4-diClPh SO₂ Single bond Sub-73 2-4314 Sub-57 3,4-diClPh SO₂ Single bond Sub-74 2-4315 Sub-57 3,4-diClPh SO₂ Single bond Sub-75 2-4316 Sub-57 3,4-diClPh SO₂ Single bond Sub-76 2-4317 Sub-57 3,4-diClPh SO₂ Single bond Sub-77 2-4318 Sub-57 3,4-diClPh SO₂ Single bond Sub-78 2-4319 Sub-57 3,4-diClPh SO₂ Single bond Sub-79 2-4320 Sub-57 3,4-diClPh SO₂ Single bond Sub-80 2-4321 Sub-58 3,4-diClPh SO₂ Single bond Sub-1  2-4322 Sub-58 3,4-diClPh SO₂ Single bond Sub-2  2-4323 Sub-58 3,4-diClPh SO₂ Single bond Sub-3  2-4324 Sub-58 3,4-diClPh SO₂ Single bond Sub-4  2-4325 Sub-58 3,4-diClPh SO₂ Single bond Sub-5  2-4326 Sub-58 3,4-diClPh SO₂ Single bond Sub-6  2-4327 Sub-58 3,4-diClPh SO₂ Single bond Sub-7  2-4328 Sub-58 3,4-diClPh SO₂ Single bond Sub-8  2-4329 Sub-58 3,4-diClPh SO₂ Single bond Sub-9  2-4330 Sub-58 3,4-diClPh SO₂ Single bond Sub-10 2-4331 Sub-58 3,4-diClPh SO₂ Single bond Sub-11 2-4332 Sub-58 3,4-diClPh SO₂ Single bond Sub-12 2-4333 Sub-58 3,4-diClPh SO₂ Single bond Sub-13 2-4334 Sub-58 3,4-diClPh SO₂ Single bond Sub-14 2-4335 Sub-58 3,4-diClPh SO₂ Single bond Sub-15 2-4336 Sub-58 3,4-diClPh SO₂ Single bond Sub-16 2-4337 Sub-58 3,4-diClPh SO₂ Single bond Sub-17 2-4338 Sub-58 3,4-diClPh SO₂ Single bond Sub-18 2-4339 Sub-58 3,4-diClPh SO₂ Single bond Sub-19 2-4340 Sub-58 3,4-diClPh SO₂ Single bond Sub-20 2-4341 Sub-58 3,4-diClPh SO₂ Single bond Sub-21 2-4342 Sub-58 3,4-diClPh SO₂ Single bond Sub-22 2-4343 Sub-58 3,4-diClPh SO₂ Single bond Sub-23 2-4344 Sub-58 3,4-diClPh SO₂ Single bond Sub-24 2-4345 Sub-58 3,4-diClPh SO₂ Single bond Sub-25 2-4346 Sub-58 3,4-diClPh SO₂ Single bond Sub-26 2-4347 Sub-58 3,4-diClPh SO₂ Single bond Sub-27 2-4348 Sub-58 3,4-diClPh SO₂ Single bond Sub-28 2-4349 Sub-58 3,4-diClPh SO₂ Single bond Sub-29 2-4350 Sub-58 3,4-diClPh SO₂ Single bond Sub-30 2-4351 Sub-58 3,4-diClPh SO₂ Single bond Sub-31 2-4352 Sub-58 3,4-diClPh SO₂ Single bond Sub-32 2-4353 Sub-58 3,4-diClPh SO₂ Single bond Sub-65 2-4354 Sub-58 3,4-diClPh SO₂ Single bond Sub-66 2-4355 Sub-58 3,4-diClPh SO₂ Single bond Sub-67 2-4356 Sub-58 3,4-diClPh SO₂ Single bond Sub-68 2-4357 Sub-58 3,4-diClPh SO₂ Single bond Sub-69 2-4358 Sub-58 3,4-diClPh SO₂ Single bond Sub-70 2-4359 Sub-58 3,4-diClPh SO₂ Single bond Sub-71 2-4360 Sub-58 3,4-diClPh SO₂ Single bond Sub-72 2-4361 Sub-58 3,4-diClPh SO₂ Single bond Sub-73 2-4362 Sub-58 3,4-diClPh SO₂ Single bond Sub-74 2-4363 Sub-58 3,4-diClPh SO₂ Single bond Sub-75 2-4364 Sub-58 3,4-diClPh SO₂ Single bond Sub-76 2-4365 Sub-58 3,4-diClPh SO₂ Single bond Sub-77 2-4366 Sub-58 3,4-diClPh SO₂ Single bond Sub-78 2-4367 Sub-58 3,4-diClPh SO₂ Single bond Sub-79 2-4368 Sub-58 3,4-diClPh SO₂ Single bond Sub-80 2-4369 Sub-59 3,4-diClPh SO₂ Single bond Sub-1  2-4370 Sub-59 3,4-diClPh SO₂ Single bond Sub-2  2-4371 Sub-59 3,4-diClPh SO₂ Single bond Sub-3  2-4372 Sub-59 3,4-diClPh SO₂ Single bond Sub-4  2-4373 Sub-59 3,4-diClPh SO₂ Single bond Sub-5  2-4374 Sub-59 3,4-diClPh SO₂ Single bond Sub-6  2-4375 Sub-59 3,4-diClPh SO₂ Single bond Sub-7  2-4376 Sub-59 3,4-diClPh SO₂ Single bond Sub-8  2-4377 Sub-59 3,4-diClPh SO₂ Single bond Sub-9  2-4378 Sub-59 3,4-diClPh SO₂ Single bond Sub-10 2-4379 Sub-59 3,4-diClPh SO₂ Single bond Sub-11 2-4380 Sub-59 3,4-diClPh SO₂ Single bond Sub-12 2-4381 Sub-59 3,4-diClPh SO₂ Single bond Sub-13 2-4382 Sub-59 3,4-diClPh SO₂ Single bond Sub-14 2-4383 Sub-59 3,4-diClPh SO₂ Single bond Sub-15 2-4384 Sub-59 3,4-diClPh SO₂ Single bond Sub-16 2-4385 Sub-59 3,4-diClPh SO₂ Single bond Sub-17 2-4386 Sub-59 3,4-diClPh SO₂ Single bond Sub-18 2-4387 Sub-59 3,4-diClPh SO₂ Single bond Sub-19 2-4388 Sub-59 3,4-diClPh SO₂ Single bond Sub-20 2-4389 Sub-59 3,4-diClPh SO₂ Single bond Sub-21 2-4390 Sub-59 3,4-diClPh SO₂ Single bond Sub-22 2-4391 Sub-59 3,4-diClPh SO₂ Single bond Sub-23 2-4392 Sub-59 3,4-diClPh SO₂ Single bond Sub-24 2-4393 Sub-59 3,4-diClPh SO₂ Single bond Sub-25 2-4394 Sub-59 3,4-diClPh SO₂ Single bond Sub-26 2-4395 Sub-59 3,4-diClPh SO₂ Single bond Sub-27 2-4396 Sub-59 3,4-diClPh SO₂ Single bond Sub-28 2-4397 Sub-59 3,4-diClPh SO₂ Single bond Sub-29 2-4398 Sub-59 3,4-diClPh SO₂ Single bond Sub-30 2-4399 Sub-59 3,4-diClPh SO₂ Single bond Sub-31 2-4400 Sub-59 3,4-diClPh SO₂ Single bond Sub-32 2-4401 Sub-59 3,4-diClPh SO₂ Single bond Sub-65 2-4402 Sub-59 3,4-diClPh SO₂ Single bond Sub-66 2-4403 Sub-59 3,4-diClPh SO₂ Single bond Sub-67 2-4404 Sub-59 3,4-diClPh SO₂ Single bond Sub-68 2-4405 Sub-59 3,4-diClPh SO₂ Single bond Sub-69 2-4406 Sub-59 3,4-diClPh SO₂ Single bond Sub-70 2-4407 Sub-59 3,4-diClPh SO₂ Single bond Sub-71 2-4408 Sub-59 3,4-diClPh SO₂ Single bond Sub-72 2-4409 Sub-59 3,4-diClPh SO₂ Single bond Sub-73 2-4410 Sub-59 3,4-diClPh SO₂ Single bond Sub-74 2-4411 Sub-59 3,4-diClPh SO₂ Single bond Sub-75 2-4412 Sub-59 3,4-diClPh SO₂ Single bond Sub-76 2-4413 Sub-59 3,4-diClPh SO₂ Single bond Sub-77 2-4414 Sub-59 3,4-diClPh SO₂ Single bond Sub-78 2-4415 Sub-59 3,4-diClPh SO₂ Single bond Sub-79 2-4416 Sub-59 3,4-diClPh SO₂ Single bond Sub-80 2-4417 Sub-82 3,4-diClPh SO₂ Single bond Sub-1  2-4418 Sub-82 3,4-diClPh SO₂ Single bond Sub-2  2-4419 Sub-82 3,4-diClPh SO₂ Single bond Sub-3  2-4420 Sub-82 3,4-diClPh SO₂ Single bond Sub-4  2-4421 Sub-82 3,4-diClPh SO₂ Single bond Sub-5  2-4422 Sub-82 3,4-diClPh SO₂ Single bond Sub-6  2-4423 Sub-82 3,4-diClPh SO₂ Single bond Sub-7  2-4424 Sub-82 3,4-diClPh SO₂ Single bond Sub-8  2-4425 Sub-82 3,4-diClPh SO₂ Single bond Sub-9  2-4426 Sub-82 3,4-diClPh SO₂ Single bond Sub-10 2-4427 Sub-82 3,4-diClPh SO₂ Single bond Sub-11 2-4428 Sub-82 3,4-diClPh SO₂ Single bond Sub-12 2-4429 Sub-82 3,4-diClPh SO₂ Single bond Sub-13 2-4430 Sub-82 3,4-diClPh SO₂ Single bond Sub-14 2-4431 Sub-82 3,4-diClPh SO₂ Single bond Sub-15 2-4432 Sub-82 3,4-diClPh SO₂ Single bond Sub-16 2-4433 Sub-82 3,4-diClPh SO₂ Single bond Sub-17 2-4434 Sub-82 3,4-diClPh SO₂ Single bond Sub-18 2-4435 Sub-82 3,4-diClPh SO₂ Single bond Sub-19 2-4436 Sub-82 3,4-diClPh SO₂ Single bond Sub-20 2-4437 Sub-82 3,4-diClPh SO₂ Single bond Sub-21 2-4438 Sub-82 3,4-diClPh SO₂ Single bond Sub-22 2-4439 Sub-82 3,4-diClPh SO₂ Single bond Sub-23 2-4440 Sub-82 3,4-diClPh SO₂ Single bond Sub-24 2-4441 Sub-82 3,4-diClPh SO₂ Single bond Sub-25 2-4442 Sub-82 3,4-diClPh SO₂ Single bond Sub-26 2-4443 Sub-82 3,4-diClPh SO₂ Single bond Sub-27 2-4444 Sub-82 3,4-diClPh SO₂ Single bond Sub-28 2-4445 Sub-82 3,4-diClPh SO₂ Single bond Sub-29 2-4446 Sub-82 3,4-diClPh SO₂ Single bond Sub-30 2-4447 Sub-82 3,4-diClPh SO₂ Single bond Sub-31 2-4448 Sub-82 3,4-diClPh SO₂ Single bond Sub-32 2-4449 Sub-82 3,4-diClPh SO₂ Single bond Sub-65 2-4450 Sub-82 3,4-diClPh SO₂ Single bond Sub-66 2-4451 Sub-82 3,4-diClPh SO₂ Single bond Sub-67 2-4452 Sub-82 3,4-diClPh SO₂ Single bond Sub-68 2-4453 Sub-82 3,4-diClPh SO₂ Single bond Sub-69 2-4454 Sub-82 3,4-diClPh SO₂ Single bond Sub-70 2-4455 Sub-82 3,4-diClPh SO₂ Single bond Sub-71 2-4456 Sub-82 3,4-diClPh SO₂ Single bond Sub-72 2-4457 Sub-82 3,4-diClPh SO₂ Single bond Sub-73 2-4458 Sub-82 3,4-diClPh SO₂ Single bond Sub-74 2-4459 Sub-82 3,4-diClPh SO₂ Single bond Sub-75 2-4460 Sub-82 3,4-diClPh SO₂ Single bond Sub-76 2-4461 Sub-82 3,4-diClPh SO₂ Single bond Sub-77 2-4462 Sub-82 3,4-diClPh SO₂ Single bond Sub-78 2-4463 Sub-82 3,4-diClPh SO₂ Single bond Sub-79 2-4464 Sub-82 3,4-diClPh SO₂ Single bond Sub-80 2-4465 Sub-83 3,4-diClPh SO₂ Single bond Sub-1  2-4466 Sub-83 3,4-diClPh SO₂ Single bond Sub-2  2-4467 Sub-83 3,4-diClPh SO₂ Single bond Sub-3  2-4468 Sub-83 3,4-diClPh SO₂ Single bond Sub-4  2-4469 Sub-83 3,4-diClPh SO₂ Single bond Sub-5  2-4470 Sub-83 3,4-diClPh SO₂ Single bond Sub-6  2-4471 Sub-83 3,4-diClPh SO₂ Single bond Sub-7  2-4472 Sub-83 3,4-diClPh SO₂ Single bond Sub-8  2-4473 Sub-83 3,4-diClPh SO₂ Single bond Sub-9  2-4474 Sub-83 3,4-diClPh SO₂ Single bond Sub-10 2-4475 Sub-83 3,4-diClPh SO₂ Single bond Sub-11 2-4476 Sub-83 3,4-diClPh SO₂ Single bond Sub-12 2-4477 Sub-83 3,4-diClPh SO₂ Single bond Sub-13 2-4478 Sub-83 3,4-diClPh SO₂ Single bond Sub-14 2-4479 Sub-83 3,4-diClPh SO₂ Single bond Sub-15 2-4480 Sub-83 3,4-diClPh SO₂ Single bond Sub-16 2-4481 Sub-83 3,4-diClPh SO₂ Single bond Sub-17 2-4482 Sub-83 3,4-diClPh SO₂ Single bond Sub-18 2-4483 Sub-83 3,4-diClPh SO₂ Single bond Sub-19 2-4484 Sub-83 3,4-diClPh SO₂ Single bond Sub-20 2-4485 Sub-83 3,4-diClPh SO₂ Single bond Sub-21 2-4486 Sub-83 3,4-diClPh SO₂ Single bond Sub-22 2-4487 Sub-83 3,4-diClPh SO₂ Single bond Sub-23 2-4488 Sub-83 3,4-diClPh SO₂ Single bond Sub-24 2-4489 Sub-83 3,4-diClPh SO₂ Single bond Sub-25 2-4490 Sub-83 3,4-diClPh SO₂ Single bond Sub-26 2-4491 Sub-83 3,4-diClPh SO₂ Single bond Sub-27 2-4492 Sub-83 3,4-diClPh SO₂ Single bond Sub-28 2-4493 Sub-83 3,4-diClPh SO₂ Single bond Sub-29 2-4494 Sub-83 3,4-diClPh SO₂ Single bond Sub-30 2-4495 Sub-83 3,4-diClPh SO₂ Single bond Sub-31 2-4496 Sub-83 3,4-diClPh SO₂ Single bond Sub-32 2-4497 Sub-83 3,4-diClPh SO₂ Single bond Sub-65 2-4498 Sub-83 3,4-diClPh SO₂ Single bond Sub-66 2-4499 Sub-83 3,4-diClPh SO₂ Single bond Sub-67 2-4500 Sub-83 3,4-diClPh SO₂ Single bond Sub-68 2-4501 Sub-83 3,4-diClPh SO₂ Single bond Sub-69 2-4502 Sub-83 3,4-diClPh SO₂ Single bond Sub-70 2-4503 Sub-83 3,4-diClPh SO₂ Single bond Sub-71 2-4504 Sub-83 3,4-diClPh SO₂ Single bond Sub-72 2-4505 Sub-83 3,4-diClPh SO₂ Single bond Sub-73 2-4506 Sub-83 3,4-diClPh SO₂ Single bond Sub-74 2-4507 Sub-83 3,4-diClPh SO₂ Single bond Sub-75 2-4508 Sub-83 3,4-diClPh SO₂ Single bond Sub-76 2-4509 Sub-83 3,4-diClPh SO₂ Single bond Sub-77 2-4510 Sub-83 3,4-diClPh SO₂ Single bond Sub-78 2-4511 Sub-83 3,4-diClPh SO₂ Single bond Sub-79 2-4512 Sub-83 3,4-diClPh SO₂ Single bond Sub-80 2-4513 Sub-61 3,4-diClPh SO₂ Single bond Sub-1  2-4514 Sub-61 3,4-diClPh SO₂ Single bond Sub-2  2-4515 Sub-61 3,4-diClPh SO₂ Single bond Sub-3  2-4516 Sub-61 3,4-diClPh SO₂ Single bond Sub-4  2-4517 Sub-61 3,4-diClPh SO₂ Single bond Sub-5  2-4518 Sub-61 3,4-diClPh SO₂ Single bond Sub-6  2-4519 Sub-61 3,4-diClPh SO₂ Single bond Sub-7  2-4520 Sub-61 3,4-diClPh SO₂ Single bond Sub-8  2-4521 Sub-61 3,4-diClPh SO₂ Single bond Sub-9  2-4522 Sub-61 3,4-diClPh SO₂ Single bond Sub-10 2-4523 Sub-61 3,4-diClPh SO₂ Single bond Sub-11 2-4524 Sub-61 3,4-diClPh SO₂ Single bond Sub-12 2-4525 Sub-61 3,4-diClPh SO₂ Single bond Sub-13 2-4526 Sub-61 3,4-diClPh SO₂ Single bond Sub-14 2-4527 Sub-61 3,4-diClPh SO₂ Single bond Sub-15 2-4528 Sub-61 3,4-diClPh SO₂ Single bond Sub-16 2-4529 Sub-61 3,4-diClPh SO₂ Single bond Sub-17 2-4530 Sub-61 3,4-diClPh SO₂ Single bond Sub-18 2-4531 Sub-61 3,4-diClPh SO₂ Single bond Sub-19 2-4532 Sub-61 3,4-diClPh SO₂ Single bond Sub-20 2-4533 Sub-61 3,4-diClPh SO₂ Single bond Sub-21 2-4534 Sub-61 3,4-diClPh SO₂ Single bond Sub-22 2-4535 Sub-61 3,4-diClPh SO₂ Single bond Sub-23 2-4536 Sub-61 3,4-diClPh SO₂ Single bond Sub-24 2-4537 Sub-61 3,4-diClPh SO₂ Single bond Sub-25 2-4538 Sub-61 3,4-diClPh SO₂ Single bond Sub-26 2-4539 Sub-61 3,4-diClPh SO₂ Single bond Sub-27 2-4540 Sub-61 3,4-diClPh SO₂ Single bond Sub-28 2-4541 Sub-61 3,4-diClPh SO₂ Single bond Sub-29 2-4542 Sub-61 3,4-diClPh SO₂ Single bond Sub-30 2-4543 Sub-61 3,4-diClPh SO₂ Single bond Sub-31 2-4544 Sub-61 3,4-diClPh SO₂ Single bond Sub-32 2-4545 Sub-61 3,4-diClPh SO₂ Single bond Sub-65 2-4546 Sub-61 3,4-diClPh SO₂ Single bond Sub-66 2-4547 Sub-61 3,4-diClPh SO₂ Single bond Sub-67 2-4548 Sub-61 3,4-diClPh SO₂ Single bond Sub-68 2-4549 Sub-61 3,4-diClPh SO₂ Single bond Sub-69 2-4550 Sub-61 3,4-diClPh SO₂ Single bond Sub-70 2-4551 Sub-61 3,4-diClPh SO₂ Single bond Sub-71 2-4552 Sub-61 3,4-diClPh SO₂ Single bond Sub-72 2-4553 Sub-61 3,4-diClPh SO₂ Single bond Sub-73 2-4554 Sub-61 3,4-diClPh SO₂ Single bond Sub-74 2-4555 Sub-61 3,4-diClPh SO₂ Single bond Sub-75 2-4556 Sub-61 3,4-diClPh SO₂ Single bond Sub-76 2-4557 Sub-61 3,4-diClPh SO₂ Single bond Sub-77 2-4558 Sub-61 3,4-diClPh SO₂ Single bond Sub-78 2-4559 Sub-61 3,4-diClPh SO₂ Single bond Sub-79 2-4560 Sub-61 3,4-diClPh SO₂ Single bond Sub-80 2-4561 Sub-60 3,4-diClPh SO₂ Single bond Sub-1  2-4562 Sub-60 3,4-diClPh SO₂ Single bond Sub-2  2-4563 Sub-60 3,4-diClPh SO₂ Single bond Sub-3  2-4564 Sub-60 3,4-diClPh SO₂ Single bond Sub-4  2-4565 Sub-60 3,4-diClPh SO₂ Single bond Sub-5  2-4566 Sub-60 3,4-diClPh SO₂ Single bond Sub-6  2-4567 Sub-60 3,4-diClPh SO₂ Single bond Sub-7  2-4568 Sub-60 3,4-diClPh SO₂ Single bond Sub-8  2-4569 Sub-60 3,4-diClPh SO₂ Single bond Sub-9  2-4570 Sub-60 3,4-diClPh SO₂ Single bond Sub-10 2-4571 Sub-60 3,4-diClPh SO₂ Single bond Sub-11 2-4572 Sub-60 3,4-diClPh SO₂ Single bond Sub-12 2-4573 Sub-60 3,4-diClPh SO₂ Single bond Sub-13 2-4574 Sub-60 3,4-diClPh SO₂ Single bond Sub-14 2-4575 Sub-60 3,4-diClPh SO₂ Single bond Sub-15 2-4576 Sub-60 3,4-diClPh SO₂ Single bond Sub-16 2-4577 Sub-60 3,4-diClPh SO₂ Single bond Sub-17 2-4578 Sub-60 3,4-diClPh SO₂ Single bond Sub-18 2-4579 Sub-60 3,4-diClPh SO₂ Single bond Sub-19 2-4580 Sub-60 3,4-diClPh SO₂ Single bond Sub-20 2-4581 Sub-60 3,4-diClPh SO₂ Single bond Sub-21 2-4582 Sub-60 3,4-diClPh SO₂ Single bond Sub-22 2-4583 Sub-60 3,4-diClPh SO₂ Single bond Sub-23 2-4584 Sub-60 3,4-diClPh SO₂ Single bond Sub-24 2-4585 Sub-60 3,4-diClPh SO₂ Single bond Sub-25 2-4586 Sub-60 3,4-diClPh SO₂ Single bond Sub-26 2-4587 Sub-60 3,4-diClPh SO₂ Single bond Sub-27 2-4588 Sub-60 3,4-diClPh SO₂ Single bond Sub-28 2-4589 Sub-60 3,4-diClPh SO₂ Single bond Sub-29 2-4590 Sub-60 3,4-diClPh SO₂ Single bond Sub-30 2-4591 Sub-60 3,4-diClPh SO₂ Single bond Sub-31 2-4592 Sub-60 3,4-diClPh SO₂ Single bond Sub-32 2-4593 Sub-60 3,4-diClPh SO₂ Single bond Sub-65 2-4594 Sub-60 3,4-diClPh SO₂ Single bond Sub-66 2-4595 Sub-60 3,4-diClPh SO₂ Single bond Sub-67 2-4596 Sub-60 3,4-diClPh SO₂ Single bond Sub-68 2-4597 Sub-60 3,4-diClPh SO₂ Single bond Sub-69 2-4598 Sub-60 3,4-diClPh SO₂ Single bond Sub-70 2-4599 Sub-60 3,4-diClPh SO₂ Single bond Sub-71 2-4600 Sub-60 3,4-diClPh SO₂ Single bond Sub-72 2-4601 Sub-60 3,4-diClPh SO₂ Single bond Sub-73 2-4602 Sub-60 3,4-diClPh SO₂ Single bond Sub-74 2-4603 Sub-60 3,4-diClPh SO₂ Single bond Sub-75 2-4604 Sub-60 3,4-diClPh SO₂ Single bond Sub-76 2-4605 Sub-60 3,4-diClPh SO₂ Single bond Sub-77 2-4606 Sub-60 3,4-diClPh SO₂ Single bond Sub-78 2-4607 Sub-60 3,4-diClPh SO₂ Single bond Sub-79 2-4608 Sub-60 3,4-diClPh SO₂ Single bond Sub-80

TABLE 3 Cpd. No. R¹ R² A B E 3-1 Sub-33 3,4-diClPh —CO— Single Bond —CH₂— 3-2 Sub-34 3,4-diClPh —CO— Single Bond —CH₂— 3-3 Sub-35 3,4-diClPh —CO— Single Bond —CH₂— 3-4 Sub-36 3,4-diClPh —CO— Single Bond —CH₂— 3-5 Sub-37 3,4-diClPh —CO— Single Bond —CH₂— 3-6 Sub-38 3,4-diClPh —CO— Single Bond —CH₂— 3-7 Sub-39 3,4-diClPh —CO— Single Bond —CH₂— 3-8 Sub-40 3,4-diClPh —CO— Single Bond —CH₂— 3-9 Sub-41 3,4-diClPh —CO— Single Bond —CH₂— 3-10 Sub-42 3,4-diClPh —CO— Single Bond —CH₂— 3-11 Sub-84 3,4-diClPh —CO— Single Bond —CH₂— 3-12 Sub-43 3,4-diClPh —CO— Single Bond —CH₂— 3-13 Sub-44 3,4-diClPh —CO— Single Bond —CH₂— 3-14 Sub-45 3,4-diClPh —CO— Single Bond —CH₂— 3-15 Sub-46 3,4-diClPh —CO— Single Bond —CH₂— 3-16 Sub-47 3,4-diClPh —CO— Single Bond —CH₂— 3-17 Sub-81 3,4-diClPh —CO— Single Bond —CH₂— 3-18 Sub-48 3,4-diClPh —CO— Single Bond —CH₂— 3-19 Sub-49 3,4-diClPh —CO— Single Bond —CH₂— 3-20 Sub-50 3,4-diClPh —CO— Single Bond —CH₂— 3-21 Sub-51 3,4-diClPh —CO— Single Bond —CH₂— 3-22 Sub-52 3,4-diClPh —CO— Single Bond —CH₂— 3-23 Sub-53 3,4-diClPh —CO— Single Bond —CH₂— 3-24 Sub-54 3,4-diClPh —CO— Single Bond —CH₂— 3-25 Sub-56 3,4-diClPh —CO— Single Bond —CH₂— 3-26 Sub-57 3,4-diClPh —CO— Single Bond —CH₂— 3-27 Sub-58 3,4-diClPh —CO— Single Bond —CH₂— 3-28 Sub-59 3,4-diClPh —CO— Single Bond —CH₂— 3-29 Sub-82 3,4-diClPh —CO— Single Bond —CH₂— 3-30 Sub-83 3,4-diClPh —CO— Single Bond —CH₂— 3-31 Sub-61 3,4-diClPh —CO— Single Bond —CH₂— 3-32 Sub-55 3,4-diClPh —CO— Single Bond —CH₂— 3-33 Sub-33 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-34 Sub-34 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-35 Sub-35 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-36 Sub-36 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-37 Sub-37 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-38 Sub-38 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-39 Sub-39 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-40 Sub-40 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-41 Sub-41 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-42 Sub-42 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-43 Sub-84 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-44 Sub-43 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-45 Sub-44 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-46 Sub-45 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-47 Sub-46 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-48 Sub-47 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-49 Sub-81 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-50 Sub-48 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-51 Sub-49 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-52 Sub-50 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-53 Sub-51 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-54 Sub-52 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-55 Sub-53 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-56 Sub-54 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-57 Sub-56 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-58 Sub-57 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-59 Sub-58 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-60 Sub-59 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-61 Sub-82 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-62 Sub-83 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-63 Sub-61 3,4-diClPh —CO— Single Bond —CH₂CH₂— 3-64 Sub-55 3,4-diClPh —CO— Singie Bond —CH₂CH₂— 3-65 Sub-33 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-66 Sub-34 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-67 Sub-35 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-68 Sub-36 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-69 Sub-37 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-70 Sub-38 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-71 Sub-39 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-72 Sub-40 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-73 Sub-41 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-74 Sub-42 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-75 Sub-84 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-76 Sub-43 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-77 Sub-44 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-78 Sub-45 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-79 Sub-46 3,4-diClPh —CO— Single Borid —(CH₂)₃— 3-80 Sub-47 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-81 Sub-81 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-82 Sub-48 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-83 Sub-49 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-84 Sub-50 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-85 Sub-51 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-86 Sub-52 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-87 Sub-53 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-88 Sub-54 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-89 Sub-56 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-90 Sub-57 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-91 Sub-58 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-92 Sub-59 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-93 Sub-82 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-94 Sub-83 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-95 Sub-61 3,4-diClPh —CO— Single Borid —(CH₂)₃— 3-96 Sub-55 3,4-diClPh —CO— Single Bond —(CH₂)₃— 3-97 Sub-33 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-98 Sub-34 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-99 Sub-35 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-100 Sub-36 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-101 Sub-37 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-102 Sub-38 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-103 Sub-39 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-104 Sub-40 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-105 Sub-41 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-106 Sub-42 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-107 Sub-84 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-108 Sub-43 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-109 Sub-44 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-110 Sub-45 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-111 Sub-46 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-112 Sub-47 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-113 Sub-81 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-114 Sub-48 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-115 Sub-49 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-116 Sub-50 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-117 Sub-51 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-118 Sub-52 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-119 Sub-53 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-120 Sub-54 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-121 Sub-56 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-122 Sub-57 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-123 Sub-58 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-124 Sub-59 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-125 Sub-82 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-126 Sub-83 3,4-diClPh —CO— Single Bond —CH₂C)Me)₂— 3-127 Sub-61 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-128 Sub-55 3,4-diClPh —CO— Single Bond —CH₂C(Me)₂— 3-129 Sub-33 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-130 Sub-34 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-131 Sub-35 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-132 Sub-36 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-133 Sub-37 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-134 Sub-38 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-135 Sub-39 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-136 Sub-40 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-137 Sub-41 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-138 Sub-42 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-139 Sub-84 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-140 Sub-43 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-141 Sub-44 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-142 Sub-45 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-143 Sub-46 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-144 Sub-47 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-145 Sub-81 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-146 Sub-48 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-147 Sub-49 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-148 Sub-50 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-149 Sub-51 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-150 Sub-52 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-151 Sub-53 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-152 Sub-54 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-153 Sub-56 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-154 Sub-57 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-155 Sub-58 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-156 Sub-59 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-157 Sub-82 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-158 Sub-83 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-159 Sub-61 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-160 Sub-55 3,4-diClPh —CO— Single Bond —CH₂-cPr— 3-161 Sub-33 3,4-diClPh —CO— Sihgle Bond —CH₂-cBu— 3-162 Sub-34 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-163 Sub-35 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-164 Sub-36 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-165 Sub-37 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-166 Sub-38 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-167 Sub-39 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-168 Sub-40 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-169 Sub-41 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-170 Sub-42 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-171 Sub-84 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-172 Sub-43 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-173 Sub-44 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-174 Sub-45 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-175 Sub-46 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-176 Sub-47 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-177 Sub-81 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-178 Sub-48 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-179 Sub-49 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-180 Sub-50 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-181 Sub-51 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-182 Sub-52 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-183 Sub-53 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-184 Sub-54 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-185 Sub-56 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-186 Sub-57 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-187 Sub-58 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-188 Sub-59 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-189 Sub-82 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-190 Sub-83 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-191 Sub-61 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-192 Sub-55 3,4-diClPh —CO— Single Bond —CH₂-cBu— 3-193 Sub-33 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-194 Sub-34 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-195 Sub-35 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-196 Sub-36 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-197 Sub-37 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-198 Sub-38 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-199 Sub-39 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-200 Sub-40 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-201 Sub-41 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-202 Sub-42 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-203 Sub-84 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-204 Sub-43 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-205 Sub-44 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-206 Sub-45 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-207 Sub-46 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-208 Sub-47 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-209 Sub-81 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-210 Sub-48 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-211 Sub-49 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-212 Sub-50 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-213 Sub-51 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-214 Sub-52 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-215 Sub-53 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-216 Sub-54 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-217 Sub-56 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-218 Sub-57 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-219 Sub-58 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-220 Sub-59 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-221 Sub-82 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-222 Sub-83 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-223 Sub-61 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-224 Sub-55 3,4-diClPh —CO— Single Bond —CH₂-cPn— 3-225 Sub-33 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-226 Sub-34 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-227 Sub-35 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-228 Sub-36 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-229 Sub-37 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-230 Sub-38 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-231 Sub-39 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-232 Sub-40 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-233 Sub-41 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-234 Sub-42 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-235 Sub-84 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-236 Sub-43 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-237 Sub-44 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-238 Sub-45 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-239 Sub-46 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-240 Sub-47 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-241 Sub-81 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-242 Sub-48 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-243 Sub-49 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-244 Sub-50 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-245 Sub-51 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-246 Sub-52 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-247 Sub-53 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-248 Sub-54 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-249 Sub-56 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-250 Sub-57 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-251 Sub-58 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-252 Sub-59 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-253 Sub-82 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-254 Sub-83 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-255 Sub-61 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-256 Sub-55 3,4-diClPh —CO— Single Bond —CH₂-cHx— 3-257 Sub-33 4-ClPh —CO— Single Bond —CH₂— 3-258 Sub-34 4-ClPh —CO— Single Bond —CH₂— 3-259 Sub-35 4-ClPh —CO— Single Bond —CH₂— 3-260 Sub-36 4-ClPh —CO— Single Bond —CH₂— 3-261 Sub-37 4-ClPh —CO— Single Bond —CH₂— 3-262 Sub-38 4-ClPh —CO— Single Bond —CH₂— 3-263 Sub-39 4-ClPh —CO— Single Bond —CH₂— 3-264 Sub-40 4-ClPh —CO— Single Bond —CH₂— 3-265 Sub-41 4-ClPh —CO— Single Bond —CH₂— 3-266 Sub-42 4-ClPh —CO— Single Bond —CH₂— 3-267 Sub-84 4-ClPh —CO— Single Bond —CH₂— 3-268 Sub-43 4-ClPh —CO— Single Bond —CH₂— 3-269 Sub-44 4-ClPh —CO— Single Bond —CH₂— 3-270 Sub-45 4-ClPh —CO— Single Bond —CH₂— 3-271 Sub-46 4-ClPh —CO— Single Bond —CH₂— 3-272 Sub-47 4-ClPh —CO— Single Bond —CH₂— 3-273 Sub-81 4-ClPh —CO— Single Bond —CH₂— 3-274 Sub-48 4-ClPh —CO— Single Bond —CH₂— 3-275 Sub-49 4-ClPh —CO— Single Bond —CH₂— 3-276 Sub-50 4-ClPh —CO— Single Bond —CH₂— 3-277 Sub-51 4-ClPh —CO— Single Bond —CH₂— 3-278 Sub-52 4-ClPh —CO— Single Bond —CH₂— 3-279 Sub-53 4-ClPh —CO— Single Bond —CH₂— 3-280 Sub-54 4-ClPh —CO— Single Bond —CH₂— 3-281 Sub-56 4-ClPh —CO— Single Bond —CH₂— 3-282 Sub-57 4-ClPh —CO— Single Bond —CH₂— 3-283 Sub-58 4-ClPh —CO— Single Bond —CH₂— 3-284 Sub-59 4-ClPh —CO— Single Bond —CH₂— 3-285 Sub-82 4-ClPh —CO— Single Bond —CH₂— 3-286 Sub-83 4-ClPh —CO— Single Bond —CH₂— 3-287 Sub-61 4-ClPh —CO— Single Bond —CH₂— 3-288 Sub-55 4-ClPh —CO— Single Bond —CH₂— 3-289 Sub-33 4-ClPh —CO— Single Bond —CH₂CH₂— 3-290 Sub-34 4-ClPh —CO— Single Bond —CH₂CH₂— 3-291 Sub-35 4-ClPh —CO— Single Bond —CH₂CH₂— 3-292 Sub-36 4-ClPh —CO— Single Bond —CH₂CH₂— 3-293 Sub-37 4-ClPh —CO— Single Bond —CH₂CH₂— 3-294 Sub-38 4-ClPh —CO— Single Bond —CH₂CH₂— 3-295 Sub-39 4-ClPh —CO— Single Bond —CH₂CH₂— 3-296 Sub-40 4-ClPh —CO— Single Bond —CH₂CH₂— 3-297 Sub-41 4-ClPh —CO— Single Bond —CH₂CH₂— 3-298 Sub-42 4-ClPh —CO— Single Bond —CH₂CH₂— 3-299 Sub-84 4-ClPh —CO— Single Bond —CH₂CH₂— 3-300 Sub-43 4-ClPh —CO— Single Bond —CH₂CH₂— 3-301 Sub-44 4-ClPh —CO— Single Bond —CH₂CH₂— 3-302 Sub-45 4-ClPh —CO— Single Bond —CH₂CH₂— 3-303 Sub-46 4-ClPh —CO— Single Bond —CH₂CH₂— 3-304 Sub-47 4-ClPh —CO— Single Bond —CH₂CH₂— 3-305 Sub-81 4-ClPh —CO— Single Bond —CH₂CH₂— 3-306 Sub-48 4-ClPh —CO— Single Bond —CH₂CH₂— 3-307 Sub-49 4-ClPh —CO— Single Bond —CH₂CH₂— 3-308 Sub-50 4-ClPh —CO— Single Bond —CH₂CH₂— 3-309 Sub-51 4-ClPh —CO— Single Bond —CH₂CH₂— 3-310 Sub-52 4-ClPh —CO— Single Bond —CH₂CH₂— 3-311 Sub-53 4-ClPh —CO— Single Bond —CH₂CH₂— 3-312 Sub-54 4-ClPh —CO— Single Bond —CH₂CH₂— 3-313 Sub-56 4-ClPh —CO— Single Bond —CH₂CH₂— 3-314 Sub-57 4-ClPh —CO— Single Bond —CH₂CH₂— 3-315 Sub-58 4-ClPh —CO— Single Bond —CH₂CH₂— 3-316 Sub-59 4-ClPh —CO— Single Bond —CH₂CH₂— 3-317 Sub-82 4-ClPh —CO— Single Bond —CH₂CH₂— 3-318 Sub-83 4-ClPh —CO— Single Bond —CH₂CH₂— 3-319 Sub-61 4-ClPh —CO— Single Bond —CH₂CH₂— 3-320 Sub-55 4-ClPh —CO— Single Bond —CH₂CH₂— 3-321 Sub-33 4-ClPh —CO— Single Bond —(CH₂)₃— 3-322 Sub-34 4-ClPh —CO— Single Bond —(CH₂)₃— 3-323 Sub-35 4-ClPh —CO— Singie Bond —(CH₂)₃— 3-324 Sub-36 4-ClPh —CO— Single Bond —(CH₂)₃— 3-325 Sub-37 4-ClPh —CO— Single Bond —(CH₂)₃— 3-326 Sub-38 4-ClPh —CO— Single Bond —(CH₂)₃— 3-327 Sub-39 4-ClPh —CO— Single Bond —(CH₂)₃— 3-328 Sub-40 4-ClPh —CO— Single Bond —(CH₂)₃— 3-329 Sub-41 4-ClPh —CO— Single Bond —(CH₂)₃— 3-330 Sub-42 4-ClPh —CO— Single Bond —(CH₂)₃— 3-331 Sub-84 4-ClPh —CO— Single Bond —(CH₂)₃— 3-332 Sub-43 4-ClPh —CO— Single Bond —(CH₂)₃— 3-333 Sub-44 4-ClPh —CO— Single Bond —(CH₂)₃— 3-334 Sub-45 4-ClPh —CO— Single Bond —(CH₂)₃— 3-335 Sub-46 4-ClPh —CO— Single Bond —(CH₂)₃— 3-336 Sub-47 4-ClPh —CO— Single Bond —(CH₂)₃— 3-337 Sub-81 4-ClPh —CO— Single Bond —(CH₂)₃— 3-338 Sub-48 4-ClPh —CO— Single Bond —(CH₂)₃— 3-339 Sub-49 4-ClPh —CO— Single Bond —(CH₂)₃— 3-340 Sub-50 4-ClPh —CO— Single Bond —(CH₂)₃— 3-341 Sub-51 4-ClPh —CO— Single Bond —(CH₂)₃— 3-342 Sub-52 4-ClPh —CO— Single Bond —(CH₂)₃— 3-343 Sub-53 4-ClPh —CO— Single Bond —(CH₂)₃— 3-344 Sub-54 4-ClPh —CO— Single Bond —(CH₂)₃— 3-345 Sub-56 4-ClPh —CO— Single Bond —(CH₂)₃— 3-346 Sub-57 4-ClPh —CO— Single Bond —(CH₂)₃— 3-347 Sub-58 4-ClPh —CO— Single Bond —(CH₂)₃— 3-348 Sub-59 4-ClPh —CO— Single Bond —(CH₂)₃— 3-349 Sub-82 4-ClPh —CO— Single Bond —(CH₂)₃— 3-350 Sub-83 4-ClPh —CO— Single Bond —(CH₂)₃— 3-351 Sub-61 4-ClPh —CO— Single Bond —(CH₂)₃— 3-352 Sub-55 4-ClPh —CO— Single Bond —(CH₂)₃— 3-353 Sub-33 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-354 Sub-34 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-355 Sub-35 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-356 Sub-36 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-357 Sub-37 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-358 Sub-38 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-359 Sub-39 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-360 Sub-40 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-361 Sub-41 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-362 Sub-42 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-363 Sub-84 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-364 Sub-43 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-365 Sub-44 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-366 Sub-45 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-367 Sub-46 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-368 Sub-47 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-369 Sub-81 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-370 Sub-48 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-371 Sub-49 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-372 Sub-50 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-373 Sub-51 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-374 Sub-52 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-375 Sub-53 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-376 Sub-54 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-377 Sub-56 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-378 Sub-57 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-379 Sub-58 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-380 Sub-59 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-381 Sub-82 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-382 Sub-83 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-383 Sub-61 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-384 Sub-55 4-ClPh —CO— Single Bond —CH₂C(Me)₂— 3-385 Sub-33 4-ClPh —CO— Single Bond —CH₂-cPr— 3-386 Sub-34 4-ClPh —CO— Single Bond —CH₂-cPr— 3-387 Sub-35 4-ClPh —CO— Single Bond —CH₂-cPr— 3-388 Sub-36 4-ClPh —CO— Single Bond —CH₂-cPr— 3-389 Sub-37 4-ClPh —CO— Single Bond —CH₂-cPr— 3-390 Sub-38 4-ClPh —CO— Single Bond —CH₂-cPr— 3-391 Sub-39 4-ClPh —CO— Single Bond —CH₂-cPr— 3-392 Sub-40 4-ClPh —CO— Single Bond —CH₂-cPr— 3-393 Sub-41 4-ClPh —CO— Single Bond —CH₂-cPr— 3-394 Sub-42 4-ClPh —CO— Single Bond —CH₂-cPr— 3-395 Sub-84 4-ClPh —CO— Single Bond —CH₂-cPr— 3-396 Sub-43 4-ClPh —CO— Single Bond —CH₂-cPr— 3-397 Sub-44 4-ClPh —CO— Single Bond —CH₂-cPr— 3-398 Sub-45 4-ClPh —CO— Single Bond —CH₂-cPr— 3-399 Sub-46 4-ClPh —CO— Single Bond —CH₂-cPr— 3-400 Sub-47 4-ClPh —CO— Single Bond —CH₂-cPr— 3-401 Sub-81 4-ClPh —CO— Single Bond —CH₂-cPr— 3-402 Sub-48 4-ClPh —CO— Single Bond —CH₂-cPr— 3-403 Sub-49 4-ClPh —CO— Single Bond —CH₂-cPr— 3-404 Sub-50 4-ClPh —CO— Single Bond —CH₂-cPr— 3-405 Sub-51 4-ClPh —CO— Single Bond —CH₂-cPr— 3-406 Sub-52 4-ClPh —CO— Single Bond —CH₂-cPr— 3-407 Sub-53 4-ClPh —CO— Single Bond —CH₂-cPr— 3-408 Sub-54 4-ClPh —CO— Single Bond —CH₂-cPr— 3-409 Sub-56 4-ClPh —CO— Single Bond —CH₂-cPr— 3-410 Sub-57 4-ClPh —CO— Single Bond —CH₂-cPr— 3-411 Sub-58 4-ClPh —CO— Single Bond —CH₂-cPr— 3-412 Sub-59 4-ClPh —CO— Single Bond —CH₂-cPr— 3-413 Sub-82 4-ClPh —CO— Single Bond —CH₂-cPr— 3-414 Sub-83 4-ClPh —CO— Single Bond —CH₂-cPr— 3-415 Sub-61 4-ClPh —CO— Single Bond —CH₂-cPr— 3-416 Sub-55 4-ClPh —CO— Single Bond —CH₂-cPr— 3-417 Sub-33 4-ClPh —CO— Single Bond —CH₂-cBu— 3-418 Sub-34 4-ClPh —CO— Single Bond —CH₂-cBu— 3-419 Sub-35 4-ClPh —CO— Single Bond —CH₂-cBu— 3-420 Sub-36 4-ClPh —CO— Single Bond —CH₂-cBu— 3-421 Sub-37 4-ClPh —CO— Single Bond —CH₂-cBu— 3-422 Sub-38 4-ClPh —CO— Single Bond —CH₂-cBu— 3-423 Sub-39 4-ClPh —CO— Single Bond —CH₂-cBu— 3-424 Sub-40 4-ClPh —CO— Single Bond —CH₂-cBu— 3-425 Sub-41 4-ClPh —CO— Single Bond —CH₂-cBu— 3-426 Sub-42 4-ClPh —CO— Single Bond —CH₂-cBu— 3-427 Sub-84 4-ClPh —CO— Single Bond —CH₂-cBu— 3-428 Sub-43 4-ClPh —CO— Single Bond —CH₂-cBu— 3-429 Sub-44 4-ClPh —CO— Single Bond —CH₂-cBu— 3-430 Sub-45 4-ClPh —CO— Single Bond —CH₂-cBu— 3-431 Sub-46 4-ClPh —CO— Single Bond —CH₂-cBu— 3-432 Sub-47 4-ClPh —CO— Single Bond —CH₂-cBu— 3-433 Sub-81 4-ClPh —CO— Single Bond —CH₂-cBu— 3-434 Sub-48 4-ClPh —CO— Single Bond —CH₂-cBu— 3-435 Sub-49 4-ClPh —CO— Single Bond —CH₂-cBu— 3-436 Sub-50 4-ClPh —CO— Single Bond —CH₂-cBu— 3-437 Sub-51 4-ClPh —CO— Single Bond —CH₂-cBu— 3-438 Sub-52 4-ClPh —CO— Single.Bond —CH₂-cBu— 3-439 Sub-53 4-ClPh —CO— Single Bond —CH₂-cBu— 3-440 Sub-54 4-ClPh —CO— Single Bond —CH₂-cBu— 3-441 Sub-56 4-ClPh —CO— Single Bond —CH₂-cBu— 3-442 Sub-57 4-ClPh —CO— Single Bond —CH₂-cBu— 3-443 Sub-58 4-ClPh —CO— Single Bond —CH₂-cBu— 3-444 Sub-59 4-ClPh —CO— Single Bond —CH₂-cBu— 3-445 Sub-82 4-ClPh —CO— Single Bond —CH₂-cBu— 3-446 Sub-83 4-ClPh —CO— Single Bond —CH₂-cBu— 3-447 Sub-61 4-ClPh —CO— Single Bond —CH₂-cBu— 3-448 Sub-55 4-ClPh —CO— Single Bond —CH₂-cBu— 3-449 Sub-33 4-ClPh —CO— Single Bond —CH₂-cPn— 3-450 Sub-34 4-ClPh —CO— Single Bond —CH₂-cPn— 3-451 Sub-35 4-ClPh —CO— Single Bond —CH₂-cPn— 3-452 Sub-36 4-ClPh —CO— Single Bond —CH₂-cPn— 3-453 Sub-37 4-ClPh —CO— Single Bond —CH₂-cPn— 3-454 Sub-38 4-ClPh —CO— Single Bond —CH₂-cPn— 3-455 Sub-39 4-ClPh —CO— Single Bond —CH₂-cPn— 3-456 Sub-40 4-ClPh —CO— Single Bond —CH₂-cPn— 3-457 Sub-41 4-ClPh —CO— Single Bond —CH₂-cPn— 3-458 Sub-42 4-ClPh —CO— Single Bond —CH₂-cPn— 3-459 Sub-84 4-ClPh —CO— Single Bond —CH₂-cPn— 3-460 Sub-43 4-ClPh —CO— Single Bond —CH₂-cPn— 3-461 Sub-44 4-ClPh —CO— Single Bond —CH₂-cPn— 3-462 Sub-45 4-ClPh —CO— Single Bond —CH₂-cPn— 3-463 Sub-46 4-ClPh —CO— Single Bond —CH₂-cPn— 3-464 Sub-47 4-ClPh —CO— Single Bond —CH₂-cPn— 3-465 Sub-81 4-ClPh —CO— Single Bond —CH₂-cPn— 3-466 Sub-48 4-ClPh —CO— Single Bond —CH₂-cPn— 3-467 Sub-49 4-ClPh —CO— Single Bond —CH₂-cPn— 3-468 Sub-50 4-ClPh —CO— Single Bond —CH₂-cPn— 3-469 Sub-51 4-ClPh —CO— Single Bond —CH₂-cPn— 3-470 Sub-52 4-ClPh —CO— Single Bond —CH₂-cPn— 3-471 Sub-53 4-ClPh —CO— Single Bond —CH₂-cPn— 3-472 Sub-54 4-ClPh —CO— Single Bond —CH₂-cPn— 3-473 Sub-56 4-ClPh —CO— Single Bond —CH₂-cPn— 3-474 Sub-57 4-ClPh —CO— Single Bond —CH₂-cPn— 3-475 Sub-58 4-ClPh —CO— Single Bond —CH₂-cPn— 3-476 Sub-59 4-ClPh —CO— Single Bond —CH₂-cPn— 3-477 Sub-82 4-ClPh —CO— Single Bond —CH₂-cPn— 3-478 Sub-83 4-ClPh —CO— Single Bond —CH₂-cPn— 3-479 Sub-61 4-ClPh —CO— Single Bond —CH₂-cPn— 3-480 Sub-55 4-ClPh —CO— Single Bond —CH₂-cPn— 3-481 Sub-33 4-ClPh —CO— Single Bond —CH₂-cPn— 3-482 Sub-34 4-ClPh —CO— Single Bond —CH₂-cHx— 3-483 Sub-35 4-ClPh —CO— Single Bond —CH₂-cHx— 3-484 Sub-36 4-ClPh —CO— Single Bond —CH₂-cHx— 3-485 Sub-37 4-ClPh —CO— Single Bond —CH₂-cHx— 3-486 Sub-38 4-ClPh —CO— Single Bond —CH₂-cHx— 3-487 Sub-39 4-ClPh —CO— Single Bond —CH₂-cHx— 3-488 Sub-40 4-ClPh —CO— Single Bond —CH₂-cHx— 3-489 Sub-41 4-ClPh —CO— Single Bond —CH₂-cHx— 3-490 Sub-42 4-ClPh —CO— Single Bond —CH₂-cHx— 3-491 Sub-84 4-ClPh —CO— Single Bond —CH₂-cHx— 3-492 Sub-43 4-ClPh —CO— Single Bond —CH₂-cHx— 3-493 Sub-44 4-ClPh —CO— Single Bond —CH₂-cHx— 3-494 Sub-45 4-ClPh —CO— Single Bond —CH₂-cHx— 3-495 Sub-46 4-ClPh —CO— Single Bond —CH₂-cHx— 3-496 Sub-47 4-ClPh —CO— Single Bond —CH₂-cHx— 3-497 Sub-81 4-ClPh —CO— Single Bond —CH₂-cHx— 3-498 Sub-48 4-ClPh —CO— Single Bond —CH₂-cHx— 3-499 Sub-49 4-ClPh —CO— Single Bond —CH₂-cHx— 3-500 Sub-50 4-ClPh —CO— Single Bond —CH₂-cHx— 3-501 Sub-51 4-ClPh —CO— Single Bond —CH₂-cHx— 3-502 Sub-52 4-ClPh —CO— Single Bond —CH₂-cHx— 3-503 Sub-53 4-ClPh —CO— Single Bond —CH₂-cHx— 3-504 Sub-54 4-ClPh —CO— Single Bond —CH₂-cHx— 3-505 Sub-56 4-ClPh —CO— Single Bond —CH₂-cHx— 3-506 Sub-57 4-ClPh —CO— Single Bond —CH₂-cHx— 3-507 Sub-58 4-ClPh —CO— Single Bond —CH₂-cHx— 3-508 Sub-59 4-ClPh —CO— Single Bond —CH₂-cHx— 3-509 Sub-82 4-ClPh —CO— Single Bond —CH₂-cHx— 3-510 Sub-83 4-ClPh —CO— Single Bond —CH₂-cHx— 3-511 Sub-61 4-ClPh —CO— Single Bond —CH₂-cHx— 3-512 Sub-55 4-ClPh —CO— Single Bond —CH₂-cHx— 3-513 Sub-33 4-FPh —CO— Single Bond —CH₂— 3-514 Sub-34 4-FPh —CO— Single Bond —CH₂— 3-515 Sub-35 4-FPh —CO— Single Bond —CH₂— 3-516 Sub-36 4-FPh —CO— Single Bond —CH₂— 3-517 Sub-37 4-FPh —CO— Single Bond —CH₂— 3-518 Sub-38 4-FPh —CO— Single Bond —CH₂— 3-519 Sub-39 4-FPh —CO— Single Bond —CH₂— 3-520 Sub-40 4-FPh —CO— Single Bond —CH₂— 3-521 Sub-41 4-FPh —CO— Single Bond —CH₂— 3-522 Sub-42 4-FPh —CO— Single Bond —CH₂— 3-523 Sub-84 4-FPh —CO— Single Bond —CH₂— 3-524 Sub-43 4-FPh —CO— Single Bond —CH₂— 3-525 Sub-44 4-FPh —CO— Single Bond —CH₂— 3-526 Sub-45 4-FPh —CO— Single Bond —CH₂— 3-527 Sub-46 4-FPh —CO— Single Bond —CH₂— 3-528 Sub-47 4-FPh —CO— Single Bond —CH₂— 3-529 Sub-81 4-FPh —CO— Single Bond —CH₂— 3-530 Sub-48 4-FPh —CO— Single Bond —CH₂— 3-531 Sub-49 4-FPh —CO— Single Bond —CH₂— 3-532 Sub-50 4-FPh —CO— Single Bond —CH₂— 3-533 Sub-51 4-FPh —CO— Single Bond —CH₂— 3-534 Sub-52 4-FPh —CO— Single Bond —CH₂— 3-535 Sub-53 4-FPh —CO— Single Bond —CH₂— 3-536 Sub-54 4-FPh —CO— Single Bond —CH₂— 3-537 Sub-56 4-FPh —CO— Single Bond —CH₂— 3-538 Sub-57 4-FPh —CO— Single Bond —CH₂— 3-539 Sub-58 4-FPh —CO— Single Bond —CH₂— 3-540 Sub-59 4-FPh —CO— Single Bond —CH₂— 3-541 Sub-82 4-FPh —CO— Single Bond —CH₂— 3-542 Sub-83 4-FPh —CO— Single Bond —CH₂— 3-543 Sub-61 4-FPh —CO— Single Bond —CH₂— 3-544 Sub-55 4-FPh —CO— Single Bond —CH₂— 3-545 Sub-33 4-FPh —CO— Single Bond —CH₂CH₂— 3-546 Sub-34 4-FPh —CO— Single Bond —CH₂CH₂— 3-547 Sub-35 4-FPh —CO— Single Bond —CH₂CH₂— 3-548 Sub-36 4-FPh —CO— Single Bond —CH₂CH₂— 3-549 Sub-37 4-FPh —CO— Single Bond —CH₂CH₂— 3-550 Sub-38 4-FPh —CO— Single Bond —CH₂CH₂— 3-551 Sub-39 4-FPh —CO— Single Bond —CH₂CH₂— 3-552 Sub-40 4-FPh —CO— Single Bond —CH₂CH₂— 3-553 Sub-41 4-FPh —CO— Single Bond —CH₂CH₂— 3-554 Sub-42 4-FPh —CO— Single Bond —CH₂CH₂— 3-555 Sub-84 4-FPh —CO— Single Bond —CH₂CH₂— 3-556 Sub-43 4-FPh —CO— Single Bond —CH₂CH₂— 3-557 Sub-44 4-FPh —CO— Single Bond —CH₂CH₂— 3-558 Sub-45 4-FPh —CO— Single Bond —CH₂CH₂— 3-559 Sub-46 4-FPh —CO— Single Bond —CH₂CH₂— 3-560 Sub-47 4-FPh —CO— Single Bond —CH₂CH₂— 3-561 Sub-81 4-FPh —CO— Single Bond —CH₂CH₂— 3-562 Sub-48 4-FPh —CO— Single Bond —CH₂CH₂— 3-563 Sub-49 4-FPh —CO— Single Bond —CH₂CH₂— 3-564 Sub-50 4-FPh —CO— Single Bond —CH₂CH₂— 3-565 Sub-51 4-FPh —CO— Single Bond —CH₂CH₂— 3-566 Sub-52 4-FPh —CO— Single Bond —CH₂CH₂— 3-567 Sub-53 4-FPh —CO— Single Bond —CH₂CH₂— 3-568 Sub-54 4-FPh —CO— Single Bond —CH₂CH₂— 3-569 Sub-56 4-FPh —CO— Single Bond —CH₂CH₂— 3-570 Sub-57 4-FPh —CO— Single Bond —CH₂CH₂— 3-571 Sub-58 4-FPh —CO— Single Bond —CH₂CH₂— 3-572 Sub-59 4-FPh —CO— Single Bond —CH₂CH₂— 3-573 Sub-82 4-FPh —CO— Single Bond —CH₂CH₂— 3-574 Sub-83 4-FPh —CO— Single Bond —CH₂CH₂— 3-575 Sub-61 4-FPh —CO— Single Bond —CH₂CH₂— 3-576 Sub-55 4-FPh —CO— Single Bond —CH₂CH₂— 3-577 Sub-33 4-FPh —CO— Single Bond —(CH₂)₃— 3-578 Sub-34 4-FPh —CO— Single Bond —(CH₂)₃— 3-579 Sub-35 4-FPh —CO— Single Bond —(CH₂)₃— 3-580 Sub-36 4-FPh —CO— Single Bond —(CH₂)₃— 3-581 Sub-37 4-FPh —CO— Single Bond —(CH₂)₃— 3-582 Sub-38 4-FPh —CO— Single Bond —(CH₂)₃— 3-583 Sub-39 4-FPh —CO— Single Bond —(CH₂)₃— 3-584 Sub-40 4-FPh —CO— Single Bond —(CH₂)₃— 3-585 Sub-41 4-FPh —CO— Single Bond —(CH₂)₃— 3-586 Sub-42 4-FPh —CO— Single Bond —(CH₂)₃— 3-587 Sub-84 4-FPh —CO— Single Bond —(CH₂)₃— 3-588 Sub-43 4-FPh —CO— Single Bond —(CH₂)₃— 3-589 Sub-44 4-FPh —CO— Single Bond —(CH₂)₃— 3-590 Sub-45 4-FPh —CO— Single Bond —(CH₂)₃— 3-591 Sub-46 4-FPh —CO— Single Bond —(CH₂)₃— 3-592 Sub-47 4-FPh —CO— Single Bond —(CH₂)₃— 3-593 Sub-81 4-FPh —CO— Single Bond —(CH₂)₃— 3-594 Sub-48 4-FPh —CO— Single Bond —(CH₂)₃— 3-595 Sub-49 4-FPh —CO— Single Bond —(CH₂)₃— 3-596 Sub-50 4-FPh —CO— Single Bond —(CH₂)₃— 3-597 Sub-51 4-FPh —CO— Single Bond —(CH₂)₃— 3-598 Sub-52 4-FPh —CO— Single Bond —(CH₂)₃— 3-599 Sub-53 4-FPh —CO— Single Bond —(CH₂)₃— 3-600 Sub-54 4-FPh —CO— Single Bond —(CH₂)₃— 3-601 Sub-56 4-FPh —CO— Single Bond —(CH₂)₃— 3-602 Sub-57 4-FPh —CO— Single Bond —(CH₂)₃— 3-603 Sub-58 4-FPh —CO— Single Bond —(CH₂)₃— 3-604 Sub-59 4-FPh —CO— Single Bond —(CH₂)₃— 3-605 Sub-82 4-FPh —CO— Single Bond —(CH₂)₃— 3-606 Sub-83 4-FPh —CO— Single Bond —(CH₂)₃— 3-607 Sub-61 4-FPh —CO— Single Bond —(CH₂)₃— 3-608 Sub-55 4-FPh —CO— Single Bond —(CH₂)₃— 3-609 Sub-33 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-610 Sub-34 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-611 Sub-35 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-612 Sub-36 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-613 Sub-37 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-614 Sub-38 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-615 Sub-39 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-616 Sub-40 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-617 Sub-41 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-618 Sub-42 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-619 Sub-84 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-620 Sub-43 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-621 Sub-44 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-622 Sub-45 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-623 Sub-46 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-624 Sub-47 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-625 Sub-81 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-626 Sub-48 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-627 Sub-49 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-628 Sub-50 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-629 Sub-51 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-630 Sub-52 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-631 Sub-53 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-632 Sub-54 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-633 Sub-56 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-634 Sub-57 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-635 Sub-58 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-636 Sub-59 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-637 Sub-82 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-638 Sub-83 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-639 Sub-61 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-640 Sub-55 4-FPh —CO— Single Bond —CH₂C(Me)₂— 3-641 Sub-33 4-FPh —CO— Single Bond —CH₂-cPr— 3-642 Sub-34 4-FPh —CO— Single Bond —CH₂-cPr— 3-643 Sub-35 4-FPh —CO— Single Bond —CH₂-cPr— 3-644 Sub-36 4-FPh —CO— Single Bond —CH₂-cPr— 3-645 Sub-37 4-FPh —CO— Single Bond —CH₂-cPr— 3-646 Sub-38 4-FPh —CO— Single Bond —CH₂-cPr— 3-647 Sub-39 4-FPh —CO— Single Bond —CH₂-cPr— 3-648 Sub-40 4-FPh —CO— Single Bond —CH₂-cPr— 3-649 Sub-41 4-FPh —CO— Single Bond —CH₂-cPr— 3-650 Sub-42 4-FPh —CO— Single Bond —CH₂-cPr— 3-651 Sub-84 4-FPh —CO— Single Bond —CH₂-cPr— 3-652 Sub-43 4-FPh —CO— Single Bond —CH₂-cPr— 3-653 Sub-44 4-FPh —CO— Single Bond —CH₂-cPr— 3-654 Sub-45 4-FPh —CO— Single Bond —CH₂-cPr— 3-655 Sub-46 4-FPh —CO— Single Bond —CH₂-cPr— 3-656 Sub-47 4-FPh —CO— Single Bond —CH₂-cPr— 3-657 Sub-81 4-FPh —CO— Single Bond —CH₂-cPr— 3-658 Sub-48 4-FPh —CO— Single Bond —CH₂-cPr— 3-659 Sub-49 4-FPh —CO— Single Bond —CH₂-cPr— 3-660 Sub-50 4-FPh —CO— Single Bond —CH₂-cPr— 3-661 Sub-51 4-FPh —CO— Single Bond —CH₂-cPr— 3-662 Sub-52 4-FPh —CO— Single Bond —CH₂-cPr- 3-663 Sub-53 4-FPh —CO— Single Bond —CH₂-cPr— 3-664 Sub-54 4-FPh —CO— Single Bond —CH₂-cPr— 3-665 Sub-56 4-FPh —CO— Single Bond —CH₂-cPr— 3-666 Sub-57 4-FPh —CO— Single Bond —CH₂-cPr— 3-667 Sub-58 4-FPh —CO— Single Bond —CH₂-cPr— 3-668 Sub-59 4-FPh —CO— Single Bond —CH₂-cPr— 3-669 Sub-82 4-FPh —CO— Single Bond —CH₂-cPr— 3-670 Sub-83 4-FPh —CO— Single Bond —CH₂-cPr— 3-671 Sub-61 4-FPh —CO— Single Bond —CH₂-cPr— 3-672 Sub-55 4-FPh —CO— Single Bond —CH₂-cPr— 3-673 Sub-33 4-FPh —CO— Single Bond —CH₂-cBu— 3-674 Sub-34 4-FPh —CO— Single Bond —CH₂-cBu— 3-675 Sub-35 4-FPh —CO— Single Bond —CH₂-cBu— 3-676 Sub-36 4-FPh —CO— Single Bond —CH₂-cBu— 3-677 Sub-37 4-FPh —CO— Single Bond —CH₂-cBu— 3-678 Sub-38 4-FPh —CO— Single Bond —CH₂-cBu— 3-679 Sub-39 4-FPh —CO— Single Bond —CH₂-cBu— 3-680 Sub-40 4-FPh —CO— Single Bond —CH₂-cBu— 3-681 Sub-41 4-FPh —CO— Single Bond —CH₂-cBu— 3-682 Sub-42 4-FPh —CO— Single Bond —CH₂-cBu— 3-683 Sub-84 4-FPh —CO— Single Bond —CH₂-cBu— 3-684 Sub-43 4-FPh —CO— Single Bond —CH₂-cBu— 3-685 Sub-44 4-FPh —CO— Single Bond —CH₂-cBu— 3-686 Sub-45 4-FPh —CO— Single Bond —CH₂-cBu— 3-687 Sub-46 4-FPh —CO— Single Bond —CH₂-cBu— 3-688 Sub-47 4-FPh —CO— Single Bond —CH₂-cBu— 3-689 Sub-81 4-FPh —CO— Single Bond —CH₂-cBu— 3-690 Sub-48 4-FPh —CO— Single Bond —CH₂-cBu— 3-691 Sub-49 4-FPh —CO— Single Bond —CH₂-cBu— 3-692 Sub-50 4-FPh —CO— Single Bond —CH₂-cBu— 3-693 Sub-51 4-FPh —CO— Single Bond —CH₂-cBu— 3-694 Sub-52 4-FPh —CO— Single Bond —CH₂-cBu— 3-695 Sub-53 4-FPh —CO— Single Bond —CH₂-cBu— 3-696 Sub-54 4-FPh —CO— Single Bond —CH₂-cBu— 3-697 Sub-56 4-FPh —CO— Single Bond —CH₂-cBu— 3-698 Sub-57 4-FPh —CO— Single Bond —CH₂-cBu— 3-699 Sub-58 4-FPh —CO— Single Bond —CH₂-cBu— 3-700 Sub-59 4-FPh —CO— Single Bond —CH₂-cBu— 3-701 Sub-82 4-FPh —CO— Single Bond —CH₂-cBu— 3-702 Sub-83 4-FPh —CO— Single Bond —CH₂-cBu— 3-703 Sub-61 4-FPh —CO— Single Bond —CH₂-cBu— 3-704 Sub-55 4-FPh —CO— Single Bond —CH₂-cBu— 3-705 Sub-33 4-FPh —CO— Single Bond —CH₂-cPn— 3-706 Sub-34 4-FPh —CO— Single Bond —CH₂-cPn— 3-707 Sub-35 4-FPh —CO— Single Bond —CH₂-cPn— 3-708 Sub-36 4-FPh —CO— Single Bond —CH₂-cPn— 3-709 Sub-37 4-FPh —CO— Single Bond —CH₂-cPn— 3-710 Sub-38 4-FPh —CO— Single Bond —CH₂-cPn— 3-711 Sub-39 4-FPh —CO— Single Bond —CH₂-cPn— 3-712 Sub-40 4-FPh —CO— Single Bond —CH₂-cPn— 3-713 Sub-41 4-FPh —CO— Single Bond —CH₂-cPn— 3-714 Sub-42 4-FPh —CO— Single Bond —CH₂-cPn— 3-715 Sub-84 4-FPh —CO— Single Bond —CH₂-cPn— 3-716 Sub-43 4-FPh —CO— Single Bond —CH₂-cPn— 3-717 Sub-44 4-FPh —CO— Single Bond —CH₂-cPn— 3-718 Sub-45 4-FPh —CO— Single Bond —CH₂-cPn— 3-719 Sub-46 4-FPh —CO— Single Bond —CH₂-cPn— 3-720 Sub-47 4-FPh —CO— Single Bond —CH₂-cPn— 3-721 Sub-81 4-FPh —CO— Single Bond —CH₂-cPn— 3-722 Sub-48 4-FPh —CO— Single Bond —CH₂-cPn— 3-723 Sub-49 4-FPh —CO— Single Bond —CH₂-cPn— 3-724 Sub-50 4-FPh —CO— Single Bond —CH₂-cPn— 3-725 Sub-51 4-FPh —CO— Single Bond —CH₂-cPn— 3-726 Sub-52 4-FPk —CO— Single Bond —CH₂-cPn— 3-727 Sub-53 4-FPh —CO— Single Bond —CH₂-cPn— 3-728 Sub-54 4-FPh —CO— Single Bond —CH₂-cPn— 3-729 Sub-56 4-FPh —CO— Single Bond —CH₂-cPn— 3-730 Sub-57 4-FPh —CO— Single Bond —CH₂-cPn— 3-731 Sub-58 4-FPh —CO— Single Bond —CH₂-cPn— 3-732 Sub-59 4-FPh —CO— Single Bond —CH₂-cPn— 3-733 Sub-82 4-FPh —CO— Single Bond —CH₂-cPn— 3-734 Sub-83 4-FPh —CO— Single Bond —CH₂-cPn— 3-735 Sub-61 4-FPh —CO— Single Bond —CH₂-cPn— 3-736 Sub-55 4-FPh —CO— Single Bond —CH₂-cPn— 3-737 Sub-33 4-FPh —CO— Single Bond —CH₂-cHx— 3-738 Sub-34 4-FPh —CO— Single Bond —CH₂-cHx— 3-739 Sub-35 4-FPh —CO— Single Bond —CH₂-cHx— 3-740 Sub-36 4-FPh —CO— Single Bond —CH₂-cHx— 3-741 Sub-37 4-FPh —CO— Single Bond —CH₂-cHx— 3-742 Sub-38 4-FPh —CO— Single Bond —CH₂-cHx— 3-743 Sub-39 4-FPh —CO— Single Bond —CH₂-cHx— 3-744 Sub-40 4-FPh —CO— Single Bond —CH₂-cHx— 3-745 Sub-41 4-FPh —CO— Single Bond —CH₂-cHx— 3-746 Sub-42 4-FPh —CO— Single Bond —CH₂-cHx— 3-747 Sub-84 4-FPh —CO— Single Bond —CH₂-cHx— 3-748 Sub-43 4-FPh —CO— Single Bond —CH₂-cHx— 3-749 Sub-44 4-FPh —CO— Single Bond —CH₂-cHx— 3-750 Sub-45 4-FPh —CO— Single Bond —CH₂-cHx— 3-751 Sub-46 4-FPh —CO— Single Bond —CH₂-cHx— 3-752 Sub-47 4-FPh —CO— Single Bond —CH₂-cHx— 3-753 Sub-81 4-FPh —CO— Single Bond —CH₂-cHx— 3-754 Sub-48 4-FPh —CO— Single Bond —CH₂-cHx— 3-755 Sub-49 4-FPh —CO— Single Bond —CH₂-cHx— 3-756 Sub-50 4-FPh —CO— Single Bond —CH₂-cHx— 3-757 Sub-51 4-FPh —CO— Single Bond —CH₂-cHx— 3-758 Sub-52 4-FPh —CO— Single Bond —CH₂-cHx— 3-759 Sub-53 4-FPh —CO— Single Bond —CH₂-cHx— 3-760 Sub-54 4-FPh —CO— Single Bond —CH₂-cHx— 3-761 Sub-56 4-FPh —CO— Single Bond —CH₂-cHx— 3-762 Sub-57 4-FPh —CO— Single Bond —CH₂-cHx— 3-763 Sub-58 4-FPh —CO— Single Bond —CH₂-cHx— 3-764 Sub-59 4-FPh —CO— Single Bond —CH₂-cHx— 3-765 Sub-82 4-FPh —CO— Single Bond —CH₂-cHx— 3-766 Sub-83 4-FPh —CO— Single Bond —CH₂-cHx— 3-767 Sub-61 4-FPh —CO— Single Bond —CH₂-cHx— 3-768 Sub-55 4-FPh —CO— Single Bond —CH₂-cHx— 3-769 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂— 3-770 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂— 3-771 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂— 3-772 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂— 3-773 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂— 3-774 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂— 3-775 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂— 3-776 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂— 3-777 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂— 3-778 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂— 3-779 Sub-84 3,4-diClPh —CO— —CH₂— —CH₂— 3-780 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂— 3-781 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂— 3-782 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂— 3-783 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂— 3-784 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂— 3-785 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂— 3-786 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂— 3-787 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂— 3-788 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂— 3-789 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂— 3-790 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂— 3-791 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂— 3-792 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂— 3-793 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂— 3-794 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂— 3-795 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂— 3-796 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂— 3-797 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂— 3-798 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂— 3-799 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂— 3-800 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂— 3-801 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-802 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-803 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-804 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-805 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-806 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-807 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-808 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-809 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-810 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-811 Sub-84 3,4-diClh —CO— —CH₂— —CH₂CH₂— 3-812 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-813 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-814 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-815 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-816 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-817 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-818 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-819 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-820 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-821 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-822 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-823 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-824 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-825 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-826 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-827 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-828 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-829 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-830 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-831 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-832 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂CH₂— 3-833 Sub-33 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-834 Sub-34 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-835 Sub-35 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-836 Sub-36 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-837 Sub-37 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-838 Sub-38 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-839 Sub-39 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-840 Sub-40 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-841 Sub-41 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-842 Sub-42 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-843 Sub-84 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-844 Sub-43 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-845 Sub-44 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-846 Sub-45 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-847 Sub-46 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-848 Sub-47 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-849 Sub-81 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-850 Sub-48 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-851 Sub-49 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-852 Sub-50 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-853 Sub-51 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-854 Sub-52 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-855 Sub-53 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-856 Sub-54 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-857 Sub-56 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-858 Sub-57 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-859 Sub-58 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-860 Sub-59 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-861 Sub-82 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-862 Sub-83 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-863 Sub-61 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-864 Sub-55 3,4-diClPh —CO— —CH₂— —(CH₂)₃— 3-865 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-866 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-867 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-868 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-869 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-870 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-871 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-872 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-873 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-874 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-875 Sub-84 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-876 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-877 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-878 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-879 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-880 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-881 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-882 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-883 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-884 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-885 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-886 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-887 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-888 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-889 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-890 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-891 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-892 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-893 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-894 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-895 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-896 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂C(Me)₂— 3-897 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-898 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-899 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-900 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-901 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-902 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-903 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-904 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-905 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-906 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-907 Sub-84 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-908 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-909 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-910 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-911 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-912 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂-cPr- 3-913 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-914 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-915 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-916 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-917 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-918 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-919 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-920 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-921 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-922 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-923 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-924 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-925 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-926 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂-cPr- 3-927 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-928 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂-cPr— 3-929 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-930 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-931 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-932 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-933 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-934 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-935 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-936 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-937 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-938 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-939 Sub-84 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-940 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-941 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-942 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-943 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-944 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-945 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-946 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-947 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-948 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-949 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-950 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-951 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-952 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-953 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-954 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-955 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-956 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-957 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-958 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-959 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-960 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂-cBu— 3-961 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-962 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-963 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-964 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-965 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-966 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-967 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-968 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-969 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-970 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-971 Sub-84 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-972 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-973 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-974 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-975 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-976 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-977 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-978 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-979 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-980 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-981 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-982 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-983 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-984 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-985 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-986 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-987 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-988 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-989 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-990 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-991 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-992 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂-cPn— 3-993 Sub-33 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-994 Sub-34 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-995 Sub-35 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-996 Sub-36 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-997 Sub-37 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-998 Sub-38 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-999 Sub-39 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1000 Sub-40 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1001 Sub-41 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1002 Sub-42 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1003 Sub-84 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1004 Sub-43 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1005 Sub-44 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1006 Sub-45 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1007 Sub-46 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1008 Sub-47 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1009 Sub-81 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1010 Sub-48 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1011 Sub-49 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1012 Sub-50 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1013 Sub-51 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1014 Sub-52 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1015 Sub-53 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1016 Sub-54 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1017 Sub-56 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1018 Sub-57 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1019 Sub-58 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1020 Sub-59 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1021 Sub-82 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1022 Sub-83 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1023 Sub-61 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1024 Sub-55 3,4-diClPh —CO— —CH₂— —CH₂-cHx— 3-1025 Sub-33 4-ClPh —CO— —CH₂— —CH₂— 3-1026 Sub-34 4-ClPh —CO— —CH₂— —CH₂— 3-1027 Sub-35 4-ClPh —CO— —CH₂— —CH₂— 3-1028 Sub-36 4-ClPh —CO— —CH₂— —CH₂— 3-1029 Sub-37 4-ClPh —CO— —CH₂— —CH₂— 3-1030 Sub-38 4-ClPh —CO— —CH₂— —CH₂— 3-1031 Sub-39 4-ClPh —CO— —CH₂— —CH₂— 3-1032 Sub-40 4-ClPh —CO— —CH₂— —CH₂— 3-1033 Sub-41 4-ClPh —CO— —CH₂— —CH₂— 3-1034 Sub-42 4-ClPh —CO— —CH₂— —CH₂— 3-1035 Sub-84 4-ClPh —CO— —CH₂— —CH₂— 3-1036 Sub-43 4-ClPh —CO— —CH₂— —CH₂— 3-1037 Sub-44 4-ClPh —CO— —CH₂— —CH₂— 3-1038 Sub-45 4-ClPh —CO— —CH₂— —CH₂— 3-1039 Sub-46 4-ClPh —CO— —CH₂— —CH₂— 3-1040 Sub-47 4-ClPh —CO— —CH₂— —CH₂— 3-1041 Sub-81 4-ClPh —CO— —CH₂— —CH₂— 3-1042 Sub-48 4-ClPh —CO— —CH₂— —CH₂— 3-1043 Sub-49 4-ClPh —CO— —CH₂— —CH₂— 3-1044 Sub-50 4-ClPh —CO— —CH₂— —CH₂— 3-1045 Sub-51 4-ClPh —CO— —CH₂— —CH₂— 3-1046 Sub-52 4-ClPh —CO— —CH₂— —CH₂— 3-1047 Sub-53 4-ClPh —CO— —CH₂— —CH₂— 3-1048 Sub-54 4-ClPh —CO— —CH₂— —CH₂— 3-1049 Sub-56 4-ClPh —CO— —CH₂— —CH₂— 3-1050 Sub-57 4-ClPh —CO— —CH₂— —CH₂— 3-1051 Sub-58 4-ClPh —CO— —CH₂— —CH₂— 3-1052 Sub-59 4-ClPh —CO— —CH₂— —CH₂— 3-1053 Sub-82 4-ClPh —CO— —CH₂— —CH₂— 3-1054 Sub-83 4-ClPh —CO— —CH₂— —CH₂— 3-1055 Sub-61 4-ClPh —CO— —CH₂— —CH₂— 3-1056 Sub-55 4-ClPh —CO— —CH₂— —CH₂— 3-1057 Sub-33 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1058 Sub-34 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1059 Sub-35 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1060 Sub-36 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1061 Sub-37 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1062 Sub-38 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1063 Sub-39 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1064 Sub-40 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1065 Sub-41 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1066 Sub-42 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1067 Sub-84 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1068 Sub-43 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1069 Sub-44 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1070 Sub-45 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1071 Sub-46 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1072 Sub-47 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1073 Sub-81 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1074 Sub-48 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1075 Sub-49 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1076 Sub-50 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1077 Sub-51 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1078 Sub-52 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1079 Sub-53 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1080 Sub-54 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1081 Sub-56 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1082 Sub-57 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1083 Sub-58 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1084 Sub-59 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1085 Sub-82 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1086 Sub-83 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1087 Sub-61 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1088 Sub-55 4-ClPh —CO— —CH₂— —CH₂CH₂— 3-1089 Sub-33 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1090 Sub-34 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1091 Sub-35 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1092 Sub-36 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1093 Sub-37 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1094 Sub-38 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1095 Sub-39 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1096 Sub-40 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1097 Sub-41 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1098 Sub-42 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1099 Sub-84 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1100 Sub-43 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1101 Sub-44 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1102 Sub-45 4-ClPh —CO— —CH_(2‘—) —(CH₂)₃— 3-1103 Sub-46 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1104 Sub-47 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1105 Sub-81 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1106 Sub-48 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1107 Sub-49 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1108 Sub-50 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1109 Sub-51 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1110 Sub-52 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1111 Sub-53 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1112 Sub-54 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1113 Sub-56 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1114 Sub-57 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1115 Sub-58 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1116 Sub-59 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1117 Sub-82 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1118 Sub-83 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1119 Sub-61 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1120 Sub-55 4-ClPh —CO— —CH₂— —(CH₂)₃— 3-1121 Sub-33 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1122 Sub-34 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1123 Sub-35 4-CPh —CO— —CH₂— —CH₂C(Me)₂— 3-1124 Sub-36 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1125 Sub-37 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1126 Sub-38 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1127 Sub-39 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1128 Sub-40 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1129 Sub-41 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1130 Sub-42 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1131 Sub-84 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1132 Sub-43 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1133 Sub-44 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1134 Sub-45 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1135 Sub-46 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1136 Sub-47 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1137 Sub-81 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1138 Sub-48 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1139 Sub-49 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1140 Sub-50 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1141 Sub-51 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1142 Sub-52 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1143 Sub-53 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1144 Sub-54 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1145 Sub-56 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1146 Sub-57 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1147 Sub-58 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1148 Sub-59 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1149 Sub-82 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1150 Sub-83 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1151 Sub-61 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1152 Sub-55 4-ClPh —CO— —CH₂— —CH₂C(Me)₂— 3-1153 Sub-33 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1154 Sub-34 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1155 Sub-35 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1156 Sub-36 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1157 Sub-37 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1158 Sub-38 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1159 Sub-39 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1160 Sub-40 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1161 Sub-4l 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1162 Sub-42 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1163 Sub-84 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1164 Sub-43 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1165 Sub-44 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1166 Sub-45 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1167 Sub-46 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1168 Sub-47 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1169 Sub-81 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1170 Sub-48 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1171 Sub-49 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1172 Sub-50 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1173 Sub-51 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1174 Sub-52 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1175 Sub-53 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1176 Sub-54 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1177 Sub-56 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1178 Sub-57 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1179 Sub-58 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1180 Sub-59 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1181 Sub-82 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1182 Sub-83 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1183 Sub-61 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1184 Sub-55 4-ClPh —CO— —CH₂— —CH₂-cPr— 3-1185 Sub-33 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1186 Sub-34 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1187 Sub-35 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1188 Sub-36 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1189 Sub-37 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1190 Sub-38 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1191 Sub-39 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1192 Sub-40 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1193 Sub-41 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1194 Sub-42 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1195 Sub-84 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1196 Sub-43 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1197 Sub-44 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1198 Sub-45 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1199 Sub-46 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1200 Sub-47 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1201 Sub-81 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1202 Sub-48 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1203 Sub-49 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1204 Sub-50 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1205 Sub-51 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1206 Sub-52 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1207 Sub-53 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1208 Sub-54 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1209 Sub-56 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1210 Sub-57 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1211 Sub-58 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1212 Sub-59 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1213 Sub-82 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1214 Sub-83 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1215 Sub-61 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1216 Sub-55 4-ClPh —CO— —CH₂— —CH₂-cBu— 3-1217 Sub-33 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1218 Sub-34 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1219 Sub-35 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1220 Sub-36 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1221 Sub-37 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1222 Sub-38 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1223 Sub-39 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1224 Sub-40 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1225 Sub-41 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1226 Sub-42 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1227 Sub-84 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1228 Sub-43 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1229 Sub-44 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1230 Sub-45 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1231 Sub-46 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1232 Sub-47 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1233 Sub-81 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1234 Sub-48 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1235 Sub-49 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1236 Sub-50 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1237 Sub-51 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1238 Sub-52 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1239 Sub-53 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1240 Sub-54 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1241 Sub-56 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1242 Sub-57 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1243 Sub-58 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1244 Sub-59 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1245 Sub-82 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1246 Sub-83 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1247 Sub-61 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1248 Sub-55 4-ClPh —CO— —CH₂— —CH₂-cPn— 3-1249 Sub-33 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1250 Sub-34 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1251 Sub-35 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1252 Sub-36 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1253 Sub-37 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1254 Sub-38 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1255 Sub-39 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1256 Sub-40 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1257 Sub-41 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1258 Sub-42 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1259 Sub-84 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1260 Sub-43 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1261 Sub-44 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1262 Sub-45 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1263 Sub-46 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1264 Sub-47 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1265 Sub-81 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1266 Sub-48 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1267 Sub-49 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1268 Sub-50 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1269 Sub-51 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1270 Sub-52 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1271 Sub-53 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1272 Sub-54 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1273 Sub-56 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1274 Sub-57 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1275 Sub-58 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1276 Sub-59 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1277 Sub-82 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1278 Sub-83 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1279 Sub-61 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1280 Sub-55 4-ClPh —CO— —CH₂— —CH₂-cHx— 3-1281 Sub-33 4-FPh —CO— —CH₂— —CH₂— 3-1282 Sub-34 4-FPh —CO— —CH₂— —CH₂— 3-1283 Sub-35 4-FPh —CO— —CH₂— —CH₂— 3-1284 Sub-36 4-FPh —CO— —CH₂— —CH₂— 3-1285 Sub-37 4-FPh —CO— —CH₂— —CH₂— 3-1286 Sub-38 4-FPh —CO— —CH₂— —CH₂— 3-1287 Sub-39 4-FPh —CO— —CH₂— —CH₂— 3-1288 Sub-40 4-FPh —CO— —CH₂— —CH₂— 3-1289 Sub-41 4-FPh —CO— —CH₂— —CH₂— 3-1290 Sub-42 4-FPh —CO— —CH₂— —CH₂— 3-1291 Sub-84 4-FPh —CO— —CH₂— —CH₂— 3-1292 Sub-43 4-FPh —CO— —CH₂— —CH₂— 3-1293 Sub-44 4-FPh —CO— —CH₂— —CH₂— 3-1294 Sub-45 4-FPh —CO— —CH₂— —CH₂— 3-1295 Sub-46 4-FPh —CO— —CH₂— —CH₂— 3-1296 Sub-47 4-FPh —CO— —CH₂— —CH₂— 3-1297 Sub-81 4-FPh —CO— —CH₂— —CH₂— 3-1298 Sub-48 4-FPh —CO— —CH₂— —CH₂— 3-1299 Sub-49 4-FPh —CO— —CH₂— —CH₂— 3-1300 Sub-50 4-FPh —CO— —CH₂— —CH₂— 3-1301 Sub-51 4-FPh —CO— —CH₂— —CH₂— 3-1302 Sub-52 4-FPh —CO— —CH₂— —CH₂— 3-1303 Sub-53 4-FPh —CO— —CH₂— —CH₂— 3-1304 Sub-54 4-FPh —CO— —CH₂— —CH₂— 3-1305 Sub-56 4-FPh —CO— —CH₂— —CH₂— 3-1306 Sub-57 4-FPh —CO— —CH₂— —CH₂— 3-1307 Sub-58 4-FPh —CO— —CH₂— —CH₂— 3-1308 Sub-59 4-FPh —CO— —CH₂— —CH₂— 3-1309 Sub-82 4-FPh —CO— —CH₂— —CH₂— 3-1310 Sub-83 4-FPh —CO— —CH₂— —CH₂— 3-1311 Sub-61 4-FPh —CO— —CH₂— —CH₂— 3-1312 Sub-55 4-FPh —CO— —CH₂— —CH₂— 3-1313 Sub-33 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1314 Sub-34 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1315 Sub-35 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1316 Sub-36 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1317 Sub-37 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1318 Sub-38 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1319 Sub-39 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1320 Sub-40 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1321 Sub-41 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1322 Sub-42 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1323 Sub-84 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1324 Sub-43 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1325 Sub-44 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1326 Sub-45 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1327 Sub-46 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1328 Sub-47 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1329 Sub-81 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1330 Sub-48 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1331 Sub-49 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1332 Sub-50 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1333 Sub-51 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1334 Sub-52 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1335 Sub-53 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1336 Sub-54 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1337 Sub-56 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1338 Sub-57 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1339 Sub-58 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1340 Sub-59 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1341 Sub-82 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1342 Sub-83 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1343 Sub-61 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1344 Sub-55 4-FPh —CO— —CH₂— —CH₂CH₂— 3-1345 Sub-33 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1346 Sub-34 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1347 Sub-35 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1348 Sub-36 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1349 Sub-37 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1350 Sub-38 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1351 Sub-39 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1352 Sub-40 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1353 Sub-41 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1354 Sub-42 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1355 Sub-84 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1356 Sub-43 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1357 Sub-44 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1358 Sub-45 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1359 Sub-46 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1360 Sub-47 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1361 Sub-81 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1362 Sub-48 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1363 Sub-49 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1364 Sub-50 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1365 Sub-51 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1366 Sub-52 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1367 Sub-53 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1368 Sub-54 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1369 Sub-56 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1370 Sub-57 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1371 Sub-58 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1372 Sub-59 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1373 Sub-82 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1374 Sub-83 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1375 Sub-61 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1376 Sub-55 4-FPh —CO— —CH₂— —(CH₂)₃— 3-1377 Sub-33 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1378 Sub-34 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1379 Sub-35 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1380 Sub-36 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1381 Sub-37 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1382 Sub-38 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1383 Sub-39 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1384 Sub-40 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1385 Sub-41 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1386 Sub-42 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1387 Sub-84 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1388 Sub-43 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1389 Sub-44 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1390 Sub-45 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1391 Sub-46 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1392 Sub-47 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1393 Sub-81 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1394 Sub-48 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1395 Sub-49 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1396 Sub-50 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1397 Sub-51 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1398 Sub-52 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1399 Sub-53 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1400 Sub-54 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1401 Sub-56 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1402 Sub-57 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1403 Sub-58 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1404 Sub-59 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1405 Sub-82 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1406 Sub-83 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1407 Sub-61 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1408 Sub-55 4-FPh —CO— —CH₂— —CH₂C(Me)₂— 3-1409 Sub-33 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1410 Sub-34 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1411 Sub-35 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1412 Sub-36 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1413 Sub-37 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1414 Sub-38 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1415 Sub-39 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1416 Sub-40 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1417 Sub-41 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1418 Sub-42 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1419 Sub-84 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1420 Sub-43 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1421 Sub-44 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1422 Sub-45 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1423 Sub-46 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1424 Sub-47 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1425 Sub-81 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1426 Sub-48 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1427 Sub-49 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1428 Sub-50 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1429 Sub-51 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1430 Sub-52 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1431 Sub-53 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1432 Sub-54 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1433 Sub-56 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1434 Sub-57 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1435 Sub-58 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1436 Sub-59 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1437 Sub-82 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1438 Sub-83 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1439 Sub-61 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1440 Sub-55 4-FPh —CO— —CH₂— —CH₂-cPr— 3-1441 Sub-33 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1442 Sub-34 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1443 Sub-35 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1444 Sub-36 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1445 Sub-37 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1446 Sub-38 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1447 Sub-39 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1448 Sub-40 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1449 Sub-41 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1450 Sub-42 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1451 Sub-84 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1452 Sub-43 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1453 Sub-44 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1454 Sub-45 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1455 Sub-46 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1456 Sub-47 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1457 Sub-81 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1458 Sub-48 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1459 Sub-49 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1460 Sub-50 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1461 Sub-51 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1462 Sub-52 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1463 Sub-53 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1464 Sub-54 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1465 Sub-56 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1466 Sub-57 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1467 Sub-58 4-FPh —CO— —CH₂— —CH₂ cBu— 3-1468 Sub-59 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1469 Sub-82 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1470 Sub-83 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1471 Sub-61 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1472 Sub-55 4-FPh —CO— —CH₂— —CH₂-cBu— 3-1473 Sub-33 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1474 Sub-34 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1475 Sub-35 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1476 Sub-36 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1477 Sub-37 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1478 Sub-38 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1479 Sub-39 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1480 Sub-40 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1481 Sub-41 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1482 Sub-42 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1483 Sub-84 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1484 Sub-43 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1485 Sub-44 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1486 Sub-45 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1487 Sub-46 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1488 Sub-47 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1489 Sub-81 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1490 Sub-48 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1491 Sub-49 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1492 Sub-50 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1493 Sub-51 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1494 Sub-52 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1495 Sub-53 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1496 Sub-54 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1497 Sub-56 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1498 Sub-57 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1499 Sub-58 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1500 Sub-59 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1501 Sub-82 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1502 Sub-83 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1503 Sub-61 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1504 Sub-55 4-FPh —CO— —CH₂— —CH₂-cPn— 3-1505 Sub-33 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1506 Sub-34 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1507 Sub-35 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1508 Sub-36 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1509 Sub-37 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1510 Sub-38 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1511 Sub-39 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1512 Sub-40 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1513 Sub-41 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1514 Sub-42 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1515 Sub-84 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1516 Sub-43 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1517 Sub-44 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1518 Sub-45 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1519 Sub-46 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1520 Sub-47 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1521 Sub-81 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1522 Sub-48 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1523 Sub-49 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1524 Sub-50 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1525 Sub-51 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1526 Sub-52 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1527 Sub-53 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1528 Sub-54 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1529 Sub-56 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1530 Sub-57 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1531 Sub-58 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1532 Sub-59 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1533 Sub-82 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1534 Sub-83 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1535 Sub-61 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1536 Sub-55 4-FPh —CO— —CH₂— —CH₂-cHx— 3-1537 Sub-33 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1538 Sub-34 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1539 Sub-35 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1540 Sub-36 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1541 Sub-37 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1542 Sub-38 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1543 Sub-39 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1544 Sub-40 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1545 Sub-41 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1546 Sub-42 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1547 Sub-84 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1548 Sub-43 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1549 Sub-44 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1550 Sub-45 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1551 Sub-46 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1552 Sub-47 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1553 Sub-81 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1554 Sub-48 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1555 Sub-49 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1556 Sub-50 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1557 Sub-51 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1558 Sub-52 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1559 Sub-53 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1560 Sub-54 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1561 Sub-56 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1562 Sub-57 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1563 Sub-58 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1564 Sub-59 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1565 Sub-82 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1566 Sub-83 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1567 Sub-61 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1568 Sub-55 3,4-diClPh —CO— Single Bond —C(Me)₂— 3-1569 Sub-33 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1570 Sub-34 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1571 Sub-35 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1572 Sub-36 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1573 Sub-37 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1574 Sub-38 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1575 Sub-39 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1576 Sub-40 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1577 Sub-41 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1578 Sub-42 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1579 Sub-84 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1580 Sub-43 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1581 Sub-44 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1582 Sub-45 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1583 Sub-46 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1584 Sub-47 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1585 Sub-81 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1586 Sub-48 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1587 Sub-49 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1588 Sub-50 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1589 Sub-51 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1590 Sub-52 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1591 Sub-53 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1592 Sub-54 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1593 Sub-56 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1594 Sub-57 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1595 Sub-58 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1596 Sub-59 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1597 Sub-82 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1598 Sub-83 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1599 Sub-61 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1600 Sub-55 3,4-diClPh —CO— —CH₂— —C(Me)₂— 3-1601 Sub-33 4-ClPh —CO— Single Bond —C(Me)₂— 3-1602 Sub-34 4-ClPh —CO— Single Bond —C(Me)₂— 3-1603 Sub-35 4-ClPh —CO— Single Bond —C(Me)₂— 3-1604 Sub-36 4-ClPh —CO— Single Bond —C(Me)₂— 3-1605 Sub-37 4-ClPh —CO— Single Bond —C(Me)₂— 3-1606 Sub-38 4-ClPh —CO— Single Bond —C(Me)₂— 3-1607 Sub-39 4-ClPh —CO— Single Bond —C(Me)₂— 3-1608 Sub-40 4-ClPh —CO— Single Bond —C(Me)₂— 3-1609 Sub-41 4-ClPh —CO— Singie Bond —C(Me)₂— 3-1610 Sub-42 4-ClPh —CO— Single Bond —C(Me)₂— 3-1611 Sub-84 4-ClPh —CO— Single Bond —C(Me)₂— 3-1612 Sub-43 4-ClPh —CO— Single Bond —C(Me)₂— 3-1613 Sub-44 4-ClPh —CO— Single Bond —C(Me)₂— 3-1614 Sub-45 4-ClPh —CO— Single Bond —C(Me)₂— 3-1615 Sub-46 4-ClPh —CO— Single Bond —C(Me)₂— 3-1616 Sub-47 4-ClPh —CO— Single Bond —C(Me)₂— 3-1617 Sub-81 4-ClPh —CO— Single Bond —C(Me)₂— 3-1618 Sub-48 4-ClPh —CO— Single Bond —C(Me)₂— 3-1619 Sub-49 4-ClPh —CO— Single Bond —C(Me)₂— 3-1620 Sub-50 4-ClPh —CO— Single Bond —C(Me)₂— 3-1621 Sub-51 4-ClPh —CO— Single Bond —C(Me)₂— 3-1622 Sub-52 4-ClPh —CO— Single Bond —C(Me)₂— 3-1623 Sub-53 4-ClPh —CO— Single Bond —C(Me)₂— 3-1624 Sub-54 4-ClPh —CO— Single Bond —C(Me)₂— 3-1625 Sub-56 4-ClPh —CO— Single Bond —C(Me)₂— 3-1626 Sub-57 4-ClPh —CO— Single Bond —C(Me)₂— 3-1627 Sub-58 4-ClPh —CO— Single Bond —C(Me)₂— 3-1628 Sub-59 4-ClPh —CO— Single Bond —C(Me)₂— 3-1629 Sub-82 4-ClPh —CO— Single Bond —C(Me)₂— 3-1630 Sub-83 4-ClPh —CO— Single Bond —C(Me)₂— 3-1631 Sub-61 4-ClPh —CO— Single Bond —C(Me)₂— 3-1632 Sub-55 4-ClPh —CO— Single Bond —C(Me)₂— 3-1633 Sub-33 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1634 Sub-34 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1635 Sub-35 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1636 Sub-36 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1637 Sub-37 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1638 Sub-38 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1639 Sub-39 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1640 Sub-40 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1641 Sub-41 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1642 Sub-42 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1643 Sub-84 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1644 Sub-43 4-ClPh —CO— —CH₂— —Cl(Me)₂— 3-1645 Sub-44 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1646 Sub-45 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1647 Sub-46 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1648 Sub-47 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1649 Sub-81 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1650 Sub-48 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1651 Sub-49 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1652 Sub-50 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1653 Sub-51 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1654 Sub-52 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1655 Sub-53 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1656 Sub-54 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1657 Sub-56 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1658 Sub-57 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1659 Sub-58 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1660 Sub-59 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1661 Sub-82 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1662 Sub-83 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1663 Sub-61 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1664 Sub-55 4-ClPh —CO— —CH₂— —C(Me)₂— 3-1665 Sub-33 4-FPh —CO— Single Bond —C(Me)₂— 3-1666 Sub-34 4-FPh —CO— Single Bond —C(Me)₂— 3-1667 Sub-35 4-FPh —CO— Single Bond —C(Me)₂— 3-1668 Sub-36 4-FPh —CO— Single Bond —C(Me)₂— 3-1669 Sub-37 4-FPh —CO— Single Bond —C(Me)₂— 3-1670 Sub-38 4-FPh —CO— Single Bond —C(Me)₂— 3-1671 Suh-39 4-FPh —CO— Single Bond —C(Me)₂— 3-1672 Sub-40 4-FPh —CO— Single Bond —C(Me)₂— 3-1673 Sub-41 4-FPh —CO— Single Bond —C(Me)₂— 3-1674 Sub-42 4-FPh —CO— Single Bond —C(Me)₂— 3-1675 Sub-84 4-FPh —CO— Single Bond —C(Me)₂— 3-1676 Sub-43 4-FPh —CO— Single Bond —C(Me)₂— 3-1677 Sub-44 4-FPh —CO— Single Bond —C(Me)₂— 3-1678 Sub-45 4-FPh —CO— Single Bond —C(Me)₂— 3-1679 Sub-46 4-FPh —CO— Single Bond —C(Me)₂— 3-1680 Sub-47 4-FPh —CO— Single Bond —C(Me)₂— 3-1681 Sub-81 4-FPh —CO— Single Bond —C(Me)₂— 3-1682 Sub-48 4-FPh —CO— Single Bond —C(Me)₂— 3-1683 Sub-49 4-FPh —CO— Single Bond —C(Me)₂— 3-1684 Sub-50 4-FPh —CO— Single Bond —C(Me)₂— 3-1685 Sub-51 4-FPh —CO— Single Bond —C(Me)₂— 3-1686 Sub-52 4-FPh —CO— Single Bond —C(Me)₂— 3-1687 Sub-53 4-FPh —CO— Single Bond —C(Me)₂— 3-1688 Sub-54 4-FPh —CO— Single Bond —C(Me)₂— 3-1689 Sub-56 4-FPh —CO— Single Bond —C(Me)₂— 3-1690 Sub-57 4-FPh —CO— Single Bond —C(Me)₂— 3-1691 Sub-58 4-FPh —CO— Single Bond —C(Me)₂— 3-1692 Sub-59 4-FPh —CO— Single Bond —C(Me)₂— 3-1693 Sub-82 4-FPh —CO— Single Bond —C(Me)₂— 3-1694 Sub-83 4-FPh —CO— Single Bond —C(Me)₂— 3-1695 Sub-61 4-FPh —CO— Single Bond —C(Me)₂— 3-1696 Sub-55 4-FPh —CO— Single Bond —C(Me)₂— 3-1697 Sub-33 4-FPh —CO— —CH₂— —C(Me)₂— 3-1698 Sub-34 4-FPh —CO— —CH₂— —C(Me)₂— 3-1699 Sub-35 4-FPh —CO— —CH₂— —C(Me)₂— 3-1700 Sub-36 4-FPh —CO— —CH₂— —C(Me)₂— 3-1701 Sub-37 4-FPh —CO— —CH₂— —C(Me)₂— 3-1702 Sub-38 4-FPh —CO— —CH₂— —C(Me)₂— 3-1703 Sub-39 4-FPh —CO— —CH₂— —C(Me)₂— 3-1704 Sub-40 4-FPh —CO— —CH₂— —C(Me)₂— 3-1705 Sub-41 4-FPh —CO— —CH₂— —C(Me)₂— 3-1706 Sub-42 4-FPh —CO— —CH₂— —C(Me)₂— 3-1707 Sub-84 4-FPh —CO— —CH₂— —C(Me)₂— 3-1708 Sub-43 4-FPh —CO— —CH₂— —C(Me)₂— 3-1709 Sub-44 4-FPh —CO— —CH₂— —C(Me)₂— 3-1710 Sub-45 4-FPh —CO— —CH₂— —C(Me)₂— 3-1711 Sub-46 4-FPh —CO— —CH₂— —C(Me)₂— 3-1712 Sub-47 4-FPh —CO— —CH₂— —C(Me)₂— 3-1713 Sub-81 4-FPh —CO— —CH₂— —C(Me)₂— 3-1714 Sub-48 4-FPh —CO— —CH₂— —C(Me)₂— 3-1715 Sub-49 4-FPh —CO— —CH₂— —C(Me)₂— 3-1716 Sub-50 4-FPh —CO— —CH₂— —C(Me)₂— 3-1717 Sub-51 4-FPh —CO— —CH₂— —C(Me)₂— 3-1718 Sub-52 4-FPh —CO— —CH₂— —C(Me)₂— 3-1719 Sub-53 4-FPh —CO— —CH₂— —C(Me)₂— 3-1720 Sub-54 4-FPh —CO— —CH₂— —C(Me)₂— 3-1721 Sub-56 4-FPh —CO— —CH₂— —C(Me)₂— 3-1722 Sub-57 4-FPh —CO— —CH₂— —C(Me)₂— 3-1723 Sub-58 4-FPh —CO— —CH₂— —C(Me)₂— 3-1724 Sub-59 4-FPh —CO— —CH₂— —C(Me)₂— 3-1725 Sub-82 4-FPh —CO— —CH₂— —C(Me)₂— 3-1726 Sub-83 4-FPh —CO— —CH₂— —C(Me)₂— 3-1727 Sub-61 4-FPh —CO— —CH₂— —C(Me)₂— 3-1728 Sub-55 4-FPh —CO— —CH₂— —C(Me)₂— 3-1729 Sub-37 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1730 Sub-38 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1731 Sub-39 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1732 Sub-40 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1733 Sub-41 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1734 Sub-42 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1735 Sub-84 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1736 Sub-81 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1737 Sub-48 3,4-diClPh —CH₂— Single Bond —CH₂— 3-1738 Sub-37 4-ClPh —CH₂— Single Bond —CH₂— 3-1739 Sub-38 4-ClPh —CH₂— Single Bond —CH₂— 3-1740 Sub-39 4-ClPh —CH₂— Single Bond —CH₂— 3-1741 Sub-40 4-ClPh —CH₂— Single Bond —CH₂— 3-1742 Sub-41 4-ClPh —CH₂— Single Bond —CH₂— 3-1743 Sub-42 4-ClPh —CH₂— Single Bond —CH₂— 3-1744 Sub-84 4-ClPh —CH₂— Single Bond —CH₂— 3-1745 Sub-81 4-ClPh —CH₂— Single Bond —CH₂— 3-1746 Sub-48 4-ClPh —CH₂— Single Bond —CH₂— 3-1747 Sub-37 4-FPh —CH₂— Single Bond —CH₂— 3-1748 Sub-38 4-FPh —CH₂— Single Bond —CH₂— 3-1749 Sub-39 4-FPh —CH₂— Single Bond —CH₂— 3-1750 Sub-40 4-FPh —CH₂— Single Bond —CH₂— 3-1751 Sub-41 4-FPh —CH₂— Single Bond —CH₂— 3-1752 Sub-42 4-FPh —CH₂— Single Bond —CH₂— 3-1753 Sub-84 4-FPh —CH₂— Single Bond —CH₂— 3-1754 Sub-81 4-FPh —CH₂— Single Bond —CH₂— 3-1755 Sub-48 4-FPh —CH₂— Single Bond —CH₂— 3-1756 Sub-37 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1757 Sub-38 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1758 Sub-39 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1759 Sub-40 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1760 Sub-41 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1761 Sub-42 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1762 Sub-84 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1763 Sub-81 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1764 Sub-48 3,4-diClPh —CH₂— Single Bond —CH₂CH₂— 3-1765 Sub-37 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1766 Sub-38 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1767 Sub-39 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1768 Sub-40 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1769 Sub-41 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1770 Sub-42 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1771 Sub-84 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1772 Sub-81 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1773 Sub-48 4-ClPh —CH₂— Single Bond —CH₂CH₂— 3-1774 Sub-37 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1775 Sub-38 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1776 Sub-39 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1777 Sub-40 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1778 Sub-41 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1779 Sub-42 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1780 Sub-84 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1781 Sub-81 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1782 Sub-48 4-FPh —CH₂— Single Bond —CH₂CH₂— 3-1783 Sub-37 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1784 Sub-38 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1785 Sub-39 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1786 Sub-40 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1787 Sub-41 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1788 Sub-42 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1789 Sub-84 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1790 Sub-81 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1791 Sub-48 3,4-diClPh —CH₂— Single Bond —(CH₂)₃— 3-1792 Sub-37 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1793 Sub-38 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1794 Sub-39 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1795 Sub-40 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1796 Sub-41 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1797 Sub-42 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1798 Sub-84 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1799 Sub-81 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1800 Sub-48 4-ClPh —CH₂— Single Bond —(CH₂)₃— 3-1801 Sub-37 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1802 Sub-38 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1803 Sub-39 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1804 Sub-40 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1805 Sub-41 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1806 Sub-42 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1807 Sub-84 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1808 Sub-81 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1809 Sub-48 4-FPh —CH₂— Single Bond —(CH₂)₃— 3-1810 Sub-37 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1811 Sub-38 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1812 Sub-39 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1813 Sub-40 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1814 Sub-41 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1815 Sub-42 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1816 Sub-84 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1817 Sub-81 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1818 Sub-48 3,4-diClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1819 Sub-37 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1820 Sub-38 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1821 Sub-39 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1822 Sub-40 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1823 Sub-41 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1824 Sub-42 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1825 Sub-84 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1826 Sub-81 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1827 Sub-48 4-ClPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1828 Sub-37 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1829 Sub-38 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1830 Sub-39 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1831 Sub-40 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1832 Sub-41 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1833 Sub-42 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1834 Sub-84 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1835 Sub-81 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1836 Sub-48 4-FPh —CH₂— Single Bond —CH₂C(Me)₂— 3-1837 Sub-37 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1838 Sub-38 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1839 Sub-39 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1840 Sub-40 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1841 Sub-41 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1842 Sub-42 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1843 Sub-84 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1844 Sub-81 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1845 Sub-48 3,4-diClPh —CH₂— Single Bond —CH₂-cPr— 3-1846 Sub-37 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1847 Sub-38 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1848 Sub-39 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1849 Sub-40 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1850 Sub-41 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1851 Sub-42 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1852 Sub-84 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1853 Sub-81 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1854 Sub-48 4-ClPh —CH₂— Single Bond —CH₂-cPr— 3-1855 Sub-37 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1856 Sub-38 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1857 Sub-39 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1858 Sub-40 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1859 Sub-41 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1860 Sub-42 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1861 Sub-84 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1862 Sub-81 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1863 Sub-48 4-FPh —CH₂— Single Bond —CH₂-cPr— 3-1864 Sub-37 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1865 Sub-38 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1866 Sub-39 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1867 Sub-40 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1868 Sub-41 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1869 Sub-42 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1870 Sub-84 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1871 Sub-81 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1872 Sub-48 3,4-diClPh —CH₂— Single Bond —C(Me)₂— 3-1873 Sub-37 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1874 Sub-38 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1875 Sub-39 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1876 Sub-40 4-ClPh —CH₂— Singie Bond —C(Me)₂— 3-1877 Sub-41 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1878 Sub-42 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1879 Sub-84 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1880 Sub-81 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1881 Sub-48 4-ClPh —CH₂— Single Bond —C(Me)₂— 3-1882 Sub-37 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1883 Sub-38 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1884 Sub-39 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1885 Sub-40 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1886 Sub-41 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1887 Sub-42 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1888 Sub-84 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1889 Sub-81 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1890 Sub-48 4-FPh —CH₂— Single Bond —C(Me)₂— 3-1891 Sub-37 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1892 Sub-38 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1893 Sub-39 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1894 Sub-40 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1895 Sub-41 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1896 Sub-42 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1897 Sub-84 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1898 Sub-81 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1899 Sub-48 3,4-diClPh —CH₂— —CH₂— —CH₂— 3-1900 Sub-37 4-ClPh —CH₂— —CH₂— —CH₂— 3-1901 Sub-38 4-ClPh —CH₂— —CH₂— —CH₂— 3-1902 Sub-39 4-ClPh —CH₂— —CH₂— —CH₂— 3-1903 Sub-40 4-ClPh —CH₂— —CH₂— —CH₂— 3-1904 Sub-41 4-ClPh —CH₂— —CH₂— —CH₂— 3-1905 Sub-42 4-ClPh —CH₂— —CH₂— —CH₂— 3-1906 Sub-84 4-ClPh —CH₂— —CH₂— —CH₂— 3-1907 Sub-81 4-ClPh —CH₂— —CH₂— —CH₂— 3-1908 Sub-48 4-ClPh —CH₂— —CH₂— —CH₂— 3-1909 Sub-37 4-FPh —CH₂— —CH₂— —CH₂— 3-1910 Sub-38 4-FPh —CH₂— —CH₂— —CH₂— 3-1911 Sub-39 4-FPh —CH₂— —CH₂— —CH₂— 3-1912 Sub-40 4-FPh —CH₂— —CH₂— —CH₂— 3-1913 Sub-41 4-FPh —CH₂— —CH₂— —CH₂— 3-1914 Sub-42 4-FPh —CH₂— —CH₂— —CH₂— 3-1915 Sub-84 4-FPh —CH₂— —CH₂— —CH₂— 3-1916 Sub-81 4-FPh —CH₂— —CH₂— —CH₂— 3-1917 Sub-48 4-FPh —CH₂— —CH₂— —CH₂— 3-1918 Sub-37 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1919 Sub-38 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1920 Sub-39 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1921 Sub-40 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1922 Sub-41 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1923 Sub-42 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1924 Sub-84 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1925 Sub-81 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1926 Sub-48 3,4-diClPh —CH₂— —CH₂— —CH₂CH₂— 3-1927 Sub-37 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1928 Sub-38 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1929 Sub-39 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1930 Sub-40 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1931 Sub-41 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1932 Sub-42 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1933 Sub-84 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1934 Sub-81 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1935 Sub-48 4-ClPh —CH₂— —CH₂— —CH₂CH₂— 3-1936 Sub-37 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1937 Sub-38 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1938 Sub-39 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1939 Sub-40 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1940 Sub-41 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1941 Sub-42 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1942 Sub-84 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1943 Sub-81 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1944 Sub-48 4-FPh —CH₂— —CH₂— —CH₂CH₂— 3-1945 Sub-37 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1946 Sub-38 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1947 Sub-39 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1948 Sub-40 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1949 Sub-41 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1950 Sub-42 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1951 Sub-84 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1952 Sub-81 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1953 Sub-48 3,4-diClPh —CH₂— —CH₂— —(CH₂)₃— 3-1954 Sub-37 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1955 Sub-38 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1956 Sub-39 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1957 Sub-40 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1958 Sub-41 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1959 Sub-42 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1960 Sub-84 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1961 Sub-81 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1962 Sub-48 4-ClPh —CH₂— —CH₂— —(CH₂)₃— 3-1963 Sub-37 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1964 Sub-38 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1965 Sub-39 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1966 Sub-40 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1967 Sub-41 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1968 Sub-42 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1969 Sub-84 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1970 Sub-81 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1971 Sub-48 4-FPh —CH₂— —CH₂— —(CH₂)₃— 3-1972 Sub-37 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1973 Sub-38 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1974 Sub-39 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1975 Sub-40 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1976 Sub-41 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1977 Sub-42 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1978 Sub-84 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1979 Sub-81 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1980 Sub-48 3,4-diClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1981 Sub-37 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1982 Sub-38 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1983 Sub-39 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1984 Sub-40 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1985 Sub-41 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1986 Sub-42 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1987 Sub-84 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1988 Sub-81 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1989 Sub-48 4-ClPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1990 Sub-37 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1991 Sub-38 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1992 Sub-39 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1993 Sub-40 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1994 Sub-41 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1995 Sub-42 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1996 Sub-84 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1997 Sub-81 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1998 Sub-48 4-FPh —CH₂— —CH₂— —CH₂C(Me)₂— 3-1999 Sub-37 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2000 Sub-38 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2001 Sub-39 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2002 Sub-40 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2003 Sub-41 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2004 Sub-42 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2005 Sub-84 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2006 Sub-81 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2007 Sub-48 3,4-diClPh —CH₂— —CH₂— —CH₂-cPr— 3-2008 Sub-37 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2009 Sub-38 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2010 Sub-39 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2011 Sub-40 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2012 Sub-41 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2013 Sub-42 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2014 Sub-84 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2015 Sub-81 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2016 Sub-48 4-ClPh —CH₂— —CH₂— —CH₂-cPr— 3-2017 Sub-37 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2018 Sub-38 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2019 Sub-39 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2020 Sub-40 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2021 Sub-41 4-FPh —CH₂— —CH₂— —CH₂-cPr- 3-2022 Sub-42 4-FPh —CH₂— —CH₂— —CH₂-cPr- 3-2023 Sub-84 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2024 Sub-81 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2025 Sub-48 4-FPh —CH₂— —CH₂— —CH₂-cPr— 3-2026 Sub-37 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2027 Sub-38 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2028 Sub-39 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2029 Sub-40 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2030 Sub-41 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2031 Sub-42 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2032 Sub-84 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2033 Sub-81 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2034 Sub-48 3,4-diClPh —CH₂— —CH₂— —C(Me)₂— 3-2035 Sub-37 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2036 Sub-38 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2037 Sub-39 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2038 Sub-40 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2039 Sub-41 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2040 Sub-42 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2041 Sub-84 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2042 Sub-81 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2043 Sub-48 4-ClPh —CH₂— —CH₂— —C(Me)₂— 3-2044 Sub-37 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2045 Sub-38 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2046 Sub-39 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2047 Sub-40 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2048 Sub-41 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2049 Sub-42 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2050 Sub-84 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2051 Sub-81 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2052 Sub-48 4-FPh —CH₂— —CH₂— —C(Me)₂— 3-2053 Sub-37 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2054 Sub-38 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2055 Sub-39 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2056 Sub-40 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2057 Sub-41 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2058 Sub-42 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2059 Sub-84 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2060 Sub-81 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2061 Sub-48 3,4-diClPh —SO₂— Single Bond —CH₂— 3-2062 Sub-37 4-ClPh —SO₂— Single Bond —CH₂— 3-2063 Sub-38 4-ClPh —SO₂— Single Bond —CH₂— 3-2064 Sub-39 4-ClPh —SO₂— Single Bond —CH₂— 3-2065 Sub-40 4-ClPh —SO₂— Single Bond —CH₂— 3-2066 Sub-41 4-ClPh —SO₂— Single Bond —CH₂— 3-2067 Sub-42 4-ClPh —SO₂— Single Bond —CH₂— 3-2068 Sub-84 4-ClPh —SO₂— Single Bond —CH₂— 3-2069 Sub-81 4-ClPh —SO₂— Single Bond —CH₂— 3-2070 Sub-48 4-ClPh —SO₂— Single Bond —CH₂— 3-2071 Sub-37 4-FPh —SO₂— Single Bond —CH₂— 3-2072 Sub-38 4-FPh —SO₂— Single Bond —CH₂— 3-2073 Sub-39 4-FPh —SO₂— Single Bond —CH₂— 3-2074 Sub-40 4-FPh —SO₂— Single Bond —CH₂— 3-2075 Sub-41 4-FPh —SO₂— Single Bond —CH₂— 3-2076 Sub-42 4-FPh —SO₂— Single Bond —CH₂— 3-2077 Sub-84 4-FPh —SO₂— Single Bond —CH₂— 3-2078 Sub-81 4-FPh —SO₂— Single Bond —CH₂— 3-2079 Sub-48 4-FPh —SO₂— Single Bond —CH₂— 3-2080 Sub-37 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2081 Sub-38 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2082 Sub-39 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2083 Sub-40 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2084 Sub-41 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2085 Sub-42 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2086 Sub-84 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2087 Sub-81 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2088 Sub-48 3,4-diClPh —SO₂— Single Bond —CH₂CH₂— 3-2089 Sub-37 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2090 Sub-38 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2091 Sub-39 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2092 Sub-40 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2093 Sub-41 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2094 Sub-42 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2095 Sub-84 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2096 Sub-81 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2097 SubA8 4-ClPh —SO₂— Single Bond —CH₂CH₂— 3-2098 Sub-37 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2099 Sub-38 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2100 Sub-39 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2101 Sub-40 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2102 Sub-41 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2103 Sub-42 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2104 Sub-84 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2105 Sub-81 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2106 Sub-48 4-FPh —SO₂— Single Bond —CH₂CH₂— 3-2107 Sub-37 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2108 Sub-38 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2109 Sub-39 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2110 Sub-40 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2111 Sub-41 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2112 Sub-42 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2113 Sub-84 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2114 Sub-81 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2115 Sub-48 3,4-diClPh —SO₂— Single Bond —(CH₂)₃— 3-2116 Sub-37 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2117 Sub-38 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2118 Sub-39 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2119 Sub-40 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2120 Sub-41 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2121 Sub-42 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2122 Sub-84 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2123 Sub-81 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2124 Sub-48 4-ClPh —SO₂— Single Bond —(CH₂)₃— 3-2125 Sub-37 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2126 Sub-38 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2127 Sub-39 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2128 Sub-40 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2129 Sub-41 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2130 Sub-42 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2131 Sub-84 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2132 Sub-81 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2133 Sub-48 4-FPh —SO₂— Single Bond —(CH₂)₃— 3-2134 Sub-37 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2135 Sub-38 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2136 Sub-39 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2137 Sub-40 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2138 Sub-41 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2139 Sub-42 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2140 Sub-84 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2141 Sub-81 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2142 Sub-48 3,4-diClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2143 Sub-37 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2144 Sub-38 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2145 Sub-39 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2146 Sub-40 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2147 Sub-41 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2148 Sub-42 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2149 Sub-84 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2150 Sub-81 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2151 Sub-48 4-ClPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2152 Sub-37 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2153 Sub-38 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2154 Sub-39 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2155 Sub-40 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2156 Sub-41 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2157 Sub-42 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2158 Sub-84 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2159 Sub-81 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2160 Sub-48 4-FPh —SO₂— Single Bond —CH₂C(Me)₂— 3-2161 Sub-37 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2162 Sub-38 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2163 Sub-39 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2164 Sub-40 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2165 Sub-41 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2166 Sub-42 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2167 Sub-84 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2168 Sub-81 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2169 Sub-48 3,4-diClPh —SO₂— Single Bond —CH₂-cPr— 3-2170 Sub-37 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2171 Sub-38 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2172 Sub-39 4-ClPh —SO₂— Single Bond —CH_(2-cPr—) 3-2173 Sub-40 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2174 Sub-41 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2175 Sub-42 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2176 Sub-84 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2177 Sub-81 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2178 Sub-48 4-ClPh —SO₂— Single Bond —CH₂-cPr— 3-2179 Sub-37 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2180 Sub-38 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2181 Sub-39 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2182 Sub-40 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2183 Sub-41 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2184 Sub-42 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2185 Sub-84 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2186 Sub-81 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2187 Sub-48 4-FPh —SO₂— Single Bond —CH₂-cPr— 3-2188 Sub-37 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2189 Sub-38 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2190 Sub-39 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2191 Sub-40 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2192 Sub-41 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2193 Sub-42 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2194 Sub-84 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2195 Sub-81 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2196 Sub-48 3,4-diClPh —SO₂— Single Bond —C(Me)₂— 3-2197 Sub-37 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2198 Sub-38 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2199 Sub-39 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2200 Sub-40 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2201 Sub-41 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2202 Sub-42 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2203 Sub-84 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2204 Sub-81 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2205 Sub-48 4-ClPh —SO₂— Single Bond —C(Me)₂— 3-2206 Sub-37 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2207 Sub-38 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2208 Sub-39 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2209 Sub-40 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2210 Sub-41 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2211 Sub-42 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2212 Sub-84 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2213 Sub-81 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2214 Sub-48 4-FPh —SO₂— Single Bond —C(Me)₂— 3-2215 Sub-37 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2216 Sub-38 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2217 Sub-39 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2218 Sub-40 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2219 Sub-41 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2220 Sub-42 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2221 Sub-84 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2222 Sub-81 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2223 Sub-48 3,4-diClPh —SO₂— —CH₂— —CH₂— 3-2224 Sub-37 4-ClPh —SO₂— —CH₂— —CH₂— 3-2225 Sub-38 4-ClPh —SO₂— —CH₂— —CH₂— 3-2226 Sub-39 4-ClPh —SO₂— —CH₂— —CH₂— 3-2227 Sub-40 4-ClPh —SO₂— —CH₂— —CH₂— 3-2228 Sub-41 4-ClPh —SO₂— —CH₂— —CH₂— 3-2229 Sub-42 4-ClPh —SO₂— —CH₂— —CH₂— 3-2230 Sub-84 4-ClPh —SO₂— —CH₂— —CH₂— 3-2231 Sub-81 4-ClPh —SO₂— —CH₂— —CH₂— 3-2232 Sub-48 4-ClPh —SO₂— —CH₂— —CH₂— 3-2233 Sub-37 4-FPh —SO₂— —CH₂— —CH₂— 3-2234 Sub-38 4-FPh —SO₂— —CH₂— —CH₂— 3-2235 Sub-39 4-FPh —SO₂— —CH₂— —CH₂— 3-2236 Sub-40 4-FPh —SO₂— —CH₂— —CH₂— 3-2237 Sub-41 4-FPh —SO₂— —CH₂— —CH₂— 3-2238 Sub-42 4-FPh —SO₂— —CH₂— —CH₂— 3-2239 Sub-84 4-FPh —SO₂— —CH₂— —CH₂— 3-2240 Sub-81 4-FPh —SO₂— —CH₂— —CH₂— 3-2241 Sub-48 4-FPh —SO₂— —CH₂— —CH₂— 3-2242 Sub-37 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2243 Sub-38 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2244 Sub-39 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2245 Sub-40 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2246 Sub-41 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2247 Sub-42 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2248 Sub-84 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2249 Sub-81 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2250 Sub-48 3,4-diClPh —SO₂— —CH₂— —CH₂CH₂— 3-2251 Sub-37 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2252 Sub-38 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2253 Sub-39 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2254 Sub-40 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2255 Sub-41 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2256 Sub-42 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2257 Sub-84 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2258 Sub-81 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2259 Sub-48 4-ClPh —SO₂— —CH₂— —CH₂CH₂— 3-2260 Sub-37 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2261 Sub-38 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2262 Sub-39 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2263 Sub-40 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2264 Sub-41 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2265 Sub-42 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2266 Sub-84 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2267 Sub-81 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2268 Sub-48 4-FPh —SO₂— —CH₂— —CH₂CH₂— 3-2269 Sub-37 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2270 Sub-38 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2271 Sub-39 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2272 Sub-40 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2273 Sub-41 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2274 Sub-42 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2275 Sub-84 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2276 Sub-81 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2277 Sub-48 3,4-diClPh —SO₂— —CH₂— —(CH₂)₃— 3-2278 Sub-37 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2279 Sub-38 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2280 Sub-39 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2281 Sub-40 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2282 Sub-41 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2283 Sub-42 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2284 Sub-84 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2285 Sub-81 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2286 Sub-48 4-ClPh —SO₂— —CH₂— —(CH₂)₃— 3-2287 Sub-37 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2288 Sub-38 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2289 Sub-39 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2290 Sub-40 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2291 Sub-41 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2292 Sub-42 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2293 Sub-84 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2294 Sub-81 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2295 Sub-48 4-FPh —SO₂— —CH₂— —(CH₂)₃— 3-2296 Sub-37 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2297 Sub-38 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2298 Sub-39 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2299 Sub-40 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2300 Sub-41 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2301 Sub-42 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2302 Sub-84 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2303 Sub-81 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2304 Sub-48 3,4-diClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2305 Sub-37 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2306 Sub-38 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2307 Sub-39 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2308 Sub-40 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2309 Sub-41 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2310 Sub-42 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2311 Sub-84 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2312 Sub-81 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2313 Sub-48 4-ClPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2314 Sub-37 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2315 Sub-38 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2316 Sub-39 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2317 Sub-40 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2318 Sub-41 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2319 Sub-42 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2320 Sub-84 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2321 Sub-81 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2322 Sub-48 4-FPh —SO₂— —CH₂— —CH₂C(Me)₂— 3-2323 Sub-37 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2324 Sub-38 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2325 Sub-39 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2326 Sub-40 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2327 Sub-41 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2328 Sub-42 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2329 Sub-84 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2330 Sub-81 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2331 Sub-48 3,4-diClPh —SO₂— —CH₂— —CH₂-cPr— 3-2332 Sub-37 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2333 Sub-38 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2334 Sub-39 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2335 Sub-40 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2336 Sub-41 4-ClPh —SO₂— —CH₂— —CH₂ cPr— 3-2337 Sub-42 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2338 Sub-84 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2339 Sub-81 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2340 Sub-48 4-ClPh —SO₂— —CH₂— —CH₂-cPr— 3-2341 Sub-37 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2342 Sub-38 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2343 Sub-39 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2344 Sub-40 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2345 Sub-41 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2346 Sub-42 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2347 Sub-84 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2348 Sub-81 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2349 Sub-48 4-FPh —SO₂— —CH₂— —CH₂-cPr— 3-2350 Sub-37 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2351 Sub-38 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2352 Sub-39 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2353 Sub-40 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2354 Sub-41 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2355 Sub-42 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2356 Sub-84 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2357 Sub-81 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2358 Sub-48 3,4-diClPh —SO₂— —CH₂— —C(Me)₂— 3-2359 Sub-37 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2360 Sub-38 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2361 Sub-39 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2362 Sub-40 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2363 Sub-41 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2364 Sub-42 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2365 Sub-84 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2366 Sub-81 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2367 Sub-48 4-ClPh —SO₂— —CH₂— —C(Me)₂— 3-2368 Sub-37 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2369 Sub-38 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2370 Sub-39 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2371 Sub-40 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2372 Sub-41 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2373 Sub-42 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2374 Sub-84 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2375 Sub-81 4-FPh —SO₂— —CH₂— —C(Me)₂— 3-2376 Sub-48 4-FPh —SO₂— —CH₂— —C(Me)₂—

Of the compounds listed above, the following are preferred, that is to say Compounds No. 1-1025 to 1-1536, 2-1537 to 2-1728, 2-1825 to 2-1920, 2-1969 to 2-2016, 2-2113 to 2-2160, 2-2257 to 2-2352, 3-1 to 3-64, and 3-97 to 3-160.

More preferred compounds are Compounds No. 1-1089 to 1-1120, 1-1217 to 1-1280, 1-1313 to 1-1344, 1-1505 to 1-1536, 2-1825 to 2-1920, 2-1969 to 2-2016, 2-2257 to 2-2352, 3-5 to 3-11, 3-17, 3-18, 3-37 to 3-43, 3-49, 3-50, 3-101, to 3-107, 3-113, 3-114, 3-133 to 3-139, 3-145 and 3-146.

Still more preferred compounds 1-1089 to 1-1120, 1-1313 to 1-1344, 2-1969 to 2-2016, 3-7, 3-8, 3-10, 3-11, 3-39, 3-40, 3-42, 3-43, 3-103, 3-104, 3-106, 3-107, 3-135, 3-136, 3-138, and 3-139.

The most preferred compounds of the present invention are as follows:

1-{2-[5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-carboxamide;

1-{2-[5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(2-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(3-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(4-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(4-chlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-carboxamide;

1-{2-[5-(4-chlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[5-(4-chlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(2-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(4-chlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(3-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(4-chlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(4-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(4-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-carboxamide;

1-{2-[5-(4-fluorophenyl)-3-(3,4,5-triethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[5-(4-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(2-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(4-fluorophenyl)-3-(3,4,5-triethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(3-pyridyl)piperidine-4-carboxamide;

1-{2-[5-(4-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(4-pyridyl)piperidine-4-carboxamide;

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide;

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperidine;

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-morpholinocarbonyl-4-phenylpiperidine;

1-{2-[2-(4-chlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide;

1-{2-[2-(4-chlorophenyl)-4-(3,4,5-triethoxybenzoyl)morpholin-2-yl]ethyl[-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[2-(4-fluorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl[-4-phenylpiperidine-4-carboxamide;

1-{2-[2-(4-fluorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[2-(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide;

1-{2-[2-(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide);

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isobenzofuran-1(3H),4′-piperidine];

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morphoin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine];

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide;

1-{2-[2-(3,4-dichlorophenyl)-4-(3,4,5-triethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isoquinoline-1(2H),4′-piperidine]-3-(4H)-one;

1-{2-[2-(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[isobenzofuran-1(3H),4′-piperidine];

1-{2-[2-(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine];

1-{2-[2-(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide;

1-{2-[2-(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[isoquinoline-1(2H),4′-piperidin]-3-(4H)-one;

1-{2-[(5R)-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(5R)-(4-chlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(5R)-(4-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morphoin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(4-chlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1-(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(4-florophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ehtyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2)-oxide;

1-{2-[(2R)-(4-chlorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(4-fluorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethyl}spiro[benzo[c]thiophene-1-(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3-isopropoxyphenyacetyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(4-chlorophenyl)-4-(3-isopropoxyphenylacetyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide;

1-{2-[(2R)-(4-fluorophenyl)-4-(3-isopropoxyphenylacetyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide; and

1-{2-[(2R)-(3,4-dichlorophenyl)-5,5-dimethyl-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1-(3H),4′-piperidine]-(2S)-oxide.

The compounds of the present invention may be prepared by a variety of processes well known for the preparation of compounds of this type, for example as illustrated by the following Reaction Schemes A to J.

wherein R¹, R², A, B, D, E, G and L are as defined above.

X, X′, Y, Y′ and Y″ may be any group or atom which is capable of being eliminated as a nucleophilic residue and are not specifically limited. Preferred examples of such groups and atoms include: halogen atoms, such as the chlorine, bromine and iodine atoms; trihalomethoxy groups, such as the trichloromethoxy group; alkanesulfonyloxy groups having from 1 to 6 carbon atoms, such as the methanesulfonyloxy and ethanesulfonyloxy groups; haloalkanesulfonyloxy groups having from 1 to 6 carbon atoms, such as the trifluoromethanesulfonyloxy and pentafluoroethanesulfonyloxy groups; and arylsulfonyloxy groups, such as the benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy groups. Of these, we prefer the halogen atoms and the alkanesulfonyloxy groups.

X may bond with R¹⁰ to represent a single bond. In this case, the compound of formula (III) becomes an acid anhydride.

E′ represents a group corresponding to the group represented by E, but in which the number of carbon atoms is one less than that of the alkylene group having from 1 to 4 carbon atoms or of the cycloalkane-1,1-diylmethyl group or of the cycloalkane-1,1-di(ylmethyl) group.

G′ represents a group corresponding to the group represented by G, but in which the number of carbon atoms is one less than that of the alkylene group having from 1 to 4 carbon atoms or of the alkenylene group having from 2 to 4 carbon atoms.

R¹⁰ represents a carboxy-protecting group which can be cleaved by a chemical process, such as hydrogenolysis, hydrolysis, electrolysis, or photolysis. Preferred examples of such protecting groups used in the reaction include:

alkyl groups having from 1 to 6 carbon atoms, such as those exemplified above in relation to R⁵ etc.;

alkenyl groups having from 2 to 6 carbon atoms, such as the vinyl, 1-propenyl, 2-propenyl, 1-methyl-2-propenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 2-ethyl-2-propenyl, 1-butenyl, 2-butenyl, 1-methyl-2-butenyl, 1-methyl-1-butenyl, 3-methyl-2-butenyl, 1-ethyl-2-butenyl, 3-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 1-ethyl-3-butenyl, 1-pentenyl, 2-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 4-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, and 5-hexenyl groups;

alkynyl groups having from 2 to 6 carbon atoms, such as the ethynyl, 2-propynyl, 1-methyl-2-propynyl, 2-butynyl, 1-methyl-2-butynyl, 1-ethyl-2-butynyl, 3-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-ethyl-3-butynyl, 2-pentynyl, 1-methyl-2-pentynyl, 4-methyl-2-pentynyl, 3-pentynyl, 1-methyl-3-pentynyl, 2-methyl-3-pentynyl, 4-pentynyl, 1-methyl-4-pentynyl, 2-methyl-4-pentynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, and 5-hexynyl groups;

haloalkyl groups having from 1 to 6 carbon atoms, such as those exemplified above in relation to substituents α;

hydroxyalkyl groups, such as the hydroxymethyl, 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 3,4-dihydroxybutyl, and 4-hydroxybutyl groups;

aliphatic acyl-substituted alkyl groups, such as the acetylmethyl group;

aralkyl groups, such as those exemplified above in relation to R⁵ etc.; and

silyl groups, such as those exemplified above in relation to ester groups.

R¹¹ represents a hydroxy-protecting group which can be cleaved by a chemical process, such as hydrogenolysis, hydrolysis, electrolysis, or photolysis. Preferred examples of such protecting groups include:

acyl groups (including alkanoyl, haloalkanoyl, alkoxyalkanoyl, alkenoyl and alkynoyl groups), such as those exemplified above in relation to R⁵ etc.;

aromatic acyl groups (including halogen-substituted, alkyl-substituted, alkoxy-substituted, nitro-substituted, alkoxycarbonyl-substituted and aryl-substituted aromatic acyl groups), such as those exemplified above in relation to R⁵;

tetrahydropyranyl or tetrahydrothiopyranyl groups, such as those exemplified above in relation to ester groups;

tetrahydrofuranyl or tetrahydrothiofuranyl groups, such as those exemplified above in relation to ester groups;

silyl groups, such as those exemplified above in relation to ester groups;

alkoxymethyl groups, such as those exemplified above in relation to ester groups;

substituted ethyl groups, such as those exemplified above in relation to ester groups;

aralkyl groups, such as those exemplified above in relation to R⁵ etc.;

alkoxycarbonyl groups, such as those exemplified above in relation to substituents α;

alkenyloxycarbonyl groups, such as those exemplified above in relation to ester groups; and

aralkyloxycarbonyl groups, such as those exemplified above in relation to ester groups.

R¹² represents a hydrogen atom or a hydroxy-protecting group, as exemplified above in relation to R¹¹.

Step A1

In this Step, a compound of formula (IV) is prepared by reacting a compound of formula (II) according to the Friedel-Crafts reaction with an acid derivative of formula (III) in the presence of a Lewis acid and in a solvent (Step A1a), optionally esterifying the resultant free carboxylic acid with a group of formula R¹⁰ when the acid derivative of formula (III) is an acid anhydride (Step A1b), and then converting a carbonyl group into an exo-methylene group according to the Wittig reaction in a solvent in the presence of a base (Step A1c).

Step A1a

There is no particular restriction on the nature of the Lewis acids used in the Friedel-Crafts reaction, and any Lewis acid commonly used in reactions of this type may equally be used here. Examples of such Lewis acids include: tri(C₁-C₆ alkyl)silyl trifluoromethanesulfonates, such as trimethylsilyl trifluoromethanesulfonate; aluminum salts, such as aluminum chloride; tin salts, such as tin tetrachloride; zinc salts, such as zinc bromide; titanium salts, such as titanium tetrachloride; perchlorates, such as trimethylsilyl perchlorate or triphenylmethyl perchlorate. Of these, we prefer the aluminum salts and the titanium salts, aluminum chloride being particularly preferred.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitro compounds, such as nitroethane and nitrobenzene. Of these, we particularly prefer the halogenated hydrocarbons.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −10 to 150° C., more preferably from 0 to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to 24 hours, more preferably from 1 to 12 hours, will usually suffice.

Step A1b

When the esterification of this Step is alkylation, the reaction may be accomplished by any one of the following processes.

Step A1b(i)

Alkylation may be accomplished by reacting the resulting carboxylic acid with a compound of formula R¹⁰—X′, wherein:

R¹⁰ is as defined above; and

X′ represents a group capable of being eliminated as a nucleophilic residue, such as a halogen atom (e.g. a chlorine, bromine or iodine atom); an alkanesulfonyloxy group having from 1 to 6 carbon atoms (e.g. a methanesulfonyloxy or ethanesulfonyloxy group); a haloalkanesulfonyloxy group having from 1 to 6 carbon atoms (e.g. a trifluoromethanesulfonyloxy or pentafluoroethanesulfonyloxy group); an arylsulfonyloxy group (e.g. a benzenesulfonyloxy, p-toluenesulfonyloxy or p-nitrobenzenesulfonyloxy group).

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable. solvents include: aliphatic hydrocarbons, such as hexane or heptane; aromatic hydrocarbons, such as benzene, toluene or xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene or dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane or diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone or cyclohexanone; nitriles, such as acetonitrile or isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The reaction is also normally and preferably carried out in the presence of a base. There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: alkali metal carbonates, such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydrogencarbonates, such as sodium hydrogencarbonate, potassium hydrogencarbonate and lithium hydrogencarbonate; alkali metal hydrides, such as lithium hydride, sodium hydride, and potassium hydride; alkali metal hydroxides, such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides, such as, lithium fluoride, sodium fluoride, and potassium fluoride; alkali metal alkoxides, such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium t-butoxide and lithium methoxide; alkali metal mercaptans, such as sodium methylmercaptan and sodium ethylmercaptan; organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline, N,N-diethylaniline, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU); and organic metal bases, such as butyllithium, lithium diisopropylamide and lithium bis(trimethylsilyl)amide.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 120° C., more preferably from 0 to 80° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 0.5 to 10 hours will usually suffice.

Step A1b(ii)

Alkylation may be accomplished by reacting the resulting carboxylic acid with a compound of formula R¹⁰—OH [wherein R¹⁰ is as defined above], using a condensing agent.

There is no particular restriction on the nature of the condensing agents used, and any condensing agent commonly used in reactions of this type may equally be used here. Examples of such condensing agents include:

(1) a combination of a phosphonate (e.g. diphenylphosphoryl azide or diethyl cyanophosphonate) and one or more of the bases described below;

(2) a carbodiimide (e.g. 1,3-dicyclohexylcarbodiimide, 1,3-diisopropylcarbodiimide or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide); a combination of one or more of the above carbodiimides and one or more of the bases described below; or a combination of one or more of the above carbodiimides and an N-hydroxy compound (e.g. N-hydroxysuccinimide, 1-hydroxybenzotriazole or N-hydroxy-5-norbornene-2,3-dicarboxyimide);

(3) combination of a disulfide (e.g. 2,2′-dipyridyl disulfide or 2,2′-dibenzothiazolyl disulfide, etc.) and a phosphine (e.g. triphenylphosphine or tributylphosphine);

(4) a carbonate [e.g. N,N′-disuccinimidyl carbonate, di-2-pyridyl carbonate or S,S′-bis(1-phenyl-1H-tetrazol-5-yl)dithiocarbonate];

(5) a phosphinic chloride [e.g. N,N′-bis(2-oxo-3-oxazolidinyl)phosphinic chloride];

(6) an oxalate [e.g. N,N′-disuccinimidyl oxalate, N,N′-diphthalimide oxalate, N,N′-bis(5-norbomene-2,3-dicarboxyimidyl)oxalate, 1,1′-bis(benzotriazolyl)oxalate, 1,1′-bis(6-chlorobenzotriazolyl)oxalate or 1,1′-bis(6-trifluoromethylbenzotriazolyl)oxalate];

(7) a combination of one or more of the above phosphines and one or more azodicarboxylates or azodicarboxyamides [e.g. diethyl azodicarboxylate, 1,1′-(azodicarbonyl)dipiperidine]; or a combination of one or more of the above phosphines and one or more of the bases described below;

(8) an N-alkyl-5-arylisoxazolium-3′-sulfonate, in which the alkyl part has from 1 to 6 carbon atoms and the aryl part is as defined and exemplified above in relation to R¹ etc. (e.g. N-ethyl-5-phenylisoxazolium-3′-sulfonate);

(9) a diheteroaryldiselenide (e.g. di-2-pyridyldiselenide);

(10) an arylsulfonyltriazolide in which the aryl part is as defined and exemplified above in relation to R¹ etc. (e.g. p-nitrobenzenesulfonyltriazolide);

(11) a 2-halo-1-alkylpyridinium halide, in which the alkyl part has from 1 to 6 carbon atoms (e.g. 2-chloro-1-methylpyridinium iodide);

(12) an imidazole (e.g. 1,1′-oxalyldiimidazole, N,N′-carbonyldiimidazole);

(13) a 3-alkyl-2-halogen-benzothiazolium fluoroborate, in which the alkyl part has from 1 to 6 carbon atoms (e.g. 3-ethyl-2-chloro-benzothiazolium fluoroborate);

(14) a 3-alkyl-benzothiazole-2-serone, in which the alkyl part has from 1 to 6 carbon atoms (e.g. 3-methyl-benzothiazol-2-serone);

(15) a phosphate (e.g. phenyldichlorophosphate or polyphosphate);

(16) a halosulfonyl isocyanate (e.g. chlorosulfonyl isocyanate);

(17) a halosilane (e.g. trimethylsilyl chloride or triethylsilyl chloride);

(18) a combination of an alkanesulfonyl halide having from 1 to 6 carbon atoms (e.g. methanesulfonyl chloride) and one or more of the bases described below; and

(19) an N,N,N′,N′-tetraalkyl haloformamidium chlorides, in which each alkyl group has from 1 to 6 carbon atoms (e.g. N,N,N′,N′-tetramethylchloroformamidium chloride).

Of these, we prefer the carbodiimides or a combination of a phosphine and an azodicarboxylate or azodicarboxyamide.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases, such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline and N,N-diethylaniline.

If desired, 4-(N,N-dimethylamino)pyridine or 4-pyrrolidinopyridine can be used in a catalytic amount in combination with one or more of the other bases. The efficiency of the reaction may also, if desired, be improved by conducting it in the presence of one or more of the following: dehydrating agents (e.g. molecular sieves), quatemary ammonium salts (e.g. benzyltriethylammonium chloride or tetrabutylammonium chloride), crown ethers (e.g. dibenzo-18-crown-6) and acid scavengers (e.g. 3,4-dihydro-2H-pyrido[1,2-a]pyrimidin-2-one).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

Step A1b(iii)

Introduction of a lower alkyl protecting group by alkylation may be accomplished by reacting the resulting carboxylic acid with a corresponding alcohol (e.g. methanol, ethanol, propanol or butanol).

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: the same alcohols as those of the reagent; aliphatic hydrocarbons, such as hexane or heptane; aromatic hydrocarbons, such as benzene, toluene or xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene or dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane or diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone or cyclohexanone; nitriles, such as acetonitrile or isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone or hexamethylphosphoric triamide. Of these, we particularly prefer the same alcohols as those of the reagent.

The reaction is carried out in the presence of an acid catalyst. There is likewise no particular restriction on the nature of the acid catalysts used, and any acid catalyst commonly used in reactions of this type may equally be used here. Examples of such acid catalysts include: Brønsted acids, such as inorganic acids (e.g. hydrogen chloride, hydrogen bromide, sulfuric acid, perchloric acid or phosphoric acid) and organic acids (e.g. acetic acid, formic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoroacetic acid or trifluoromethanesulfonic acid); and Lewis acids (e.g. boron trichloride, boron trifluoride or boron tribromide) or acidic ion-exchange resins.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C., more preferably from 50 to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 30 minutes to 5 hours, will usually suffice.

Step A1c

In the Wittig reaction, there is likewise no particular restriction on the nature of the Wittig reagents used, and any Wittig reagent commonly used in reactions of this type may equally be used here. Examples of such Wittig reagents include: methyltriphenylphosphonium halides, such as methyltriphenylphosphonium bromide and methyltriphenylphosphonium iodide.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diusopropyl ether and tetrahydrofuran; nitrites, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; and sulfoxides, such as dimethyl sulfoxide and sulfolane. Of these, we particularly prefer the aromatic hydrocarbons, most preferably benzene.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: alkali metal carbonates, such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydrogencarbonates, such as sodium hydrogencarbonate, potassium hydrogencarbonate and lithium hydrogencarbonate; alkali metal hydrides, such as lithium hydride, sodium hydride and potassium hydride; alkali metal and alkaline earth metal hydroxides, such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides, such as sodium fluoride and potassium fluoride; and alkali metal alkoxides, such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium t-butoxide and lithium methoxide. Of these, we particularly prefer the alkali metal hydrides and alkali metal alkoxides, most preferably the alkali metal alkoxides.

The reaction can take place over a wide range of termperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 100° C., more preferably from 0 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 30 minutes to 12 hours, will usually suffice.

Step A2

In this Step a compound of formula (V) is prepared by reducing the ester compound of formula (IV) (which may have been prepared as described in Step A1) in a solvent using a reducing agent to convert the ester group into a primary hydroxy group and then protecting this hydroxy group with a group R¹¹.

There is no particular restriction on the nature of the reducing agents used, and any reducing agent commonly used in reactions of this type may equally be used here. Examples of such reducing agents include: hydride reagents, such as alkali metal borohydrides (e.g. sodium borohydride or lithium borohydride), aluminum hydride compounds (e.g. lithium aluminum hydride or lithium tri-t-butoxyaluminohydride), sodium tellurium hydride and organic aluminum hydride reducing agents [e.g. diisobutylaluminum hydride or sodium bis(methoxyethoxy)aluminum hydride]. Of these, we particularly prefer the aluminum hydride compounds and organic aluminum hydride reducing agents, most preferably the aluminum hydride compounds.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; and ethers, such as diethyl ether, diisopropyl ether, tetrahydrofiran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether. Of these, we particularly prefer the ethers, most preferably diethyl ether and tetrahydrofuran.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −78 to 50° C., more preferably from −20 to 20° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 5 minutes to 24 hours, more preferably from 10 minutes to 2 hours, will usually suffice.

Introduction of the protecting group R¹¹ may be accomplished by any one of the following processes.

Step A2(i)

The protecting group R¹¹ may be introduced by reacting the unprotected compound with a suitable amount, preferably from 1 to 4 equivalents (more preferably from 2 to 3 equivalents) of a compound of formula R¹¹—X″ or R¹¹—O—R¹¹ (R¹¹ in the latter compound should be a group of the acyl type)

wherein

R¹¹ is as defined above, preferably a silyl group, of which, we particularly prefer the t-butyldimethylsilyl group;

X″ represents any group capable of being eliminated as a nucleophilic residue, for example: a halogen atom, such as a chlorine, bromine or iodine atom; an alkoxycarbonyloxy group having from 1 to 6 carbon atoms in the alkoxy part, such as a methoxycarbonyloxy or ethoxycarbonyloxy group; a haloalkanoyloxy group having from 2 to 6 carbon atoms, such as a chloroacetoxy, dichloroacetoxy, trichloroacetoxy or trifluoroacetoxy group; an alkanesulfonyloxy group having from 1 to 6 carbon atoms, such as a methanesulfonyloxy or ethanesulfonyloxy group; a haloalkanesulfonyloxy group having from 1 to 6 carbon atoms, such as a trifluoromethanesulfonyloxy or pentafluoroethanesulfonyloxy group; an arylsulfonyloxy group in which the aryl part is as defined and exemplified above in relation to R¹ etc., such as a benzenesulfonyloxy, p-toluenesulfonyloxy or P-nitrobenzenesulfonyloxy group. Of these, we particularly prefer the halogen atoms, the alkanesulfonyloxy groups and the arylsulfonyloxy groups.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetarnide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide. Of these, we particularly prefer the amides.

The reaction may be carried out in the presence of a base. There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, imidazole, quinoline, N,N-dimethylaniline and N,N-diethylaniline. Of these, we particularly prefer triethylamine and 4-(N,N-dimethylarnino)pyridine.

Furthermore, 4-N,N-dimethylamino)pyridine or 4-pyrrolidinopyridine can be used in a catalytic amount in combination with one or more of the other bases. The efficiency of the reaction may, if desired, be further improved by carrying it out in the presence of one or more of the following: quatemary ammonium salts (e.g. benzyltriethylammonium chloride or tetrabutylammonium chloride) and crown ethers (e.g. dibenzo-18-crown-6).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 100° C., more preferably from −10 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 1 day, more preferably from 30 minutes to 10 hours., will usually suffice.

Specific examples of the compound of formula R¹¹—X include: acyl halides, such as aliphatic acyl halides (e.g. acetyl chloride, propionyl chloride, butyryl bromide, valeryl chloride and hexanoyl chloride); alkoxycarbonyl halides having from 1 to 6 carbon atoms in the alkoxy part (e.g. methoxycarbonyl chloride, methoxycarbonyl bromide, ethoxycarbonyl chloride, propoxycarbonyl chloride, butoxycarbonyl chloride and hexyloxycarbonyl chloride); arylcarbonyl halides (e.g. benzoyl chloride, benzoyl bromide and naphthoyl chloride); and silyl halides, such as t-butyldimnethylsilyl chloride, trirnethylsilyl chloride, triethylsilyl chloride, triethylsilyl bromide, triisopropylsilyl chloride, dimethylisopropylsilyl chloride, diethylisopropylsilyl chloride, t-butyldiphenylsilyl chloride, diphenylmethylsilyl chloride, triphenylsilyl chloride or corresponding silyl trifluoromethanesulfonates; aralkyl halides, such as benzyl chloride and benzyl bromide; carbonyloxyalkyl halides having from 1 to 6 carbon atoms in the alkyl part, such as pivaloyloxymethyl chloride and ethoxycarbonyloxymethyl chloride.

Specific examples of the compound of formula R¹¹—O—R¹¹: include aliphatic carboxylic anhydrides, such as acetic anhydride, propionic anhydride, valeric anhydride and hexanoic anhydride. An mixed acid anhydride (e.g. a mixed anhydride of formic acid and acetic acid) can also be used.

Step A2(ii)

The protecting group R¹¹ may be introduced by reacting the unprotected compound with a compound of formula R¹¹—OH [wherein R¹¹ is one of the groups of the acyl type included in those defined above] in a solvent in the presence of a condensing agent, as exemplified above in relation to Step A1b(ii), and in the presence or absence of a base.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base used in Step A2(ii) may be any of those exemplified above in relation to Step A2(i).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

Step A2(iii)

The protecting group R¹¹ may be introduced by reacting the unprotected compound with a compound of formula R¹¹—OH [wherein R¹¹ is one of the groups of the acyl type included in those defined above] in a solvent and in the presence of a dialkyl halophosphate (e.g. diethyl chlorophosphate) and a base.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

The base used in Step A2(iii) may be any of those exemplified above in relation to Step A2(i).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0° C. to the reflux temperature of the solvent used, more preferably from room temperature to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

Step A3

In this Step, a compound of formula (VI) is prepared by oxidizing the exo-methylene group of a compound of formula (V) in a solvent using an oxidizing agent to convert the compound into a diol form.

There is likewise no particular restriction on the nature of the oxidizing agents used, and any oxidizing agent commonly used in reactions of this type may equally be used here. Examples of such oxidizing agents include: manganese oxides, such as potassium permanganate and manganese dioxide; ruthenium oxides, such as ruthenium (IV) oxide; selenium compounds, such as selenium dioxide; and osmium compounds, such as osmium tetroxide and potassium osmate dihydrate (K₂OsO₄2H₂O). We particularly prefer to use a catalytic amount of osmium tetroxide and a reoxidizing agent for osmium compounds. Examples of such reoxidizing agents include: metal ferricyanides, such as potassium ferricyanide (III); oxides of amines, such as 4-methylmorpholine oxide; inorganic oxidizing agents, such as persulfate compounds (e.g. potassium persulfate or sodium persulfate); peroxides, such as t-butyl hydroperoxide; hypochlorite compounds, such as t-butyl hypochlorite; and nitrites, such as methyl nitrite. Of these, we particularly prefer the metal ferricyanides and oxides of amines.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride and chloroform; ethers, such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; amides, such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols, such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol and isoamyl alcohol; esters, such as ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; dilute acids, such as aqueous sulfuric acid; dilute bases, such as an aqueous solution of sodium hydroxide; water; ketones, such as acetone and methyl ethyl ketone; organic bases, such as pyridine; nitriles, such as acetonitrile; or a mixture of any two or more of the above solvents. Of these, we particularly prefer acetone or a mixture of acetone and water.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from −5 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 to 24 hours, more preferably from 2 to 12 hours, will usually suffice.

An optically active diol derivative having a specific absolute configuration can be produced by optionally conducting an asymmetric dihydroxylation reaction using a chiral ligand. The asymmetric dihydroxylation reaction can be accomplished, for example, by the process of Sharpless et al. (Chemical Review, Vol. 94, page 2483 (1994)).

Examples of the oxidizing agent used for this reaction include from 0.0001 to 0.1 equivalents (more preferably from 0.001 to 0.005 equivalents) of osmium tetroxide. Examples of the chiral ligand include hydroquinidines, such as hydroquinidine 1,4-phthalazinediyl diether ((DHQD)₂-PHAL) and hydroquinidine 2,5-diphenyl-4,6-pyrimidinediyl diether ((DHQD)₂-PYR) (preferably (DHQD)₂-PHAL). Examples of the oxidizing agent for reoxidizing osmium compounds include potassium ferricyanide (III) and potassium carbonate.

Examples of the solvent used include a mixture of water and one or more of the following organic solvents: halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride or chloroform; ethers, such as diethyl ether, tetrahydrofuran, dioxane or dimethoxyethane; amides, such as dimethylformamide, dimethylacetamide or hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols, such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol or isoamyl alcohol; ketones, such as acetone or methyl ethyl ketone; esters, such as ethyl acetate, propyl acetate, butyl acetate or diethyl carbonate; and nitriles, such as acetonitrile, preferably a mixture of water and an alcohol. Of these, we particularly prefer a mixture of water and t-butanol.

A compound of formula (VI) wherein D is a sulfur atom can be produced by converting the exo-methylene group of the compound of formula (V) into thiirane according to a conventional process, followed by ring-opening with a hydroxy ion.

Step A4

In this Step, a compound of formula (VII) is prepared by: (a) converting a primary hydroxy group of a compound of formula (VI) into a group that can be eliminated (this reaction takes place in the presence of a base in the presence or absence of a solvent); and (b) then reacting the resulting compound with an azidation reagent in a solvent in the presence or absence of a catalyst to convert it into an azide group.

The reactions are normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reactions or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride and chloroform; ethers, such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; nitriles, such as acetonitrile; and amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; more preferably a halogenated hydrocarbon or an ether in the first stage reaction or an amide in the second stage reaction.

There is no particular restriction on the nature of the bases used in the first stage reaction, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline, N,N-diethylaniline, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Of these, we particularly prefer triethylamine, pyridine and 4-(N,N-dimethylamino)pyridine.

The reaction is most preferably accomplished using pyridine as a solvent and adding a catalytic amount of 4-(N,N-dimethylamino)pyridine.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 50° C., more preferably from −10 to 20° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 15 minutes to 24 hours, more preferably from 30 minutes to 6 hours, will usually suffice.

The group capable of being eliminated is the same group as that defined above for X. The reagent for forming the elimination group, is preferably a corresponding halide, and examples of such a reagent include sulfonyl halides, such as methanesulfonyl chloride and p-toluenesulfonyl chloride. The reaction may be conducted in the same manner as that employed to introduce the protecting group R¹¹.

There is likewise no particular restriction on the nature of the azidation reagents used in the second stage reaction, and any azidation reagent commonly used in reactions of this type may equally be used here. Examples of such azidation reagents include: diarylphosphoryl azides, such as diphenylphosphoryl azide; trialkylsilyl azides, such as trimethylsilyl azide and triethylsilyl azide; and alkali metal azides, such as sodium azide, potassium azide and lithium azide. Of these, we particularly prefer the alkali metal azides.

Examples of the catalyst which may be used include trialkylsilyl triflates, such as trimethylsilyl triflate and triethylsilyl triflate; Lewis acids, such as boron trifluoride etherate, aluminum chloride and zinc chloride.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 20 to 180° C., more preferably from 50 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 30 minutes to 8 hours, will usually suffice.

Step A5

In this Step, an amino compound of formula (VIII) is prepared by reducing the azide group of a compound of formula (VII) in a solvent.

The reduction process may be carried out using any reagent capable of reducing an azide group to form an amino group, and is not specifically limited. Preferably, the reaction is conducted at a temperature of from 20 to 150° C. (more preferably from 50 to 100° C.) for a period of from 15 minutes to 1 day (more preferably from 1 to 12 hours) in a water-containing solvent (preferably an ether, such as tetrahydrofuran) using triphenylphosphine as the reducing agent.

Alternatively, the reaction may be accomplished by conducting a catalytic hydrogenation reaction at a temperature of from −10 to 100° C. (more preferably from 0 to 50° C.) for a period of from 1 hour to 4 days (more preferably from 2 hours to 2 days) in an organic solvents, such as an alcohol (e.g. methanol or ethanol), an ester (e.g. ethyl acetate, propyl acetate, butyl acetate or diethyl acetate), an ether (e.g. tetrahydrofuran or dioxane) or a fatty acid (e.g. acetic acid) or a mixture of any one or more of these organic solvent and water (preferably alcohols) using a catalyst, such as palladium-on-carbon, platinum or Raney nickel.

Step A6

In this Step, a compound of formula (X) is prepared by the acylation reaction of the amino group of a compound of formula (VIII) with a compound of formula (IX) in a solvent in the presence of a base (Step A6a), followed by ring-closing alkylation on a group of formula DH, to form a cyclic amide (Step A6b).

Step A6a

The acylation reaction in this stage is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline and N,N-diethylaniline.

If desired, 4-(N,N-dimethylamino)pyridine or 4-pyrrolidinopyridine can be used in a catalytic amount in combination with one or more of the other bases. The efficiency of the reaction may, if desired, be improved by carrying it out in the presence of one or more of the following: dehydrating agents (e.g. molecular sieves), quaternary ammonium salts (e.g. benzyltriethylammonium chloride or tetrabutylammonium chloride), crown ethers (e.g. dibenzo-18-crown-6) and acid scavengers (e.g. 3,4-dihydro-2H-pyrido[1,2-a]pyrimidin-2-one).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

In case of the carboxylic acid derivative wherein the group X′ of the compound of formula (IX) represents a hydroxy group, this reaction can also be accomplished by reacting the compounds of formulae (VIII) and (IX) with the condensing agent described in Step A1b(ii) in the above solvent in the presence or absence of the above base.

Step A6b

The ring-closing alkylation reaction in this stage is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile, propionitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; and sulfoxides, such as dimethyl sulfoxide and sulfolane. Of these, we particularly prefer the ethers and amides, most preferably tetrahydrofuran or dimethylformamide.

There is likewise no particular restriction on the nature of the bases used, and any base cormmonly used in reactions of this type may equally be used here. Examples of such bases include: alkali metal carbonates, such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydrogencarbonates, such as sodium hydrogencarbonate, potassium hydrogencarbonate and lithium hydrogencarbonate; alkali metal hydrides, such as lithium hydride, sodium hydride and potassium hydride; alkali metal hydroxides, such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides, such as sodium fluoride and potassium fluoride; and alkali metal alkoxides, such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium t-butoxide and lithium methoxide. Of these, we particularly prefer the alkali metal hydrides and alkali metal alkoxides.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 100° C., more preferably from 0 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 30 minutes to 12 hours, will usually suffice.

Step A7

In this Step, a compound of formula (XI) is prepared by reducing the amide group of a compound of formula (X) in a solvent using a reducing agent to convert into an imino group; it is then optionally reprotected with a group R¹².

The reaction in the main step is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; and ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether. Of these, we particularly prefer the ethers, most preferably diethyl ether or tetrahydrofuran.

There is likewise no particular restriction on the nature of the reducing agents used, and any reducing agent commonly used in reactions of this type may equally be used here. Examples of such reducing agents include: hydride reagents, such as alkali metal borohydrides (e.g. sodium borohydride or lithium borohydride), aluminum hydride compounds (e.g. lithium aluminum hydride or lithium tri-t-butoxyaluminohydride), sodium tellurium hydride, and organic aluminum hydride reducing agents [e.g. diisobutylaluminum hydride or sodium bis(methoxyethoxy)aluminum hydride] and borane reducing agents (e.g. borane-dimethyl sulfide complex or borane-tetrahydrofiran complex, etc.). Of these, we particularly prefer the aluminum hydride compounds and borane reducing agents, further still more prefer the borane reducing agents, most preferably borane-dimethyl sulfide complex.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −78 to 150° C., more preferably from −20 to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 5 minutes to 24 hours, more preferably from 10 minutes to 2 hours, will usually suffice.

Step A8

In this Step, a compound of formula (XIII) in which an imino group of the compound of formula (XI) is modified with a group of formula —A—B—R¹ (A, B and R¹ are as defined above) is prepared by reacting the compound of formula (XI) with a compound of formula (XII) in a solvent and in the presence of a base.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds, such as nitroethane and nitrobenzene; and nitrites, such as acetonitrile and isobutyronitrile. Of these, we particularly prefer the halogenated hydrocarbons and ethers, most preferably methylene chloride or tetrahydrofuran.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline, N,N-diethylaniline, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO) and 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU). Of these, we particularly prefer triethylamine or diisopropylethylamine.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 100° C., more preferably from 0 to 20° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 5 minutes to 24 hours, more preferably from 10 minutes to 12 hours, will usually suffice.

When A represents a carbonyl group, this Step may also be accomplished by reacting the compound of formula (XI) with a compound of formula R¹—B—A—OH (in which A, B and R¹ are as defined above) and a condensing agent in a solvent in the presence or absence of a base.

Examples of the condensing agent which may be used include those described above in relation to Step A1b(ii). Of these, we prefer a combination of a phosphonate and one or more of the bases described below.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline and N,N-diethylaniline.

If desired, 4-(dimethylamino)pyridine or 4-pyrrolidinopyridine can be used in a catalytic amount in combination with one or more of the other bases. The efficiency of the reaction may, if desired, be improved by carrying it out in the presence of one or more of the following: dehydrating agents (e.g. molecular sieves), quaternary ammonium salts (e.g. benzyltriethylammonium chloride or tetrabutylammonium chloride), crown ethers (e.g. dibenzo-18-crown-6) and acid scavengers (e.g. 3,4-dihydro-2H-pyrido[1,2-a]pyrimidin-2-one).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

Step A9

In this Step, a compound of formula (XIV) is prepared by removing the group R¹² (where R¹² is a group other than a hydrogen atom) from the compound of formula (XIII) and converting the resulting hydroxy group into an elimination group Y″, which may be effected by the procedure described in the first stage of Step A4.

The method used to remove the group R¹² will vary depending on the nature of that group. However, methods of removing such groups are well known in this technical field.

For example, when the group R¹² is a silyl group, it can normally be removed by treatment with a compound forming a fluorine anion (e.g. tetrabutylammonium fluoride, hydrogen fluoride, hydrogen fluoride-pyridine or potassium fluoride) or by treatment with an organic acid (e.g. acetic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoromethanesulfonic acid or B-bromocatechol borane) or an inorganic acid (e.g. hydrochloric acid).

When the group R¹² is removed by the fluorine anion, the reaction may sometimes be promoted by adding an organic acid, such as formic acid, acetic acid or proplonic acid.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitrites, such as acetonitrile and isobutyronitrile; water; and organic acids, such as acetic acid; or a mixture of any two or more thereof.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C., more preferably from 10 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 to 48 hours, more preferably from 2 to 12 hours, will usually suffice.

When the group R¹² is an aralkyl or aralkyloxycarbonyl group, it may preferably be removed by contacting it with a reducing agent (preferably by a catalytic hydrogenation reaction at ambient temperature in the presence of a catalyst) in a solvent or by using an oxidizing agent.

The catalytic hydrogenation reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: alcohols, such as methanol, ethanol and isopropanol; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran and dioxane; aromatic hydrocarbons, such as benzene, toluene and xylene; aliphatic hydrocarbons, such as hexane and cyclohexane; esters, such as ethyl acetate and propyl acetate; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone and hexamethylphosphoric triamide; fatty acids, such as formic acid and acetic acid; water; or a mixture of any two or more thereof. Of these, we particularly prefer the alcohols, fatty acids and a mixture of an alcohol and an ether, a mixture of an alcohol and water or a mixture of a fatty acid and water.

There is likewise no particular restriction on the nature of the catalysts used, and any catalyst commonly used in catalytic, hydrogenation reactions of this type may equally be used here. Examples of such catalysts include: palladium-on-carbon, palladium black, Raney nickel, platinum oxide, platinum black, rhodium-aluminum oxide, triphenylphosphine-rhodium chloride and palladium-barium sulfate.

There is no particular restriction on the pressure employed, and the reaction is normally conducted under a pressure within the range of from 1 to 10 atmospheres.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 100° C., more preferably from 20 to 70° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 5 minutes to 48 hours, more preferably from 1 to 24 hours, will usually suffice.

If the protecting group is to be removed by oxidation, the reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. A water-containing organic solvent is preferred. Examples of suitable organic solvents include: ketones, such as acetone; halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride, chloroform and carbon tetrachloride; nitrites, such as acetonitrile; ethers, such as diethyl ether, tetrahydrofuran and dioxane; amides, such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; and sulfoxides, such as dimethyl sulfoxide.

There is likewise no particular restriction on the nature of the oxidizing agents used, and any oxidizing agent commonly used in reactions of this type may equally be used here. Examples of such oxidizing agents include: potassium persulfate, sodium persulfate, cerium ammonium nitrate (CAN) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours will usually suffice.

It is also possible to remove the protecting group by reaction with an alkali metal (e.g. metallic lithium or metallic sodium) in liquid ammonia or an alcohol (e.g. methanol or ethanol) at a temperature of from −78 to −20° C.

It is also possible to remove the protecting group by reaction with aluminum chloride-sodium iodide or an alkylsilyl halide (e.g. trimethylsilyl iodide) in a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: nitrites, such as acetonitrile; halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride and chloroform; or a mixture of any two or more thereof.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 5 minutes to 3 days will usually suffice.

When the reaction substrate has a sulfur atom, aluminum chloride-sodium iodide is preferably used.

When the group R¹² is an aliphatic acyl group, an aromatic acyl group or an alkoxycarbonyl group, it is preferably removed by treating it with a base in a solvent.

There is no particular restriction on the nature of the bases used provided that it has no adverse effect on any other part of the compound, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: metal alkoxides, such as sodium methoxide; alkali metal carbonates, such as sodium carbonate, potassium carbonate or lithium carbonate; alkali metal hydroxides, such as sodium hydroxide, potassium hydroxide, lithium hydroxide or barium hydroxide; or various forms of ammonia, such as aqueous ammonia or concentrated ammonia-methanol.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent and any solvent commonly used for hydrolysis reactions may equally be employed here. Examples of suitable solvents include: water; organic solvents, such as alcohols (e.g. methanol, ethanol or propanol) and ethers (e.g. tetrahydrofuran or dioxane); or a mixture of water and one or more of the above organic solvents are preferred.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, in order to inhibit secondary reactions, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 to 10 hours will usually suffice.

When the group R¹² is an alkoxymethyl group, a tetrahydropyranyl group, a tetrahydrothiopyranyl group, a tetrahydrofuranyl group, a tetrahydrothiofuranyl group or a substituted ethyl group, it is normally removed by treatment with an acid in a solvent.

There is likewise no particular restriction on the nature of the acids used, and any acid commonly used in reactions of this type may equally be used here. Examples of such acids include: Bronsted acids, such as inorganic acids (e.g. hydrochloric acid, sulfuric acid or nitric acid); organic acids (e.g. acetic acid, trifluoroacetic acid, methanesulfonic acid or p-toluenesulfonic acid); and Lewis acids, such as boron trifluoride. A strong acidic cation exchange resins, such as Dowex (trade mark) 50W, can also be used.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; alcohols, such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol, isoamyl alcohol, diethylene glycol, glycerin, octanol, cyclohexanol and methylcellosolve; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; water; or a of any two or more mixture thereof. Of these, we particularly prefer the halogenated hydrocarbons, esters and ethers.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −10 to 100° C., more preferably from −5 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 5 minutes to 48 hours, more preferably from 30 minutes to 10 hours, will usually suffice.

When the group R¹² is an alkenyloxycarbonyl group, it is preferably removed by treatment with a base under the same condition as are used to remove the group R¹² when that group is an aliphatic acyl group, an aromatic acyl group or an alkoxycarbonyl group.

In case of an allyloxycarbonyl group, it may be removed by using palladium and triphenylphosphine or bis(methyldiphenylphosphine)(1,5-cyclooctadiene)iridium(I)hexafluorophosphate, which is simple and can be conducted with little side reactions.

Step A10

In this Step, a compound of formula (I), which is a compound of the present invention, is prepared by reacting a compound of formula (XIV) with a compound of formula (XV) in a solvent and in the presence of a base.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane, heptane, ligroin and petroleum ether, aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds, such as nitroethane and nitrobenzene; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide and sulfolane. Of these, we prefer the amides, ethers and nitriles, most preferably the amides.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: a combination of a metal iodide (e.g. potassium iodide) and an inorganic base, such as an alkali metal carbonate (e.g. sodium carbonate, potassium carbonate or lithium carbonate), an alkali metal hydrogencarbonate (e.g. sodium hydrogencarbonate, potassium hydrogencarbonate or lithium hydrogencarbonate), an alkali metal hydride (e.g. lithium hydride, sodium hydride or potassium hydride), an alkali metal hydroxide (e.g. sodium hydroxide, potassium hydroxide, barium hydroxide or lithium hydroxide) or an alkali metal fluoride (e.g. sodium fluoride or potassium fluoride); or an organic base such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)-4-methylpyridine, quinoline, N,N-dimethylaniline, N,N-diethylaniline, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Of the various bases, we particularly prefer the combination of a metal iodide and an inorganic base, most preferably a combination of a metal iodide and an alkali metal hydrogencarbonate.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C., more preferably from 20 to 120° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to 48 hours, more preferably from 1 to 12 hours, will usually suffice.

After the completion of the respective reactions described above, the compounds produced by these reactions may be collected from the reaction mixture by a conventional process.

For example, in one suitable isolation procedure, the reaction mixture is appropriately neutralized and, after insoluble matter, if any, has been removed by filtration, a water-immiscible solvent (e.g. ethyl acetate) is added. The organic layer is separated, and washed with, for example, water, and the desired compound is dried, for example over anhydrous magnesium sulfate or anhydrous sodium sulfate. Then, the solvent is distilled off to give the desired compound.

The desired compound can, if desired, be isolated and purified by any one or more of the following procedures: recrystallization; reprecipitation; or another process which is normally used for isolation and purification of organic compounds, for example an adsorption column chromatography process using a carrier, such as silica gel, alumina or magnesium-silica gel, Florisil; a process using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trade mark) LH-20 (manufactured by Pharmacia Co.), Amberlite (trade mark) XAD-11 (manufactured by Rohm & Haas Co.), Diaion (trade mark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); a process using ion-exchange chromatography; or a normal/reverse phase liquid chromatography process (preferably high performance liquid chromatography) using silica gel or alkylated silica gel.

When isomers must be isolated, the isolation can be conducted by the above isolation and purification means after the completion of the reactions of the above respective steps or at the suitable time after the completion of the desired steps.

Reaction Scheme B

This provides an alternative method of preparing the compound of formula (IV), which may thereafter be used as shown in Reaction Scheme A to prepare the compound of the present invention.

In the above formulae, R² is as defined above.

Step B1

In this Step, a compound of formula (IV) is prepared by: reacting a compound of formula (XVI) with metallic magnesium according to the process of Ito et al. [described in Bull. Chem. Soc. Jpn., Vol. 64, page 3746 (1991)], to give a Grignard reagent; coupling this Grignard reagent with diketene of formula (XVII) in a solvent in the presence or absence of a Lewis acid and in the presence of a catalytic amount (preferably from 0.1 to 0.5 equivalents) of a palladium catalyst; and reacting the resulting carboxylic acid according to the optional step described in Step A1 to esterify it.

The reaction can be accomplished in a good yield with few by-products when conducted in the presence of the Lewis acid, which is, accordingly preferred. There is no particular restriction on the nature of the Lewis acid, if used, and any Lewis acid commonly used in reactions of this type may equally be used here. Examples of such Lewis acids include: trialkylsilyl trifluoromethanesulfonates having from 1 to 6 carbon atoms in the alkyl part, such as trimethylsilyl trifluoromethanesulfonate; aluminum salts, such as aluminum chloride; tin salts, such as tin tetrachloride; zinc salts, such as zinc bromide or zinc chloride; titanium salts, such as titanium tetrachloride; or perchlorates, such as trimethylsilyl perchlorate or triphenylmethyl perchlorate. Of these, we particularly prefer the zinc salts, most preferably zinc chloride.

The palladium catalyst used may be any one which contains palladium, and is not particularly limited. Preferred examples include organophosphine palladium compounds, such as dichloro bis(triphenylphosphine)palladium(II).

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether. Of these, we particularly prefer diethyl ether.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 50° C., more preferably from 0 to 20° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 15 minutes to 8 hours, more preferably from 30 minutes to 2 hours, will usually suffice.

After the completion of the above reaction, the desired compound of formula (IV) may be isolated from the reaction mixture by conventional means.

For example, in one suitable isolation procedure, the reaction mixture is appropriately neutralized and, after insoluble matter, if any, has been removed by filtration, a water-immiscible solvent (e.g. ethyl acetate) is added. The organic layer is separated and washed with, for example, water. The desired compound is then dried, for example over anhydrous magnesium sulfate or anhydrous sodium sulfate. Then, the solvent is distilled off to give the desired compound.

The desired compound can, if desired, be isolated and purified by any one or more of the following procedures: recrystallization; reprecipitation; or another process which is normally used for isolation and purification of organic compounds, for example an adsorption column chromatography process using a carrier, such as silica gel, alumina or magnesium-silica gel, Florisil; a process using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trade mark) LH-20 (manufactured by Pharmacia Co.), Amberlite (trade mark) XAD-11 (manufactured by Rohm & Haas Co.), Diaion (trade mark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); a process using ion-exchange chromatography; or a normal/reverse phase liquid chromatography process (preferably high performance liquid chromatography) using silica gel or alkylated silica gel.

Reaction Scheme C

This provides an alternative method of preparing the compound of formula (XI), which may thereafter be used as shown in Reaction Scheme A to prepare the compound of the present invention.

In the above formulae, R², R¹¹, R¹², D, E and G are as defined above.

R¹³ represents a hydrogen atom or a hydroxy-protecting group and may be any of the same groups defined and exemplified above for the group R¹¹.

R¹⁴ represents an amino-protecting group, and examples thereof include the aliphatic acyl groups, the aromatic acyl groups, the alkoxycarbonyl groups, the alkenyloxycarbonyl groups, the aralkyloxycarbonyl groups and the silyl groups as defined and exemplified above, preferably an alkoxycarbonyl group. Of these, we particularly prefer the t-butoxycarbonyl group.

Step C1

In this Step, an epoxy compound of formula (XVIII) is prepared by reacting the exo-methylene group of a compound of formula (V) with an oxidizing agent in a solvent.

There is likewise no particular restriction on the nature of the oxidizing agents used, and any oxidizing agent commonly used in epoxidation reactions of olefins may equally be used here. Examples of such oxidizing agents include: peracids, such as m-chloroperbenzoic acid, 3,5-dinitroperbenzoic acid, o-carboxyperbenzoic acid, peracetic acid, pertrifluoroacetic acid and perphthalic acid; hydrogen peroxide; peroxides, such as t-butyl hydroperoxide (which may be used in combination with vanadium or a molybdenum complex); and a combination of a succinimide (e.g. N-bromosuccinimide) and an alkali. Of these, we particularly prefer the peracids, most preferably m-chloroperbenzoic acid.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride and chloroform; ethers, such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; amides, such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols, such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol and isoamyl alcohol; dilute acids, such as aqueous sulfuric acid; dilute bases, such as an aqueous solution of sodium hydroxide; water; ketones, such as acetone and methyl ethyl ketone; organic bases, such as pyridine; nitriles, such as acetonitrile; or a mixture of any two or more of the above solvents. Of these, we particularly prefer methylene chloride.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from −5 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 to 24 hours, more preferably from 2 to 12 hours, will usually suffice.

An optically active epoxy compound having a specific absolute configuration can be produced by conducting an asymmetric epoxidation reaction using a chiral ligand, for example, according to the process of Sharpless et al. or the process of Jacobsen et al. [see Catalytic Asymmetric Synthesis, VCH Publishers Inc. (1993)].

Step C2

In this Step, a compound of formula (XX) is prepared by ring-opening the epoxy group of the epoxy compound of formula (XVM) using an amino alcohol compound of formula (XIX) in the presence or absence of a base (Step C2a) and then protecting the secondary amino group thus formed with a group R¹⁴ (Step C2b).

Step C2a

The ring opening reaction in the first stage is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile, propionitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide and sulfolane. Of these, we particularly prefer the nitriles.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: alkali metal perchlorates, such as lithium perchlorate and sodium perchlorate; alkali metal carbonates, such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydrogencarbonates, such as sodium hydrogencarbonate, potassium hydrogencarbonate and lithium hydrogencarbonate; alkali metal hydrides, such as lithium hydride, sodium hydride and potassium hydride; alkali metal hydroxides, such as sodium hydroxide, potassium hydroxide, barium hydroxide and lithium hydroxide; alkali metal fluorides, such as sodium fluoride and potassium fluoride; alkali metal alkoxides, such as sodium methoxide, sodium ethoxide, potassium methoxide, potassium ethoxide, potassium t-butoxide and lithium methoxide; alkali metal mercaptans, such as sodium methylmercaptan, sodium ethylmercaptan; and organic bases such as N-methylmorpholine, triethylamine, tripropylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)4methylpyridine, quinoline, N,N-dimethylaniline, N,-diethylaniline, 1,5-diazabicyclo[4.3.0]non-5-ene(DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO) and 1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 150° C., more preferably from room temperature to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

Step C2b

Protection of the secondary amino group with a group R¹⁴ in this stage may be carried out as follows.

Step C2b(i)

The unprotected compound is reacted with a suitable amount, for example from 1 to 4 equivalents (preferably from 2 to 3 equivalents) of a compound of formula R¹⁴—X″ (in which R¹⁴ is as defined above and in which X″ represents an elimination group capable of being eliminated as a nucleophilic residue, and is not specifically limited), or with a compound of formula R¹⁴—O—R¹⁴ (in which R¹⁴ is a group of the acyl type selected from those defined above for R¹⁴), in a solvent in the presence or absence of a base. Preferred examples of such elimination groups include: halogen atoms, such as the chlorine, bromine and iodine atoms; alkoxycarbonyloxy groups having from 1 to 6 carbon atoms in the alkoxy part, such as the methoxycarbonyloxy and ethoxycarbonyloxy groups; haloalkylcarbonyloxy groups having from 1 to 6 carbon atoms in the alkyl part, such as the chloroacetoxy, dichloroacetoxy, trichloroacetoxy and trifluoroacetoxy groups; alkanesulfonyloxy groups having from 1 to 6 carbon atoms, such as the methanesulfonyloxy and ethanesulfonyloxy groups; haloalkanesulfonyloxy groups having from 1 to 6 carbon atoms, such as the trifiuoromethanesulfonyloxy and pentafluoroethanesulfonyloxy groups; arylsulfonyloxy groups in which the aryl part is as defined and exemplified above in relation to R¹ etc., such as the benzenesulfonyloxy, p-toluenesulfonyloxy and p-nitrobenzenesulfonyloxy groups. Of these, we particularly prefer the halogen atoms, the haloalkanesulfonyloxy groups and the arylsulfonyloxy groups.

Specific examples of such compounds of formula R¹⁴—X″ include: acyl halides, such as aliphatic acyl halides (e.g. acetyl chloride, propionyl chloride, butyryl chloride, valeryl chloride and hexanoyl chloride), alkoxycarbonyl halides having from 1 to 6 carbon atoms in the alkoxy part (e.g. methoxycarbonyl chloride, methoxycarbonyl bromide, ethoxycarbonyl chloride, propoxycarbonyl chloride, butoxycarbonyl chloride and hexyloxycarbonyl chloride), and arylcarbonyl halides, (e.g. benzoyl chloride, benzoyl bromide and naphthoyl chloride); silyl halides, such as t-butyldimethylsilyl chloride, trimethylsilyl chloride, triethylsilyl chloride, triethylsilyl bromide, triisopropylsilyl chloride, dimethylisopropylsilyl chloride, diethylisopropylsilyl chloride, t-butyldiphenylsilyl chloride, diphenylmethylsilyl chloride and triphenylsilyl chloride or the corresponding silyl trifluoromethane-sulfonates; aralkyl halides, such as benzyl chloride and benzyl bromide; or carbonyloxyalkyl halides, such as pivaloyloxymethyl chloride or ethoxycarbonyl-oxymethyl chloride.

Specific examples of such compounds of formula R¹⁴—O—R¹⁴ include aliphatic carboxylic anhydrides, such as acetic anhydride, propionic anhydride, valeric anhydride or hexanoic anhydride, and carbonates, such as di-t-butyl dicarbonate. A mixed acid anhydride (e.g. the mixed anhydride of forrric and acetic acids) can also be used.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; and amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: organic bases such as N-methylmorpholine, triethylamine, tributylamine, diisopropylethylamine, dicyclohexylamine, N-methylpiperidine, pyridine, 4-pyrrolidinopyridine, picoline, 4-(N,N-dimethylamino)pyridine, 2,6-di(t-butyl)4methylpyridine, quinoline, N,N-dimethylaniline and N,N-diethylaniline.

If desired, 4(N,N-dimethylamino)pyridine or 4-pyrrolidinopyridine can be used in a catalytic amount in combination with one or more of the other bases. The efficiency of the reaction may, if desired, be improved by effecting it in the presence of one or more of the following: quatemary ammonium salts (e.g. benzyltriethylammonium chloride or tetrabutylammonium chloride) and crown ethers (e.g. dibenzo-18-crown-6).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20° C. to the reflux temperature of the solvent employed, more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 1 hour to 1 day, will usually suffice.

Step C2b(ii)

The unprotected compound is reacted with a compound of formula R¹⁴—OH (in which R¹⁴ is a group of the acyl type selected from those defined above for R¹⁴) in a solvent in the presence of a condensing agent and in the presence or absence of a base.

Examples of condensing agents which may be used include those given above in Step A1b(ii).

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofiran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether, nitrites, such as acetonitrile and isobutyronitrile; and amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide.

Examples of bases which may be used in this step are as given above in relation to Step C2b(i).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 80° C., more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 1 day, will usually suffice.

Step C2b(iii)

Particularly, when R¹⁴ is a t-butoxycarbonyl group or a benzyloxycarbonyl group, the compound formed in Step C1b is reacted with a t-butoxycarbonylating agent or a benzyloxycarbonylating agent in a solvent in the presence of a base, and thus the secondary amino group can be protected with the R¹⁴ group.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; water; and mixtures of water with any one or more of the above organic solvents.

The bases employed in this Step may be any of those suggested above in Step C1c(i).

There is likewise no particular restriction on the nature of the t-butoxy-carbonylating agents used, and any t-butoxycarbonylating agent commonly used in reactions of this type may equally be used here. Examples of such t-butoxy-carbonylating agents include: di-t-butyl dicarbonate, 2-(t-butoxycarbonyloxy-imino)-2-phenyl acetonitrile, t-butyl S-(4,6-dimethylpyrimidin-2-yl)thiolcarboxylate and 1,2,2,2-tetrachloroethyl t-butyl carbonate, more preferably di-t-butyl dicarbonate.

There is likewise no particular restriction on the nature of the benzyloxycarbonylating agents used, and any benzyloxycarbonylating agent commonly used in reactions of this type may equally be used here. Examples of such benzyloxycarbonylating agents include: benzyloxycarbonyl chloride, benzyloxycarbonyl cyanide and dibenzyl dicarbonate.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20° C. to 80° C., more preferably from 0° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to three days, more preferably from 30 minutes to 24 hours, will usually suffice.

Step C3

In this Step, a compound of formula (XXI) is prepared by dehydrating a compound of formula (XX) using the Mitsunobu reaction

There is no particular restriction on the nature of the reagents used in the Mitsunobu reaction, and any reagent commonly used in reactions of this type may equally be used here. Examples of such reagents include: combination of azo compounds, such as dialkyl azodicarboxylates having from 1 to 6 carbon atoms in the alkyl part (e.g. diethyl azodicarboxylate or diisopropyl azodicarboxylate) or azodicarbonyls [e.g. 1,1′-(azodicarbonyl)dipiperidine]; and phosphines, such as triarylphosphines in which the aryl part is as defined and exemplified above in relation to R¹ etc. (e.g. triphenylphosphine) or trialkylphosphines having from 1 to 6 carbon atoms in each alkyl part (e.g. tributylphosphine). Of these, we particularly prefer the combination of a dialkyl azodicarboxylate and a triarylphosphine, most preferably a combination of diethyl azodicarboxylate and triphenylphosphine.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether, nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; and sulfoxides, such as dimethyl sulfoxide and sulfolane. Of these, we prefer the aromatic hydrocarbons and the ethers.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20 to 100° C., more preferably from 0 to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 30 minutes to 12 hours, will usually suffice.

In the course of carrying out the present step, a group R¹¹ is sometimes removed. In that case, the hydroxy group can be protected again according to the second part of Step A2.

Step C4

In this Step, a compound of formula (XI) is prepared by simultaneously or separately conducting the following:

(i) removal of the amino-protecting group R¹⁴ to leave an amino group, and

(ii) optional removal of a group R¹² when the group R¹² is a hydroxy-protecting group.

Step C4(i)

The reaction employed to remove the group R¹⁴ will vary, depending on the nature of the group, but reactions which may be employed to remove such groups are well known in this technical field.

Step C4(i)a

For example, if the amino-protecting group is a silyl group, it is normally removed by treatment with a compound which forms fluorine anions, such as tetrabutylammonium fluoride.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: ethers, such as tetrahydrofuran or dioxane.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of about room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 18 hours will usually suffice.

Step C4(i)b

When the amino-protecting group is an aliphatic acyl group, an aromatic acyl group, an alkoxycarbonyl group or a substituted methylene group which forms a Schiff base, it can be removed by treatment with an acid or a base in the presence of an aqueous solvent.

There is no particular restriction on the nature of the acids used, and any acid commonly used in reactions of this type may equally be used here. Examples of such acids include: inorganic acids, such as hydrochloric acid, sulfuric acid, phosphoric acid and hydrogen bromide; and Lewis acids, such as B-bromocatechol borane. Of these, we prefer B-bromocatechol borane or hydrochloric acid.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitro compounds, such as nitroethane and nitrobenzene. Of these, we particularly prefer the halogenated hydrocarbons.

There is likewise no particular restriction on the nature of the bases used, provided that it has no adverse effect on any other part of the compound, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: metal alkoxides, such as sodium methoxide; alkali metal carbonates, such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal hydroxides, such as sodium hydroxide, potassium hydroxide and lithium hydroxide; and ammonia in various forms, such as aqueous ammonia or concentrated methanolic ammonia.

In the hydrolysis using a base, isomerization sometimes occurs.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, and any solvent commonly used for hydrolysis reactions may be used, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: water, organic solvents, such as alcohols (e.g. methanol, ethanol or propanol) and ethers (e.g. tetrahydrofuran or dioxane); or a mixture of water and one or more of the above organic solvents.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, in order to inhibit side reactions, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 to 10 hours will usually suffice.

Step C4(i)c

When the amino-protecting group is an aralkyl or aralkyloxycarbonyl group, we prefer to remove it by contacting it with a reducing agent in a solvent (preferably by catalytic hydrogenation at ambient temperature in the presence of catalyst) or by using an oxidizing agent.

The catalytic hydrogenation reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: organic solvents, such as alcohols (e.g. methanol, ethanol or isopropanol), ethers (e.g. diethyl ether, tetrahydrofuran or dioxane), aromatic hydrocarbons (e.g. toluene, benzene or xylene), esters (e.g. ethyl acetate or propyl acetate) and aliphatic acids (e.g. acetic acid) or a mixture of one or more of these organic solvents and water.

There is likewise no particular restriction on the nature of the catalysts used in the catalytic hydrogenation reaction, and any catalyst commonly used in reactions of this type may equally be used here. Examples of such catalysts include: palladium-on-carbon, palladium black, Raney nickel, platinum oxide, platinum black, rhodium-aluminum oxide, triphenylphosphine-rhodium chloride and palladium-barium sulfate.

There is no particular restriction on the pressure employed, and the reaction is normally conducted under a pressure within the range of from 1 to 10 atmospheres.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 to 24 hours will usually suffice.

The oxidation reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. A mixture of water and an organic solvent is preferred. Examples of suitable organic solvents include: ketones, such as acetone; halogenated hydrocarbons, especially halogenated aliphatic hydrocarbons, such as methylene chloride, chloroform and carbon tetrachloride; nitriles, such as acetonitrile; ethers, such as diethyl ether, tetrahydroflran and dioxane; and amides, such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide.

There is likewise no particular restriction on the nature of the oxidizing agents used, and any oxidizing agent commonly used in oxidation reactions of this type may equally be used here. Examples of such oxidizing agents include: potassium persulfate, sodium persulfate, cerium ammonium nitrate (CAN) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ).

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours will usually suffice.

Step C4(i)d

When the amino-protecting group is an alkenyloxycarbonyl group, it is preferably removed by treating the protected compound with a base under the same conditions as are employed when the amino-protecting group is an aliphatic acyl group, an aromatic acyl group, an alkoxycarbonyl group or a substituted methylene group which forms a Schiff base.

In case of an allyloxycarbonyl group, it may be removed by using palladium and triphenylphosphine or nickel tetracarbonyl, which is a simple process that can be conducted with few side reactions.

Step C4(ii)

The removal of the group R¹² may be carried out according to the same procedure as that described in Step A9.

After the completion of any of the above reactions, the desired compound may be isolated from the reaction mixture by conventional means.

For example, in one suitable isolation procedure, the reaction mixture is appropriately neutralized and, after insoluble matter, if any, is removed by filtration, a water-immiscible organic solvent (e.g. ethyl acetate) is added. The organic layer is then separated and washed with, for example, water. The desired compound is then dried over, for example, anhydrous magnesium sulfate or anhydrous sodium sulfate. The solvent is then removed by distillation to give the desired compound.

The desired compound can, if desired, be isolated and purified by any one or more of the following procedures: recrystallization; reprecipitation; or another process which is normally used for isolation and purification of organic compounds, for example an adsorption column chromatography process using a carrier, such as silica gel, alumina or magnesium-silica gel, Florisil; a process using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trade mark) LH-20 (manufactured by Pharmacia Co.), Amberlite (trade mark) XAD-11 (manufactured by Rohm & Haas Co.), Diaion (trade mark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); a process using ion-exchange chromatography; or a normal/reverse phase liquid chromatography process (preferably high performance liquid chromatography) using silica gel or an alkylated silica gel.

Reaction Scheme D

In this Reaction Scheme, a compound of formula (I) in which E represents a methylene group, that is to say a compound of formula (Ia), is prepared from a compound of formula (VIII), which may have been prepared as described in Reaction Scheme A, above.

Step D1

In this Step, a compound of formula (XIa) is prepared by reacting the amino group and the group of formula DH of a compound of formula (VIII) with paraformaldehyde in the presence or absence of an acid catalyst and in the presence or absence of a solvent to form an oxazolidine or thiazolidine ring.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane, heptane, ligroin and petroleum ether; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, ethyl acetate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitro compounds, such as nitroethane and nitrobenzene; nitriles, such as acetonitrile, isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide; and sulfoxides, such as dimethyl sulfoxide and sulfolane. Of these, we prefer the aromatic hydrocarbons, most preferably benzene and toluene.

There is likewise no particular restriction on the nature of the acid catalysts used, and any acid catalyst commonly used in reactions of this type may equally be used here. Examples of such acid catalysts include: Bronsted acids, such as inorganic acids (e.g. hydrochloric acid, hydrobrornic acid, sulfuric acid, perchloric acid or phosphoric acid) or organic acids (e.g. acetic acid, formic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, camphorsulfonic acid, trifluoroacetic acid or trifluoromethanesulfonic acid). Of these, we prefer the organic acids, most preferably p-toluenesulfonic acid.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 50 to 200° C., more preferably from 80 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to 48 hours, more preferably from 1 to 12 hours, will usually suffice.

Steps D2, D3 & D4

These Steps correspond to Steps A8, A9 and A10, respectively, and may be carried out using the same reagents and reaction conditions, ultimately to give a compound of formula (Ia).

The desired compound can, if desired, be isolated and purified by any one or more of the following procedures: recrystallization; reprecipitation; or another process which is normally used for isolation and purification of organic compounds, for example an adsorption column chromatography process using a carrier, such as silica gel, alumina or magnesium-silica gel, Florisil; a process using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trade mark) LH-20 (manufactured by Pharmacia Co.), Amberlite (trade mark) XAD-1 I (manufactured by Rohm & Haas Co.), Diaion (trade mark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); a process using ion-exchange chromatography; or a normal/reverse phase liquid chromatography process (preferably high performance liquid chromatography) using silica gel or an alkylated silica gel.

Reaction Scheme E

In this Reaction Scheme, a highly preferred compound of formula (I) in which L represents a fused ring system having a sulfoxide group in which the sulfur atom is in the S-configuration, that is to say the optically active sulfoxide compound of formula (Ib), is prepared.

In the above formulae:

Ar, R¹, R², A, B, D, E, J and Y″ are as defined above;

S*→O represents a sulfoxide group in which the sulfur atom is in the S-configuration.

This reaction corresponds to Step A10 and may be carried out using the same reagents and reaction conditions, to give a compound of formula (Ib).

Reaction Scheme F

This Reaction Scheme provides an alternative method of preparing the optically active sulfoxide compound of formula (Ib).

In the above formulae:

R¹, R², A, B, D, E, G′, J, Ar and S*→O are as defined above; and

Step F1

In this Step, an aldehyde derivative of formula (XXII) is prepared by oxidizing an alcohol derivative of formula (XIIIf). This reaction is usually carried out in a solvent in the presence of an oxidizing agent.

There is no particular restriction on the nature of the oxidation reactions used, and any oxidation reaction commonly used for forming an aldehyde from a primary alcohol may equally be used here. Examples of such oxidation reactions include: Collins oxidation which is carried out in methylene chloride using pyridine and chromic acid; PCC oxidation which is carried out in methylene chloride using pyridinium chlorochromate (PCC); PDC oxidation which is carried out in methylene chloride using pyridinium dichromate (PDC); DMSO oxidation such as Swem oxidation which is carried out in methylene chloride using an electrophilic agent (e.g., acetic anhydride, trifluoroacetic anhydride, thionyl chloride, sulfuryl chloride, oxalyl chloride, dicyclohexylcarbodiimide, diphenylketene-1-tolylimine, N,N-diethylaminoacetylene, N,N-Dimethylamino-phenylacetylene, sulfur trioxide and pyridine complex) and dimethyl sulfoxide (DMSO); and manganese dioxide oxidation which is carried out in methylene chloride or benzene using manganese dioxide.

Preferably, Swern oxidation which is carried out in methylene chloride using oxalyl chloride and DMSO is employed.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −100° C. to room temperature, more preferably from −78° C. to −20° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to two days, more preferably from 10 minutes to 6 hours, will usually suffice.

Step F2

In this Step, an optically active sulfoxide derivative of formula (Ib) is prepared by reacting a compound of formula (XXIII) with the compound of formula (XXII) by means of a reductive amination reaction.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: alcohols such as methanol, ethanol and propanol; and ethers such as diethyl ether, tetrahydrofuran and dioxane. Of these, we prefer the alcohols, most preferably methanol or ethanol.

There is likewise no particular restriction on the nature of the reducing agents used, and any reducing agent commonly used in reactions of this type may equally be used here. Examples of such reducing agents include: hydride reagents such as alkali metal borohydrides such as sodium cyanoborohydride, sodium borohydride and lithium borohydride; aluminum hydride compounds such as lithium aluminum hydride and lithium tri-t-butoxyaluminohydride; sodium tellurium hydride; and organoaluminum hydride reducing agents such as diisobutylaluminum hydride and sodium bibs(methoxyethoxy)aluminum hydride. Of these, we prefer the alkali metal borohydrides, most preferably sodium cyanoborohydride.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −10° C. to 100° C., more preferably from room temperature to 80° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to two days, more preferably from one hour to 6 hours, will usually suffice.

Reaction Scheme G

This provides an alternative method of preparing a compound of formula (XI), which may then be used to prepare a compound of the present invention.

In the above formulae:

R², R¹¹, R¹², R¹³, R¹⁴, D, E and G are as defined above; and

This Reaction Scheme describes the preparation of compounds of formula (XI) wherein the ring has from 6 to 8-members.

Step G1

In this Step, a compound of formula (XX) is prepared by converting the primary hydroxy group of the diol compound of formula (VI) into a group to be eliminated (Step G1a), which is then replaced by the amino group of an amino alcohol compound of formula (XIX) to form a secondary amino group (Step G1b), which is then protected with an R¹⁴ group (Step G1c).

Step G1a

The conversion of the primary hydroxy group of the diol compound of formula (VI) into a group to be eliminated may be effected by the procedure described in the first stage of Step A4.

Step G1b

The reaction of replacing the group to be eliminated in the resulting compound by an amino group of the amino alcohol compound of formula (XIX) is usually carried out in a solvent using a metal salt.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydroflran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitriles, such as acetonitrile, propionitrile and isobutyronitrile; and amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methyl-pyrrolidone and hexamethylphosphoric triamide. Of these, we prefer the nitriles, more preferably acetonitrile.

There is likewise no particular restriction on the nature of the metal salts used, and any metal salt commonly used in reactions of this type may equally be used here. Examples of such metal salts include: metal perchlorates, such as lithium perchlorate, magnesium perchlorate and sodium perchlorate; metal chlorides, such as calcium chloride, zinc chloride and cobalt chloride; metal tetrafluoroborates, such as lithium tetrafluoroborate and potassium tetrafluoroborate; and zinc trifluoromethanesulfonate, preferably metal perchlorates, more preferably lithium perchlorate.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20° C. to 150° C., more preferably from room temperature to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to 2 days, more preferably from 2 hours to 24 hours, will usually suffice.

Step G1c

The final step of protecting the secondary amino group with the R¹⁴ group may be carried out as described in Step C2b.

Step G2

In this Step, a compound of formula (XXI) is prepared by subjecting the compound of formula (XX) to a Mitsunobu reaction so as to effect dehydration and ring closure.

This reaction is essentially the same as that described in Step C3, and may be carried out using the same reagents and reaction conditions.

It should be noted that the R¹¹ and R¹⁴ groups may be eliminated during the process of this step. In such cases, the imino group can, if necessary, be protected again with the R¹⁴ group according to the procedures of Step G1c; while the hydroxy group can be protected again with the R¹¹ group, according to the procedures of Steps A2(i) to (iii).

Step G3

In this Step, a compound of formula (XI) is prepared by removing the R¹¹ and R¹⁴ groups of the compound of formula (XXI). This reaction is essentially the same as that described in Step C4(i), and may be carried out using the same reagents and reaction conditions.

Reaction Scheme H

This Reaction Scheme illustrates the preparation of a compound of formula (XXXII), which corresponds to the compound of formula (V) wherein the group represented by G has two carbon atoms.

In the above formulae

R², R¹⁰, and R¹¹ are as defined above;

R¹⁵ represents an alkyl group having from 1 to 6 carbon atoms, as defined and exemplified above in relation to R⁵, preferably a methyl, ethyl, propyl or isopropyl group, or two groups R¹⁵ may together represent an alkylene group having from 1 to 6 carbon atoms, preferably a methylene, ethylene or trimethylene group; and

W″ represents a halogen atom, more preferably a chlorine atom.

Step H1

In this Step, a β-ketoester derivative of formula (XXIX) is prepared from a compound of formula (XXVIII). This reaction may be effected by conventional procedures according to, for example, the method of J. Wemple et al. [Synthesis, 290 (1993)].

Step H2

In this Step, a ketal is prepared by reacting the β-ketoester derivative of formula (XXIX) with an alcohol having the formula R¹⁵—OH (wherein R¹⁵ is as defined above), with an alkanediol having the formula HO—R¹⁵′—OH (wherein R¹⁵′ represents an alkylene group to be formed by the two R¹⁵ groups together) or with an orthoformic acid ester having the formula (R¹⁵—O)₃CH (wherein R¹⁵ is as defined above). This reaction may be carried out, for example, in the alcohol or the alkanediol in the presence or absence of an acid catalyst with heating.

Examples of alcohols having the formula R¹⁵—OH include methanol, ethanol, propanol and isopropanol, preferably ethanol.

Examples of alkanediols having the formula HO—R¹⁵′—OH include ethylene glycol and propylene glycol.

Examples of orthoformic acid esters having the formula (R¹⁵—O)₃CH include trimethoxymethane and triethoxymethane, preferably triethoxymethane.

This step is preferably carried out with heating in ethanol in the presence of ethyl orthoformate using p-toluenesulfonic acid as the catalyst.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 40° C. to 150° C., more preferably from 50° C. to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to two days, more preferably from two hours to 12 hours, will usually suffice.

Step H3

In this Step, the ester of formula (XXX) is reduced to form a primary hydroxy group, the ketal group is then deprotected, and then the primary hydroxy group is protected with a group R¹¹, to prepare a compound of formula (XXXI).

The reaction to reduce the ester is essentially the same as that in the first stage of Step A2, and may be carried out using the same reagents and reaction conditions.

The deprotection of the ketal group is usually carried out in a solvent in the presence of an acid, preferably in chloroform using trifluoroacetic acid.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20° C. to 100° C., more preferably from −10° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 30 minutes to 2 hours, will usually suffice.

The reaction protecting the primary hydroxy group may be carried out according to any of Steps A2(i) to (iii), preferably according to Step A2(i).

Step H4

In this Step, a compound of formula (XXXII) is prepared by converting the carbonyl group of the compound of formula (XXXI) into an exo-methylene group by the Wittig reaction in a solvent in the presence of a base. The reaction in this step is essentially the same as that in Step A1c, and may be carried out using the same reagents and reaction conditions.

In the above formulae, G, R² and R¹¹ are as defined above.

This is another process for preparing the compound of formula (V), which may then be used in Reaction Scheme A or C.

Step 11

In this Step, a compound of formula (V) is prepared by reacting a compound of formula (XVI) with metallic magnesium by any conventional method to prepare a Grignard reagent and thereafter carrying out a cross coupling reaction of the above-mentioned Grignard reagent with a compound of formula (XXXIII) using a palladium catalyst or a nickel catalyst.

There is no particular restriction on the nature of the palladium catalysts used, and any palladium catalyst commonly used in reactions of this type may equally be used here. Examples of such palladium catalysts include: tetrakis(triphenylphosphine)palladium(0), bis(acetonitrile)palladium(II) chloride, bis(triphenylphosphine)palladium(II) chloride, [1,1′-bis(diphenylphosphino)-ferrocene]palladium(II) chloride, tris(dibenzylideneacetone)dipalladium(0), [1,2-bis(diphenylphosphino)ethane]dichloropalladium(II) and palladium(II) acetate.

There is likewise no particular restriction on the nature of the nickel catalysts used, and any nickel catalyst commonly used in reactions of this type may equally be used here. Examples of such nickel catalysts include: bis(triphenylphosphine)-nickel(II) chloride, [1,3-bis(diphenylphosphino)propane]nickel(II) chloride and nickel(II) acetylacetonate.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, and dimethoxyethane diethylene glycol dimethyl ether, more preferably diethyl ether or tetrahydrofuran.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0° C. to 120° C., more preferably from at room temperature to 80° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 30 minutes to 5 hours, will usually suffice.

Reaction Scheme J

This Reaction Scheme illustrates the preparation of the optically active sulfoxide compound of formula (XXII) used as a starting material in Reaction Scheme E.

In the above formulae:

R¹⁴, J, the ring Ar and the formula S*→O are as defined above.

Q represents a hydroxy group or a halogen atom such as a chlorine, bromine, iodine or fluorine atom; and.

Q′ represents a halogen atom, preferably a bromine atom.

Step J1

In this Step, a compound of formula (XXXV) is prepared from a compound of formula (XXXIV)

Step J1a

When Q represents a hydroxy group, this step can be achieved by converting the hydroxy group of the compound of formula (XXXIV) into an acetylthio group, followed by hydrolysis of the acetylthio group using a base so as to remove the acetyl group.

The first stage of these reactions may be achieved:

(a) by converting the hydroxy group of the compound of formula (XXXIV) into a group to be eliminated, followed by reaction of the group to be eliminated with a salt of thioacetic acid; or

(b) by carrying out a Mitsunobu reaction using thioacetic acid.

The reaction converting the hydroxy group into a group to be eliminated in (a) may be carried out according to the latter substep in Step A9; whereas the thioacetyl group substitution reaction is usually achieved by reaction with a salt of thioacetic acid in a solvent.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitriles, such as acetonitrile, propionitrile and isobutyronitrile; and amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide. Of these, we prefer the amides, more preferably dimethylformamide.

Examples of salts of thioacetic acid which may be employed in this reaction include metal salts of thioacetic acid such as lithium thioacetate, sodium thioacetate and potassium thioacetate.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20° C. to 150° C., more preferably from room temperature to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to two days, more preferably from 2 hours to 24 hours, will usually suffice.

The Mitsunobu reaction in (b) described above may be carried out in the same manner as in Step C3 except that the compound of formula (XXXIV) and thioacetic acid are employed.

The reaction eliminating the acetyl moiety in the acetylthio group can be achieved by treating it with a base in a solvent.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: metal alkoxides, such as sodium methoxide; alkali metal carbonates, such as sodium carbonate, potassium carbonate and lithium carbonate; alkali metal and alkaline earth metal hydroxides, such as sodium hydroxide, potassium hydroxide, lithium hydroxide and barium hydroxide; and various forms of ammonia such as aqueous ammonia water or concentrated methanolic ammonia

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, and any solvent commonly employed in hydrolysis reactions may be used, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: water; organic solvents, for example, alcohols (such as methanol, ethanol or propanol), ethers (such as tetrahydrofuran or dioxane) or a mixture of water with any one or more of these organic solvents.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, in order to control side reactions, we find it convenient to carry out the reaction at a temperature of from 0 to 150° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from one to 10 hours will usually suffice.

Step J1b

Where Q is a halogen atom, this step can be achieved by heating the compound of formula (XXXIV) and thiourea in a solvent to effect reaction therebetween, followed by hydrolysis.

The first stage of this reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include alcohols, such as methanol, ethanol and isopropanol.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from room temperature to 150° C., more preferably from 50° C. to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to four days, more preferably from 12 hours to 24 hours, will usually suffice.

The hydrolysis in the latter substep is usually carried out in a mixture of water with one or more of the alcohols described above.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from room temperature to 150° C., more preferably from 50° C. to 100° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 30 minutes to 6 hours, more preferably from 30 minutes to 2 hours, will usually suffice.

Step J2

In this Step, a compound of formula (XXXV) is reacted with a compound of formula (XXXVI) in a solvent in the presence of a base to provide a compound of formula (XXXVII).

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methylpyrrolidinone and hexamethylphosphoric triamide. Of these, we prefer the ethers, most preferably tetrahydrofuran.

There is likewise no particular restriction on the nature of the bases used, and any base commonly used in reactions of this type may equally be used here. Examples of such bases include: alkali metal hydrides, such as lithium hydride, sodium hydride and potassium hydride; and organometallic bases, such as butyllithium, sec-butyllithium, t-butyllithium, lithium diisopropylamide and lithium bis(trimethylsilyl)amide. Of these, we prefer the organometallic bases, most preferably butyllithium.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −100° C. to 100° C., more preferably from −78° C. to 0° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 0.5 hour to 10 hours, more preferably from 1 hour to 6 hours, will usually suffice.

Step J3

In this Step, a compound of formula (XXXVII) is dehydrated in the presence or absence of a solvent and in the presence of an acid to close a ring and to prepare a compound of formula (XXXVII).

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: alcohols, such as methanol and ethanol; aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, isophorone and cyclohexanone; nitriles, such as acetonitrile and isobutyronitrile; amides, such as formamide, dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, N-methyl pyrrolidinone and hexamethylphosphoric triamide. Of these, we prefer methanol or ethanol.

There is likewise no particular restriction on the nature of the acids used, and any acid commonly used in reactions of this type may equally be used here. Examples of such acids include: Brønsted acids, such as inorganic acids (e.g. hydrogen chloride, hydrobromic acid, sulfuric acid, perchloric acid or phosphoric acid) and organic acids (e.g. acetic acid, formic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, trifluoroacetic acid and trifluoromethanesulfonic acid), and Lewis acids, such as boron trichloride, boron trifluoride and boron tribromide, or acidic ion exchange resins. Of these, we prefer the inorganic acids, most preferably sulfuric acid.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from 0° C. to 150° C., more preferably from 50° C. to 120° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 24 hours, more preferably from 5 hours to 24 hours, will usually suffice.

Step J4

In this Step, an optically active sulfoxide derivative of formula (XXXIX) from a compound of formula (XXXVIII) and is achieved by

(a) directly carrying out an asymmetric oxidation of the compound of formula (XXXVIII) or

(b) oxidizing the compound of formula (XXXVIII) and thereafter optically resolving the compound by a diastereomeric method.

(a) The asymmetric oxidation in which a sulfoxide is obtained from a sulfide may be a chemical method using an optically active oxidizing agent, a chemical method using a combination of an chiral ligand and an oxidizing agent or a biological method using baker's yeasts and microorganisms. Such an asymmetric oxidation is, for example, described in the following references:

1) G. Solladie, Synthesis 185 (1981):

2) K. K. Andersen, The Chemistry of Sulfones and Sulfoxides: S. Patai, Z. Rappoport, C. J. M. Stirling., Eds. Wiley & Sons, Ltd.; Chichester, England, 1988, Chapter 3, pp 55-94: G. H. Posner., ibid. Chapter 16, pp 823-849:

3) H. B. Kagan et al., Synlett 643 (1990):

4) H. B. Kagan, Asymmetric Oxidation of Sulfides in Catalytic Asymmetric Synthesis 1, Ojima Ed. VCH, pp 203-226 (1993):

5) F. A. Davis et al., J.Am.Chem.Soc., 114, 1428 (1992).

Of these, the asymmetric oxidation is preferable, in which (3′S, 2R)-(−)-N-(phenylsulfonyl) (3,3-dichlorocamphoryl)oxazolidine or (+)-[(8,8-dimethoxycamphoryl) sulfonyl] oxazolidine as reported by F. A. Davis et al. is used.

Where the asymmetric oxidation is carried out according to the method of F. A. Davis et al., the reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: water; alcohols, such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol and isoamyl alcohol; aliphatic hydrocarbons, such as hexane and heptane; aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride, chloroform, carbon tetrachloride, dichloroethane, chlorobenzene and dichlorobenzene; esters, such as ethyl formate, propyl acetate, butyl acetate and diethyl carbonate; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, dimethoxyethane and diethylene glycol dimethyl ether; nitrites, such as acetonitrile and isobutyronitrile; and pyridine.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −50° C. to 50° C., more preferably from −20° C. to room temperature. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 10 minutes to 3 days, more preferably from 2 hours to 1 day, will usually suffice.

(b) When carrying out optical resolution by a diastereomeric method, a compound of formula (XXXVIII) is first oxidized by a conventional method to synthesize a racemate of the sulfoxide derivative. Then, an optically active sulfoxide derivative (XXXIX) can be obtained by removing the protecting group, as described in Step C4(i), and thereafter by forming a salt using an appropriate optically active carboxylic acid as an optical resolving reagent, and by carrying out fractional recrystallization.

The oxidation reaction of the former step is ordinarily carried out in the presence or absence of a solvent and using an oxidizing agent.

There is likewise no particular restriction on the nature of the oxidizing agents used, and any oxidizing agent commonly used in reactions of this type in which a sulfide is oxidized to produce a sulfoxide may equally be used here. Examples of such oxidizing agents include: peracids, such as m-chloroperbenzoic acid, 3,5-dinitroperbenzoic acid, o-carboxyperbenzoic acid, peracetic acid, pertrifluoroacetic acid and perphthalic acid; and a combination of a succinimide, such as N-bromosuccinimide and an alkali, more preferably a peracids, most preferably m-chloroperbenzoic acid.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. Examples of suitable solvents include: aromatic hydrocarbons, such as benzene, toluene and xylene; halogenated hydrocarbons, such as methylene chloride and chloroform; ethers, such as diethyl ether, tetrahydrofuran, dioxane and dimethoxyethane; amides, such as dimethylformamide, dimethylacetamide and hexamethylphosphoric triamide; sulfoxides, such as dimethyl sulfoxide; alcohols, such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol and isoamyl alcohol; dilute acids, such as aqueous sulfuric acid; dilute bases, such as aqueous sodium hydroxide; water; ketones, such as acetone and methyl ethyl ketone; organic bases, such as pyridine; nitrites, such as acetonitrile; or a mixture of any two or more of these solvents, more preferably a halogenated hydrocarbon, and most preferably methylene chloride.

The reaction can take place over a wide range of temperatures, and the precise reaction temperature is not critical to the invention. The preferred reaction temperature will depend upon such factors as the nature of the solvent, and the starting material or reagent used. However, in general, we find it convenient to carry out the reaction at a temperature of from −20° C. to 80° C., more preferably from −5° C. to 50° C. The time required for the reaction may also vary widely, depending on many factors, notably the reaction temperature and the nature of the reagents and solvent employed. However, provided that the reaction is effected under the preferred conditions outlined above, a period of from 1 hour to 24 hours, more preferably from 2 hours to 12 hours, will usually suffice.

The optical resolving agent employed for carrying out optical resolution is not particularly limited and examples include tartaric acid, camphor-10-sulfonic acid and mandelic acid, particularly preferably mandelic acid.

The reaction is normally and preferably effected in the presence of a solvent. There is no particular restriction on the nature of the solvent to be employed, provided that it has no adverse effect on the reaction or on the reagents involved and that it can dissolve the reagents, at least to some extent. A suitable solvent is acetonitrile.

The salt thus obtained by the resolution is converted to a corresponding amine by using an aqueous alkali, such as aqueous sodium hydroxide, followed by extraction with a solvent which is not dissolved in water (for example, an aromatic hydrocarbon, such as benzene, toluene or xylene; a halogenated hydrocarbon, such as methylene chloride or chloroform; or an ether, such as diethyl ether) to isolate an optically active sulfoxide derivative of formula (XXXIX).

Step J5

In this Step, a compound of formula (XXII) is prepared by removing the protective group R¹⁴ group from the compound of formula (XXXIX). The reaction may be carried out using any of the procedures described in Step C4(i).

After the completion of any of the above reactions, the desired compound may be isolated from the reaction mixture by conventional means.

For example, in one suitable isolation procedure, the reaction mixture is appropriately neutralized and, after insoluble matter, if any, has been removed by filtration, a water-immiscible solvent (e.g. ethyl acetate) is added. The organic layer is separated and washed with, for example, water. The desired compound is then dried, for example over anhydrous magnesium sulfate or anhydrous sodium sulfate. Then, the solvent is distilled off to give the desired compound.

The desired compound can, if desired, be isolated and purified by any one or more of the following procedures: recrystallization; reprecipitation; or another process which is normally used for isolation and purification of organic compounds, for example an adsorption column chromatography process using a carrier, such as silica gel, alumina or magnesium-silica gel, Florisil; a process using a synthetic adsorbent, for example, partition column chromatography using Sephadex (trade mark) LH-20 (manufactured by Pharmacia Co.), Amberlite (trade mark) XAD-11 (manufactured by Rohm & Haas Co.), Diaion (trade mark) HP-20 (manufactured by Mitsubishi Kasei Co., Ltd.); a process using ion-exchange chromatography; or a normal/reverse phase liquid chromatography process (preferably high performance liquid chromatography) using silica gel or alkylated silica gel.

The starting materials [for example, the compound of formula (XXXIV), etc.] can be purchased commercially or the materials can be easily synthesized according to well known preparation methods.

BIOLOGICAL ACTIVITY

The novel compounds of the present invention have a superior antagonistic effect on substance P and neurokinin A receptors. Moreover, since they have low toxicity, they are useful for the prevention and therapy of tachykinin-mediated diseases, examples of which include diseases of the central nervous system including anxiety, depression, psychosis and schizophrenia; neurodegenerative diseases including dementia of AIDS, Alzheimer's senile dementia, Alzheimer's disease, Down's syndrome, demyelinating disease, amyotrophic lateral sclerosis, neuropathy, peripheral neuropathy and neuralgia; respiratory diseases including chronic obstructive lung disease, bronchitis, pneumonia, bronchoconstriction, asthma and cough; inflammatory diseases, such as inflammatory bowel diseases (IBD), psoriasis, fibrosis, arthrosteitis, degenerative arthritis and rheumatoid arthritis; allergic diseases including eczema and rhinitis; hypersensitivity diseases including hypersensitivity to vines; ophthalmological diseases including conjunctivitis, vernal conjunctivitis, vernal catarrh, destruction of the blood-aqueous humor barrier caused by various inflammatory eye diseases, elevated intraocular pressure and miosis; skin diseases including contact dermatitis, atopic dermatitis, urticaria and other eczematoid dermatitis; addictions including alcohol dependency; somatic diseases caused by stress; sympathetic reflex dystrophy including hand and shoulder syndrome; dysthymia; undesirable immune reactions including rejection of grafts, diseases relating to immunopotentiation including systemic lupus erythematosus or immunosuppression; digestive diseases including diseases caused by abnormalities in nerves regulating the organs, colitis, ulcerative colitis and Crohn's disease; emesis including emesis induced by adverse effects of X-ray irradiation and chemotherapy, poisons, toxins, pregnancy, vestibular disorders, postoperative illness, gastrointestinal occlusion, reduced gastrointestinal movement, visceral pain, migraine headache, increased intracranial pressure, reduced intracranial pressure or administration of various drugs; urinary bladder functional diseases including cystitis and urinary incontinence; eosinophilia caused by collagen diseases, scleriasis and Fasciola hepatica infection; diseases caused by abnormal blood flow due to vasodilation or vasoconstriction including angina pectoris, migraine headache and Reynauds's disease; and, pain of pain nociceptive reception including migraine headache, headache and toothache.

The compounds of the present invention can be administered orally, for example in the form of tablets, capsules, granules, powders or syrups, or administered parenterally, for example in the form of injection preparations or suppositories. These preparations may be produced using additives, such as excipients [e.g. sugar derivatives, such as lactose, sucrose, glucose, mannitol or sorbitol; starch derivatives, such as corn starch, potato starch, α-starch, dextrin or carboxymethyl starch; cellulose derivatives, such as crystalline cellulose, low substitution degree hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxymethylcellulose calcium or internally cross-linked carboxymethylcellulose sodium; gum arabic; dextran; organic excipients, such as pullulan; silicate derivatives, such as light anhydrous silicic acid, synthetic aluminum silicate or magnesium aluminate metasilicate; phosphates, such as calcium phosphate; carbonates, such as calcium carbonate; inorganic excipients, such as sulfates (e.g. calcium sulfate), ]; lubricants [e.g. stearic acid and metal stearates, such as calcium stearate, and magnesium stearate; talc; colloidal silica; waxes, such as bee gum, and spermaceti; boric acid; adipic acid; sulfates, such as sodium sulfate; glycol; fumaric acid; sodium benzoate; L leucine; fatty acid sodium salts; laurylsulfates, such as sodium laurylsulfate, and magnesium laurylsulfate; silicic acids, such as anhydrous silicic acid, and silicate hydrate; and the above starch derivatives]; binders [e.g. polyvinyl pyrrolidone, macrogol and the same compounds as those of the above excipients]; disintegrators [e.g. the same compounds as those of the above excipients and chemically modified starchcelluloses, such as croscarmellose sodium, carboxymethylstarch sodium, and cross-linked polyvinylpyrrolidone]; stabilizers [e.g. paraoxybenzoates, such as methylparaben, and propylparaben; alcohols, such as chlorobutanol, benzyl alcohol, and phenethyl alcohol; benzalkonium chloride; phenols, such as phenol, cresol; thimerosal; dehydroacetic acid; and sorbic acid]; corrigents [e.g. normally used sweetening agents, sour agents, and perfumes]; and diluents according to a per se known process.

The dose varies depending on the severity of the disease, as well as the age and body weight of the patient, and the administration route. For example, in the case of oral administration, it is advantageous that the compound of the present invention should be administered one to several times per day with a dose of from 0.01 mg/kg body weight (preferably 0.1 mg/kg body weight, lower limit) to 100 mg/kg body weight (preferably 50 mg/kg body weight, upper limit) according to the severity of diseases. In case of intravenous administration, it is advantageous that the compound of the present invention is administered one to several times per day with a dose of 0.01 mg/kg body weight (preferably 0.05 mg/kg body weight, lower limit) to 100 mg/kg body weight (preferably 50 mg/kg body weight, upper limit) according to the severity of the disease.

The biological activity of the compounds of the present invention may be assessed by the following tests.

NK₁Receptor Binding Test

(a) Preparation of Crude Lung Membrane Fraction

A crude membrane fraction was prepared from the lung of male Hartley guinea pigs. The guinea pigs were bled from the cava abdominalis under chloroform anaesthesia and the pulmonary airway tissue was extracted immediately.

The extracted lung was perfused with a buffer (1) (50 mM Tris-HCl, pH 7.4), thinly cut in the buffer, and then homogenised in a buffer (2) [buffer (1) containing 120 mM sodium chloride and 5 mM potassium chloride] using a Polytron homogenizer. The tissue mass was removed from the homogenate by filtration with a nylon mesh (50 μm) and the supernatant was centrifuged (30,000×g, 30 minutes, 4° C.). The resultant pellet was resuspended in an ice-cooled buffer (3) [buffer (1) containing 10 mM EDTA and 300 mM potassium chloride], allowed to stand at 4° C. for 60 minutes and then washed centrifugally twice (30,000×g, 15 minutes, 4° C.).

The crude membrane fraction was preserved at −80° C. before use.

(b) Receptor Binding Test

To a mixed solution (250 μl) of the test drug and [³H]-substance P (final concentration: 1 nM) (50 mM Tris-HCl, pH 7.4; 6 mM manganese chloride, 800 μg/ml BSA, 8 μg/ml chymostatin, 8 μg/ml leupeptin, 80 μg/ml bacitracin, 20 μg/ml phosphoramidon) was added a crude lung membrane fraction solution (250 μl), followed by incubation at room temperature for 30 minutes.

At the end of this time, a lung membrane ingredient was recovered on a GF/B glass fiber filter (manufactured by Whatman Co.) using an automatic filtering device (manufactured by Brandel Co.).

The glass filter was used after being pre-treated with a 0.1% polyethyleneimine solution for about 4 hours so as to inhibit non-specific binding as little as possible. The membrane ingredient-recovered filter was transferred to a mini-plastic vial containing a pico flow (4 ml) and the radioactivity was measured using a liquid scintillation counter (LSC3000, manufactured by Beckman Co.).

The results are shown in Table 4:

TABLE 4 Test Compound IC₅₀ (ng/ml) Compound of Example 75 5.9 Compound A 38 Compound B >1000 Compound C 6.5

As can be seen from the above results, the compound of the present invention exhibited an activity against NK₁ receptors which is at least equal to that of Compound C, which exhibited the strongest activity of the closest compounds of the prior art.

NK₂ Receptor Binding Test

(a) Preparation of Crude Ileum Membrane Fraction

A crude membrane fraction was prepared from the ileum of male Hartley guinea pigs. The guinea pigs were bled from the cava abdominalis under chloroform anaesthesia and the ileum was extracted immediately.

After the contents, secreta and epithelium of the lumen had been scraped off using a glass slide, the extracted ileum was thinly cut in a buffer (1) (50 mM Tris-HCl, pH 7.4) and then homogenised in a buffer (2) [buffer (1) containing 120 mM sodium chloride and 5 mM potassium chloride] using a Polytron homogenizer.

The tissue mass was removed from the homogenate by filtration with a nylon mesh (50 μm) and the supernatant was centrifuged (30,000×g, 30 minutes, 4° C.). The resultant pellet was resuspended in an ice-cooled buffer (3) [buffer (1) containing 10 mM EDTA and 30 mM potassium chloride], allowed to stand at 4° C. for 60 minutes and then washed centrifugally twice (30,000×g, 15 minutes, 4° C.).

The crude membrane fraction was preserved at −80° C. before use.

(b) Receptor Binding Test

To a mixed solution (250 μl) of the test drug and [³H]-SR-48968 (manufactured by Amasham Co., final concentration: 1 nM) (50 mM Tris-HCl, pH 7.4; 4.6 mM manganese chloride, 800 μg/ml BSA, 8 μg/ml chymostatin, 8 μg/ml leupeptin, 80 μg/ml bacitracin, 20 g/ml phosphoramidon) was added a crude ileum membrane fraction solution (250 μl), followed by incubation at room temperature for 30 minutes.

At the end of this time, a membrane ingredient was recovered on a GF/B glass fiber filter (manufactured by Whatman Co.) using an automatic filtering device (manufactured by Brandel Co.). The glass filter was used after pre-treatment with a 0.1% polyethyleneimine solution for about 4 hours so as to inhibit non-specific binding as little as possible.

The membrane ingredient-recovered filter was transferred to a mini-plastic vial containing a pico flow (4 ml) and the radioactivity was measured using a liquid scintillation counter (LSC3000, manufactured by Beckman Co.).

The compound of the present invention showed a good activity to NK₁ and NK₂ receptors in comparison with the compounds of the prior art.

The results are shown in Table 5:

TABLE 5 Test Compound IC₅₀ (ng/ml) Compound of Example 75 0.85 Compound A 18 Compound B 2.2 Compound C 31

As can be seen from the above results, the compound of the present invention exhibited an activity against NK₂ receptors which is greater than that of any of the closest compounds of the prior art. Moreover, Compound C, which exhibited the strongest activity in the NK₁ binding test, here exhibited very weak activity.

Inhibitory Effect on SP-Induced Increased Vascular Permeability

The inhibitory effect on increased vascular permeability induced by substance P (SP), an NK₁ receptor agonist, was assessed based on the amount of pigment leakage as an index using guinea pigs (body weight: approx. 400 g, male Hartley guinea pigs). Immediately after administering pigment (Evans blue: 20 mg/kg, i.v.) and the test drug in that order into the femoral vein of the guinea pigs under pentobarbital anaesthesia (25 mg/kg, i.p.), increased vascular permeability was induced by administration of SP (1 mg/kg, i.v.). Fifteen minutes later, the guinea pigs were sacrificed by chloroform anaesthesia and the amount of pigment that leaked into the primary bronchus was measured according to the method of Harada (J. Pharm. Pharmacol., 23, 218, 1971). Inhibitory effect was determined based on the amount of pigment leakage found in guinea pigs not treated with the test drug, and expressed as the percent of inhibition (%) and the dose level that caused inhibition of 50% (ID₅₀).

The results are shown in Table 6:

TABLE 6 Test Compound ID₅₀ (mg/kg, i.v.) Compound of Example 75 0.025 Compound of Example 76 0.047 Compound A 5.8 Compound B >10 Compound C 0.019

As can be seen from the above results, the compounds of the present invention exhibited an inhibitory effect on Substance P-induced increased vascular permeability which is at least equal to that of Compound C, which exhibited the strongest activity of the closest compounds of the prior art.

Inhibitory Effect on NKA-Induced Bronchoconstriction

The inhibitory effect on bronchoconstriction induced with [Nle¹⁰]-NKA[4-10], an NK₂ receptor agonist having higher specificity than neurokinin A (NKA), was assessed based on airway pressure as an index according to the modified method of Konzett-Rössler [Naunyn-Schmiedebergs Arch.Exp.Pathol.Pharmakol., 195, 71, (1940)] using guinea pigs (body weight: approximately 500 g, male Hartley guinea pigs).

After canulating the trachea of the guinea pigs under pentobarbital anaesthesia (30 mg/kg, s.c.) and treatment with gallamine (20 mg/kg, i.v.), the animals were ventilated artificially with a constant volume respiration pump (UgoBasile, 7025) at a frequency of 60 per minute and a tidal volume of 8 ml/kg. Airway pressure during artificial respiration was amplified by means of a pressure transducer (Nihon Koden, TP-200T) installed in a branch of the trachea cannula, detected (Nihon Koden, AP-610G), and recorded with a recorder (Nihon Koden, WT-685G). Following pre-treatment with atropine (1 mg/kg, i.v.) and propranolol (1 mg/kg, i.v.), the test drug was administered intravenously. Five minutes later, bronchoconstriction was induced with [Nle¹⁰]-NKA[4-10] at 4 mg/kg, i.v., and then airway pressure was measured for 10 minutes. The inhibitory effect was determined based on the intensity of bronchoconstriction of guinea pigs not treated with the test drug, and expressed as the percent of inhibition (%) and the dose level that caused inhibition of 50% (ID50).

The results are shown in Table 7:

TABLE 7 Test Compound ID₅₀ (mg/kg, i.v.) Compound of Example 75 0.074 Compound of Example 76 0.047 Compound A >10 Compound B 0.37 Compound C 1.7

As can be seen from the above results, the compounds of the present invention exhibited an activity against NK₂ receptors which is greater than that of any of the closest compounds of the prior art.

It is apparent from the above data that the compounds of the present invention exhibited strong activity against both NK₁ and NK₂ receptors. Moreover, the compounds of the present invention have an activity against the NK₁ receptors which is at least equal to that of the closest prior art compounds, and has a stronger activity against the NK₂ receptors than that of the closest prior art compounds.

PREPARATION 1 N,N-Dimethyl-1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxamide

1.0 g (3.27 mmole) of t-butoxycarbonyl-4-phenylpiperidine-4-carboxylic acid was dissolved in 20 ml of anhydrous methylene chloride, and 690 mg (3.6 mmole) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 490 mg (3.6 mmole) of 1-hydroxybenzotriazole, 1.3 ml (7.53 mmole) of diisopropylethylamine and 295 mg (3.93 mmole) of dimethylamine hydrochloride were added to the resulting solution, which was then stirred under a nitrogen atmosphere at room temperature for 15 hours. At the end of this time, the reaction mixture was diluted with methylene chloride, washed with water and with a saturated aqueous solution of sodium chloride, in that order, and then dried over anhydrous sodium sulfate.

The solvent was then removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography using a gradient elution method, with mixtures of ethyl acetate and hexane ranging from 10:1 to 7:1 by volume as the eluent, to give 925 mg (yield 85%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.34 (2H, doublet of triplets, J=6.7 & 1.9 Hz); 7.26-7.21 (3H, multiplet); 3.96 (2H, broad singlet); 3.21 (2H, broad singlet); 2.85 (3H, broad singlet); 2.60 (3H, broad singlet); 2.31 (2H, doublet, J=12.05 Hz); 1.87 (2H, broad singlet); 1.45 (9H, singlet). Mass spectrometric analysis (EI) m/z: 332 (M⁺). “EI” represents “Electron Ionization”.

PREPARATION 2 N,N-Dimethyl-4-phenylpiperidine-4-carboxamide Hydrochloride

900 mg (2.7 mmole) of N,N-dimethyl-1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxamide (prepared as described in Preparation 1) were dissolved in 10 ml of ethyl acetate, and 5 ml of a 4 N solution of hydrogen chloride in dioxane were added, whilst ice-cooling. The mixture was then stirred at 0° C. for 1 hour. At the end of this time, the crystals which had deposited were collected by filtration, to give 690 mg (yield 95%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, hexadeuterated dimethyl sulfoxide) δ ppm: 9.02 (1H, broad singlet); 7.43 (2H, triplet, J=7.6 Hz); 7.31 (1H, doublet, J=7.2 Hz); 7.23 (2H, doublet, J=7.1 Hz); 3.25 (2H, doublet, J=13.1 Hz); 3.03 (2H, triplet, J=12.1 Hz); 2.79 (3H, broad singlet); 2.54 (3H, broad singlet); 2.37 (2H, doublet, J=12.9 Hz); 2.11 (2H, doublet of triplets, J=13.4 & 3.3 Hz). Mass spectrometric analysis (EI) m/z: 232 (free form, M⁺).

PREPARATION 3 Spiro[Benzo[c]thiophene-1(3H),4′-piperidine]hydrochloride

3(a) 1′-Cyanospiro[benzo[c]thiophene-1(3H),4′-piperidine]

2.34 g (22.1 mmole) of bromine cyanide were dissolved in 20 ml of anhydrous chloroform, and an anhydrous chloroform solution of 2.2 g (10 mmole) of 1′-methylspiro[benzo[c]thiophene-1(3H),4′-piperidine] [synthesised according to the process described in J. Org. Chem., Vol. 41, page 2628 (1976)] was added dropwise under reflux under a nitrogen atmosphere over a period of 20 minutes. The mixture was then heated under reflux for 9 hours, after which the reaction mixture was cooled and poured into ice-cooled aqueous 1 N aqueous hydrochloric acid. The chloroform layer was then separated, washed with water and dried over anhydrous sodium sulfate.

The solvent was then removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a 1:9 by volume mixture of ethyl acetate and hexane as the eluent, to obtain 1.3 g (yield 56%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.38-7.27 (3H, multiplet); 7.21 (1H, doublet of doublets, J=1.9 & 6.4 Hz); 4.20 (2H, singlet); 3.51 (2H, multiplet); 3.37 (2H, doublet of triplets, J=2.2 & 12.9 Hz); 2.29 (2H, doublet of triplets, J=4.6 & 12.9 Hz); 1.91 (2H, multiplet). Mass spectrometric analysis (FAB) m/z: 231 (M+H)⁺ FAB is “Fast Atom Bombardment”.

3(b) 1′-t-Butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]

1.3 g (5.64 mmole) of 1′-cyanospiro[benzo[c]thiophene-1(3H),4′-piperidine] [prepared as described in step (a) above] were dissolved in 20% w/v aqueous hydrochloric acid, and the solution was heated under reflux for 20 hours. At the end of this time, the reaction mixture was cooled and washed with ethyl acetate. The aqueous layer was separated and made basic by the addition of a 10% w/v aqueous solution of sodium hydroxide; it was then extracted three times with chloroform. The solvent was then removed from the combined extracts by distillation under reduced pressure, and the resulting residue was dissolved in anhydrous methylene chloride. 1.15 ml (8.18 mmole) of triethylamine were then added, and 1.45 g (6.64 mmole) of di-t-butyl dicarbonate were added, whilst ice-cooling. The mixture was then stirred at room temperature for 2 hours. At the end of this time, the reaction mixture was diluted with methylene chloride and washed, in turn, with water and with a saturated aqueous solution of sodium chloride. The organic layer was separated and dried over anhydrous sodium sulfate, after which the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a 3:97 by volume mixture of ethyl acetate and hexane as the eluent, to obtain 1.65 g (yield 96%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.28-7.24 (3H, multiplet); 7.17-7.15 (1H, multiplet); 4.23 (2H, broad singlet); 4.19 (2H, singlet); 3.02 (2H, broad singlet); 2.07 (2H, doublet of triplets, J=4.4 & 13 Hz); 1.88 (2H, multiplet); 1.49 (9H, singlet). Mass spectrometric analysis (EI) m/z: 305 (M⁺).

3(c) Spiro[Benzo[c]thiophene-1(3H),4′-piperidine]hydrochloride

150 mg (0.49 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine] [prepared as described in step (b) above] were dissolved in 3 ml of anhydrous methylene chloride, and 1 ml of a 4 N solution of hydrogen chloride in dioxane was added. The mixture was then stirred at room temperature for 1 hour. At the end of this time, the crystals which deposited were collected by filtration, to give 108 mg (yield 91%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, hexadeuterated dimethyl sulfoxide) δ ppm: 9.77 (2H, broad singlet); 7.37-7.25 (4H, multiplet); 4.24 (2H, singlet); 3.67 (2H, doublet, J=12.6 Hz); 3.26 (2H, doublet of triplets, J=12.6 & 2.5 Hz); 2.74 (2H, doublet of triplets, J=3.8 & 14.0 Hz); 2.09 (2H, doublet, J=14.0 Hz). Mass spectrometric analysis (FAB) m/z: 206 (M+H)⁺ (free form).

PREPARATION 4 Spiro[Benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide Hydrochloride

4(a) 1′-t-Butoxycarbonylspiro[benzo[c]thiophene-1(3H)4′-piperidine]-2-oxide

485 mg (1.59 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine] [prepared as described in Preparation 3(b)] were dissolved in 5 ml of anhydrous methylene chloride, and 148 mg (1.76 mmole) of sodium hydrogencarbonate were added, followed by 325 mg (1.88 mmole, content: 85%) of m-chloroperbenzoic acid, whilst ice-cooling. The reaction mixture was stirred, whilst ice-cooling, for 30 minutes, after which it was diluted with methylene chloride and then washed, in turn, with water and with a saturated aqueous solution of sodium chloride. The solution was dried over anhydrous sodium sulfate, and then the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by thin-layer chromatography, using a 2:1 by volume mixture of ethyl acetate and hexane as the developing solvent, to give 498 mg (yield 98%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.37-7.32 (3H, multiplet); 7.25-7.23 (1H, multiplet); 4.37 (1H, doublet, J=16.7 Hz); 4.13 (2H, broad singlet); 4.05 (2H, doublet, J=16.7 Hz); 3.21 (2H, broad singlet); 2.43 (1H, multiplet); 2.21 (1H, multiplet); 1.70 (1H, multiplet); 1.61 (1H, multiplet); 1.50 (9H, singlet). Mass spectrometric analysis (FAB) m/z: 322 (M+H)⁺.

4(b) Spiro[Benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide Hydrochloride

295 mg (0.92 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide [prepared as described in step (a) above] were dissolved in 3 ml of methylene chloride, and 1 ml of a 4 N solution of hydrogen chloride in dioxane was added, whilst ice-cooling. The mixture was stirred, whilst ice-cooling, for 1 hour, and then the crystals which deposited were collected by filtration, to give 173 mg (yield 75%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, hexadeuterated dimethyl sulfoxide) δ ppm: 9.13 (2H, broad singlet); 7.44-7.36 (3H, multiplet); 7.33-7.31 (1H, multiplet); 4.66 (1H, doublet, J=17 Hz); 4.08 (1H, doublet, J=17 Hz); 3.49-3.37 (2H, multiplet); 3.15-3.00 (2H, multiplet); 2.66-2.57 (1H, multiplet); 2.27-2.23 (1H, multiplet); 2.18-2.10 (1H, multiplet); 1.97-1.93 (1H, multiplet). Mass spectrometric analysis (FAB) m/z: 222 (M+H)⁺ (free form).

PREPARATION 5 Spiro[Benzo[c]thiophene-1(3H),4′-piperidine]-2,2-dioxide Hydrochloride

5(a) 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2,2-dioxide

190 g (0.59 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide [prepared as described in Preparation 4(a)] were dissolved in 30 ml of methanol, and 10 ml of an aqueous solution containing 270 mg (1.77 mmole) of Oxone (trade mark) were added. The reaction mixture was stirred at room temperature for 5 days, after which it was poured into water and then extracted twice with chloroform. The organic extract was separated and then dried over anhydrous sodium sulfate, after which the solvent was removed by distillation under reduced pressure. The resulting residue was purified by thin-layer chromatography, using a 1:1 by volume mixture of ethyl acetate and hexane as the developing solvent, to give 175 mg (yield 88%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.52-7.27 (3H, multiplet); 7.23-7.20 (1H, multiplet); 4.36 (2H, singlet); 4.10 (2H, broad singlet); 3.44 (2H, broad singlet); 2.38 (2H, multiplet); 2.00 (2H, multiplet); 1.50 (9H, singlet). Mass spectrometric analysis (FAB) m/z: 337 (M⁺).

5(b) Spiro[benzo[c]thiophene-1(3H),4′-piperidine]-2,2-dioxide Hydrochloride

170 mg (0.5 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2,2-dioxide [prepared as described in step (a) above] were dissolved in 3 ml of methylene chloride, and 1 ml of a 4 N solution of hydrogen chloride in dioxane was added, whilst ice-cooling. The mixture was then stirred, whilst ice-cooling, for 1 hour, after which the crystals which deposited were collected by filtration, to give 131 mg (yield 95%) of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, hexadeuterated dimethyl sulfoxide) δ ppm: 9.32 (2H, broad singlet) 7.51-7.35 (4H, multiplet). 4.74 (2H, singlet). 3.45-3.67 (2H, multiplet). 3.24-3.12 (2H, multiplet). 2.47-2.43 (4H, multiplet). Mass spectrometric analysis (FAB) m/z: 238 (M+H)⁺ (free form).

PREPARATION 6 Spiro[Benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide Hydrochloride

6(a) 1′-t-Butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]

81.0 g (0.40 mole) of 2-bromobenzylthiol were dissolved in 800 ml of tetrahydrofuran, and 516 ml of a solution containing 0.84 mole of butyllithium (as a 1.6 M solution in hexane) were added dropwise thereto over a period of 6 hours at a temperature of −78° C. The mixture was then stirred for 1.5 hours at the same temperature, after which 800 ml of a tetrahydrofuran solution containing 79.5 g (0.40 mole) of 1-t-butoxycarbonyl-4-piperidone was added dropwise thereto over a period of 3 hours. The solution was then stirred for a further 1 hour, and then a saturated aqueous solution of ammonium chloride was added, and the mixture was extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. 2 liters of 4 N aqueous sulfuric acid were added to the residue, and then the mixture was heated under reflux for 14 hours. At the end of this time, the solution was made basic by the addition of 350 g (8.75 mole) of sodium hydroxide, whilst ice-cooling, and then 102 g (0.47 mole) of di-t-butyl dicarbonate were added thereto. The mixture was then stirred for 1 hour. At the end of this time, the product was extracted with methylene chloride, and the organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a 97:3 by volume mixture of hexane and ethyl acetate as the eluent, to give 56 g of the title compound as white crystals, melting at 131.0-132.5° C. (after crystallisation from hexane/ethyl acetate).

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.28-7.24 (3H, multiplet); 7.17-7.15 (1H, multiplet); 4.23 (2H, broad singlet); 4.19 (2H, singlet); 3.02 (2H, broad singlet); 2.07 (2H, doublet of triplets, J=4.4 & 13 Hz); 1.88 (2H, multiplet); 1.49 (9H, singlet). Infrared absorption spectrum ν_(max) cm⁻¹ (KBr): 2970, 1680, 1428, 1234, 1163. Mass spectrometric analysis (FAB) m/z: 306 (M+H)⁺.

6(b) 1′-t-Butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide

42.0 g (0.14 mole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine] [prepared as described in step (a) above] were dissolved in 420 ml of chloroform, and 12.7 g (0.15 mole) of sodium hydrogencarbonate were added thereto. 28.0 g (0.14 mole) of m-chloroperbenzoic acid (purity 85%) were then added little by little, whilst ice-cooling. The Mixture was then stirred for 30 minutes, whilst ice-cooling, after which 10 g of potassium iodide were added, and the mixture was stirred for a further 30 minutes at room temperature. The reaction mixture was washed with water and then with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. At the end of this time, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a 1:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 42 g of the title compound as white crystals, melting at 103-107° C. (after crystallisation from diisopropyl ether).

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.37-7.32 (3H, multiplet); 7.25-7.23 (1H, multiplet); 4.37 (1H, doublet, J=16.7 Hz); 4.13 (2H, broad singlet); 4.05 (2H, doublet, J=16.7 Hz); 3.21 (2H, broad singlet); 2.43 (1H, multiplet); 2.21 (1H, multiplet); 1.70 (1H, multiplet); 1.61 (1H, multiplet); 1.50 (9H, singlet). Infrared absorption spectrum ν_(max) cm⁻¹ (KBr): 2985, 1686, 1429, 1368, 1286, 1167. Mass spectrometric analysis (FAB) m/z: 322 (M+H)⁺.

6(c) Spiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide

42.0 g (0.13 mole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide [prepared as described in step (b) above] were dissolved in 420 ml of 2-propanol, and 150 ml of a 4 N solution of hydrogen chloride in dioxane was added thereto, whilst ice-cooling. The mixture was then stirred for 4 hours. At the end of this time, 200 ml of diethyl ether were added to the mixture, and the mixture was allowed to stand for 1 hour, whilst ice-cooling. The precipitated crystals were then collected by filtration. The crystals were dissolved in 200 ml of a 5% w/v aqueous solution of sodium hydroxide. The product was extracted with methylene chloride, and the organic extract was dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, to give 21.7 g of the title compound as a white amorphous product.

6(d) Spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (S)-(+)W-mandelate

33.51 g (0.15 mole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide [prepared as described in step (c) above] were dissolved in 3350 ml of acetonitrile whilst heating, and then 11.52 g (75.7 mmole) of (S)-(+)-mandelic acid was dissolved in the resulting solution. The mixture was allowed to stand overnight at room temperature, and the crystals which precipitated were collected by filtration to give 19.62 g of the title compound as white crystals. The mother liquor was concentrated by evaporation under reduced pressure, and the resulting residue was dissolved in a 5% w/v aqueous solution of sodium hydroxide; it was then extracted with methylene chloride. The organic extract was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure, to give 22.01 g (99.5 mmole) of a residue. This residue was dissolved in 2200 ml of acetonitrile with heating, and then 7.22 g (47.5 mmole) of (R)-(−)-mandelic acid were dissolved therein. The mixture was allowed to stand overnight at room temperature, and the crystals which precipitated were collected by filtration to give 15.91 g of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2R)-oxide (R)-(−)-mandelate as white crystals. The mother liquor was concentrated by evaporation under reduced pressure, and the resulting residue was dissolved in a 5% w/v aqueous solution of sodium hydroxide and extracted with methylene chloride. The organic extract was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure, to give 11.51 g (52.0 mmole) of a residue. This residue was dissolved in 1100 ml of acetonitrile with heating, and then 3.95 g (26.0 mmole) of (S)-(+)-mandelic acid were dissolved therein. The mixture was allowed to stand overnight at room temperature. The crystals which precipitated were collected by filtration to give 4.73 g of the title compound as white crystals.

The whole of the title compound thus obtained was combined, and 24.00 g of the compound was dissolved again in 9.6 liters of acetonitrile with heating and the solution was allowed to stand overnight at room temperature. 20.13 g of precipitated crystals, melting at 197-200° C., were obtained. This product was converted into 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide, and HPLC (High Performance Liquid Chromatography) analysis indicated that its optical purity is 99.8% ee.

[α]_(D) ²⁴+78.3 (c=1, methanol); Infrared absorption spectrum ν_(max) cm⁻¹ (KBr): 3388, 3029, 1629, 1332, 1017. Mass spectrometric analysis(EI) m/z: 221 (free form, M⁺).

6(e) 1′-t-Butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

19.88 g (53.2 mmole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (S)-(+)-mandelate [prepared as described in step (d) above] were dissolved in 200 ml of a 5% w/v aqueous solution of sodium hydroxide and extracted three times, each time with 200 ml of methylene chloride. The combined organic extracts were dried over anhydrous magnesium sulfate, and then the solvent was removed by distillation under reduced pressure. 11.80 g of the resulting residue were dissolved in 300 ml of methylene chloride, and 11.2 ml (79.8 mmole) of triethylamine and 17.4 g (79.8 mmole) of di-t-butyl dicarbonate were added to the resulting solution, in that order, whilst ice-cooling. The mixture was then stirred overnight at room temperature. At the end of this time, the reaction mixture was diluted with 200 ml of methylene chloride and washed with a 10% w/v aqueous solution of citric acid and then with a saturated aqueous solution of sodium hydrogencarbonate. It was then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 4:6 to 3:7 by volume as the eluent; it was then recrystallized from diisopropyl ether, to give 13.1 g of the title compound as white crystals, melting at 129.0-130.5° C.

[α]_(D) ²⁴+57.1 (c=1, methanol); HPLC Analysis Column: ChiralCel OD (250×4.6 mmφ) Eluent: hexane:2-propanol=80:20 by volume Flow rate: 0.8 ml/min Retention time: 18.1 min.

The Nuclear Magnetic Resonance spectrum, Infrared absorption spectrum and Mass spectrometric analysis of this isomer agreed with those of the racemate produced as described in Preparation 6(b).

6(f) Spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide Hydrochloride

13.0 g (40.4 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide [prepared as described in step (e) above] were dissolved in 130 ml of 2-propanol, and 50 ml of a 4 N solution of hydrogen chloride in dioxane were added thereto, whilst ice-cooling. The mixture was stirred for 1 hour at the same temperature, after which it was stirred for a further 6 hours at room temperature. The reaction mixture was then concentrated by evaporation under reduced pressure. 200 ml of diethyl ether were then added to the residue, and the solvent was removed by distillation under reduced pressure; this procedure was repeated 3 times in all. The resulting residue was recrystallized from 300 ml of a 1:2 by volume mixture of methanol and diethyl ether, to give 9.10 g of the title compound as white crystals, melting at 209.5-210.5° C.

[α]_(D) ²⁴+63.8 (c=1, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CD₃OD) δ ppm: 7.38-7.46 (4H, multiplet); 4.69 (1H, doublet, J=17.2 Hz); 4.17 (1H, doublet, J=17.2 Hz); 3.52-3.63 (2H, multiplet); 3.25-3.40 (2H, multiplet); 2.62 (1H, multiplet); 2.51 (1H, multiplet); 2.22 (1H, multiplet); 2.06 (1H, multiplet).

6(g) 1′-t-Butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-2(S)-oxide

250 mg (0.82 mmole) of 1′-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4′-piperidine] were dissolved in 5 ml of methylene chloride, and 308 mg (0.82 mmol) of (3′S,2R)-(−)-N-(phenylsulfonyl)(3,3-dichlorocamphoryl)oxaziridine synthesized according to the method of F. A. Davis et al. [J. Am. Chem. Soc., 114, 1428 (1992)] were added to the resulting solution. The resulting mixture was then stirred overnight at room temperature. 500 mg of potassium iodide were added to the mixture, and the mixture was stirred for 30 minutes. It was then washed with water and with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the residue was purified by silica gel column chromatography, using a 1:2 by volume mixture of hexane and ethyl acetate as the eluent, to give 245 mg of the title compound.

Optical purity: 94% ee.

PREPARATION 7

3-(3,4-Dichlorophenyl)-3-butenol t-butyldimethylsilyl Ether

7(a) 3-(3,4-Dichlorophenyl)-3-oxo-1-propanol

119 g (0.46 mole) of ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate were dissolved in 2.4 liters of ethanol, and 115 ml (0.68 mole) of ethyl orthoformate and 4.4 g (22.8 mmole) of p-toluenesulfonic acid were added thereto. The mixture was then heated under reflux for 8 hours. At the end of this time, the reaction solution was poured into 1 liter of a saturated aqueous solution of sodium hydrogen-carbonate and extracted three times, each time with 700 ml of ethyl acetate. The organic extracts were combined, washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure, and the resulting residue was dissolved in 800 ml of tetrahydrofuran and then added dropwise to 4 liters of a suspension of 25.9 g (0.68 mole) of lithium aluminum hydride in tetrahydrofuran over a period of 1 hour, whilst ice-cooling. The mixture was stirred at 0° C. for 2 hours, and then 250 ml of water and 125 ml of a 10% w/v aqueous solution of sodium hydroxide were added thereto, and the mixture was stirred for a further 1 hour at room temperature. It was then filtered through a Celite (trade mark) filter aid, and the filtrate was poured into 1 liter of a saturated aqueous solution of sodium chloride and then extracted with ethyl acetate. The organic extract was dried over anhydrous sodium sulfate and concentrated by evaporation under reduced pressure. The resulting residue was dissolved in 500 ml of chloroform. 500 ml of 50% v/v aqueous trifluoroacetic acid were added to the resulting solution over a period of 30 minutes, whilst ice-cooling, and the mixture was stirred for a further 30 minutes at the same temperature. At the end of this time, the reaction solution was diluted with 300 ml of methylene chloride, and the organic layer was washed with water and then with a saturated aqueous solution of sodium hydrogencarbonate, after which it was dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a 9:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 46 g of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 8.05 (1H, doublet, J=2.0 Hz); 7.79 (1H, doublet of doublets, J=2.0 & 8.1 Hz); 7.57 (1H, doublet, J=8.1 Hz); 4.04 (2H, multiplet); 3.19 (2H, triplet, J=5.3 Hz); 2.44 (1H, triplet, J=6.6 Hz, which disappeared on the addition of D₂O).

7(b) 3-(3,4-Dichlorophenyl)-3-oxo-1-propanol t-butyldimethylsilyl Ether

46.0 g (0.21 mole) of 3-(3,4-dichlorophenyl)-3-oxo-1-propanol [prepared as described in step (a) above] were dissolved in 460 ml of dimethylformamide, and 35 ml (0.25 mole) of triethylamine and 38.0 g (0.25 mole) of t-butyldimethyl-chlorosilane were added to the resulting solution. The mixture was then stirred for 2 hours at 0° C. At the end of this time, the reaction mixture was poured into water and extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a 96:4 by volume mixture of hexane and ethyl acetate as the eluent, to give 66.1 g of the title compound as white crystals.

Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 8.06 (1H, doublet, J=2.0 Hz); 7.80 (1H, doublet of doublets, J=2.0 & 8.3 Hz); 7.55 (1H, doublet, J=8.3 Hz); 4.04 (2H, triplet, J=6.3 Hz); 3.13 (2H, triplet, J=6.3 Hz); 0.85 (9H, singlet); 0.04 (6H, singlet).

7(c) 3-(3,4-Dichlorophenyl)-3-butenol t-butyldimethylsilyl Ether

215 g (0.60 mole) of methyltriphenylphosphonium bromide and 54 g (0.48 mole) of potassium t-butoxide were added to 2 liters of dried benzene, and the mixture was stirred for 9 hours at room temperature. At the end of this time, 40 g (0.12 mole) of 3-(3,4-dichlorophenyl)-3-oxo-1-propanol t-butyldimethylsilyl ether [prepared as described in step (b) above] were dissolved in 800 ml of benzene and the resulting solution was slowly added dropwise to the mixture over a period of 2.5 hours. 1 liter of water was then added to the reaction mixture, and the mixture was stirred for 30 minutes, whilst ice-cooling. The organic layer was separated, and then washed with water and with a saturated aqueous solution of sodium chloride, after which it was dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using hexane as the eluent, to give 23.5 g of the title compound. The physicochemical properties of this product were the same as those of the product produced as described in Example 1(b).

PREPARATION 8 3-(3,4-Dichlorophenyl)-3-butenol t-butyldimethylsilyl Ether

129 mg (5.31 mmole) of magnesium flakes were added to 2 ml of diethyl ether, and a small amount of iodine was added to the mixture. 1 ml of a diethyl ether solution containing 1.01 g (4.47 mmole) of 3,4-dichlorobromobenzene was then added dropwise to the mixture, and the mixture was stirred for 1 hour at room temperature under a nitrogen atmosphere to give a Grignard reagent.

500 mg (1.60 mmole) of 3-iodo-3-butenol t-butyldimethylsilyl ether and 34 mg (0.048 mmole) of dichlorobis(triphenylphosphine)palladium (II) were dissolved in 5 ml of anhydrous tetrahydrofuran, and the previously prepared Grignard reagent was added dropwise thereto at room temperature under a nitrogen atmosphere. While the reaction temperature was raised, the diethyl ether was distilled off, and then the reaction mixture was heated at 60° C. for 1 hour. At the end of this time, the reaction mixture was poured into an aqueous solution of ammonium chloride and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using hexane as the eluent, to give 422 mg of the title compound. The physicochemical properties of this product were the same as those of the product produced as described in Example 1(b).

EXAMPLE 1 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-carboxamide

1(a) Methyl 3-(3,4-dichlorophenyl)-3-butenoate

11.31 g (0.47 mole) of magnesium flakes were added to 300 ml of diethyl ether, followed by a small amount of iodine. The mixture was then allowed to stand for 1 hour, after which a solution of 102.87 g (0.46 mole) of 1-bromo-3,4-dichlorobenzene in 150 ml of diethyl ether was slowly added dropwise. A further 150 ml of diethyl ether was added, and then 60.33 g (44.3 mmole) of anhydrous zinc chloride was slowly added and the mixture was stirred for 1 hour. 3.10 g (4.42 mmole) of dichlorobis(triphenylphosphine)palladium (II) were then added, and a solution of 34.15 ml (42.8 mmole) of diketene in 600 ml of diethyl ether was added dropwise. The reaction mixture was then stirred at room temperature for 30 minutes, after which it was poured into 1 liter of ice-cooled 1 N aqueous hydrochloric acid and extracted three times, each time with 500 ml of diethyl ether. The combined organic extracts were extracted three times, each time with 700 ml of a 1 N aqueous solution of sodium hydroxide. The combined aqueous extracts were acidified with concentrated aqueous hydrochloric acid, whilst ice-cooling, and extracted three times, each time with 500 ml of diethyl ether, and then the combined organic extracts were dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dissolved in 350 ml of methanol. 10 ml of concentrated aqueous sulfuric acid were added, and the solution was heated under reflux for 30 minutes. At the end of this time, the reaction mixture was cooled in air and neutralised with a saturated aqueous solution of sodium hydrogencarbonate. The methanol was then removed by distillation under reduced pressure, and the resulting residue was extracted with three times, each time with 200 ml of methylene chloride. The combined organic extracts were dried over anhydrous magnesium sulfate, and then the solvent was removed by distillation under reduced pressure. The resulting residue was distilled under reduced pressure to obtain 69.13 g (yield 62%) of the title compound as a pale yellow oil, boiling at 144-146° C. (5 mm Hg).

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.51 (1H, doublet, J=2.2 Hz); 7.40 (1H, doublet, J=8.2 Hz); 7.25 (1H, doublet of doublets, J=8.2 & 2.2 Hz); 5.55 (1H, singlet); 5.30 (1H, singlet); 3.67 (3H, singlet); 3.49 (2H, singlet).

1(b) 3-(3,4-Dichlorophenyl)-3-butenol t-butyldimethylsilyl Ether

11.76 g (0.28 mole) of lithium aluminum hydride were suspended in 500 ml of anhydrous tetrahydrofuran, and a solution of 69.06 g (0.28 mole) of methyl 3-(3,4-dichlorophenyl)-3-butenoate [prepared as described in step (a) above] in 500 ml of anhydrous tetrahydrofuran was slowly added dropwise under a nitrogen atmosphere at 0° C. over a period of 15 minutes. The reaction mixture was then stirred at the same temperature for 30 minutes, after which 500 ml of water and 500 ml of a 10% w/v aqueous solution of sodium hydroxide were slowly added. The mixture was then stirred at room temperature for 1 hour. It was then filtered through a Celite (trade mark) filter aid, and the filtrate was extracted three times, each time with 500 ml of ethyl acetate. The combined organic extracts were then dried over anhydrous magnesium sulfate. The solvent was removed from the extract by distillation under reduced pressure, and the resulting residue was dried under reduced pressure. The residue was then dissolved in 250 ml of anhydrous dimethylformamide, and then 47.12 ml (0.34 mole) of triethylamine, 6.88 g (0.06 mole) of 4-dimethylaminopyridine and 50.96 g (0.34 mole) of t-butyldimethylsilyl chloride were added, in that order, whilst ice-cooling. The mixture was then stirred, whilst ice-cooling, for 2 hours. At the end of this time, 1 liter of ethyl acetate was added to the reaction mixture, and the mixture was washed, in turn, with ice-cooled 10% w/v aqueous hydrochloric acid and with a saturated aqueous solution of sodium chloride. It was then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 50:1 to 20:1 by volume as the eluent, to obtain 43.52 g (yield 47%) of the title compound as a colorless oil.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.50 (1H, doublet, J=2.1 Hz); 7.38 (1H, doublet, J=8.1 Hz); 7.24 (1H, doublet of doublets, J=8.1 & 2.1 Hz); 5.35 (1H, singlet); 5.16 (1H, singlet); 3.70 (2H, triplet, J=6.9 Hz); 2.67 (2H, triplet, J=6.9 Hz); 0.86 (9H, singlet); 0.00 (6H, singlet).

1(c) 4-t-Butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)butane-1,2-diol

790 mg (1.01 mmole) of hydroquinidine 1,4-phthalazinediyl diether, 100.19 g (0.30 mole) of potassium ferricyanide (III), 42.06 g (0.30 mole) of potassium carbonate and 0.516 ml (0.20 mmole) of osmium tetraoxide (as a 0.393 M solution in toluene) were dissolved in 500 ml of t-butanol and 500 ml of water, and 33.61 g (0.10 mole) of 3-(3,4-dichlorophenyl)-3-butenol t-butyldimethylsilyl ether [prepared as described in step (b) above] were added, whilst cooling, at 0° C. The mixture was then stirred at 0° C. for 5 hours. At the end of this time, 150 g of sodium sulfite were added and the reaction mixture was stirred at room temperature for 1 hour. It was then extracted three times, each time with 800 ml of ethyl acetate, and the combined organic extracts were dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 5:1 to 1:1 by volume as the eluent to obtain 32.3 g (yield 87%) of the title compound as a colorless oil of optical purity 97% ee.

[α]_(D) ²⁴+11.39 (c=1.01, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.57 (1H, doublet, J=2.1 Hz); 7.43 (1H, doublet, J=8.1 Hz); 7.24 (1H, doublet of doublets, J=8.1 & 2.1 Hz); 5.00 (1H, singlet); 3.80 (1H, doubled doublet of doublets, J=10.4, 3.8 & 3.8 Hz); 3.5-3.7 (3H, multiplet); 2.51 (1H, doublet of doublets, J=8.0 & 5.2 Hz); 2.37 (1H, doubled doublet of doublets, J=15.0, 11.1 & 4.0 Hz); 1.86 (1H, doubled doublet of doublets, J=15.0, 2.9 & 2.9 Hz); 0.89 (9H, singlet); 0.04 (3H, singlet); −0.01 (3H, singlet).

1(d) 1-Azido-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol

32.07 g (87.8 mmole) of 4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)butane-1,2-diol [prepared as described in step (c) above] and 1.07 g (8.76 mmole) of 4-dimethylaminopyridine were dissolved in 320 ml of pyridine, and 10.19 ml (0.132 mole) of methanesulfonyl chloride was slowly added dropwise, whilst ice-cooling. The mixture was then stirred under a nitrogen atmosphere at the same temperature for 2 hours. The reaction mixture was then poured into 1500 ml of ice-cooled 10% w/v aqueous hydrochloric acid and then extracted three times, each time with 200 ml of ethyl acetate. The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dried under reduced pressure. The residue was then dissolved in 300 ml of anhydrous dimethylformamide, and 11.41 g (0.18 mole) of sodium azide were added. The mixture was then heated under a nitrogen atmosphere at 120° C. for 4 hours. At the end of this time, the reaction mixture was cooled to room temperature, poured into 1000 ml of a saturated aqueous solution of sodium chloride and then extracted three times, each time with 500 ml of ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 10:1 to 5:1 by volume as the eluent, to obtain 29.3 g (yield 85%) of the title compound as a colorless oil.

[α]_(D) ²⁴−48.56 (c=1.04, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.59 (1H, doublet, J=2.2 Hz); 7.44 (1H, doublet, J=8.3 Hz); 7.24 (1H, doublet of doublets, J=8.3 & 2.2 Hz); 5.12 (1H, singlet); 3.81 (1H, doubled doublet of doublets, J=10.6, 4.1 & 3.0 Hz); 3.51 (1H, doubled doublet of doublets, J=10.6, 10.6 & 2.8 Hz); 3.40 (1H, doublet, J=12.5 Hz); 3.31 (1H, doublet, J=12.5 Hz); 2.35 (1H, doubled doublet of doublets, J=15.8, 10.6 & 4.1 Hz); 1.91 (1H, doubled doublet of doublets, J=15.8, 3.0 & 2.8 Hz); 0.88 (9H, singlet); 0.02 (3H, singlet); −0.04 (3H, singlet).

1(e) 1-Amino-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol

10.00 g (25.6 mmole) of 1-azido-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol [prepared as described in step (d) above] were dissolved in 100 ml of tetrahydrofuran and 0.6 ml of water, and 7.39 g (28.2 mmole) of triphenylphosphine were added to the resulting solution. The mixture was then stirred under a nitrogen atmosphere at 80° C. for 4 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, hexane was added to the resulting residue and the deposited crystals were removed by filtration. The filtrate was concentrated by evaporation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 30:1 to 10:1 by volume as the eluent, to obtain 3.83 g (yield 41%) of the title compound as a colorless oil.

[α]_(D) ²⁴+3.94 (c=0.71, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.56 (1H, doublet, J=2.2 Hz); 7.42 (1H, doublet, J=8.6 Hz); 7.22 (1H, doublet of doublets, J=8.6 & 2.2 Hz); 4.91 (1H, broad singlet); 3.73 (1H, doubled doublet of doublets, J=10.3, 4.6 & 3.7 Hz); 3.53 (1H, doubled doublet of doublets, J=10.3, 10.2 & 3.7 Hz); 2.91 (1H, doublet, J=13.1 Hz); 2.86 (1H, doublet, J=13.1 Hz); 2.16 (1H, doubled doublet of doublets, J=14.6, 10.2 & 4.6 Hz); 1.88 (1H, doubled doublet of doublets, J=14.6, 3.7 & 3.7 Hz); 1.44 (2H, broad singlet); 0.87 (9H, singlet); 0.01 (3H, singlet); −0.04 (3H, singlet).

1(f) 2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethanol t-butyldimethylsilyl Ether

1.35 g (3.71 mmole) of 1-amino-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol [prepared as described in step (e) above] were dissolved in 50 ml of benzene, and 167 mg (5.57 mmole) of paraformaldehyde and 13 mg of p-toluenesulfonyl chloride were added to the resulting solution. The mixture was then heated under reflux under a nitrogen atmosphere at 100° C. for 3 hours, using a Dean-Stark apparatus. At the end of this time, the solvent was removed by distillation under reduced pressure, and 100 ml of ethyl acetate were added to the residue. The resulting solution was washed with a saturated aqueous solution of sodium hydrogencarbonate and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to yield 2-[(5R)-(3,4-dichlorophenyl)oxazolidin-5-yl]ethanol t-butyldimethylsilyl ether. This compound was dissolved in 50 ml of methylene chloride, and 0.62 ml (4.45 mmole) of triethylamine and 45 mg (0.37 mmole) of 4-dimethylaminopyridine were added to the resulting solution. 1.03 g (4.47 mmole) of 3,4,5-trimethoxybenzoyl chloride were then added, whilst ice-cooling, and the mixture was stirred at 0° C. for 1 hour. 100 ml of methylene chloride were added to the reaction mixture, and the mixture was washed with 10% w/v aqueous hydrochloric acid, with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order. It was then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of ethyl acetate and hexane ranging from 1:5 to 2:1 by volume as the eluent, to obtain 1.27 g (yield 60%) of the title compound as a white amorphous substance.

[α]_(D) ²⁴+61.73 (c=1.39, methanol).

1(g) 2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethanol Methanesulfonate

3.95 g (6.92 mmole) of 2-[(5R)-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethanol t-butyldimethylsilyl ether [prepared as described in step (f) above] were dissolved in 70 ml of a 3:3:1 by volume mixture of acetic acid, tetrahydrofuran and water. The mixture was then heated under a nitrogen atmosphere at 80° C. for 8 hours. At the end of this time, the solution was neutralised by the addition of a saturated aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate. The organic layer was then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dissolved in 30 ml of pyridine. 70 mg (0.57 mmole) of dimethylaminopyridine and 0.66 ml (8.53 mmole) of methanesulfonyl chloride were added, whilst ice-cooling, to the resulting solution, and the mixture was then stirred under a nitrogen atmosphere at 0° C. for 2 hours. At the end of this time, the reaction mixture was poured into 200 ml of ice-cooled 10% w/v aqueous hydrochloric acid and then extracted three times, each time with 100 ml of ethyl acetate. The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 5:1 to 1:1 by volume as the eluent, to obtain 3.02 g (yield 82%) of the title compound as a white amorphous substance.

[α]_(D) ²⁴+53.1 (c=1.0, methanol).

1(h) 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-carboxamide

150 mg (0.28 mmole) of 2-[(5R)-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethanol methanesulfonate [prepared as described in step (g) above] and 75 mg (0.31 mmole) of 4-phenylpiperidine-4-carboxamide hydrochloride were dissolved in 3 ml of anhydrous dimethylformamide, and 71 mg (0.85 mmole) of sodium hydrogencarbonate and 70 mg (0.42 mmole) of potassium iodide were added to the resulting solution. The mixture was then heated under a nitrogen atmosphere at 80° C. for 6 hours. At the end of this time, 50 ml of a saturated aqueous solution of sodium chloride were added to the reaction mixture, which was then extracted three times, each time with 50 ml of ethyl acetate. The combined organic extracts were then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel thin-layer chromatography, using a 10:1 by volume mixture of methylene chloride and methanol as the developing solvent, to give 127 mg (yield 71%) of the title compound as a white amorphous substance.

[α]_(D) ²⁴+25.2 (c=0.48, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.50-7.10 (8H, multiplet); 6.67 (2H, singlet); 5.30-4.85 (2H, multiplet); 5.18 (2H, singlet); 4.13-3.70 (2H, multiplet); 3.87 (3H, singlet); 3.85 (6H, singlet); 2.67-1.93 (12H, multiplet). Infrared absorption spectrum ν_(max) (KBr) cm⁻¹: 2940, 1678, 1640, 1584, 1456, 1416, 1236, 1128. Elemental analysis: Calculated for C₃₃H₃₇N₃O₆Cl₂.½H₂O: C: 60.77%; H: 5.83%; N: 6.45%; Cl: 10.89%; Found: C: 60.63%; H: 5.94%; N: 6.39%; Cl: 10.93%. Mass spectrometric analysis (FAB) m/z: 642 (M+H)⁺.

The compounds of the following Examples 2-4 were produced following the same procedure as described in Example 1 above.

EXAMPLE 2 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide)

Yield: 76%; [α]_(D) ²⁴+19.2 (c=1.05, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.60-7.10 (8H, multiplet); 6.71 (2H, broad singlet); 5.50-4.90 (2H, multiplet); 3.88 (9H, singlet); 3.40-1.40 (20H, multiplet). Infrared absorption spectrum ν_(max) (KBr) cm⁻¹: 2938, 1633, 1584, 1464, 1416, 1236, 1128. Elemental analysis: Calculated for C₃₅H₄₁N₃O₆Cl₂.H₂O: C: 61.05%; H: 6.29%; N: 6.10%; Cl: 10.30%; Found: C: 60.66%; H: 6.25%; N: 5.80%; Cl: 10.65%.

EXAMPLE 3 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-(pyrrolidin-1-ylcarbonyl)-phenylpiperidine

Yield: 82%; [α]_(D) ²⁴+23.2 (c=0.49, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.52-7.40 (2H, multiplet); 7.33-7.00 (6H, multiplet); 6.68 (2H, singlet); 5.30-4.85 (2H, multiplet); 4.09-3.65 (2H, multiplet); 3.87 (3H, singlet); 3.86 (6H, singlet); 3.56-3.41 (2H, broad singlet); 2.89-2.60 (4H, multiplet); 2.48-2.29 (4H, multiplet); 2.20-1.98 (10H, multiplet). Infrared absorption spectrum ν_(max) (KBr) cm⁻¹: 2948, 1625, 1584, 1464, 1415, 1235, 1128. Elemental analysis: Calculated for C₃₇H₄₃N₃O₆Cl₂.½H₂O: C: 62.98%; H: 6.28%; N: 5.95%; Cl: 10.04%; Found: C: 63.01%; H: 6.43%; N: 5.97%; Cl: 9.71%. Mass spectrometric analysis (FAB) m/z: 696 (M+H)⁺.

EXAMPLE 4 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethyl}-4-morpholinocarbonyl-4-phenylpiperidine

Yield: 63%; [α]_(D) ²⁴+20.5 (c=1.04, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.60-7.10 (8H, multiplet); 6.70 (2H, singlet); 5.40-4.90 (2H, multiplet); 3.87 (9H, singlet); 4.10-1.40 (22H, multiplet). Infrared absorption spectrum ν_(max) (KBr) cm⁻¹: 2966, 1637, 1584, 1455, 1416, 1233, 1128. Elemental analysis: Calculated for C₃₇H₄₃N₃O₇Cl₂.½H₂O: C: 61.58%; H: 6.15%; N: 5.82%; Cl: 9.83%; Found: C: 61.47%; H: 6.62%; N: 5.45%; Cl: 9.67%. Mass spectrometric analysis (FAB) m/z: 712 (M+H)⁺.

EXAMPLES 5 TO 40

The compounds shown in the following formulae (A-1) and (A-2) were also prepared by the same procedure as described above. The meanings of the various substituent groups shown in these formulae are summarised in the corresponding one of Tables A-1 and A-2. For convenience, the products of Examples 1 to 4 are also summarised in these Tables.

TABLE A-1 Example No.

[α]_(D) ²⁴ (methanol) FAB Mass spectrometry [M + H]⁺  1

+25.2 (c = 0.48) 642  2

+19.2 (c = 1.05) 670  3

+23.2 (c = 0.49) 696  4

+20.5 (c = 1.04) 712  5

+23.3 (c = 0.49) 656  6

+26.7 (c = 0.48) 641  7

+21.1 (c = 0.50) 615  8

+21.8 (c = 1.06) 855  9

+18.7 (c = 1.03) 642 10

+33.1 (c = 0.95) 656 11

+28.7 (c = 0.44) 656 12

+29.9 (c = 0.41) 670 13

+27.9 (c = 1.04) 642 14

+35.8 (c = 1.07) 656 15

+25.6 (c = 0.85) 661 16

+1.6  (c = 0.54) 642 17

+17.0 (c = 0.50) 669 18

+19.9 (c = 0.43) 670 19

+27.4 (c = 1.02) 684 20

+10.8 (c = 1.04) 704 21

+26.5 (c = 0.60) 626 22

+19.8 (c = 0.55) 643 23

+24.0 (c = 1.07) 654 24

+71.8 (c = 1.02) 691

TABLE A-2 Example No.

[α]_(D) ²⁴ (methanol) FAB Mass spectrometry [M + H]⁺ 25

+25.2 (c = 0.46) 688 26

+21.6 (c = 0.48) 702 27

+22.6 (c = 0.48) 687 28

+20.7 (c = 0.48) 661 29

+17.5 (c = 0.12) 901 30

+17.2 (c = 1.05) 688 31

+33.6 (c = 1.03) 702 32

+23.1 (c = 0.50) 702 33

+26.8 (c = 0.42) 716 34

+17.0 (c = 1.03) 688 35

+24.6 (c = 1.08) 702 36

+19.5 (c = 0.99) 707 37

+3.3  (c = 0.57) 688 38

+18.6 (c = 0.51) 715 39

+28.8 (c = 0.48) 716 40

+23.8 (c = 0.73) 730

EXAMPLE 41 1-{3-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]propyl}-4-phenylpiperidine-4-carboxamide

41(a) Methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate

1.00 (6.80 mmole) of dichlorobenzene and 0.72 g (7.14 mmole) of succinic anhydride were suspended in 3 ml of dichloroethane and 1.36 g (10.2 mmole) of aluminum chloride powder were added. The mixture was then stirred at 60° C. for 3 hours. At the end of this time, the reaction mixture was ice-cooled and 1 N aqueous hydrochloric acid was added. The mixture was then extracted with methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was dissolved in 30 ml of methanol, and 0.20 ml of an aqueous solution of sulfuric acid was added. The solution was then heated under reflux for 2 hours, after which the reaction mixture was cooled to room temperature, poured into water and then extracted with diethyl ether. The organic extract was washed with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, and dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and diethyl ether ranging from 17:3 to 7:3 by volume as the eluent, to obtain 0.25 g (yield 14%) of the title compound as pale orange crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 8.07 (1H, doublet, J=2 Hz); 7.81 (1H, doublet of doublets, J=2 & 8 Hz); 7.56 (1H, doublet, J=8 Hz); 3.71 (3H, singlet); 3.27 (2H, triplet, J=7 Hz); 2.78 (2H, triplet, J=7 Hz).

41(b) Methyl 4-(3,4-dichlorophenyl)-4-pentenoate

330 mg (0.92 mmole) of methyltriphenylphosphonium bromide and 105 mg (0.94 mmole) of potassium t-butoxide were suspended in 4 ml of dried benzene, and the mixture was stirred under a stream of nitrogen at room temperature for 4 hours. A solution prepared by dissolving 200 mg of methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate [prepared as described in step (a) above] in 1 ml of benzene was added to the reaction mixture, and the mixture was then stirred for 18 hours. At the end of this time, the reaction mixture was filtered through a Celite (trade mark) filter aid and washed with diethyl ether. The filtrate was then concentrated by evaporation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a 23:2 by volume mixture of hexane and diethyl ether as the eluent, to give 95 mg (yield 64%) of the title compound as a pale yellow oil.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.48 (1H, doublet, J=2 Hz); 7.40 (1H, doublet, J=8 Hz); 7.23 (1H, doublet of doublets, J=2 & 8 Hz); 5.32 (1H, singlet); 5.14 (1H, singlet); 3.67 (3H, singlet); 2.79 (2H, triplet, J=8 Hz); 2.48 (2H, triplet, J=8 Hz).

41(c) 4-(3,4-Dichlorophenyl-4-penten-1-ol t-butyldimethylsilyl Ether

Following a procedure similar to that described in Example 1(b), but using methyl 4-(3,4-dichlorophenyl)-4-pentenoate [prepared as described in step (b) above], the title compound was obtained in a yield of 93%.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.49 (1H, doublet, J=2 Hz); 7.38 (1H, doublet, J=9 Hz); 7.24 (1H, doublet of doublets, J=2 & 9 Hz); 5.30 (1H, singlet); 5.13 (1H, doublet, J=1 Hz); 3.62 (2H, triplet, J=6 Hz); 2.52 (2H, triplet, J=8 Hz); 1.60-1.68 (2H, multiplet); 0.90 (9H, singlet); 0.04 (6H, singlet).

41(d) (2R)-5-(t-Butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)pentane-1,2-diol

Following a procedure similar to that described in Example 1(c), but using 4-(3,4-dichlorophenyl)-4-penten-1-ol t-butyldimethylsilyl ether [prepared as described in step (c) above], the title compound was obtained in a yield of 90%.

Optical purity: 98% ee; [α]_(D) ²⁴−2.08 (c=0.48, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.56 (1H, doublet, J=2 Hz); 7.41 (1H, doublet, J=8 Hz); 7.23 (1H, doublet of doublets, J=2 & 8 Hz); 4.96 (1H, singlet); 3.53-3.70 (4H, multiplet); 1.98-2.14 (3H, multiplet); 1.35-1.57 (2H, multiplet); 0.91 (9H, singlet); 0.082 (3H, singlet); 0.078 (3H, singlet).

41(e) (2R)-1-Azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Following a procedure similar to that described in Example 1 (d), but using (2R)-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)pentane-1,2-diol [prepared as described in step (d) above], the title compound was obtained in a yield of 86%.

[α]_(D) ²⁴−48.2 (c=0.61, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl3) δ ppm: 7.58 (1H, doublet, J=2 Hz); 7.42 (1H, doublet, J=9 Hz); 7.23 (1H, doublet of doublets, J=2 & 9 Hz); 4.93 (1H, singlet); 3.67 (1H, multiplet); 3.58 (1H, multiplet); 3.43 (1H, doublet, J=12 Hz); 3.31 (1H, doublet, J=12 Hz); 2.13 (1H, multiplet); 2.04 (1H, multiplet); 1.54 (1H, multiplet); 1.40 (1H, multiplet); 0.91 (9H, singlet); 0.09 (3H, singlet); 0.08 (3H, singlet).

41(f) (2R)-1-Amino-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol

Following a procedure similar to that described in Example 1(e), but using (2R)-1-azido-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol [prepared as described in step (e) above], the title compound was obtained in a yield of 76%.

[α]_(D) ²⁴−8.13 (c=0.48, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.54 (1H, doublet, J=2 Hz); 7.40 (1H, doublet, J=9 Hz); 7.21 (1H, doublet of doublets, J=2 & 9 Hz); 4.57 (1H, broad singlet); 3.50-3.62 (2H, multiplet); 2.96 (1H, doublet, J=13 Hz); 2.82 (1H, doublet, J=13 Hz); 1.93 (1H, multiplet); 1.80 (1H, multiplet); 1.33-1.60 (2H, multiplet); 0.89 (9H, singlet); 0.04 (6H, singlet).

41(g) 3-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]-1-propanol t-butyldimethylsilyl Ether

Following a procedure similar to that described in Example 1(f), but using (2R)-1-amino-5-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-2-pentanol [prepared as described in step (f) above], the title compound was obtained in a yield of 48%.

[α]_(D) ²⁴+37.73 (c=0.44, methanol).

41(h) 3-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]-1-propanol Methanesulfonate

Following a procedure similar to that described in Example 1(g), but, using 3-[(5R)(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]-1-propanol t-butyldimethylsilyl ether [prepared as described in step (g) above], the title compound was obtained in a yield of 93%.

[α]_(D) ²⁴+52.90 (c=0.62, methanol).

41(i) 1-{3-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]propyl}-4-phenylpiperidine-4-carboxamide

Following a procedure similar to that described in Example 1(h), but using 3-[(5R)-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]-1-propanol methanesulfonate [prepared as described in step (h) above] the title compound was obtained in a yield of 66%.

[α]_(D) ²⁴+35.9 (c=0.48, methanol); Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.60-7.10 (8H, multiplet); 6.68 (2H, broad singlet); 5.40-4.90 (4H, multiplet); 3.88 (9H, singlet); 3.87 (9H, singlet); 4.10-1.10 (16H, multiplet). Infrared absorption spectrum ν_(max) (KBr) cm⁻¹: 3440, 3353, 2940, 1676, 1641, 1585; Elemental analysis: Calculated for C₃₄H₃₉N₃O₆Cl₂.½H₂O: C: 61.35%; H: 6.06%; N: 6.31%; Cl: 10.65%; Found: C: 61.81%; H: 6.22%; N: 6.50%; Cl: 10.26%. Mass spectrometric analysis (FAB) m/z: 656 (M+H)⁺.

EXAMPLES 42 TO 50

The compounds shown in the following formula (A-3) were also prepared by the same procedure as described in Example 41 above. The meanings of the various substituent groups shown in these formulae are summarised in Table A-3. For convenience, the product of Example 41 is also summarised in this Table.

TABLE A-3 Example No.

[α]_(D) ²⁴ (methanol) FAB Mass spectrometry [M + H]⁺ 41

+35.9 (c = 0.48) 656 42

+36.4 (c = 0.50) 710 43

+36.0 (c = 0.45) 670 44

+38.3 (c = 0.57) 655 45

+41.8 (c = 0.49) 629 46

+34.6 (c = 0.46) 670 47

+50.3 (c = 0.50) 675 48

+32.5 (c = 0.54) 656 49

+37.9 (c = 0.46) 683 50

+41.3 (c = 0.44) 684

EXAMPLE 51 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound 2-1969)

51(a) 3-(3,4-Dichlorophenyl)-3,4-epoxy-1-butanol t-Butyldimethylsilyl Ether

3.00 g (9.05 mmole) of 3-(3,4-dichlorophenyl)-3-butenol t-butyldimethylsilyl ether [prepared as described in Example 1(b)] were dissolved in 60 ml of methylene chloride, and 2.52 g (30.0 mmole) of sodium hydrogencarbonate and 3.88 g (15.7 mmole) of 3-chloroperbenzoic acid (content: 70%) were added to the resulting solution. The mixture was then stirred at room temperature for 3 hours. At the end of this time, the reaction mixture was diluted with methylene chloride and then washed with a 1 N aqueous solution of sodium hydroxide and with a saturated aqueous solution of sodium chloride. The organic layer was then dried over anhydrous sodium sulfate, and the solvent was removed by evaporation under reduced pressure. The resulting residue was then purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and diethyl ether ranging from 24:1 to 19:1 by volume as the eluent, to obtain 2.70 g of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.47 (1H, doublet, J=2 Hz); 7.38 (1H, doublet, J=8 Hz); 7.21 (1H, doublet of doublets, J=2 & 8 Hz); 3.57-3.72 (2H, multiplet); 3.01 (1H, doublet, J=5 Hz); 2.68 (1H, doublet, J=5 Hz); 2.27 (1H, multiplet); 2.01 (1H, multiplet); 0.84 (9H, singlet); −0.016 (3H, singlet); −0.024 (3H, singlet).

51(b) 4-(t-Butyldimethylsilyloxyy-2-(3,4-dichlorophenyl)-1-[N-(t-butoxycarbonyl)-N-(2-hydroxyethyl)amino]-2-butanol

1.50 g (4.32 mmole) of 3-(3,4-dichlorophenyl)-3,4-epoxy-1-butanol t-butyldimethylsilyl ether [prepared as described in step (a) above] and 1.84 g (17.3 mmole) of lithium perchlorate were dissolved in 30 ml of acetonitrile. The mixture was then stirred under a nitrogen atmosphere at room temperature for 10 minutes. 2.11 g (34.5 mmole) of 2-aminoethanol were added to the reaction mixture, and the mixture was heated under reflux for 5 hours. At the end of this time, the reaction mixture was cooled to room temperature, diluted with ethyl acetate and then washed with a saturated aqueous solution of sodium chloride. The organic layer was separated and dried over anhydrous sodium sulfate, and then the solvent was removed by distillation under reduced pressure.

The resulting residue was dissolved in 30 ml of methylene chloride, and 0.89 ml (6.42 mmole) of triethylamine and 943 mg (4.32 mmole) of di-t-butyl dicarbonate were added to the resulting solution. The mixture was then stirred at room temperature for 16 hours. At the end of this time, the reaction mixture was poured into water and extracted with methylene chloride. The extract was then washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a 3:2 by volume mixture of hexane and ethyl acetate as the eluent, to give 1.94 g of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.30-7.75 (3H, multiplet); 5.30 and 5.57 (total 1H, each broad singlet); 3.05-4.00 (9H, multiplet); 2.00-2.40 (2H, multiplet); 1.53 (9H, singlet); 0.94 (9H, singlet); 0.09 (3H, singlet); 0.07 (3H, singlet). Infrared absorption spectrum ν_(max) (KBr) cm⁻¹: 3298, 2955, 2936, 2885, 2857, 1659. Mass spectrometric analysis (FAB) m/z: 508 (M+H)⁺.

51(c) 2-[4-t-Butoxycarbonyl-2-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-Butyldimethylsilyl Ether

10.4 g (20.5 mmole) of 4-(t-butyldimethylsilyloxy)-2-(3,4-dichlorophenyl)-1-[N-(t-butoxycarbonyl)-N-(2-hydroxyethyl)amino]-2-butanol [prepared as described in step (b) above] and 8.03 g (30.6 mmole) of triphenylphosphine were dissolved in 180 ml of anhydrous toluene and a solution of 5.33 g (30.6 mmole) of diethyl azodicarboxylate in 20 ml of toluene was added dropwise under a nitrogen atmosphere at room temperature. The mixture was then stirred for 2 hours. At the end of this time, the reaction mixture was poured into an aqueous solution of ammonium chloride and extracted with ethyl acetate. The mixture was then washed with a saturated aqueous solution of sodium chloride. The organic extract was dried over anhydrous sodium sulfate, and then the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 23:2 to 9:1 by volume as the eluent, to obtain 8.85 g of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.56 (1H, broad singlet); 7.43 (1H, doublet, J=9 Hz); 7.28 (1H, doublet of doublets, J=2 & 9 Hz); 4.20-4.55 (1H, broad singlet); 3.00-3.80 (8H, multiplet); 1.80-2.10 (2H, multiplet); 1.35-1.60 (9H, broad singlet); 0.85 (9H, multiplet); −0.01 (6H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (CHCl₃): 2957, 2931, 2859, 1730, 1687. Mass spectrometric analysis (FAB) m/z: 490 (M+H)⁺.

51(d) 2-[2-(3,4-Dichlorophenyl)morpholin-2-yl]ethanol

7.80 g (15.9 mmole) of 2-[4-t-butoxycarbonyl-2-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether [prepared as described in step (c) above] were dissolved in 150 ml of methylene chloride and 7.05 g (35.5 mmole) of B-bromocatecholborane were added. The mixture was then stirred under a stream of nitrogen at room temperature for 2 hours. At the end of this time, 150 ml of water were added to the reaction mixture, and the mixture was then stirred for a further 2 hours. The reaction mixture was made basic by adding a 1 N aqueous solution of sodium hydroxide. It was then extracted with methylene chloride and the extract was washed with a saturated aqueous solution of sodium chloride. The organic extract was then dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 19:1 to 17:3 by volume as the eluent, to obtain 4.40 g of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.51 (1H, doublet, J=2 Hz); 7.48 (1H, doublet, J=8 Hz); 7.24 (1H, doublet of doublets, J=2 & 8 Hz); 3.76 (1H, doublet of triplets, J=3 & 12 Hz); 3.66 (1H, multiplet); 3.58 (2H, triplet, J=6 Hz); 3.36 (1H, doublet, J=13 Hz); 3.11 (1H, doublet, J=13 Hz); 2.97 (1H, multiplet); 2.79 (1H, doublet of triplets, J=3 & 13 Hz); 2.14 (1H, doublet of triplets, J=6 & 15 Hz); 1.79 (1H, doublet of triplets, J=6 & 15 Hz).

51(e) 2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol

1.28 g (4.63 mmole) of 2-[2-(3,4-dichlorophenyl)morpholin-2-yl]ethanol [prepared as described in step (d) above] were dissolved in 30 ml of methylene chloride, and 2.66 g (26.3 mmole) of triethylamine, 1.28 g (5.55 mmole) of 3,4,5-trimethoxybenzoyl chloride and 5 mg of 4-dimethylaminopyridine were added to the resulting solution. The mixture was then stirred at room temperature for 6 hours. At the end of this time, the reaction solution was poured into an aqueous solution of sodium hydrogencarbonate and extracted with methylene chloride. The extract was then washed with a saturated aqueous solution of sodium chloride. The organic extract was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and acetone ranging from 4:1 to 7:3 by volume as the eluent, to obtain 1.72 g of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.80-7.80 (3H, multiplet); 6.47 (2H, singlet); 3.40-4.80 (8H, multiplet); 3.84 and 3.86 (total 9H, each singlet); 1.75-2.25 (2H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3429, 2940, 2838, 1630, 1585. Mass spectrometric analysis (EI) m/z: 469 (M)⁺.

51(f) 2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol Methanesulfonate

388 mg (0.83 mmole) of 2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol [prepared as described in step (e) above] were dissolved in 5 ml of methylene chloride, and 126 mg (1.25 mmole) of triethylamine and 0.078 ml (1.01 mmole) of methanesulfonyl chloride were added to the resulting solution. The mixture was then stirred at room temperature for 2 hours. The reaction mixture was then diluted with methylene chloride, after which it was washed with 1 N aqueous hydrochloric acid and with a saturated aqueous solution of sodium chloride, in that order. The organic extract was dried over anhydrous sodium sulfate, and then the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 1:4 to 0:1 by volume as the eluent, to obtain 424 mg of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.90-7.80 (3H, multiplet); 6.52 (2H, singlet); 3.40-4.35 (8H, multiplet); 3.86 and 3.87 (total 9H, each singlet); 2.93 (3H, singlet); 2.10-2.55 (2H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2999, 2966, 2939, 2875, 1634, 1585. Mass spectrometric analysis (FAB) m/z: 548 (M+H)⁺.

51(g) 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}phenylpiperidine-4-carboxamide

200 mg (0.36 mmole) of 2-[2-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol methanesulfonate [prepared as described in step (f) above], 105 mg (0.44 mmole) of 4-phenylpiperidine-4-carboxamide hydrochloride, 100 mg (1.19 mmole) of sodium hydrogencarbonate and 100 mg (0.60 mmole) of potassium iodide were suspended in 2 ml of dimethylformamide, and the mixture was then stirred under a stream of nitrogen at 80° C. for 6 hours. The reaction mixture was then poured into water and extracted with ethyl acetate. The extract was then washed with an aqueous solution of sodium thiosulfate, with water and with a saturated aqueous solution of sodium chloride, in that order. The organic extract was then dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by thin-layer chromatography, using a 9:1 by volume mixture of methylene chloride and methanol as the developing solvent and then crystallized from hexane, to give 205 mg (yield 86%) of the title compound.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.80-7.75 (8H, multiplet); 6.48 (2H, singlet); 5.18 (2H, singlet); 1.80-4.70 (18H, multiplet); 3.83 and 3.85 (total 9H, each singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3440, 3356, 2937, 2831, 1679, 1631, 1584. Mass spectrometric analysis (FAB) m/z: 656 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₉N₃O₆Cl₂.1/10H₂O: C: 62.02%; H: 6.00%; N: 6.38%; Cl: 10.76% Found: C: 61.54%; H: 6.07%; N: 6.25%; Cl: 11.35%.

The compounds of the following Examples 52-69 were produced following the same procedure as described in Example 1 above.

EXAMPLE 52 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-19712)

Yield: 84%; Mass spectrometric analysis (FAB) m/z: 684 (M+H)⁺; Elemental analysis: Calculated for C₃₆H₄₃N₃O₆Cl₂: C: 63.16%; H: 6.33%; N: 6.14%; Cl: 10.36%; Found: C: 63.28%; H: 6.64%; N: 5.79%; Cl: 9.96%.

EXAMPLE 53 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperidine (Compound No. 2-1972)

Yield: 76%; Mass spectrometric analysis (FAB) m/z: 710 (M+H)⁺; Elemental analysis: Calculated for C₃₈H₄₅N₃O₆Cl₂.1/10H₂O: C: 64.06%; H: 6.39%; N: 5.90%; Cl: 9.95%; Found: C: 63.62%; H: 6.37%; N: 5.75%; Cl: 9.96%.

EXAMPLE 54 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-morpholinocarbonyl-4-phenylpiperidine (Compound No. 2-1973)

Yield: 68%; Mass spectrometric analysis (FAB) m/z: 726 (M+H)⁺; Elemental analysis: Calculated for C₃₈H₄₅N₃O₇Cl₂.1/10H₂O: C: 62.65%; H: 6.25%; N: 5.77%; Cl: 9.73%; Found: C: 62.26%; H: 6.18%; N: 5.66%; Cl: 9.87%.

EXAMPLE 55 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isobenzofuran-1(3H),4′-piperidine] (Compound No. 2-2006)

Yield: 63%; Mass spectrometric analysis (FAB) m/z: 641 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₈N₂O₆Cl₂.1/10H₂O: C: 63.47%; H: 5.98%; N: 4.35%; Cl: 11.02%; Found: C: 63.04%; H: 6.10%; N: 4.24%; Cl: 11.10%.

EXAMPLE 56 1-{2-[2-(3,4-Dichlorophenyl-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-1-methanesulfonylspiro(indoline-3,4′-piperidine) (Compound No. 2-2014)

Yield: 85%; Mass spectrometric analysis (FAB) m/z: 718 (M+H)⁺; Elemental analysis: Calculated for C₃₅H₄₁N₃O₇SCl₂: C: 58.49%; H: 5.75%; N: 5.85%; Cl: 9.87%; S: 4.46%. Found: C: 58.26%; H: 5.80%; N: 5.74%; Cl: 10.02%; S: 4.33%.

EXAMPLE 57 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine] (Compound No. 2-2008)

Yield: 78%; Mass spectrometric analysis (FAB) m/z: 657 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₈N₂O₅SCl₂H₂O: C: 60.44%; H: 5.97%; N: 4.15%; Cl: 10.49%; S: 4.74%; Found: C: 60.68%; H: 5.95%; N: 3.92%; Cl: 10.60%; S: 4.85%.

EXAMPLE 58 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-2-oxide (compound 2-2010)

Yield: 60%; Mass spectrometric analysis (FAB) m/z: 673 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₈N₂O₆SCl₂: C: 60.62%; H: 5.69%; N: 4.16%; Cl: 10.53%; S: 4.76%; Found: C: 60.50%; H: 5.94%; N: 4.09%; Cl: 10.35%; S: 4.71%.

EXAMPLE 59 1-{2-[2-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isoquinoline-1(2H),4′-piperidine]-3(4H-one (Compound No. 2-2015)

Yield: 80%; Mass spectrometric analysis (FAB) m/z: 668 (M+H)⁺; Elemental analysis: Calculated for C₃₅H₃₉N₃O₆Cl₂: C: 62.87%; H: 5.88%; N: 6.29%; Cl: 10.61%; Found: C: 62.95%; H: 5.98%; N: 6.07%; Cl: 10.77%.

EXAMPLE 60 1-{2-[2-(3,4-Dichlorophenyl)-4-(2-pyridylcarbonyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound No. 2-2353)

Yield: 73%; Mass spectrometric analysis (FAB) m/z: 567 (M+H)⁺; Elemental analysis: Calculated for C₃₀H₃₂N₄O₃Cl₂.1/2H₂O: C: 62.50%; H: 5.77%; N: 9.72%; Cl: 12.30%; Found: C: 62.19%; H: 5.88%; N: 9.39%; Cl: 13.12%.

EXAMPLE 61 1-{2-[2-(3,4-Dichlorophenyl)-4-(2-pyridylcarbonyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-2355)

Yield: 70%; Mass spectrometric analysis (FAB) m/z: 595 (M+H)⁺; Elemental analysis: Calculated for C₃₂H₃₆N₄O₃Cl₂.1/2H₂O: C: 63.57%; H: 6.17%; N: 9.27%; Cl: 11.73%; Found: C: 63.34%; H: 6.26%; N: 9.23%; Cl: 11.97%.

EXAMPLE 62 1-{2-[2-(3,4-Dichlorophenyl)-4-(2-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound No. 2-1585)

Yield: 75%; Mass spectrometric analysis (FAB) m/z: 596 (M+H)⁺; Elemental analysis: Calculated for C₃₂H₃₅N₃O₄Cl₂.1/2H₂O: C: 63.47%; H: 5.99%; N: 6.94%; Cl: 11.71%; Found: C: 63.02%; H: 6.12%; N: 6.74%; Cl: 12.97%.

EXAMPLE 63 1-{2-[2-(3,4-Dichlorophenyl-4-(2-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-1586)

Yield: 77%; Mass spectrometric analysis (FAB) m/z: 624 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₉N₃O₄Cl₂.1/2H₂O: C: 64.45%; H: 6.36%; N: 6.63%; Cl: 11.19%; Found: C: 64.29%; H: 6.42%; N: 6.68%; Cl: 11.57%.

EXAMPLE 64 1-{2-[2-(3,4-Dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound No. 2-1633)

Yield: 80%; Mass spectrometric analysis (FAB) m/z: 596 (M+H)⁺; Elemental analysis: Calculated for C₃₂H₃₅N₃O₄Cl₂.1/2H₂O: C: 63.47%; H: 5.99%; N: 6.94%; Cl: 11.71%; Found: C: 63.44%; H: 5.79%; N: 6.79%; Cl: 11.47%.

EXAMPLE 65 1-{2-[2-(3,4-Dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-1635)

Yield: 80%; Mass spectrometric analysis (FAB) m/z: 624 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₉N₃O₄Cl₂.1/5H₂O: C: 65.01%; H: 6.32%; N: 6.69%; Cl: 11.29%; Found: C: 64.79%; H: 6.47%; N: 6.42%; Cl: 10.93%.

EXAMPLE 66 1-{2-[2-(3,4-Dichlorophenyl)-4-(4-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound No. 2-1681)

Yield: 94%; Mass spectrometric analysis (FAB) m/z: 596 (M+H)⁺; Elemental analysis: Calculated for C₃₂H₃₅N₃O₄Cl₂.1/5H₂O: C: 64.04%; H: 5.95%; N: 7.00%; Cl: 11.82%; Found: C: 63.67%; H: 5.97%; N: 6.70%; Cl: 12.20%.

EXAMPLE 67 1-{2-[2-(3,4-Dichlorophenyl)-4-(4-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-1683)

Yield: 78%; Mass spectrometric analysis (FAB) m/z: 624 (M+H)⁺; Elemental analysis: Calculated for C₃₄H₃₉N₃O₄Cl₂: C: 65.38%; H: 6.29%; N: 6.73%; Cl: 11.35%; Found: C: 65.32%; H: 6.94%; N: 6.61%; Cl: 10.97%.

EXAMPLE 68 1-{2-[2-(3,4-Dichlorophenyl)-4-(2-pyrazinylcarbonyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound No. 2-2497)

Yield: 31%; Mass spectrometric analysis (FAB) m/z: 568 (M+H)⁺; Elemental analysis: Calculated for C₂₉H₃₁N₅O₃Cl₂.H₂O: C: 59.39%; H: 5.67%; N: 11.87%; Cl: 12.09%;. Found: C: 59.58%; H: 5.82%; N: 11.30%; Cl: 12.56%.

EXAMPLE 69 1-{2-[2-(3,4-Dichlorophenyl)-4-(2-pyrazinylcarbonyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-2499)

Yield: 33%; Mass spectrometric analysis (FAB) m/z: 596 (M+H)⁺; Elemental analysis: Calculated for C₃₁H₃₅N₅O₃Cl₂.H₂O: C: 60.58%; H: 6.07%; N: 11.40%; Cl: 11.54%; Found: C: 60.57%; H: 5.95%; N: 9.97%; Cl: 12.88%.

EXAMPLE 70 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide (Compound No. 2-1969)

70(a) 1-(Chloroacetyl)amino-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol

3.60 g (9.88 mmole) of 1-amino-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol [prepared as described in Example 1(e)], 1.64 ml (11.8 mmole) of triethylamine and 121 mg (0.99 mmole) of 4-dimethylaminopyridine were dissolved in 100 ml of methylene chloride, and 0.94 ml (11.8 mmole) of chloroacetyl chloride were added dropwise, whilst ice-cooling. The mixture was then stirred at the same temperature for 2 hours. At the end of this time, 100 ml of methylene chloride were added to the reaction mixture, and the resulting mixture was washed with ice-cooled 10% w/v aqueous hydrochloric acid, with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order. It was then dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of ethyl acetate and hexane ranging from 1:5 to 1:2 by volume as the eluent, to obtain 3.32 g (yield 76%) of the title compound as a colorless oil.

Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 7.64 (1H, doublet, J=2.1 Hz); 7.47 (1H, doublet, J=8.4 Hz); 7.28 (1H, doublet of doublets, J=8.4 & 2.1 Hz); 7.03 (1H, broad triplet), 5.27 (1H, singlet); 4.04 (2H, AB-quartet, J=15.1 Hz, Δδ=0.08 ppm); 3.81 (1H, doublet of triplets, J=10.5 & 3.7 Hz); 3.72 (1H, doublet of doublets, J=13.5 & 6.2 Hz); 3.53 (1H, doublet of doublets, J=10.9 & 2.3 Hz); 3.45 (1H, doublet of doublets, J=13.5 & 5.4 Hz); 2.24 (1H, doubled doublet of doublets, J=14.8, 10.9 & 4.1 Hz); 1.93 (1H, doublet of triplets, J=14.8 & 2.8 Hz); 0.92 (9H, singlet); 0.06 (3H, singlet); 0.00 (3H, singlet).

70(b) 2-[(2R)-(3,4-Dichlorophenyl)-5-oxomorpholin-2-yl]ethanol t-Butyldimethylsilyl Ether

219 mg (5.48 mmole) of sodium hydride (as a 60% w/v suspension in mineral oil) were suspended in 30 ml of anhydrous tetrahydrofuran, and a solution prepared by dissolving 1.61 g (3.65 mmole) of 1-(chloroacetyl)amino-4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-2-butanol [prepared as described in step (a) above] in 30 ml of anhydrous tetrahydrofuran was slowly added dropwise, whilst ice-cooling, over 30 minutes. The mixture was then stirred at the same temperature for 4 hours. At the end of this time, the reaction mixture was poured into ice-cooled 10% w/v aqueous hydrochloric acid and extracted three times, each time with 100 ml of ethyl acetate. The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, and the resulting residue was purified by silica gel flash column chromatography, using a gradient elution method, with mixtures of ethyl acetate and hexane ranging from 1:4 to 2:1 by volume as the eluent, to obtain 700 mg (yield 47%) of the title compound.

[α]_(D) ²⁴=+67.65 (c=0.81, methanol). Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 7.532 (1H, doublet, J=2.2 Hz); 7.526 (1H, doublet, J=8.1 Hz); 7.27 (1H, doublet of doublets, J=8.1 & 2.2 Hz); 6.76 (1H, broad singlet); 4.17 (2H, AB-quartet, J=17.3 Hz, Δδ=0.24 ppm); 3.98 (1H, doublet of doublets, J=13.0 & 3.9 Hz); 3.76 (1H, doublet of doublets, J=13.0 & 2.0 Hz); 3.63 (1H, multiplet); 3.29 (1H, multiplet); 2.12 (2H, multiplet); 0.91 (9H, singlet); 0.04 (3H, singlet); 0.03 (3H, singlet).

70(c) 2-[(2R)-(3,4-Dichlorophenyl)morpholin-2-yl]ethanol

580 mg (1.43 mmole) of 2-[(2R)-(3,4-dichlorophenyl)-5-oxomorpholin-2-yl]ethanol t-butyldimethylsilyl ether [prepared as described in step (b) above] were dissolved in 6 ml of anhydrous tetrahydrofuran. The solution was then heated under reflux under a stream of nitrogen and 0.60 ml (6.0 mmole) of a 10 M boranedimethyl sulfide complex was added dropwise. The mixture was then stirred for 2 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and 5 ml of 1 N aqueous hydrochloric acid were added. The mixture was then stirred at 100° C. for 1 hour. The reaction mixture was air-cooled, made basic by the addition of a 1 N aqueous solution of sodium hydroxide, diluted with a saturated aqueous solution of sodium chloride and then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 9:1 to 17:3 by volume as the eluent, to obtain 360 mg of the title compound.

[α]_(D) ²⁴=+16.22 (c=0.45, methanol).

The nuclear magnetic resonance spectrum, infrared spectrum and mass spectrometric analysis agreed with those of the racemate produced as described in Example 51(d).

70(d) 2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol

Following a procedure similar to that described in Example 51(e), but using 2-[(2R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol [prepared as described in step (c) above], the title compound was obtained in a yield of 92%.

[α]_(D) ²⁴=+30.65 (c=0.56, methanol).

The nuclear magnetic resonance spectrum, infrared spectrum and mass spectrometric analysis agreed with those of the racemate produced as described in Example 51(e).

70(e) 2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol Methanesulfonate

30.0 g (63.8 mmole) of 2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol [prepared as described in step (d) above] were dissolved in 500 ml of methylene chloride. 11.5 ml (83.0 mmole) of triethylamine and 5.93 ml (76.6 mmole) of methanesulfonyl chloride were then added, in that order, to the mixture, whilst ice-cooling, and the mixture was stirred at room temperature for 2 hours under a nitrogen atmosphere. The reaction mixture was then diluted with methylene chloride and washed with 1 N aqueous hydrochloric acid, and then with a saturated aqueous solution of sodium chloride, after which it was dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 1:4 to 1:9 by volume as the eluent, to give 34.8 g of the title compound.

[α]_(D) ²⁴+26.36 (c=0.66, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.90-7.80 (3H, multiplet); 6.52 (2H, singlet); 3.40-4.35 (8H, multiplet); 3.86 & 3.87 (total 9H, each singlet); 2.93 (3H, singlet); 2.10-2.55 (2H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2999, 2966, 2939, 2875, 1634, 1585; Mass spectrometric analysis (FAB) m/z: 548 (M+H)⁺.

70(f) 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-carboxamide

Following a procedure similar to that described in Example 51(g), but using 2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol methanesulfonate [prepared as described in step (e) above], the title compound was obtained in a yield of 79%.

[α]_(D) ²⁴=+7.53 (c=0.50, methanol). Elemental analysis: Calculated for C₃₄H₃₉N₃O₆Cl₂.1/5H₂O: C: 61.85%; H: 6.01%; N: 6.36%; Cl: 10.74%; Found: C: 61.51%; H: 6.18%; N: 6.13%; Cl: 10.72%.

The nuclear magnetic resonance spectrum, infrared spectrum and mass spectrometric analysis agreed with those of the racemate produced as described in Example 51(g).

The compounds of the following Examples 71-74 were produced following the same procedure as described in Example 70 above.

EXAMPLE 71 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]-ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-1971)

Yield: 84%; [α]_(D) ²⁴=+7.04 (c=0.45, methanol). Elemental analysis: Calculated for C₃₆H₄₈N₃O₆Cl₂: C: 62.69%; H: 7.02%; N: 6.09%; Cl: 10.28%; Found: C: 62.37%; H: 6.42%; N: 5.94%; Cl: 10.72%.

EXAMPLE 72 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H,4′-piperidine]-2-oxide (Compound No. 2-2010)

Yield: 66%; [α]_(D) ²⁴=−2.50 (c=0.50, methanol). Elemental analysis: Calculated for C₃₄H₃₈N₂O₆SCl₂: C: 60.62%; H: 5.69%; N: 4.16%; Cl: 10.53%; S: 4.76%; Found: C: 60.17%; H: 5.68%; N: 4.00%; Cl: 10.47%; S: 4.55%.

EXAMPLE 73 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isoquinoline-1(2H),4′-piperidin]-3(4H)-one (Compound No. 2-2015)

Yield: 75%; [α]_(D) ²⁴=+2.58 (c=0.40, methanol). Elemental analysis: Calculated for C₃₅H₃₉N₃O₆Cl₂: C: 62.87%; H: 5.88%; N: 6.29%; Cl: 10.61%; Found: C: 62.46%; H: 6.01%; N: 6.08%; Cl: 9.63%.

EXAMPLE 74 1-{2-[(2R)-(3,4-Dichlorophenyl-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}-4-phenylpiperidine-4-(N,N-dimethylcarboxamide) (Compound No. 2-1635)

Yield: 78%; [α]_(D) ²⁴=+9.67 (c=0.50, methanol). Elemental analysis: Calculated for C₃₄H₃₉N₃O₄Cl₂.1/5H₂O: C: 65.01%; H: 6.32%; N: 6.69%; Cl: 11.29%; Found: C: 64.84%; H: 6.46%; N: 6.52%; Cl: 11.58%.

EXAMPLE 75 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidine-5-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (Compound No. 3-10)

600 mg (1.12 mmole) of 2-[(5R)-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)oxazolidin-5-yl]ethanol methanesulfonate [prepared as described in Example 1(g)], 318 mg (1.23 mmole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide hydrochloride (prepared as described in Preparation 6), 283 mg (3.37 mmole) of sodium hydrogencarbonate, and 280 mg (1.69 mmole) of sodium iodide were suspended in 10 ml of anhydrous dimethylformamide, and the mixture was heated at 80° C. for 8 hours under a nitrogen atmosphere. The reaction mixture was then poured into 100 ml of a saturated aqueous solution of sodium chloride and then extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, and then the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 40:1 to 20:1 by volume as the eluent, and then crystallized from diisopropyl ether, to give 496 mg of the title compound as white crystals.

[α]_(D) ²⁴+41.0 (c=1, methanol). HPLC analysis; Column: YMC-Pack ODS-A (250×4.6 mmφ); Eluent: CH₃CN:H₂O=40:60, 0.1% AcONH₄; Flow rate: 1.0 ml/min; Retention time: 28.6 min; Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.1-7.6 (7H, multiplet); 6.70 (2H, singlet); 4.9-5.3 (total 2H, broad singlet); 4.32 (1H, doublet, J=16.7 Hz); 4.00 (1H, doublet, J=16.7 Hz); 3.7-4.2 (2H, multiplet); 3.87 & 3.89 (total 9H, each singlet); 1.5-3.1 (12H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2940, 1642, 1584, 1416, 1237, 1128. Mass spectrometric analysis (FAB) m/z 659 (M+H)⁺; Elemental analysis; Calculated for C₃₃H₃₆N₂O₆SCl₂.1/2H₂O: C: 59.28%; H: 5.58%; N: 4.19%; S: 4.79%; Cl: 10.60%; Found: C: 59.36%; H: 5.58%; N: 4.12%; S: 4.73%; Cl: 10.60%.

EXAMPLE 76 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (Compound No. 3-42)

76(a) 4-(t-Butyldimethylsilyloxy)-(2R)-(3,4-dichlorophenyl)-1-[N-(t-butoxycarbonyl)-N-(2-hydroxyethyl)amino]-2-butanol

39.9 g (109 mmole) of 4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)butane-1,2-diol [prepared as described in Example 1(c)] were dissolved in 80 ml of pyridine, and 31.3 g (164 mmole) of p-toluenesulfonyl chloride were added to the resulting solution. The mixture was then stirred at room temperature for 2 days under a nitrogen atmosphere. At the end of this time, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with water and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was dissolved in 600 ml of acetonitrile, and 35.0 g (329 mmole) of lithium perchlorate and 33.4 g (547 mmole) of 2-aminoethanol were added to the resulting solution. The mixture was then heated under reflux for 16 hours. At the end of this time, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, and washed with a saturated aqueous solution of sodium chloride. The organic layer was then separated and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dissolved in 700 ml of methylene chloride. 22.8 ml (164 mmole) of triethylamine and 26.3 g (120 mmole) of di-t-butyl dicarbonate were added to the resulting solution, and the mixture was stirred at room temperature for 12 hours. The reaction mixture was then poured into water and extracted with methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 4:1 to 7:3 by volume as the eluent, to give 49.9 g of the title compound.

[α]_(D) ²⁴+3.92 (c=0.72, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.30-7.75 (3H, multiplet); 5.30 & 5.57 (total 1H, each broad singlet); 3.05-4.00 (9H, multiplet); 2.00-2.40 (2H, multiplet); 1.53 (9H, singlet); 0.94 (9H, singlet); 0.09 (3H, singlet); 0.07 (3H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3420, 2957, 2933, 2885, 2861, 1687. Mass spectrometric analysis (FAB) m/z: 508 (M+H)⁺.

76(b) 2-[4-t-Butoxycarbonyl-(2R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-Butyldimethylsilyl Ether

49.9 g (98.1 mmole) of 4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)-1-[N-(t-butoxycarbonyl)-N-(2-hydroxyethyl)amino]-2-butanol [prepared as described in step (a) above] and 30.9 g (118 mmole) of triphenylphosphine were dissolved in 600 ml of dried toluene. 51.3 g of a 40% w/v toluene solution containing 118 mmole of diethyl azodicarboxylate were added dropwise to the resulting solution at room temperature under a nitrogen atmosphere, and the mixture was stirred for 2 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 47:3 to 23:2 by volume as the eluent, to give 43.2 g of the title compound.

[α]_(D) ²⁴+32.67 (c=0.60, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.56 (1H, broad singlet); 7.43 (1H, doublet, J=9 Hz); 7.28 (1H, doublet of doublets, J=2 & 9 Hz); 3.00-4.55 (8H, multiplet); 1.80-2.10 (2H, multiplet); 1.35-1.60 (9H, broad singlet); 0.85 (9H, singlet); −0.01 (6H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (CHCl₃): 2957, 2931, 2859, 1687. Mass spectrometric analysis (FAB) m/z: 490 (M+H)⁺.

76(c) (2R)-(3,4-Dichlorophenyl)-2-(2-hydroxyethyl)morpholine Hydrochloride

43.1 g (87.9 mmole) of 2-[4-t-butoxycarbonyl-(2R)-(3,4-dichlorophenyl)morpholin-2-yl]ethanol t-butyldimethylsilyl ether [prepared as described in step (b) above] were dissolved in 600 ml of a 4 N solution of hydrogen chloride in dioxane, and the mixture was stirred at 60° C. for 4 hours. At the end of this time, the solvent was removed by distillation under reduced pressure, and diethyl ether was added to the resulting residue. The solvent was then removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol/ethyl acetate, to give 24.1 g of the title compound.

[α]_(D) ²⁴+48.07 (c=0.57, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, hexadeuterated dimethyl sulfoxide) δ ppm: 8.60-9.80 (2H, broad singlet); 7.72 (1H, singlet); 7.70 (1H, doublet, J=9 Hz); 7.44 (1H, doublet of doublets, J=2 & 9 Hz); 4.53 (1H, broad singlet); 3.89 (1H, doublet of triplets, J=4 & 13 Hz); 3.75 (1H, doublet, J=14 Hz); 3.68 (1H, multiplet); 3.30-3.45 (2H, multiplet); 2.93-3.13 (3H, multiplet); 2.09 (1H, multiplet); 1.90 (1H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3378, 2966, 2893, 2812, 2783, 2724, 2656, 2530, 1598. Mass spectrometric analysis (FAB) m/z: 276 (M+H)⁺ (free form).

76(d) 2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol

22.9 g (82.9 mmole) of (2R)-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine hydrochloride [prepared as described in step (c) above] were suspended in 500 ml of methylene chloride. 27.6 ml (199 mmole) of triethylamine, 21.0 g (91.0 mmole) of 3,4,5-trimethoxybenzoyl chloride, and 100 mg of 4-dimethylaminopyridine were then added to the resulting suspension, and the mixture was stirred at room temperature for 12 hours. At the end of this time, the reaction mixture was poured into water and extracted with methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and acetone ranging from 4:1 to 7:3 by volume as the eluent, to give 30.0 g of the title compound.

[α]_(D) ²⁴+30.65 (c=0.56, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.80-7.80 (3H, multiplet); 6.47 (2H, singlet); 3.40-4.80 (8H, multiplet); 3.84 & 3.86 (total 9H, each singlet); 1.75-2.25 (2H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3429, 2940, 2838, 1630, 1585. Mass spectrometric analysis (EI) m/z: 469 (M⁺).

76(e) [(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanal

0.88 ml (10.1 mmole) of oxalyl chloride was dissolved in 10 ml of methylene chloride, and 5 ml of a methylene chloride solution containing 0.79 ml (11.1 mmole) of dimethyl sulfoxide were added dropwise to the resulting solution at −78° C. under a nitrogen atmosphere. The mixture was then stirred for 30 minutes. 10 ml of a methylene chloride solution containing 950 mg (2.02 mmole) of 2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol [prepared as described in step (d) above] were added dropwise to the resulting mixture, and the mixture was stirred for 4 hours. At the end of this time, a further 2.24 ml (16.2 mmole) of triethylamine was added, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was then poured into water and extracted with methylene chloride. The organic extract was washed with water, and then with a saturated aqueous solution of sodium chloride, after which it was dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and acetone ranging from 23:2 to 21:4 by volume as the eluent, to give 878 mg of the title compound.

[α]_(D) ²⁴+36.15 (c=0.65, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 9.56 (1H, singlet); 6.90-7.80 (3H, multiplet); 6.50 (2H, singlet); 3.40-4.60 (6H, multiplet); 3.85-3.87 (total 9H, each singlet); 2.70-3.05 (2H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2962, 2930, 2838, 1723, 1636, 1585. Mass spectrometric analysis (FAB) m/z: 468 (M+H)⁺.

76(f) 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

15.00 g (27.4 mmole) of 2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethanol methanesulfonate [prepared as described in Example 70(e)], 7.76 g (30.1 mmole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide hydrochloride (prepared as described in Preparation 6), 6.89 g (82.0 mmole) of sodium hydrogencarbonate, and 6.81 g (41.0 mmole) of potassium iodide were suspended in 150 ml of anhydrous dimethylformamide. The mixture was then heated at 80° C. for 8 hours under a nitrogen atmosphere. The reaction mixture was then poured into 400 ml of a saturated aqueous solution of sodium chloride and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 40:1 to 20:1 by volume as the eluent, and then crystallized from hexane, to give 15.5 g of the title compound as white crystals.

[α]_(D) ²⁴+14.0 (c=1, methanol). HPLC analysis; Column: YMC-Pack ODS-A (250×4.6 mmφ); Eluent: CH₃CN:H₂O=40:60, 0.1% AcONH₄; Flow rate: 1.0 ml/min; Retention time: 23.7 min; Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.1-7.8 (7H, multiplet); 6.49 (2H, broad singlet); 4.31 (1H, doublet, J=16.8 Hz); 3.99 (1H, doublet, J=16.8 Hz); 3.86 & 3.84 (total 9H, each singlet); 3.3-4.0 (6H, multiplet); 1.5-3.1 (12H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2939, 1636, 1584, 1464, 1426, 1329, 1237, 1128. Mass spectrometric analysis (FAB) m/z: 673 (M+H)⁺. Elemental analysis: Calculated for C₃₄H₃₈N₂O₆SCl₂.1/2H₂O: C: 59.82%; H: 5.76%; N: 4.10%; S: 4.70%; Cl, 10.39%; Found: C: 60.20%; H: 6.14%; N: 4.04%; S: 4.54%; Cl, 10.38%.

76(g) 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

150 mg (0.32 mmole) of [(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholine-2-yl]ethanal [prepared as described in step (e) above] and 99 mg (0.38 mmole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2)-oxide hydrochloride (prepared as described in Preparation 6) were dissolved in 1 ml of methanol. 100 mg of molecular sieves 3A (powder) and 209 mg (3.33 mmole) of sodium cyanoborohydride were added to the resulting solution, and the mixture was heated under reflux for 8 hours under a nitrogen atmosphere. The reaction mixture was filtered through a Celite (trade mark) filter aid. The filtrate was poured into water and extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 97:3 to 19:1 by volume as the eluent, to give 184 mg of the title compound. Various physico-chemical properties of this product agreed with those of the product synthesised as described in Example 76(f).

EXAMPLE 77 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-[(3-isopropoxyphenyl)acetyl]morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (Compound No. 3-811)

77(a) 2-{(2R)-(3,4-Dichlorophenyl)-4-[(3-isopropoxyphenyl)acetyl]morpholin-2-yl}ethanol

1.03 g (5.28 mmole) of 3-isopropoxyphenylacetic acid were dissolved in 50 ml of methylene chloride, and 1.10 g (5.76 mmole) of WSC.HCl (Water Soluble Carbodiimide.HCl), 780 mg (5.76 mmole) of 1-hydroxybenzotriazol.H₂O, 1.61 ml (11.5 mmole) of triethylamine, and 1.50 g (4.80 mmole) of (2R)-(3,4-dichlorophenyl)-2-(2-hydroxyethyl)morpholine hydrochloride [prepared as described in Example 76(c)] were added to the resulting solution, in that order. The mixture was then stirred at room temperature for 15 hours under a nitrogen atmosphere. At the end of this time, a saturated aqueous solution of ammonium chloride was added to the reaction mixture, which was then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 3:1 to 2:1 by volume as the eluent, to give 1.81 g of the title compound.

[α]_(D) ²⁴−8.2 (c=0.60, methanol). Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 6.45-7.57 (7H, multiplet); 4.74 (1H, doublet, J=13.9 Hz); 4.37-4.52 (1H, multiplet); 3.22-3.90 (9H, multiplet); 2.10-2.21 (1H, broad singlet); 1.87-2.09 (2H, multiplet); 1.30 (3H, singlet); 1.28 (3H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3693, 3622, 3589, 2981, 2934, 1645, 1608, 1583. Mass spectrometric analysis (FAB) m/z: 452 (M+H)⁺.

77(b) 2-{(2R)-(3,4-Dichlorophenyl)-4-[(3-isopropoxyphenyl)acetyl]morpholin-2-yl}ethanol Methanesulfonate

1.81 g (4.00 mmole) of 2-{(2R)-(3,4-dichlorophenyl)-4-[(3-isopropoxyphenyl)acetyl]morpholin-2-yl}ethanol [prepared as described in step (a) above] were dissolved in 5 ml of pyridine, and 45 mg (0.40 mmole) of 4-dimethylaminopyridine and 0.46 ml (6.00 mmole) of methanesulfonyl chloride were added to the resulting solution, whilst ice-cooling. The mixture was then stirred at 0° C. for 2 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was poured into ice-cooled 10% w/v aqueous hydrochloric acid, and then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 1:1 to 1:2 by volume as the eluent, to give 2.00 g of the title compound as a colorless oil.

[α]_(D) ²⁴−6.3 (c=0.70, methanol). Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 6.51-7.59 (7H, multiplet); 4.40-4.63 (2H, multiplet); 3.17-4.26 (9H, multiplet); 2.93 (3H, singlet); 2.08-2.32 (2H, multiplet); 1.31 (3H, singlet); 1.29 (3H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2981, 2934, 1645, 1608, 1583. Mass spectrometric analysis (FAB) m/z: 530 (M+H)⁺.

77(c) 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-[(3-isopropoxyphenyl)acetyl]morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

630 mg (1.19 mmole) of 2-{(2R)-(3,4-dichlorophenyl)-4-[(3-isopropoxyphenyl)acetyl]morpholin-2-yl}ethanol methanesulfonate [prepared as described in step (b) above], 367 mg (1.43 mmole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide hydrochloride (prepared as described in Preparation 6), 299 mg (3.56 mmole) of sodium hydrogencarbonate, and 296 mg (1.78 mmole) of potassium iodide were suspended in 6 ml of anhydrous dimethylformamide, and the suspension was heated at 80° C. for 6 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was poured into a saturated aqueous solution of sodium chloride and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a 25:1 by volume mixture of methylene chloride and methanol as the eluent, and then crystallized from hexane, to give 400 mg of the title compound as white crystals, melting at 85-88° C.

[α]_(D) ²⁴+2.5 (c=0.51, methanol). HPLC analysis; Column: YMC-Pack ODS-A (250×4.6 mmφ); Eluent: CH₃CN:H₂O=60:40, 0.1% AcONH₄; Flow rate: 1.0 ml/min; Retention time: 23.7 min; Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.55-7.61 (11H, multiplet); 4.71 (1H, doublet, J=13.8 Hz); 4.40-4.51 (1H, multiplet); 4.31 (3H, doublet, J=16.8 Hz); 3.99 (1H, doublet, J=16.8 Hz); 3.25-3.85 (8H, multiplet); 2.56-2.97 (2H, multiplet); 2.01-2.45 (6H, multiplet); 1.88-2.45 (2H, multiplet); 1.48-1.59 (1H, multiplet); 1.30 (3H, singlet); 1.29 (3H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2975, 2923, 1645, 1607, 1582, 1047. Mass spectrometric analysis (FAB) m/z: 655 (M+H)⁺; Elemental analysis; Calculated for C₃₅H₄₀N₂O₄SCl₂.1/2H₂O: C: 63.25%; H: 6.22%; N: 4.21%; S: 4.82%; Cl: 10.67%; Found: C: 62.96%; H: 6.38%; N: 4.08%; S: 4.71%; Cl: 10.41%.

EXAMPLE 78 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (Compound No. 3-74)

78(a) 4-(t-Butyldimethylsilyloxy)-(2R)-(3,4-dichlorophenyl)-1-[N-(t-butoxycarbonyl)-N-(3-hydroxypropyl)amino]-2-butanol

Following a procedure similar to that described in Example 76(a), but using 5.00 g (13.7 mmole) of 4-t-butyldimethylsilyloxy-(2R)-(3,4-dichlorophenyl)butane-1,2-diol [prepared as described in Example 1(c)] and 5.15 g (68.6 mmole) of 3-amino-1-propanol as the starting materials, 6.00 g of the title compound were obtained.

[α]_(D) ²⁴−1.31 (c=1.22, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.20-7.70 (3H, multiplet); 5.04 & 5.32 (total 1H, each singlet); 3.15-3.85 (9H, multiplet); 1.95-2.30 (2H, multiplet); 1.65-1.85 (2H, multiplet); 1.45 (9H, singlet); 0.86 (9H, singlet); −0.08 & −0.01 (total 6H, each singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (CHCl₃): 3432, 2957, 2885, 2861, 1675. Mass spectrometric analysis (FAB) m/z: 522 (M+H)⁺;

78(b) 2-[4-t-Butoxycarbonyl-(2R)-(3,4-dichlorophenyl)hexahydro-1,4-oxazepin-2-yl]ethanol t-Butyldimethylsilyl Ether

300 mg (0.57 mmole) of 4-(t-butyldimethylsilyloxy)-(2R)-(3,4-dichlorophenyl)-1-[N-(t-butoxycarbonyl)-N-(3-hydroxypropyl)amino]-2-butanol [prepared as described in step (a) above] were dissolved in 2 ml of pyridine, and 196 mg (1.03 mmole) of p-toluenesulfonyl chloride were added to the resulting solution. The mixture was then stirred at room temperature for 16 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was poured into water and extracted with ethyl acetate. The organic extract was washed with water and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dissolved in 3 ml of 2-methyl-2-propanol, and 67 mg (0.58 mmole) of potassium t-butoxide were added to the resulting solution. The mixture was then heated at 80° C. for 8 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was cooled to room temperature, poured into water, and then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 47:3 to 23:2 by volume as the eluent, to give 56 mg of the title compound.

[α]_(D) ²⁴+14.19 (c=0.74, methanol). Nuclear Magnetic Resonance Spectrum (270 MHz, CDCl₃) δ ppm: 7.17-7.65 (3H, multiplet); 3.10-4.10 (8H, multiplet); 1.75-2.30 (4H, multiplet); 1.37 & 1.44 (total 9H, each singlet); 0.82 (9H, singlet); −0.07 & −0.05 (total 6H, each singlet). Mass spectrometric analysis (FAB) m/z: 504 (M+H)⁺.

78(c) 2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethanol Methanesulfonate

Following a procedure similar to that described in Examples 76(c), 76(d) and 70(e), but using 2-[4-t-butoxycarbonyl-(2R)-(3,4-dichlorophenyl)hexahydro-1,4-oxazepin-2-yl]ethanol t-butyldimethylsilyl ether [prepared as described in step (b) above], the title compound was obtained in a 65% yield.

[α]_(D) ²⁴+19.41 (c=0.45, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.20-7.65 (3H, multiplet); 6.62 (2H, singlet); 0.75-4.90 (12H, multiplet); 3.87 & 3.89 (total 9H, each singlet); 2.86 (3H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2935, 1637, 1585. Mass spectrometric analysis (FAB) m/z: 562 (M+H)⁺.

78(d) 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

Following a procedure similar to that described in Example 76(f), but using 2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)hexahydro-1,4-oxazepin-2-yl]ethanol methanesulfonate [prepared as described in step (c) above], the title compound was obtained in a 59% yield.

[α]_(D) ²⁴+19.33 (c=0.1, methanol). HPLC analysis; Column: YMC-Pack ODS-A (250×4.6 mmφ); Eluent: CH₃CN:H₂O=40:60, 0.1% AcONH₄; Flow rate: 1.0 ml/min; Retention time: 17.7 min; Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.15-7.75 (7H, multiplet); 6.62 (2H, broad singlet); 0.75-4.80 (29H, multiplet); 4.29 (1H, doublet, J=17 Hz); 3.97 (1H, doublet, J=17 Hz). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2928, 2855, 2836, 1637, 1584. Mass spectrometric analysis (FAB) m/z: 687 (M+H)⁺.

EXAMPLE 79 1-{3-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]propyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (Compound No. 3-42)

79(a) Methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate

8.50 g (84.9 mmole) of succinic anhydride and 24.8 g (93.0 mmole) of aluminum bromide were added, in that order, to 150 ml of 1,2-dichlorobenzene, and the mixture was stirred at room temperature for 5 hours. At the end of this time, the reaction mixture was poured into ice-cold water and extracted with methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dissolved in 100 ml of methanol. 1.0 ml sulfuric acid was added to the resulting solution, and the mixture was heated under reflux for 4 hours. At the end of this time, the reaction mixture was cooled to room temperature, poured into water, and then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium hydrogencarbonate and with a saturated aqueous solution of sodium chloride, in that order, after which it was dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and diethyl ether ranging from 17:3 to 7:3 by volume as the eluent, to give 9.10 g of the title compound as pale orange crystals.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 8.07 (1H, doublet, J=2 Hz); 7.81 (1H, doublet of doublets, J=2 & 8 Hz); 7.56 (1H, doublet, J=8 Hz); 3.71 (3H, singlet); 3.27 (2H, triplet, J=7 Hz); 2.78 (2H, triplet, J=7 Hz). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3093, 3061, 2954, 1746, 1678, 1583. Mass spectrometric analysis (EI) m/z: 260 (M⁺).

79(b) Methyl 4-(3,4-dichlorophenyl)-4-pentenoate

1.75 g (49.0 mmole) of methyltriphenylphosphonium bromide and 5.50 g (49.0 mmole) of potassium t-butoxide were suspended in 200 ml of dried benzene, and the mixture was stirred at room temperature for 6 hours under a nitrogen atmosphere. At the end of this time, 8.50 g of methyl 4-(3,4-dichlorophenyl)-4-oxobutanoate [prepared as described in step (a) above] were dissolved in 40 ml of benzene, and the resulting solution was added to the reaction mixture. The mixture was then stirred for 1 hour. The reaction mixture was then poured into water and extracted with ethyl acetate. The organic extract was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and diethyl ether ranging from 19:1 to 23:2 by volume as the eluent, to give 4.20 g of the title compound as a pale orange oil.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.48 (1H, doublet, J=2 Hz); 7.40 (1H, doublet, J=8 Hz); 7.23 (1H, doublet of doublets, J=2 & 8 Hz); 5.32 (1H, singlet); 5.14 (1H, singlet); 3.67 (3H, singlet); 2.79 (2H, triplet, J=8 Hz); 2.48 (2H, triplet, J=8 Hz). Infrared absorption spectrum ν_(max)cm⁻¹ (film): 2952, 1740, 1630, 1550. Mass spectrometric analysis (EI) m/z: 258 (M⁺).

79(c) 4-(3,4-Dichlorophenyl)-4-penten-1-ol t-Butyldimethylsilyl Ether

Following a procedure similar to that described in Example 1(b), but using methyl 4-(3,4-dichlorophenyl)-4-pentenoate [prepared as described in step (b) above], the title compound was obtained in a 93% yield.

Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.49 (1H, doublet, J=2 Hz); 7.38 (1H, doublet, J=9 Hz); 7.24 (1H, doublet of doublets, J=2 & 9 Hz); 5.30 (1H, singlet); 5.13 (1H, doublet, J=1 Hz); 3.62 (2H, triplet, J=6 Hz); 2.52 (2H, triplet, J=8 Hz); 1.60-1.68 (2H, multiplet); 0.90 (9H, singlet); 0.04 (6H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (film): 2954, 2929, 2887, 2858, 1627, 1550. Mass spectrometric analysis (FAB) m/z: 345 (M+H)⁺.

79(d) (2R)-5-t-Butyldimethylsilyloxy-2-(3,4-dichlorophenyl)pentane-1,2-diol

Following a procedure similar to that described in Example 1(c), but using 4-(3,4-dichlorophenyl)-4-penten-1-ol t-butyldimethylsilyl ether [prepared as described in step (c) above], the title compound was obtained in a 94% yield.

Optical purity: 98% ee; [α]_(D) ²⁴−2.08 (c=0.48, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.56 (1H, doublet, J=2 Hz); 7.41 (1H, doublet, J=8 Hz); 7.23 (1H, doublet of doublets, J=2 & 8 Hz); 4.96 (1H, singlet); 3.53-3.70 (4H, multiplet); 1.98-2.14 (3H, multiplet); 1.35-1.57 (2H, multiplet); 0.91 (9H, singlet); 0.082 (3H, singlet); 0.078 (3H, singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (CHCl₃): 3584, 3311, 2956, 2932, 2861. Mass spectrometric analysis (FAB) m/z: 379 (M⁺).

79(e) (2R)-5-(t-Butyldimethylsilyloxy)-2-(3,4-dichorophenyl)-1-[N-(t-butoxycarbonyl)-N-(2-hydroxyethyl)amino]-2-pentanol

Following a procedure similar to that described in Example 76(a), but using (2R)-5-t-butyldimethylsilyloxy-2-(3,4-dichlorophenyl)pentane-1,2-diol [prepared as described in step (d) above], the title compound was obtained in a 95% yield.

[α]_(D) ²⁴−14.75 (c=0.61, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.15-7.65 (3H, multiplet); 5.30 & 5.79 (total 1H, each singlet); 2.50-3.95 (9H, multiplet); 1.85-2.25 (2H, multiplet); 1.30-1.60 (2H, multiplet); 1.43 (9H, singlet); 0.89 (9H, singlet); 0.04 & 0.05 (total 6H, each singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3355, 2955, 2931, 2894, 2858, 1668. Mass spectrometric analysis (FAB) m/z: 522 (M+H)⁺.

79(f) (2R)-3-[4-t-Butoxycarbonyl-2-(3,4-dichlorophenyl)morpholin-2-yl]-1-propanol t-Butyldimethylsilyl Ether

Following a procedure similar to that described in Example 76(b), but using (2R)-5-(t-butyldimethylsilyloxy)-2-(3,4-dichorophenyl)-1-[N-(t-butoxycarbonyl)-N-(2-hydroxyethyl)amino]-2-pentanol [prepared as described in step (e) above], the title compound was obtained in a 92% yield.

[α]_(D) ²⁴+58.15 (c=0.54, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.40-7.65 (3H, multiplet); 4.14 (1H, doublet, J=14 Hz); 3.42-3.75 (5H, multiplet); 3.23 (2H, doublet, J=14 Hz); 1.15-2.00 (4H, multiplet); 1.44 & 1.52 (total 9H, each broad singlet); 0.85 (9H, singlet); 0.00 & 0.01 (total 6H, each singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (CHCl₃): 2957, 2931, 2860, 1668. Mass spectrometric analysis (FAB) m/z: 504 (M+H)⁺.

79(g) 3-[(2R)-(3,4-Dichlorophenyl-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]-1-propanol

3.43 g (6.80 mmole) of (2R)-3-[4-t-butoxycarbonyl-2-(3,4-dichlorophenyl)morpholin-2-yl]-1-propanol t-butyldimethylsilyl ether [prepared as described in step (f) above] were dissolved in 60 ml of methylene chloride, and 2.98 g (15.0 mmole) of B-bromocatecholborane were added to the resulting solution. The mixture was then stirred at room temperature for 2 hours under a nitrogen atmosphere. At the end of this time, 60 ml of water were poured into the reaction mixture, which was then stirred for a further 2 hours. The mixture was then made basic by the addition of a 1 N aqueous solution of sodium hydroxide and then extracted with methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The resulting residue was dissolved in 40 ml of methylene chloride, and 1.23 ml (8.87 mmole) of triethylamine, 1.65 g (7.15 mmole) of 3,4,5-trimethoxybenzoyl chloride and 10 mg of 4-dimethylaminopyridine were added to the resulting solution. The mixture was then stirred at room temperature for 12 hours. At the methylene chloride. The organic extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography using a 7:3 by volume mixture of methylene chloride and acetone as the eluent, to give 2.13 g of the title compound.

[α]_(D) ²⁴+30.78 (c=methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.80-7.80 (multiplet); 6.48 (2H, broad singlet); 3.30-4.80 (8H, multiplet); 3.84 & 3.86 (total 9H, each singlet); 1.10-2.35 (4H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3426, 2942, 2872, 1632, 1584. Mass spectrometric analysis m/z: 484 (M+H)⁺.

79(h) 3-[(2R)-(3,4-Dichlorophenyl-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]-1-propanol Methanesulfonate

Following a procedure similar to that described in Example 70(e), but using 3-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]-1-propanol [prepared as described in step (g) above], the title compound was obtained in a 84% yield.

[α]_(D) ²⁴+27.87 (c=0.54, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.80-7.80 (3H, multiplet); 6.50 (2H, singlet); 3.20-4.50 (8H, multiplet); 3.85 & 3.86 (total 9H, each singlet); 2.97 (3H, singlet); 1.35-2.35 (4H, multiplet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 3001, 2939, 2875, 2839, 1634, 1585. Mass spectrometric analysis (FAB) m/z: 562 (M+H)⁺.

79(i) 1-{3-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]propyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

Following a procedure similar to that described in Example 76(g), but using 3-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]-1-propanol methanesulfonate [prepared as described in step (h) above], the title compound was obtained in a 68% yield.

[α]_(D) ²⁴+26.97 (c=0.55, methanol). HPLC analysis; Column: YMC-Pack ODS-A (250×4.6 mmφ); Eluent: CH₃CN:H₂O=40:60, 0.1% AcONH₄; Flow rate: 1.0 ml/min; Retention time: 23.4 min; Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 6.80-7.80 (7H, multiplet); 6.48 (2H, broad singlet); 0.80-4.70 (20H, multiplet); 4.32 (1H, doublet, J=17 Hz); 4.00 (1H, doublet, J=17 Hz); 3.84 & 3.86 (total 9H, each singlet). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 2940, 2872, 2834, 2771, 1636, 1584. Mass spectrometric analysis (FAB) m/z: 687 (M+H)⁺.

EXAMPLE 80 1-{2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4-dimethoxybenzenesulfonyl)oxazolidin-5-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (Compound No. 3-2055)

80(a) 2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4-dimethoxybenzenesulfonyl)oxazolidin-5-yl]ethanol t-Butyldimethylsilyl Ether

1.00 g (2.72 mmole) of 2-[(5R)-(3,4-dichlorophenyl)oxazolidin-5-yl]ethanol t-butyldimethylsilyl ether [prepared as described in the first part of Example 1(f)] was dissolved in 10 ml of pyridine, and 773 mg (3.27 mmole) of 3,4-dimethoxybenzenesulfonyl chloride were added to the resulting solution, whilst ice-cooling. The mixture was then stirred for 2 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was poured into 100 ml of ice-cooled 10% w/v aqueous hydrochloric acid, and then extracted with ethyl acetate. The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 10:1 to 2:1 by volume as the eluent, to give 1.27 g of the title compound as white crystals.

[α]_(D) ²⁴−5.74 (c=1.29, methanol). Infrared absorption spectrum ν_(max)cm⁻¹ (KBr): 1588, 1510, 1468, 1264, 1155, 1140.

80(b) 2-[(5R)-(3,4-Dichlorophenyl)-3-(3,4-dimethoxybenzenesulfonyl)oxazolidin-5-yl]ethanol Methanesulfonate

1.19 g (2.06 mmole) of 2-[(5R)-(3,4-dichlorophenyl)-3-(3,4-dimethoxybenzenesulfonyl)oxazolidin-5-yl]ethanol t-butyldimethylsilyl ether [prepared as described in step (a) above] were dissolved in 20 ml of a 3:3:1 by volume mixture of acetic acid, tetrahydrofuran and water, and the resulting mixture was then heated at 80° C. for 2 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was then neutralised with a saturated aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was dissolved in 10 ml of pyridine. 23 mg (0.19 mmole) of 4-dimethylaminopyridine and 0.22 ml (2.84 mmole) of methanesulfonyl chloride were then added to the resulting solution, whilst ice-cooling. The mixture was then stirred for 2 hours at 0° C. under a nitrogen atmosphere. At the end of this time, the reaction mixture was poured into 200 ml of ice-cooled 10% w/v aqueous hydrochloric acid, and then extracted with ethyl acetate, The organic extract was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of hexane and ethyl acetate ranging from 2:1 to 1:2 by volume as the eluent, to give 992 mg of the title compound as white crystals.

[α]_(D) ²⁴−3.80 (c=0.5, methanol). Nuclear Magnetic Resonance Spectrum (400 MHz, CDCl₃) δ ppm: 7.33 (1H, doublet, J=8.6 Hz); 7.30 (1H, doublet of doublets, J=8.6 & 2.1 Hz); 7.14 (1H, doublet, J=2.2 Hz); 7.11 (1H, doublet, J=2.1 Hz); 6.92 (1H, doublet of doublets, J=8.7 & 2.2 Hz); 6.80 (1H, doublet, J=8.7 Hz); 5.08 (1H, doublet, J=5.7 Hz); 4.98 (1H, doublet, J=5.7 Hz); 4.11 (1H, multiplet); 3.94 (3H, singlet); 3.86 (3H, singlet); 3.82 (1H, multiplet); 3.70 (2H, AB-quartet, J=11.3 Hz, Δδ=0.08 ppm); 2.88 (3H, singlet); 2.16 (2H, multiplet). Mass spectrometric analysis (FAB) m/z: 540 (M+H)⁺.

80(c) 1-{2-[(5R)-(3,4-Dichlorophenyl-3-(3,4-dimethoxybenzenesulfonyl)-oxazolidin-5-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide

105 mg (0.19 mmole) of 2-[(5R)-(3,4-dichlorophenyl)-3-(3,4-dimethoxybenzenesulfonyl)oxazolidin-5-yl]ethanol methanesulfonate [prepared as described in step (b) above], 55 mg (0.21 mmole) of spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide hydrochloride (prepared as described in Preparation 6), 49 mg (0.58 mmole) of sodium hydrogencarbonate, and 48 mg (0.29 mmole) of potassium iodide were suspended in 2 ml of anhydrous dimethylformamide. The resulting mixture was then heated at 80° C. for 8 hours under a nitrogen atmosphere. At the end of this time, the reaction mixture was poured into 10 ml of a saturated aqueous solution of sodium chloride and extracted with ethyl acetate. The organic extract was dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography, using a gradient elution method, with mixtures of methylene chloride and methanol ranging from 40:1 to 20:1 by volume as the eluent, and then crystallized from diisopropyl ether, to give 82 mg of the title compound as white crystals.

[α]_(D) ²⁴+2.5 (c=0.52, methanol). HPLC analysis Column: YMC-Pack ODS-A (250×4.6 mmφ) Eluent: CH₃CN:H₂O=40:60, 0.1% AcONH₄ Flow rate: 1.0 ml/min Retention time: 21.4 min Infrared absorption spectrum ν_(max) cm⁻¹ (KBr): 1674, 1587, 1509, 1469, 1350, 1264, 1155, 1140, 1039. Mass spectrometric analysis (FAB) m/z: 665 (M+H)⁺.

EXAMPLE 81 1-{2-[(2R)-(3,4-Dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}-1-methylspiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide iodide (the methyl iodide salt of Compound No. 3-42)

300 mg (0.45 mmole) of 1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H),4′-piperidine]-(2S)-oxide (prepared as described in Example 76) were dissolved in 3 ml of acetonitrile, and 30 μl (0.48 mmole) of methyl iodide were added to the resulting solution. The mixture was then stirred overnight at room temperature under a nitrogen atmosphere. At the end of this time, the solvent was removed by distillation under reduced pressure. The resulting residue was crystallized from diisopropyl ether, to give 312 mg of the title compound as pale-yellow crystals.

[α]_(D) ²⁴+42.0 (c=1.0, methanol). HPLC analysis Column: YMC-Pack ODS-A (250×4.6 mmφ) Eluent: CH₃CN:H₂O=40:60, 0.1% AcONH₄ Flow rate: 1.0 ml/min Retention time: 9.9 mm Infrared absorption spectrum ν_(max) cm⁻¹ (KBr): 3444, 1632, 1584, 1464, 1126. Mass spectrometric analysis (FAB) m/z: 687 (free form, M⁺) Elemental analysis: Calculated for C₃₅H₄₁N₂O₆SCl₂I: C: 51.54%; H: 5.07%; N: 3.44%; S: 3.93%; Cl: 8.69%; I: 15.56%. Found: C: 51.14%; H: 5.39%; N: 3.42%; S: 4.01%; Cl: 8.50%; I: 15.96%. 

We claim:
 1. A method for the treatment of an inflammatory disease which comprises administering to an animal suffering from said inflammatory disease a pharmaceutically effective amount of a compound of the following formula (I):

or a quaternary ammonium ion thereof of the following formula (Ia):

or a pharmaceutically acceptable salt or ester thereof, wherein: R¹ and R² are the same as or different from each other, and each represents a carbocyclic aryl group, said aryl group being unsubstituted or being substituted by at least one substituent selected from the group consisting of substituents α, defined below; A represents a methylene group, a carbonyl group or a sulfonyl group; B represents a single bond between the groups represented by A and R¹, an alkylene group having from 1 to 4 carbon atoms or an alkenylene group having from 2 to 4 carbon atoms; D represents an oxygen atom; E represents an alkylene group having 2 carbon atoms; G represents an alkylene group having from 1 to 4 carbon atoms or an alkenylene group having from 2 to 4 carbon atoms; L represents a group of formula —C(R⁴)(R⁵)— wherein R⁴ and R⁵ together with the carbon atom to which they are attached represent a heterocyclic group having from 5 to 10 ring atoms which is unsubstituted or substituted by at least one substituent selected from the group consisting of substituents β defined below, said heterocyclic group having a single hetero-atom selected from the group consisting of a nitrogen atom, an oxygen and a sulfur atom, or R⁴ and R⁵ together with the carbon atom to which they are attached represent said heterocyclic group which is fused to a carbocyclic aryl group or an aromatic heterocyclic group, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent selected from the group consisting of substituents a defined below; R⁷ represents a straight or branched alkyl group having from 1 to 6 carbon atoms; and said substituents α are selected from the group consisting of a halogen atom, an alkyl group having from 1 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, an aliphatic carboxylic acyl group having from 1 to 6 carbon atoms, an alkanesulfonyl group having from 1 to 6 carbon atoms, a haloalkanesulfonyl group having from 1 to 6 carbon atoms, a hydroxy group, a carboxy group, an alkoxycarbonyl group having from 1 to 6 carbon atoms in the alkoxy part, an acylamino group having from 1 to 6 carbon atoms, an alkanesulfonylamino group having from 1 to 6 carbon atoms, a haloalkanesulfonylamino group having from 1 to 6 carbon atoms, an amino group, a cyano group, and an alkylene group having from 1 to 8 carbon atoms to form a cycloalkyl group fused with the aryl or heterocyclic ring; said substituents β are: when substituting a carbon atom, an oxo group, or when substituting a nitrogen atom, selected from the group consisting of an aliphatic acyl group, an alkanesulfonyl group having from 1 to 6 carbon atoms, an alkyl group having from 1 to 6 carbon atoms which is unsubstituted or is substituted by at least one substituent selected from the group consisting of substituents γ, defined below, a carbocyclic aryl group which is unsubstituted or is substituted by at least one substituent selected from the group consisting of said substituents α, and an aralkyl group in which an alkyl group having from 1 to 4 carbon atoms is substituted by from 1 to 3 carbocyclic aryl groups as defined above, or when substituting a sulfur atom, one or two oxygen atoms form a sulfoxide or sulfone group; and said substituents γ are selected from the group consisting of a halogen atom, an alkoxy group having from 1 to 6 carbon atoms, an aliphatic carboxylic acyl group having from 1 to 6 carbon atoms, an alkanesulfonyl group having from 1 to 6 carbon atoms, a haloalkanesulfonyl group having from 1 to 6 carbon atoms, a hydroxy group, a carboxy group, an alkoxycarbonyl group having from 1 to 6 carbon atoms in the alkoxy part, an acylamino group having from 1 to 6 carbon atoms, an amino group and a cyano group.
 2. The method of claim 1, wherein E is an ethylene group.
 3. The method of claim 1, wherein R¹ and R² are the same or different and each represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of said substituents α; A is a carbonyl group; B is a single bond; and G is an alkylene group having from 1 to 4 carbon atoms.
 4. The method of claim 2, wherein R¹ and R² are the same or different and each represents a carbocyclic aryl group, or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α; A is a carbonyl group; B is a single bond; and G is an alkylene group having from 1 to 4 carbon atoms.
 5. The method of claim 1, wherein R⁴ and R⁵ together with the carbon atom to which they are attached represent a group of formula:

J represents an alkylene group having from 1 to 6 carbon atoms; Ar represents a ring carbocyclic aryl group or aromatic heterocyclic group fused to the ring containing J and S, said aryl group and said aromatic heterocyclic group being unsubstituted or being substituted by at least one substituent selected from the group consisting of substituents α, defined above; and S*→O represents a sulfoxide group in which the sulfur atom is in the S-configuration.
 6. The method of claim 5, wherein R¹ represents a carbocyclic group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α; R² represents a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α; A represents a carbonyl group; B represents a single bond; G represents a C₁₋₄ alkylene group; J represents a C₁₋₁₄ alkylene group; and the ring Ar represents an unsubstituted carbocyclic aryl group, a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α or an aromatic heterocyclic group.
 7. The method of claim 1, wherein the inflammatory disease is selected from the group consisting of rheumatism and arthrosis deformans.
 8. The method of claim 1, wherein the method is for treatment of an inflammatory disease.
 9. The method of claim 2, wherein the R¹ and R² are the same or different and each is an unsubstituted carbocyclic aryl group, or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α.
 10. The method of claim 2, wherein R² is an unsubstituted carbocyclic group or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α.
 11. The method of claim 2, wherein A is a carbonyl group.
 12. The method of claim 2, wherein B is a single bond.
 13. The method of claim 2, wherein G is an alkylene group having from 1 to 4 carbon atoms.
 14. The method of claim 2, wherein G is an alkylene group having from 2 or 3 carbon atoms.
 15. The method of claim 9, wherein R² is an unsubstituted carbocyclic aryl group or a carbocyclic group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α.
 16. The method of claim 15, wherein A is a carbonyl group.
 17. The method of claim 16, wherein B is a single bond.
 18. The method of claim 17, wherein G is an alkylene group having 1 to 4 carbon atoms.
 19. The method of claim 18, wherein G is an alkylene group having 2 or 3 carbon atoms.
 20. The method of claim 5, wherein R¹ is an unsubstituted carbocyclic aryl group, or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α.
 21. The method of claim 5, wherein R¹ is an unsubstituted carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of an alkyl group having from 1 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms, and an alkoxy group having from 1 to 6 carbon atoms.
 22. The method of claim 5, wherein R¹ is an unsubstituted carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of said substituents α.
 23. The method of claim 5, wherein R² is an unsubstituted carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 halogen atoms.
 24. The method of claim 5, wherein A is a carbocyclic group.
 25. The method of claim 5, wherein B is a single bond.
 26. The method of claim 5, wherein E is an ethylene group.
 27. The method of claim 5, wherein G is a C₁₋₄ alkylene group.
 28. The method of claim 5, wherein G is a C₂₋₃ alkylene group.
 29. The method of claim 5, wherein J is a C₁₋₄ alkylene group.
 30. The method of claim 5, wherein J is a methylene or ethylene group.
 31. The method of claim 5, wherein the ring Ar is an aryl group, an aryl group substituted with from 1 to 3 substituents selected from the group consisting of substituents α or an aromatic heterocyclic group.
 32. The method of claim 5, wherein the ring Ar is a carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of substituents α.
 33. The method of claim 5, wherein R¹ is an unsubstituted carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 substituents selected from the group consisting of an alkyl group having from 1 to 6 carbon atoms, a haloalkyl group having from 1 to 6 carbon atoms and an alkoxy group having from 1 to 6 carbon atoms; R² is an unsubstituted carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 halogen atoms; A is a carbonyl group; B is a single bond; E is an ethylene group; G is a C₂₋₃ alkylene group; J is a methylene or ethylene group; and the ring Ar is an unsubstituted carbocyclic aryl group or a carbocyclic aryl group substituted with from 1 to 3 groups selected from the group consisting of said substituents α.
 34. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isobenzofuran-1(3H), 4′-piperidine] or a pharmaceutically acceptable salt or ester thereof.
 35. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperdine] or a pharmaceutically acceptable salt or ester thereof.
 36. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-2-oxide or a pharmaceutically acceptable salt or ester thereof.
 37. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[isoquinoline-1(2H), 4′-piperidine]-3(4H)-one or a pharmaceutically acceptable salt or ester thereof.
 38. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[isobenzofuran-1(3H), 4′-piperidine] or a pharmaceutically acceptable salt or ester thereof.
 39. The method of claim 1 wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[isobenzo[c]thiophene-1(3H), 4′-piperidine] or a pharmaceutically acceptable salt or ester thereof.
 40. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-2-oxide or a pharmaceutically acceptable salt or ester thereof.
 41. The method of claim 1, wherein the compound is 1-{2-[2(3,4-dichlorophenyl)-4-(3-methoxybenzoyl)morpholin-2-yl]ethyl]spiro[isoquinoline-1(2H), 4′-piperidine]-3(4H)-one or a pharmaceutically acceptable salt or ester thereof.
 42. The method of claim 1, wherein the compound is 1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-(2S)-oxide or a pharmaceutically acceptable salt or ester thereof.
 43. The method of claim 1, wherein the compound is 1-{2-[(2R)-(4-chlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-2S)-oxide or a pharmaceutically acceptable salt or ester thereof.
 44. The method of claim 1, wherein the compound is 1-{2-[(2R)-(4-fluorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2-yl]ethyl]spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-2(S)-oxide or a pharmaceutically acceptable salt or ester thereof.
 45. The method of claim 1, wherein the compound is 1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3-isopropoxyphenylacetyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-2S-oxide or a pharmaceutically acceptable salt or ester thereof.
 46. The method of claim 1, wherein the compound is 1-(2-[(2R)-(4-chlorophenyl)-4-(3-isopropoxyphenylacetyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine]-(2S)-oxide or a pharmaceutically acceptable salt or ester thereof.
 47. The method of claim 1, wherein the compound is 1-{2-[(2R)-(4-fluorophenyl)-4(3-isopropoxyphenylacetyl)morpholin-2-yl]ethyl}spiro[benzo[c]thiophene-1(3H), 4′-piperidine](2S)-oxide or a pharmaceutically acceptable salt or ester thereof.
 48. The method of claim 1, wherein R⁴ and R⁵, together with the carbon atom to which they are attached, represent a heterocyclic group which is fused to an aromatic heterocyclic group selected from the group consisting of furyl, thienyl, pyrrolyl, azepinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, pyranyl, pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl.
 49. The method of claim 1, wherein the administering is orally.
 50. The method of claim 1, wherein the administering is parenterally.
 51. The method of claim 49, wherein the administering is to a patient in a dose of 0.01 mg/kg body weight to 100 mg/kg body weight. 